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Luis Arturo Martinez-Lemus Curriculum Vitae (December 2016)

ADDRESS

Professional

Department of Medical Pharmacology and Physiology Dalton Cardiovascular Research Center University of Missouri-Columbia 134 Research Park Drive Columbia, MO 65211 USA

Phone: 573-882-3244 Fax: 573-884-4232 E-Mail: martinezlemusl@missouri.edu

EDUCATION Postdoctoral Training

Texas A&M University System Health Science Center, College Station, Texas 77843. Field of study: Medical Physiology with emphasis on vascular smooth muscle cell biology and the microcirculation. Preceptor: Dr. G.A. Meininger. (January 1999-December 2004).

Ph.D.

Texas A&M University, College Station, Texas 77843. Major field: Avian Physiology. GPA: 4.00/4.00. Advisor: Dr. T.W. Odom. Dissertation title: ”Implications of the functional characteristics of the heart and pulmonary vasculature of chickens in pulmonary hypertension syndrome.” (December 1998).

M.S.

Auburn University, Auburn, Alabama 36849. Major Field: Avian Physiology. GPA: 3.91/4.00. Advisor: Dr. G.R. McDaniel. Thesis title: ”Endocrinology of tibial dyschondroplasia in broiler chickens”. (June 1994).

D.V.M.

Universidad Nacional Autonoma de México (UNAM), Mexico City, Mexico. Concentration in Avian Medicine. GPA 10.00/10.00 with honors. (January 1991).

PROFESSIONAL POSITIONS Current

• Associate Professor: Department of Medical Pharmacology and Physiology, and Dalton Cardiovascular Research Center Investigator, University of Missouri-Columbia, Columbia, Missouri. (September 2012-Present)

• Courtesy Joint Appointment Faculty: Department of Biological Engineering, University of Missouri-Columbia, Columbia, Missouri. (February 2012-Present).

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Past

• Assistant Professor: Department of Medical Pharmacology and Physiology, and Dalton Cardiovascular Research Center Investigator, University of Missouri-Columbia, Columbia, Missouri. (November 2005-August 2012)

• Research Assistant Professor: Department of Medical Physiology, College of Medicine, Texas A&M University, College Station, Texas. (January 2005-November 2005).

• Assistant Research Scientist: Department of Medical Physiology, College of Medicine, Texas

A&M University, College Station, Texas. (July 2002-December 2004). • Postdoctoral Fellow: Department of Medical Physiology, College of Medicine, Texas A&M

University, College Station, Texas. (July 2000-June 2002). • Postdoctoral Research Associate: Department of Medical Physiology, College of Medicine,

Texas A&M University System Health Science Center, College Station, Texas. (January 1999-June 2000).

• Visiting Scientist: Physiologisches Institut-Lehrstuhl Vegetative Physiologie, Medizinische

Fakultät, Ludwig Maximilians Universität München, Germany. (August 1999-August 2000).

• Research Associate: Poultry Science Department, Texas A&M University, College Station, Texas. (June 1994-December 1998).

• Foreign Officials Course Interpreter: Poultry Inspection Course. Translating English to Spanish

and vice versa during lectures and visitations to poultry processing plants. (January 1997). • Research Assistant: Poultry Science Department, Auburn University, Auburn, Alabama.

(June1991-May 1994). • Academic Assistant: Department of Avian Medicine and Zootechnics, UNAM, Mexico City,

Mexico. (January 1990-May 1991).

• Laboratory Assistant: Laboratory of Avian Pathology, UNAM, Mexico City, Mexico. (January 1988-December 1989).

HONORS AND AWARDS

• APS CV-Section Fellow: Honored as Fellow of the American Physiological Society (Cardiovascular Section). (April 2014).

• Trainee travel award: Awarded travel expenses by the National Heart, Lung and Blood Institute, National Institutes of Health (NHLBI, NIH) to attend the XIIIth International Vascular Biology Meeting in Toronto, Canada. (July 2004).

• Research Career Enhancement Award: Selected by the American Physiological Society as a

recipient of one of the 2002 Research Career Enhancement awards ($4,000.00). (July 2002).

• Certificate of Excellence Award: Awarded for giving the best graduate student presentation in the physiology section of the annual Poultry Science Association meeting at Penn State University, State College, PA. (August 1998).

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• Tom Slick Graduate Research Fellowship Award: Selected by the College of Agriculture and

Life Sciences of Texas A&M University as a recipient of the Tom Slick Graduate Research Fellowship Award. (1998).

• Awarded an honorary diploma as a graduate student excelling in leadership and academic

achievement by the Office of Special Programs at Auburn University. (1994).

• Phi Kappa Phi: Honorary Society. (1994). • Honored as one of the top ten master's students at Auburn University. (1993).

• Gamma Sigma Delta: Honorary Society of Agriculture. (1992). • Winner of one of 25 National Feed Ingredients Association scholarships awarded nationwide to

students with outstanding scholastic and leadership records. (1991). • Awarded a silver medal by El Diario de Mexico for being one of the best students in Mexico.

(1990). • Awarded the silver medal Gabino Barreda for being the best student of the 1989 class in the

College of Veterinary Medicine, UNAM, Mexico City, Mexico. (1990). • Best Research Presentation Award: Received at the 16a ANECA-40th WPDC Acapulco,

Mexico. (1990). • Awarded an honorary diploma for being the best student in the College of Veterinary Medicine,

UNAM, Mexico City, Mexico. (1985, 1986, 1987, 1988, 1989). HONORS AND AWARDS BY TRAINEES

• John R. Pappenheimer Postdoctoral Travel Award: Awarded to Marius C. Staiculescu by the Microcirculatory Society to attend the 2013 Experimental Biology Meeting in Boston, MA.

• Zweifach Student Travel Award: Awarded to Francisco I. Ramirez-Perez by the Microcirculatory Society to attend the 2016 Experimental Biology Meeting in San Diego CA.

PROFESSIONAL SOCIETIES

• European Society for Microcirculation • American Physiological Society • Microcirculatory Society • Poultry Science Association

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GRANT SUPPORT Extramural Pending

• National Institutes of Health (NIH). “Restoring vasodilator actions of insulin in patients with type 2 diabetes.” Principal Investigator, Jaume Padilla. Co-Investigator, Luis A. Martinez-Lemus (15% Effort), $1,250,000.00 for 2017-2021.

• National Institutes of Health (NIH). “Endothelial Mineralocorticoid Receptor Activation of ENaC mediates Aortic and Cardiac Fibrosis and Stiffness.” Principal Investigator, James Sowers. Co-Investigator, Luis A. Martinez-Lemus (5% Effort), $1,250,000.00 for 2017-2021.

• National Institutes of Health (NIH). “Role of Macrophage Recruitment in Modulating Cell Specific

MR induced Cardiac Stiffness.” Principal Investigator, James Sowers. Co-Investigator, Luis A. Martinez-Lemus (5% Effort), $1,250,000.00 for 2017-2021.

• National Institutes of Health (NIH). “Smooth muscle mineralocorticoid receptors, coronary

vascular dysfunction, and obesity-associated cardiac diastolic dysfunction in females.” Principal Investigator, Shawn Bender. Co-Investigator, Luis A. Martinez-Lemus (5% Effort), $1,250,000.00 for 2017-2021.

Current

• National Institutes of Health (NIH). “Mechanisms of Microvascular Remodeling Progression.” Principal Investigator, Luis A. Martinez-Lemus (30% Effort). Competitive Renewal, $1,000,000.00 for 2016-2019.

• National Institutes of Health (NIH). “Mineralocorticoid and Estrogen Receptor Alpha Signaling in the Pathogenesis of Vascular Stiffness in Insulin Resistance.” Principal Investigator, Camila Manrique. Mentor, Luis A. Martinez-Lemus (No Charge). K08 Award $605,600.00 for 2015-2020.

• National Science Foundation (NSF). “Collaborative Research: Sens-and Act Systems for Substance Release Modeling Drug Delivery Triggered by Immune-Sensing Based on Nanostructured Electrodes.” Multi-Investigator Grant. Principal Investigator, Evgeny Katz. Co-Principal Investigator Luis A. Martinez-Lemus (5% Effort), $440,541.00 for 2014-2017.

• Department of Veterans Affairs. CDA-2 IK2 BX002030-01, Career Development Award.

Mineralocorticoid Receptor-Mediated Vascular Insulin Resistance.” Principal Investigator, Shawn Bender. Collaborator, Luis A. Martinez-Lemus (No Charge), $778,545.00 for 2013-2018.

Past

• National Institutes of Health (NIH). “Mechanisms of Microvascular Remodeling Progression.” Principal Investigator, Luis A. Martinez-Lemus (40% Effort), $1,250,000.00 for 2009-2014. One year No-Cost extension to 2015. Scored at 120 (3.5%).

• National Institutes of Health (NIH). “Mechanisms of Microvascular Control and Coordination in Health and Disease.” Principal Investigator, Gerald A. Meininger. Core Director, Luis A.

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Martinez-Lemus (15% Effort), $8,470,000.00 for 2010-2014. One year No-Cost extension to 2015.

• American Heart Association. Postdoctoral Fellowship #0225084Y. “Mechanisms of Acute Remodeling in Resistance Arteries” Principal investigator, Luis A. Martinez-Lemus (100% effort), $82,000.00 for 2002-2004.

• American Heart Association. Scientist Development Grant. “Remodeling of the Resistance

Vasculature: Early Mechanisms.” Principal Investigator, Luis A. Martinez-Lemus (50% effort), $260,000.00 for 2005-2008.

Intramural Past

• University of Missouri, Research Board. “Oxidative Stress and Vascular Remodeling.” Principal Investigator, Luis A. Martinez-Lemus, $49,698.00 for 2009-2010.

• University of Missouri-Columbia, Program for Research Infrastructure and Matching Expenses (PRIME) Fund. “A Confocal / Multiphoton Microscopy System” Principal Investigator, Luis A. Martinez-Lemus (Instrumentation), $53,000.00 for 2007.

PROFESSIONAL ACTIVITIES Extramural Grant Review

• NIH, Special Emphasis Panel. ZRG1 CB-T(30)I. Shared Instrumentation: Confocal Microscopy and Imaging Review Group, Fall 2016.

• Veterans Affairs Office of Research. Cardiology B (CARB; vascular disease) panel, Summer 2016, Fall 2016.

• NIH, Special Emphasis Panel. ZRG1. Vascular and Hematology Integrated Review Group, Summer 2016.

• NIH Review Study-University of Wisconsin-Madison, 2016. • American Heart Association – National. Vascular Biology and Blood Pressure/Regulation, 2016. • American Heart Association – National. Vascular Wall Biology, 2014. • Science Foundation Ireland (ad hoc), 2010. • CONICYT, Chile (ad hoc), 2010. • American Heart Association – National. Member, Vascular Biology and Blood Pressure/

Regulation, 2006-2010. • USDA/NRI Animal Health and Well-Being (ad hoc), 2003.

Intramural Grant Review

• University of Missouri Institute for Clinical and Translational Science (iCATS) (ad hoc), 2010. • University of Missouri Research Board – 2009, 2014. • University of Missouri NSF Major Research Instrumentation Program, Track 1 Instrument

Acquisition, Pre-selection (2015)

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Committees International

• International Society for Resistance Arteries (ISRA) 2014 Tri-annual Conference Organization Scientific Committee (2013-2014)

National

• Elected Microcirculatory Society: Treasurer (2016-2018) • American Physiological Society: Fellowship Committee (2016-2019) • Microcirculatory Society: Finance Committee (2014-2016) • American Physiological Society: NIH Liaison Committee (2012-2015) • Elected Microcirculatory Society: Councilor (2011-2014) • Microcirculatory Society: Membership Committee (2010-2013) • American Physiological Society-Cardiovascular Section: Fellowship Committee (2008-2011) • Microcirculatory Society: Program Committee (2007-2010)

University

• Appointed member of the 2016 Search Committee for a tenure-track position at the Department of Medical Pharmacology and Physiology, University of Missouri – Columbia.

• Appointed member of the 2016 Cardiovascular Day Organizing Committee, University of Missouri – Columbia (2016).

• Appointed member of the Appointment and Promotions Committee for non-tenure track faculty within the Dalton Cardiovascular Research Center, University of Missouri-Columbia (2006-present).

• Appointed member of the Dalton Cardiovascular Research Center Safety Committee (2009-Present).

• Appointed member of the Gender and Racial Diversity Equity Council Representation. School of Medicine, University of Missouri-Columbia (2009-2012).

• Appointed member of the School of Medicine Research Council, University of Missouri-Columbia (2009-2012).

• Appointed member of the 2010 Cardiovascular Day Organizing Committee, University of Missouri – Columbia (2010).

• Appointed member of the Committee on developing guidelines for Joint appointments at the Department of Medical Pharmacology and Physiology (2009).

• Appointed Co-Director of the Microscopy Imaging Core at the Dalton Cardiovascular research Center, University of Missouri-Columbia (2007-PRESENT).

• Appointed member of the Curriculum Committee for the Department of Medical Pharmacology and Physiology, University of Missouri-Columbia (2007).

• Appointed member of the Structure and Function of the Graduate Education Committee for the Department of Medical Pharmacology and Physiology, University of Missouri-Columbia (2007).

• Appointed member of the committee for the control of Salmonella and New Castle Disease in Poultry, Mexico City, Mexico. (1991).

• Elected student representative at the University Congress, UNAM, Mexico City, Mexico. (1990). • Elected president of the 1989 class of veterinary students, College of Veterinary Medicine,

UNAM, Mexico City, Mexico. (1989). • Appointed as student member of the Library Council, College of Veterinary Medicine, UNAM,

Mexico City, Mexico. (1988-1990). • Elected student member of the University Council, UNAM, Mexico City, Mexico (1988-1990).

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Department of Veterans Affairs

• Appointed member of the subcommittee for animal studies, at the Harry S. Truman Memorial Veterans Hospital, 800 Hospital Drive Columbia, MO 65201(December 2016-2019).

• Appointed member of the subcommittee for animal studies, at the Harry S. Truman Memorial Veterans Hospital, 800 Hospital Drive Columbia, MO 65201(December 2013-2016).

Scientific Meetings

• Session Moderator for “Cardiovascular Day.” University of Missouri-Columbia, Columbia, MO, February 23, 2016.

• Chairman of the session entitled “The Role of Cytoskeletal Structures in Tone Development”

held at the Smooth Muscle Underground meeting in Boston, MA on April 19, 2013. • Co-Organizer of the Smooth Muscle Underground 2013 meeting held at the Omni Parker House

Hotel in Boston, MA on Friday April 19, 2013. • Served as Judge for the Dean’s Award and Poster Presentations at the 2011 School of

Medicine Research Day on November 3, 2011. Columbia, MO. • Served as Judge for the Dean’s Award and Poster Presentations at the 2010 School of

Medicine Research Day on November 11, 2010. Columbia, MO. • Session Moderator for “Cardiovascular Day.” University of Missouri-Columbia, Columbia, MO,

February 16, 2010. • Co-Chairman of the Symposium entitled “Spotlight on Remodeling (Part I): Cellular and

Molecular Mechanisms” held at the 9th World Congress for Microcirculation, Paris, France, September 25-28, 2010.

• Session Moderator for “Cardiovascular Day.” University of Missouri-Columbia, Columbia, MO,

February 16, 2009. • Served as Judge for the Poster Presentations at the 2009 School of Medicine Research Day on

November 12, 2009. Columbia, MO. • Co-Chairman of the session entitled “The Role of Hemodynamic Factors in Angioadaptation”

held at the 8th World Congress for Microcirculation, Milwaukee, Wisconsin, August 15-19, 2007.

Scientific Journals Editorship

• Associate Editor for “Frontiers in Physiology-Vascular Physiology,” 2016-Present. • Editorial Board Member for “CardioRenal Medicine,” 2012-Present. • Editorial Board Member for “Microcirculation,” 2010-2015. • Review Editorial Board for “Frontiers in Vascular Physiology,” 2010-2015.

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• Associate Editor for the Physiology and Reproduction section of “Poultry Science,” 2003-2009. Reviewer

• Journal of Vascular Research • Arteriosclerosis, Thrombosis, and Vascular Biology • American Journal of Physiology • Clinical and Experimental Medicine • The Anatomical Record • BMC Cell Biology • Hospital Practice • Microcirculation • Hypertension • Clinical and Experimental Pharmacology and Physiology • Anatomical Record • PLOS-One • Biomechanics and Modeling in Mechanobiology (BMMB) • Scientific Reports • Frontiers • Journal of Regenerative Medicine and Tissue Engineering • Journal of Visualized Experiments (JoVE) • Journal of Physiology and Pharmacology • Biochimica et Biophysica Acta (BBA) Molecular Cell Research • Microvascular Research • Metalloproteinases in Medicine • The Journal of Physiology • Diabetology and Metabolic Syndrome

Invited Presentations

• Resistance Artery Plasticity: Role of the smooth muscle cytoskeleton. University of Georgia. Athens, GA, USA (November 7, 2016).

• Vascular Remodeling: Role of the smooth muscle cytoskeleton. Georgia State University. Atlanta, GA, USA (October 5, 2016).

• Vascular Smooth muscle cell stiffness and arterial remodeling. University of Southern Denmark. Odense, Denmark (June 16, 2015).

• Vascular Smooth muscle cell stiffness and arterial remodeling. Danish Cardiovascular Research Academy, 2015 Summer Meeting at The Sandbjerg Estate. Sonderborg, Denmark (June 11, 2015).

• Local mechanisms of resistance artery remodeling. University of Calgary. Calgary, Canada.

(February 18, 2015).

• Effects of maternal obesity and the use of ART on offspring health. Reproductive Biology, Fall 2014 Seminar Series. University of Columbia, MO (September 17, 2014).

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• Role of the vascular smooth muscle cytoskeleton on the inward remodeling of resistance arteries. International Symposium on Resistance Arteries (ISRA) 2014. Banff, Canada (September 7-11, 2014).

• Mecanismos de la remodelación hacia adentro en las arterias de resistencia. Universidad de Guadalajara, Centro Univesitario de los Lagos. Lagos de Moreno, México (May 2014).

• Mechanisms of vascular wall plasticity in resistance arteries. Kansas City University of Medicine and Biosciences. Kansas City, MO 64112 (December 2013).

• Characteristics of the internal elastic lamina in inwardly remodeled arteries. Joint meeting of The British Microcirculation Society and The Microcirculatory Society. Keble College, University of Oxford, U.K. (July 4-6, 2012).

• Acute Adaptations of vascular smooth muscle cells in continuously constricted resistance arteries. Presentation at the symposium “Physiological remodeling of resistance arteries” Experimental Biology 2012, San Diego, CA (April 2012).

• Searching the route from vasoconstriction to inward remodeling. Department of Physiology and Pharmacology, Center for Cardiovascular and Respiratory Sciences, Robert C. Byrd Health Sciences Center, West Virginia University. Morgantown, WV 26506 (September 2011).

• Reducing the deficit: From vasoconstriction to remodeling. Department of Biomedical Sciences, College of Veterinary Medicine, University of Missouri-Columbia. Columbia, MO 65211, (September 2011).

• Early mechanisms of vasoconstriction-induced arteriolar remodeling. 10th International Symposium on resistance Arteries. Rebild, Denmark, May, 2011.

• The Role of Reactive Oxygen Species and Matrix Metalloproteinases in Small Artery

remodeling. 9th World Congress for Microcirculation. Paris, France, September 26, 2010.

• Small artery plasticity and smooth muscle length regulation. 2010 Annual Meeting of the Societies for Experimental Biology. Anaheim, CA, April 28, 2010.

• The role of integrins in the control of skeletal muscle arteriolar diameter. 2008 APS Intersociety Meeting: The Integrative Biology of Exercise-V. Hilton Head, South Carolina, USA (September 24-27 2008).

• Integrins in the Acute and Chronic Control of Vascular Diameter. Department of Biomedical

Sciences, College of Veterinary Medicine, University of Missouri-Columbia. Columbia, MO 65211, (February 2008).

• Vascular smooth muscle cell plasticity and vascular remodeling. In the symposium ““The Role of

Hemodynamic Factors in Angioadaptation.” 8th World Congress for Microcirculation, Milwaukee, Wisconsin (August, 2007).

• Intrinsic acute and chronic control of vascular diameter in the microcirculation. Hospital “20 de

Noviembre” ISSSTE, Mexico City, Mexico (November 2006).

• Cellular plasticity: An early mechanism in vascular remodeling. Department of Medical Pharmacology and Physiology, University of Missouri-Columbia, Columbia, Missouri. (2005).

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• Mechanisms for long-term regulation of vascular tone: Cellular plasticity and Vascular remodeling. Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas. (2004).

• Vascular smooth muscle cell plasticity: A mechanism of vascular remodeling in hypertension.

Department of Medical Physiology, Texas A&M University, College Station, Texas. (2004). • Extracellular matrix and integrin interactions: Do smooth muscle cells move as part of adaptive

remodeling event. In the symposium “Mechanisms of vascular remodeling: Temporal events from stimulus to structural and functional changes.” Experimental Biology 2002, New Orleans, LA. (April 2002).

• Cardiovascular Function and Pulmonary Hypertension. Department of Animal and Poultry

Science, University of Guelph, Guelph, Ontario, Canada. (2001).

• The Chicken as a Model of Pulmonary Hypertension. Department of Medical Physiology, Texas A&M University, College Station, Texas. (1998).

• Pulmonary Hypertension Syndrome in Broiler Chickens. Department of Poultry Science, Auburn

University, Auburn, Alabama. (1998). TEACHING EXPERIENCE 2009-2016 Teaching advance imaging techniques (Fuorescence, Confocal and Multiphoton

Microcopy) as part of the course entitled “Skills in Biomedical Research” (course # MPP8420).

2009-2016 Coordinating the Journal Club for graduate students at the Department of Medical

Pharmacology and Physiology, University of Missouri-Columbia (course # MPP9422). 2008-2016 Teaching Microvascular Function to graduate students in the Department of Medical

Pharmacology and Physiology, University of Missouri-Columbia (course # MPP9434). 2010-2016 Teaching Extracellular Matrix-Dependent signaling to graduate students in the course

entitled “Transmembrane Signaling” within the Department of Medical Pharmacology and Physiology, University of Missouri-Columbia (course #MPP9426).

2010-2016 Tutor for second year medical students in the Problem Based Learning Course for

Endocrinology and the Gastrointestinal Systems. 2014-2015 Tutor for second year medical students in the Problem Based Learning Course for

Pathophysiology I, School of Medicine, University of Missouri-Columbia. 2013 Tutor for second year medical students in the Problem Based Learning Course for

Respiratory and Cardiovascular Systems. 2009-2013 Final presentation instructor for the curse of Epigenetics in the Department of Animal

Sciences, University of Missouri-Columbia. 2008-2009 Final presentation instructor for the curse of Physiology in the Department of Biomedical

Sciences, University of Missouri-Columbia.

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2005 Teaching Human Physiology (Cardiovascular Physiology) to students accepted in the

Joint Admission Medical Program (JAMP) created by the Texas Legislature, Texas A&M University, College Station, Texas.

2005 Teaching Cardiovascular Physiology to graduate students (Cardiovascular Sciences

689), Texas A&M University, College Station, Texas. 2004 Teaching Human Physiology (Cardiovascular Physiology) to students accepted in the

Joint Admission Medical Program (JAMP) created by the Texas Legislature, Texas A&M University, College Stat ion, Texas.

2004 Teaching Cardiovascular Physiology to graduate students (Cardiovascular Sciences

689), Texas A&M University, College Stat ion, Texas. 2003 Teaching Human Physiology (Cardiovascular Physiology) to students accepted in the

Joint Admission Medical Program (JAMP) created by the Texas Legislature. Texas A&M University, College Stat ion, Texas.

2002 Teaching Human Physiology (Respiratory Physiology) to Clinical Psychologists as a part

of a Long Distance Learning Program, Texas A&M University, College Station, Texas. 1994-1998 Delivering lectures in bone, cardiovascular and cell physiology to graduate and

undergraduate students. Texas A&M University, College Station, Texas. 1991-1994 Teaching undergraduate laboratories of Poultry Science, and Poultry Breeding, Fertility,

and Hatching. Auburn University, Auburn, Alabama. 1990-1991 Teaching Avian Diseases, and Poultry Science. UNAM, Mexico City, Mexico. PUBLICATIONS Refereed Journal Articles 1. Martinez, L.A., J.S. Jeffrey, and T.W. Odom, 1997. Electrocardiographic diagnosis of

cardiomyopathies in Aves. Poult. Avian Biol. Rev. 8:9-20. 2. Martinez-Lemus, L.A., M.W. Miller, J.S. Jeffrey, and T.W. Odom, 1998. Echocardiographic

evaluation of cardiac structure and function in broiler and Leghorn chickens. Poult. Sci. 77:1045-1050.

3. Martinez-Lemus, L.A., R.K. Hester, E.J. Becker, J.S. Jeffrey, and T.W. Odom, 1999. Pulmonary

artery endothelium-dependent vasodilation is impaired in a chicken model of pulmonary hypertension. Am. J. Physiol. 277 (Regulatory Integrative Comp. Physiol. 46): R190-R197.

4. Jeffrey, J.S., L.A. Martinez-Lemus, A.K. Reddy, C.S. Lessard, and T.W. Odom, 1999. Application

of phonocardiography for detecting hypoxia-induced cardiovascular adaptation in the chicken. Avian Dis. 43:668-686.

5. Martinez-Lemus, L.A., M.W. Miller, J.S. Jeffrey, and T.W. Odom, 2000. Echocardiographic study

of pulmonary hypertension syndrome in broiler chickens. Avian Dis. 44:74-84.

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6. Waitkus-Edwards K. R., L. A. Martinez-Lemus, X. Wu, J. P. Trzeciakowski, M. J. Davis, G. E.

Davis, and G. A. Meininger, 2002. α4β1 Integrin activation of L-type calcium channels in vascular smooth muscle causes arteriole vasoconstriction. Circ. Res. 90:473-480. (Featured in cover and editorial).

7. Platts, S.H., L. A. Martinez-Lemus, and G.A. Meininger, 2002. Microtubule-dependent regulation

of vasomotor tone requires rho kinase. J. Vasc. Res. 39:173-182. 8. Hill, M. A., S. J. Potocnik, L. A. Martinez-Lemus, and G. A. Meininger, 2003. Delayed arteriolar

relaxation after prolonged agonist exposure: Functional remodeling involving tyrosine phosphorylation. Am. J. Physiol. Heart Circ Physiol. 285:H849-H856.

9. Martinez-Lemus, L.A., X. Wu, E. Wilson, M. A. Hill, M. J. Davis, G. E. Davis, and G. A. Meininger,

2003. Integrins as unique receptors for vascular control. J. Vasc. Res. 40:211-233. 10. Forough, R., X. Wang, L.A. Martinez-Lemus, D. Thomas, Z. Sun, K. Motamed, J.L. Parker, G.A.

Meininger, 2003. Cell-based and direct gene transfer-induced angiogenesis via a secreted chimeric fibroblast growth factor-1 (sp-FGF-1) in the chick chorioallantoic membrane (CAM). Angiogenesis 6:47-54.

11. Martinez-Lemus, L.A., R.K. Hester, E.J. Becker, G.A. Ramirez, and T.W. Odom, 2003. Pulmonary

artery vasoactivity in broiler and Leghorn chickens: An age profile. Poult. Sci. 82:1957-1964. 12. Martinez-Lemus, L.A., M.A. Hill, S.S. Bolz, U. Pohl, and G.A. Meininger, 2004. Acute

Mechanoadaptation of Vascular Smooth Muscle Cells in Response to Continuous Arteriolar Vasoconstriction: Implications for Functional Remodeling. FASEB J. 18:708-710.

13. Odom, T. W., L. A. Martinez-Lemus, R. K. Hester, E. J. Becker, J. S. Jeffrey, G. A. Meininger, and

G. A. Ramirez, 2004. In vitro hypoxia differentially affects constriction and relaxation responses of isolated pulmonary arteries from broiler and Leghorn chickens. Poult. Sci. 83:835-841.

14. Martinez-Lemus, L. A., Z. Sun, A. Trache, J.P. Trzeciakowski, and G.A. Meininger, 2005. Integrins

and the regulation of the microcirculation: from arterioles to molecular studies using atomic force microscopy. Microcirculation 12:99-112. (Invited)

15. Martinez-Lemus, L.A., T. Crow, M.J. Davis, G.A. Meininger, 2005. Alphavbeta3- and alpha5beta1-

integrin blockade inhibits myogenic constriction of skeletal muscle resistance arterioles. Am. J. Physiol. 289:H322-H329.

16. Arce-Menocal J., E. Avila-Gonzalez, C. Lopez-Coello, and L.A. Martinez-Lemus, 2005. Use of

electrocardiography for genetic selection in broiler breeders: Effects on live performance and ascites incidence. J. App. Poult. Res. 14:281-288.

17. Sun, Z., L.A. Martinez-Lemus, A. Trache, J.P. Trzeciakowski, G.E. Davis, U. Pohl and G.A.

Meininger, 2005. Mechanical properties of the interaction between fibronectin and alpha5beta1-integrin on vascular smooth muscle cells studied using atomic force microscopy. Am. J. Physiol. 289:H2526-H2535.

18. Chao, J-T., L.A. Martinez-Lemus, S.J. Kaufman, G.A. Meininger, K.S. Ramos, and E. Wilson,

2006. Modulation of α7 integrin-mediated adhesion and expression by platelet-derived growth factor in vascular smooth muscle cells. Am. J. Physiol. 290:C972-C980.

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19. Hill, M.A., Z. Sun, L.A. Martinez-Lemus, and G.A. Meininger, 2007. New technologies to dissect the arteriolar myogenic response. Trends. Pharmacol. Sci. 28:308-315.

20. Martinez-Lemus, L.A., 2008. Persistent agonist-induced vasoconstriction is not required for

angiotensin-II to mediate inward remodeling of isolated arterioles with myogenic tone. J. Vasc. Res. 45:211-221.

21. Sun, Z., L.A. Martinez-Lemus, M.A. Hill, and G.A. Meininger, 2008. Extracellular matrix-specific

focal adhesions in vascular smooth muscle produce mechanically active adhesion sites. Am. J. Physiol. 295:C268-C278.

22. Martinez-Lemus, L.A., M.A. Hill, and G.A. Meininger, 2009. The plastic nature of the vascular wall:

a continuum of vascular events contributing to control of vascular diameter and structure. Physiology 24:45-57. (Invited Review)

23. Arce-Menocal, J., E. Avila-Gonzalez, C. Lopez-Coello, L.A. Martinez-Lemus, 2009. Body weight,

feed-particle size, and ascites incidence revisited. J. Appl. Poult. Res. 18:465-471. 24. Martinez-Lemus, L.A., M.A. Hill, and G.A. Meininger, 2009. The plastic nature of the vascular wall:

Reply to Lee, Sandow, and DeMey. Physiology 24:273-275. (Invited Letter to the Editor) 25. Huang S, Z. Sun, Z. Li, L.A. Martinez-Lemus, and G.A. Meininger, 2010. Modulation of

microvascular smooth muscle adhesion and mechanotransduction by integrin-linked kinase. Microcirculation 17:113-127.

26. Martinez-Lemus, L.A., M.A. Hill, and G.A. Meininger, 2010. The plastic nature of the vascular wall: Reply to Folkow. Physiology 25:266-267. (Invited Letter to the Editor)

27. Jackson T.Y., Z. Sun, L.A. Martinez-Lemus, M.A. Hill, and G.A. Meininger, 2010. N-cadherin and integrin blockade inhibit arteriolar myogenic reactivity but not pressure-induced increases in intracellular Ca2+. Front. Physiol. 1:165.

28. Gao X.,* L.A. Martinez-Lemus,* and C. Zhang, 2011. Endothelium-derived hyperpolarizing factor and diabetes. World J. Cardiol. 3:25-31. *Equal contributors.

29. Martinez-Lemus, L.A., G. Zhao, E.L. Galiñanes, and M. Boone, 2011. Inward remodeling of

resistance arteries requires reactive oxygen species-dependent activation of matrix metalloproteinases. Am. J. Physiol. 300:H2005-H2015.

30. Martinez-Lemus, L.A., and E.L. Galiñanes, 2011. Matrix metalloproteinases and small artery

remodeling. Drug Discovery Today: Disease Models. 8:21-28 (Invited Review) 31. Clifford P.S., S.R. Ella, A.J. Stupica, Z. Nourian, L.A. Martinez-Lemus, K.A. Dora, Y. Yang, M.J.

Davis, U. Pohl, G.A. Meininger, and M.A. Hill, 2011. Spatial distribution and mechanical function of elastin in resistance arteries: a role in bearing longitudinal stress. Arterioscler. Thromb. Vasc. Biol. 31:2889-2896.

32. Martinez-Lemus, L.A., 2012. The dynamic structure of arterioles. Basic Clin. Pharmacol. Toxicol.

110:5-11 (Invited Review) 33. Kim, J.A., H.J. Jang, L.A. Martinez-Lemus, and J.R. Sowers, 2012. Activation of mTOR/p70S6

kinase by ANG II inhibits insulin-stimulated endothelial nitric oxide synthase and vasodilation. Am. J. Physiol. 302: E201-208.

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34. Staiculescu, M.C., E.L. Galiñanes, G. Zhao, U. Ulloa, M. Jin, M.I. Beig, G.A. Meininger, and L.A.

Martinez-Lemus, 2013. Prolonged vasoconstriction of resistance arteries involves vascular smooth muscle actin polymerization leading to inward remodeling. Cardiovasc. Res. 98:428-436.

35. Kim, D.J., L.A. Martinez-Lemus, and G.E. Davis, 2013. EB1, p150Glued and Clasp1 control

endothelial tubulogenesis through microtubule assembly. Blood 121:3521-3530. 36. Castorena-Gonzalez, J.A., C. Foote, K. MacVittie, J. Halamek, L. Halamkova, L.A. Martinez-

Lemus, and E. Katz, 2013. Biofuel cell operating in vivo in rat. Electroanalysis 25:1579-1584. 37. Schenewerk, A.L., F. Ramirez-Perez, C. Foote, T. Ji, L.A. Martinez-Lemus, and R.M. Rivera,

2013. Effects of the Use of Assisted Reproduction and High Caloric Diet Consumption on Body Weight and Cardiovascular Health of Juvenile Mouse Offspring. Reproduction 147:111-23. PMID: 24163396.

38. Castorena-Gonzalez, J.A., M.C. Staiculescu, C. Foote, L, Polo-Parada, and L.A. Martinez-Lemus,

2014. The obligatory role of the actin cytoskeleton on inward remodeling induced by dithiothreitol activation of endogenous transglutaminase in isolated arterioles. Am. J. Physiol. 306:H485-H495.

39. Hong, Z., Z. Sun, M. Li, Z. Li, F. Bunyak, I. Ersoy, J.P. Trzeciakowski, M.C. Staiculescu, M.

Jin, L.A. Martinez-Lemus, M.A. Hill, K. Palaniappan, and G.A. Meininger, 2014. Vasoactive agonists exert dynamic and coordinated effects on vascular smooth muscle elasticity, cytoskeletal remodeling and adhesion. J. Physiol. 592:1249-1266.

40. Castorena-Gonzalez, J.C., M.C. Staiculescu, C. Foote, and L.A. Martinez-Lemus, 2014.

Mechanisms of the inward remodeling process in resistance vessels: Is the actin cytoskeleton involved? Microcirculation 21:219-229.

41. Martinez-Lemus, L.A. 2014. Current Opinions on the Control and Role of Vascular Smooth

Muscle Cell Adhesion, Calcium Sensitization and the Cytoskeleton in Vascular Structure and Function. Microcirculation 21:197-200.

42. Jia G., A.R. Aroor, L.A. Martinez-Lemus, and J.R. Sowers, 2014. Over-nutrition, mTOR Signaling and Cardiovascular Diseases, Am. J. Physiol. Regul. Integr. Comp. Physiol., 307:R1198-R1206. (Invited Review)

43. Staiculescu, M.C., F.I. Ramirez-Perez, J.A. Castorena-Gonzalez, Z. Hong, Z. Sun, G.A.

Meininger, and L.A. Martinez-Lemus, 2014. Lysophosphatidic acid induces integrin activation in vascular smooth muscle and alters arteriolar myogenic vasoconstriction. Front. Physiol., 5:413.

44. Ramirez-Perez, F.I., A. Schenewerk, K.L. Coffman, C. Foote, T. Ji, R.M. Rivera, and L.A. Martinez-Lemus, 2014. Effects of the Use of Assisted Reproductive Technologies and an Obesogenic Environment on Resistance Artery Function and Diabetes Biomarkers in Mice Offspring. PLoS ONE, 9:e112651.

45. Staiculescu, M.C., C. Foote, G.A. Meininger, L.A. Martinez-Lemus, 2014. The Role of Reactive Oxygen Species in Microvascular Remodeling. International Journal of Molecular Sciences, 15:23792-23835.

46. Jia, G., A.R. Aroor, L.A. Martinez-Lemus and J.R. Sowers, 2015. Mitochondrial functional impairment in response to environmental toxins in the cardiorenal metabolic syndrome. Archives of toxicology 89: 147-153.

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47. Jia, G., L.A. Martinez-Lemus, and J.R. Sowers, 2015. Interaction of Adipogenesis and

Angiogenesis in Dietary-Induced Obesity. Diabetes 64: 2326-2328.

48. DeMarco, V.G., J. Habibi, G. Jia, A.R. Aroor, F.I. Ramirez-Perez, L.A. Martinez-Lemus, S.B. Bender, M. Garro, M.R. Hayden, Z. Sun, G.A. Meininger, C. Manrique, A. Whaley-Connell, J. R. and Sowers, 2015. Low-Dose Mineralocorticoid Receptor Blockade Prevents Western Diet-Induced Arterial Stiffening in Female Mice. Hypertension 66: 99-107.

49. Bender, S.B., J.A. Castorena-Gonzalez, M. Garro, C.C. Reyes-Aldasoro, J.R. Sowers, V.G. DeMarco, and L.A. Martinez-Lemus, 2015. Regional variation in arterial stiffening and dysfunction in Western diet-induced obesity. Am. J. Physiol. 309:H574-582. (Featured in Editorial)

50. Jia, G., A.R. Aroor, V.G. DeMarco, L.A. Martinez-Lemus, G.A. Meininger, and J.R. Sowers, 2015. Vascular stiffness in insulin resistance and obesity. Front. Physiol. 6:231.

51. Jia, G., J. Habibi, V.G. DeMarco, L.A. Martinez-Lemus, L. Ma, A.T. Whaley-Connell, A.R. Aroor, T.L. Domeier, Y. Zhu, G.A. Meininger, K.B. Mueller, I.Z. Jaffe, and J.R. Sowers, 2015. Endothelial Mineralocorticoid Receptor Deletion Prevents Diet-Induced Cardiac Diastolic Dysfunction in Females. Hypertension. doi 10.1161/HYPERTENSIONAHA.115.06015

52. Foote, C.A., J.A. Castorena-Gonzalez, M.C. Staiculescu, P.S. Clifford, M.A. Hill, G.A. Meininger, and L.A. Martinez-Lemus, 2015. Brief serotonin exposure initiates arteriolar inward remodeling processes in vivo that involve transglutaminase activation and actin cytoskeleton reorganization. Am J Physiol Heart Circ Physiol:ajpheart 00666 02015. doi 10.1152/ajpheart.00666.2015

53. Restaino, R.M., L.K. Walsh, T. Morishima, J.R. Vranish, L.A. Martinez-Lemus, P.J. Fadel, and J. Padilla. 2016. Endothelial dysfunction following prolonged sitting is mediated by a reduction in shear stress. Am J Physiol Heart Circ Physiol:ajpheart 00943 02015. doi 10.1152/ajpheart.00943.2015

54. Manrique, C., G. Lastra, F.I. Ramirez-Perez, D. Haertling, V.G. DeMarco, A.R. Aroor, G. Jia, D. Chen, B.J. Barron, M. Garro, J. Padilla, L.A. Martinez-Lemus, and J.R. Sowers. 2016. Endothelial estrogen receptor alpha does not protect against vascular stiffness induced by Western Diet in female mice. Endocrinology:en20151681. doi 10.1210/en.2015-1681

55. Jia, G., J. Habibi, A.R. Aroor, L.A. Martinez-Lemus, V.G. DeMarco, F.I. Ramirez-Perez, Z. Sun, M.R. Hayden, G.A. Meininger, K.V. Barrett Mueller, I.Z. Jaffe, and J.R. Sowers. 2016. Endothelial Mineralocorticoid Receptor Mediates Diet Induced Aortic Stiffness in Females. Circ Res. doi 10.1161/CIRCRESAHA.115.308269

56. Pennington, K.A., F.I. Ramirez-Perez, K.E. Pollock, O.O. Talton, C.A. Foote, C.C. Reyes-Aldasoro, H.H. Wu, T. Ji, L.A. Martinez-Lemus, and L.C. Schulz. 2016. Maternal Hyperleptinemia Is Associated with Male Offspring's Altered Vascular Function and Structure in Mice. PLoS ONE 11:e0155377. doi 10.1371/journal.pone.0155377

57. Hill, M.A., Z. Nourian, I.L. Ho, P.S. Clifford, L.A. Martinez-Lemus, and G.A. Meininger. 2016. Small Artery Elastin Distribution and Architecture - Focus on Three Dimensional Organization. Microcirculation. doi 10.1111/micc.12294

58. Manrique, C., J. Habibi, A.R. Aroor, J.R. Sowers, G. Jia, M.R. Hayden, M. Garro, L.A. Martinez-Lemus, F.I. Ramirez-Perez, T. Klein, G.A. Meininger, and V.G. DeMarco. 2016. Dipeptidyl

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peptidase-4 inhibition with linagliptin prevents western diet-induced vascular abnormalities in female mice. Cardiovasc Diabetol 15:94. doi 10.1186/s12933-016-0414-5

59. Foote, C.A., J.A. Castorena-Gonzalez, F.I. Ramirez-Perez, G. Jia, M.A. Hill, C.C. Reyes-Aldasoro, J.R. Sowers, and L.A. Martinez-Lemus. 2016. Arterial Stiffening in Western Diet-Fed Mice Is Associated with Increased Vascular Elastin, Transforming Growth Factor-beta, and Plasma Neuraminidase. Front Physiol 7:285. doi 10.3389/fphys.2016.00285

60. Padilla, J., F.I. Ramirez-Perez, J. Habibi, B. Bostick, A.R. Aroor, M.R. Hayden, G. Jia, M. Garro, V.G. DeMarco, C. Manrique, F.W. Booth, L.A. Martinez-Lemus, and J.R. Sowers. 2016. Regular Exercise Reduces Endothelial Cortical Stiffness in Western Diet-Fed Female Mice. Hypertension. doi 10.1161/HYPERTENSIONAHA.116.07954

Book Chapters 1. Martinez-Lemus, L.A. and M.H. Laughlin. Microcirculation, Lymph and Edema. In Dukes’

Physiology of Domestic Animals. 13th Edition. Ed: William O. Reece. Wiley-Blackwell, Iowa, p. 372-385, 2015.

Proceedings 1. Martinez, L.A., 1990. Dermatitis gangrenosa. Pages 122-127 in: Memorias de la 1er jornada

medico avicola, UNAM, Mexico City, Mexico. 2. Martinez, L.A., M.T. Casaubon, and R. Navarro, 1991. Estudio estructural del corazon en lineas

de aves resistentes y susceptibles al sindrome ascitico. Pages 169-171 in: Memorias de la 16a Convencion Nacional ANECA-Proceedings of the 40th Western Poultry Disease Conference, Acapulco, Mexico.

3. Odom, T.W., B.M. Hargis, J.S. Jeffrey, and L.A. Martinez, 1995. El analisis vectorcardiografico:

Una tecnica no invasiva para predecir la susceptibilidad al sindrome ascitico. Pages 229-234 in: Memorias de la 20a Convencion Nacional ANECA Acapulco, Mexico.

4. Martinez, L.A., M.W. Miller, J.S. Jeffrey, and T.W. Odom, 1995. Utilizacion de la imagen por

ultrasonido y del analisis de flujo de Doppler, para supervisar el desarrollo del sindrome ascitico en pollos de engorda. Pages 198-202 in: Memorias de la 20a Convencion Nacional ANECA Acapulco, Mexico.

5. Odom, T.W., R.K. Hester, L.A. Martinez, and J.S. Jeffrey, 1996. Role of L-arginine on in vitro

vasoactivity of pulmonary arteries in the broiler chicken. Pages 234-237 in: Memorias de la 21a Convencion Nacional ANECA-Proceedings of the 45th Western Poultry Disease Conference, Cancun, Mexico.

6. Jeffrey, J.S., L.A. Martinez, V.H. Stanley, J.D. Williams, and T.W. Odom, 1996. Comparison of

cardiophysiologic parameters between fast- and slow-growing broiler chicken lines with or without hypoxic exposure. Pages 228-231 in: Memorias de la 21a Convencion Nacional ANECA-Proceedings of the 45th Western Poultry Disease Conference, Cancun, Mexico.

7. Martinez, L.A., J.S. Jeffrey, and T.W. Odom, 1996. Comparison of frontal plane vectors as

predictors of pulmonary hypertension syndrome in broiler chickens. Pages 231-234 in: Memorias

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de la 21a Convencion Nacional ANECA-Proceedings of the 45th Western Poultry Disease Conference, Cancun, Mexico.

8. Meininger, G.A., K.R. Waitkus-Edwards, X. Wu, L.A. Martinez-Lemus, J.P. Trzeciakowski, G.E.

Davis, and M.J. Davis, 2001. Alpha-4 beta-1 integrin-mediated vasoconstriction of isolated arterioles occurs through activation of L-type calcium channels. Symposium 33-6 in: Proceedings of the 7th World Congress for Microcirculation, Sydney, Australia.

9. Meininger, G.A., Z. Sun, A. Trache, and L.A. Martinez-Lemus, 2003. Role of [Ca2+]i in

mechanotransduction in arterioles. Symposium entitled "Novel Ca2+ Signaling Mechanism in Vascular Myocytes: Cyclic ADP-ribose, Ryanodine Receptor and Ca2+-induced Ca2+ Release" at the Annual Meeting of Experimental Biology. In Acta Physiologica Scandinavica.

10. Martinez-Lemus, L.A., G.A. Meininger, and M.A. Hill, 2007. Vascular smooth muscle cell plasticity

and vascular remodeling. Pages 121-126 in, Proceedings of the 8th World Congress for Microcirculation, Milwaukee, Wisconsin, USA.

Abstracts 1. Martinez, L.A., G.R. McDaniel, and M.K. Eckman, 1992. Performance of broiler breeders treated

with Salinomycin, Amprolium and Coccivac, and challenged with Eimeria spp. Poultry Sci. 71(suppl. 1):289.

2. Martinez, L.A., M.T. Casaubon, and R. Navarro, 1992. Structure study of the heart of chickens

resistant and susceptible to Ascitic Syndrome. Poultry Sci. 71 (suppl. 1):S91. 3. Martinez, L.A., and G.R. McDaniel, 1993. Egg and semen production of broiler breeders treated

with either Salinomycin, Amprolium or Coccivac. Poultry Sci. 72(suppl. 1):S88. 4. Martinez, L.A., R.J. Lien, and G.R. McDaniel, 1993. Shank lengths and plasma thyroid hormone

concentrations of broiler cockerels from lines divergently selected for tibial dyschondroplasia. Poultry Sci. 72(suppl.1):72.

5. Martinez, L.A., G.R. McDaniel, and R.J. Lien, 1994. Plasma growth hormone, thyroid hormone,

and insulin-like growth factor-I concentrations following thyrotropin releasing hormone challenge in tibial dyschondroplastic and normal broilers. Poultry Sci. 73(suppl. 1):56.

6. Odom, T.W., R.K. Hester, L.A. Martinez, and J.S. Jeffrey, 1995. In vitro vasoactivity of avian

pulmonary arteries: Physiological implications of endothelium-derived relaxing factor. Poultry Sci. 74(suppl. 1):109.

7. Odom, T.W., B.M. Hargis, L.A. Martinez, and J.S. Jeffrey, 1995. Vectorelectrocardiographic

analysis: A non-invasive technique for predicting susceptibility to ascites syndrome. Poultry Sci. 74(suppl. 1):108.

8. Jeffrey, J.S., H.W. Sampson, J.D. Williams, L.A. Martinez, and T.W. Odom, 1995. Effect of

hypoxic incubation on pulmonary vascular development in chickens from fast- and slow-growing lines using morphometric analysis. AVMA Official Convention Program, 132:141.

9. Jeffrey, J.S., L.A. Martinez, H.W. Sampson, R.W. Davis, and T.W. Odom, 1995. Ultrastructure

examination of pulmonary arteries in two chicken lines following in ovo administration of angiogenic agents. Poultry Sci. 74(suppl. 1):338.

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10. Jeffrey, J.S., L.A. Martinez, C.S. Lessard, A.K. Reddy, and T.W. Odom, 1995.

Phonocardiographic evaluation of fast and slow-growing chickens for detection of ascites syndrome. Poultry Sci. 74(suppl. 1):107.

11. Martinez, L.A., M.W. Miller, J.S. Jeffrey, and T.W. Odom, 1995. Echocardiographic monitoring of

heart function in broilers exposed to normobaric or hypobaric conditions. Poultry Sci. 74(suppl. 1):105.

12. Martinez, L.A., J.S. Jeffrey, H.W. Sampson, and T.W. Odom, 1995. Effects of basic fibroblast

growth factor in ovo administration on pulmonary arterioles of fast and slow growing chickens. Poultry Sci. 74(suppl. 1):339.

13. Odom, T.W., R.K. Hester, E. Becker, L.A. Martinez, H. Sittertz-Bhatkar, G.A. Ramirez, and J.S.

Jeffrey, 1996. Effect of NG-nitro-L-arginine methyl ester and mechanical damage of the pulmonary endothelium on the relaxation responses in fast-and slow-growing chickens. Poultry Sci. 75(suppl. 1):180.

14. Odom, T.W., R.K. Hester, E.J. Becker, L.A. Martinez, G.A. Ramirez, and J.S. Jeffrey, 1996. Effect

of L-arginine and L-citrulline on vasodilation of broiler chicken pulmonary arteries in vitro. Poultry Sci. 75 (suppl. 1):194.

15. Odom, T.W., R.K. Hester, E.J. Becker, L.A. Martinez, G.A. Ramirez, and J.S. Jeffrey, 1996. Effect

of in vitro hypoxic and normoxic conditions in fast- and slow-growing chicken pulmonary arteries. Poultry Sci. 75(suppl. 1):76.

16. Jeffrey, J.S., L.A. Martinez, V.H. Stanley, and T.W. Odom, 1996. Utility of various lead

combinations for electrocardiographic profiling of broilers in normoxic and hypoxic conditions. Poultry Sci. 75(suppl. 1):77.

17. Martinez, L.A., J.S. Jeffrey, H.W. Sampson, and T.W. Odom, 1996. Effects of adenosine in ovo

administration on pulmonary arteriolar development of fast- and slow-growing chicken embryos. Poultry Sci. 75(suppl. 1):305.

18. Odom, T.W., R.K. Hester, E.J. Becker, L.A. Martinez, G.A. Ramirez, and J.S. Jeffrey, 1997. Avian

pulmonary artery relaxations in vitro: Comparisons between low and high right ventricular hypertrophy ratios. Poultry Sci. 76(suppl. 1):98.

19. Odom, T.W., R.K. Hester, E.J. Becker, L.A. Martinez, G.A. Ramirez, and J.S. Jeffrey, 1997. Effect

of normoxia and hypoxia on relaxation of avian pulmonary arteries in vitro. FASEB 11:466. 20. Ramirez, G.A., L.A. Martinez, J.S. Jeffrey, and T.W. Odom, 1997. L-arginine mediated protection

against Salmonella enteritidis organ invasion in neonatal chicks is associated with increased nitrate and nitrite serum concentrations. Poultry Sci. 76(suppl.1):265.

21. Martinez, L.A., R.K. Hester, E.J. Becker, G.A. Ramirez, J.S. Jeffrey, and T.W. Odom, 1997. Age

profile of pulmonary artery vasoactivity in broiler chickens. Poultry Sci. 76(suppl. 1):99. 22. Odom, T.W., W.M. Chilian, J.L. Patterson, L.A. Martinez-Lemus, G.A. Ramirez, and J.S. Jeffrey,

1998. The proliferative capacity of pulmonary arterial endothelial cells from a broiler and a Leghorn chicken line in cell culture. Poultry Sci. 77(suppl. 1):113.

19

23. Martinez-Lemus, L.A., R.K. Hester, E.J. Becker, G.A. Ramirez, J.S. Jeffrey, and T.W. Odom, 1998. Pulmonary artery relaxation responses and nitric oxide synthesis are reduced in broiler chickens exposed to hypobaric conditions. Poultry Sci. 77(suppl. 1):396.

24. Ramirez, G.A., L.A. Martinez-Lemus, and T.W. Odom, 1999. Attenuation of L-arginine mediated

protection against Salmonella enteritidis organ invasion and nitric oxide synthesis by L-NAME. Poultry Sci. 78(suppl. 1):13.

25. Martinez-Lemus, L.A., M.A. Hill, S.S. Bolz, U. Pohl, and G.A. Meininger, 2001. Changes in

vascular smooth muscle cell shape suggest rapid remodeling events occur in the arteriolar wall during vasoconstriction. The FASEB Journal 15(4):A32.

26. T. W. Odom, M.A. Thompson, K.P. Floren, G.A. Ramirez, N. Puebla-Osorio, L.A. Martinez-

Lemus, and J. S. Thomas, 2001. Cardiopulmonary and blood gas responses to cold exposure in broiler chickens. Poultry Sci. 80 (suppl. 1):392.

27. Carpenter, A.R., L. A. Martinez-Lemus, J. Thomas, and T.W. Odom, 2001. Thrombocyte

aggregation does not correspond with nitric oxide and cardiovascular parameters in broiler chickens with pulmonary hypertension. Poultry Sci. 80 (suppl. 1):392.

28. Martinez-Lemus, L.A., M.A. Hill, and G.A. Meininger, 2002. Arterioles exhibit rapid remodeling in

response to short-term exposure to vasoconstrictors. The FASEB Journal 16(4):LB12. 29. G.A. Meininger, M.J. Davis, X. Wu, Z. Sun, A. Trache, and L.A. Martinez-Lemus. Are integrins

important for the myogenic mechanism? Myogenic Centennial Conference, Stowe, Vermont, June 2002.

30. Meininger, G.A., L.A. Martinez-Lemus, Z. Sun, A. Trache, X. Wu, E. Wilson, M.J. Davis and U.

Pohl, 2002. Role of extracellular matrix-integrin interactions in short and long-term responses to pressure. J. Vasc. Res. 39(suppl 1):90(5.3).

31. Thompson, M.A., K.P. Floren, G.A. Ramirez, L.A. Martinez-Lemus, N. Puebla-Osorio, J.S.

Thomas, and T.W. Odom, 2002. Supplementation of DETA/NO Attenuates Cold Exposure-Induced Pulmonary Hypertension Syndrome in Broilers. Poultry Sci. 81(suppl. 1):79.

32. Martinez-Lemus, L.A., T. Crow, M.A. Hill, and G.A. Meininger, 2003. Alpha-2 adrenoceptor

antagonism prevents norepinephrine-induced rapid arteriolar remodeling. The FASEB Journal 17(4):A552.

33. Hill, M.A., S.J. Potocnik, L.A. Martinez-Lemus, and G.A. Meininger, 2003. Tyrosine kinase, but

not Rho kinase, inhibition prevents prolonged norepinephrine exposure-induced changes in relaxation. The FASEB Journal 17(4):A143.

34. Hill, M.A., L.A. Martinez-Lemus, S. J. Potocnik and G.A. Meininger. Functional remodeling in

response to prolonged agonist exposure delays arteriolar relaxation. FASEB Summer Conference on Smooth Muscle Biology, Snow Mass, Colorado July 5-10, 2003.

35. Sun, Z., J.P. Trzeciakowski, L.A. Martinez-Lemus, A. Trache, and G.A. Meininger, 2004.

Application of force with an atomic force microscope with a fibronectin-alpha5 beta1 integrin focal contact in vascular smooth muscle cells (VSMC) induces a force generating response. 48th Annual Meeting of the Biophysical Society. February 14-18. Baltimore.

20

36. Sun, Z., L.A. Martinez-Lemus, A. Trache, J.P. Trzeciakowski, and G.A. Meininger, 2004. Vascular smooth muscle cells (VSMC) retract in response to fibronectin-integrin α5β1 force application. The FASEB Journal 18 (5):A655.

37. Martinez-Lemus, L.A., T. Crow, M.J. Davis, G.A. Meininger, 2004. α5β1 and αvβ3 integrins are

required for myogenic constriction of arterioles. The XIII International Vascular Biology Meeting. June 1-5, Toronto, Canada. Cardiovascular Pathology 13(suppl. 1):191.

38. J.T. Chao, L.A. Martinez-Lemus, N. Paria, G.A. Meininger, K.S. Ramos, and E. Wilson, 2004.

PDGF Enhances α7 Integrin Expression in Vascular Smooth Muscle Cells. American Society of Cell Biology.

39. Meininger, G.A., L.A. Martinez-Lemus, Z. Sun, and A. Trache, 2005. Integrins, extracellular matrix

and mechanical factors related to arteriolar remodeling. Symposium sponsored by the American Association of Anatomists at the Annual Meeting of Experimental Biology, San Diego, April 3, 2005. The FASEB Journal.

40. Martinez-Lemus, L.A., M.A. Hill, and G.A. Meininger. Vasoconstriction and vascular smooth

muscle plasticity: implications in acute arteriolar remodeling. Cardiovascular Day XIII, University of Missouri-Columbia, Columbia, Missouri, USA, February 6, 2006.

41. Sun, Z., L.A. Martinez-Lemus, and G.A. Meininger. Mechanical force applied through integrin-

fibronectin interactions induces contractile activity in vascular smooth muscle cells (VSMC). Cardiovascular Day XIII, University of Missouri-Columbia, Columbia, Missouri, USA, February 6, 2006.

42. Hill, M.A., T.V. Murphy, L. Sun, L.A. Martinez-Lemus, and G.A. Meininger. Mechanisms of

myogenic tone and roles of tyrosine kinases, integrin receptors and microvascular control. 11th International Vascular Neuroeffector Mechanisms and Cardiovascular Pharmacology and Medicine Symposia, Shanghai-Suzhou, China, July, 2006.

43. Meininger, G.A., L.A. Martinez-Lemus, M.A. Hill, and J.D. Humphrey. When does active

vasoconstriction become acute vascular remodeling? European Society for Microcirculation, Amsterdam, The Netherlands, August 30-September 2, 2006.

44. Hill, M.A., Z. Sun, L.A. Martinez-Lemus, and G.A. Meininger, 2006. Novel imaging approaches

provide a driving force to advance the field of vascular cell mechanotransduction. Nanomedicine 2: 286.

45. Boone, M. and L.A. Martinez-Lemus, Matrix metalloproteinase-inhibition prevents

vasoconstriction-dependent inward remodeling of isolated arterioles. Cardiovascular Day XIV, University of Missouri-Columbia, Columbia, Missouri, USA, February 26, 2007.

46. Jackson, T.Y., L.A. Martinez-Lemus, M.A. Hill, and G.A. Meininger. 2007. A role for cadherins in

arteriolar myogenic responsiveness. 8th World Congress for Microcirculation. Milwaukee. Wisconsin, USA, August, 2007.

47. Jackson, T.Y., L.A. Martinez-Lemus, M.A. Hill, and G.A. Meininger. 2008. A role for cadherins in

vascular myogenic response. International Symposium on Resistance Arteries, Hamilton Island, Australia, published in Journal of Vascular Research, February 2008.

48. Bosanquet, J.P., V.G. DeMarco, K.C. Dellsperger, and L.A. Martinez-Lemus. 2008. Angiotensin II

induces reactive oxygen species formation and augments 5-HT-induced vasoconstriction in

21

isolated pulmonary arterioles. Cardiovascular Day XV, Universiry of Missouri-Columbia, Columbia, MO, March 2008.

49. Jackson, T.Y., L.A. Martinez-Lemus, M.A. Hill, and G.A. Meininger. 2008. The role of cadherins in

arteriolar myogenic responsivness. Cardiovascular Day XV, Universiry of Missouri-Columbia, Columbia, MO, March 2008.

50. Jackson, T.Y., L.A. Martinez-Lemus, M.A. Hill, and G.A. Meininger. 2008. Cadherins play a role in

arteriolar myogenic responsivness. Annual Meeting of the Societies for Experimental Biology. San Diego, CA, April 2008. Published in FASEB J., 2008.

51. Bosanquet, J.P., V.G. DeMarco, K.C. Dellsperger, and L.A. Martinez-Lemus. 2008. Angiotensin II

induces reactive oxygen species formation and augments 5-HT-induced vasoconstriction in isolated pulmonary arterioles. Annual Meeting of the Societies for Experimental Biology. San Diego, CA, April 2008. Published in FASEB J., 2008.

52. Jackson, T.Y., L.A. Martinez-Lemus, M.A. Hill, and G.A. Meininger. 2008. The role of cadherins in

arteriolar myogenic responsiveness. Cardiovascular Day XV, Universiry of Missouri-Columbia, Columbia, MO, March 2008.

53. Jackson, T.Y., L.A. Martinez-Lemus, M.A. Hill, and G.A. Meininger. 2008. Cadherins play a role in

arteriolar myogenic responsiveness. Annual Meeting of the Societies for Experimental Biology. San Diego, CA, April 2008. Published in FASEB J., 2008.

54. Bosanquet, J.P., V.G. DeMarco, K.C. Dellsperger, and L.A. Martinez-Lemus. 2008. Angiotensin II

induces reactive oxygen species formation and augments 5-HT-induced vasoconstriction in isolated pulmonary arterioles. Annual Meeting of the Societies for Experimental Biology. San Diego, CA, April 2008. Published in FASEB J., 2008.

55. Martinez-Lemus, L.A., Z. Guiling, J.P. Bosanquet. 2008. Matrix metalloproteinase-inhibition

prevents the acute inward remodeling induced by prolonged vasoconstriction in isolated arterioles. Annual Meeting of the Societies for Experimental Biology. San Diego, CA, April 2008. Published in FASEB J., 2008.

56. Martinez-Lemus, L.A., M.A. Hill, and G.A. Meininger. 2008. The role of integrins in the control of

skeletal muscle arteriolar diameter. 2008 APS Intersociety Meeting: The Integrative Biology of Exercise-V. Hilton Head, South Carolina, USA, September 24-27 2008 (Invited Presentation).

57. Martinez-Lemus, L.A. 2008. Remodeling of the resistance vasculature: early mechanisms. 2008

American Heart Association Research Symposium. New Orleans, LA, November 7, 2008. 58. Martinez-Lemus, L.A., and G. Zhao. 2009. Vasoconstriction-induced inward remodeling of

isolated arterioles requires reactive oxygen species. Annual Meeting of the Societies for Experimental Biology. New Orleans, LA, April 2009. Published in FASEB J., 2009.

59. Zhao G. and Martinez-Lemus, L.A. 2009. Rho kinase inhibition prevents acute vasoconstriction-

induced inward remodeling in isolated arterioles. Presented at the meeting of the Microcirculatory Society entitled “Frontiers in Microcirculation: Control Processes and Clinical Applications. Columbia, MO, October 16-17 2009. Published in Microcirculation, 2009.

60. Clifford P.S., S.R. Ella, L.A. Martinez-Lemus, K.A. Dora, Y. Yang, M.J. Davis, G.A. Meininger, and

M.A. Hill. 2009. Adventitial elastin fibers longitudinally constrain arteriolar smooth muscle cells. Presented at the meeting of the Microcirculatory Society entitled “Frontiers in Microcirculation:

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Control Processes and Clinical Applications. Columbia, MO, October 16-17 2009. Published in Microcirculation, 2009.

61. Jackson T.Y., L.A. Martinez-Lemus, M.A. Hill, and G.A. Meininger. 2009. Cadherin and integrin

blockade inhibit myogenic responses while not preventing pressure induced increases in Ca2+. Presented at the meeting of the Microcirculatory Society entitled “Frontiers in Microcirculation: Control Processes and Clinical Applications. Columbia, MO, October 16-17 2009. Published in Microcirculation, 2009.

62. Martinez-Lemus, L.A., and G. Zhao. 2010. Vasoconstriction-induced inward remodeling of isolated arterioles involves reactive oxygen species-dependent activation of matrix metalloproteinases. Annual Meeting of the Societies for Experimental Biology. Anaheim, CA, April 2010. Published in FASEB J., 2010.

63. Sun, Z., S. Huang, Z. Li, L.A. Martinez-Lemus, and G.A. Meininger, 2010. Modulation of

microvascular smooth muscle adhesion and mechanotransduction by integrin-linked kinase. Annual Meeting of the Societies for Experimental Biology. Anaheim, CA, April 2010. Published in FASEB J., 2010.

64. Rivera, R.M. S.R. Huffman, G. Zhao, and L.A. Martinez-Lemus. 2010. Effects of assisted

reproductive technologies (ART) and/or fat-based hypercaloric diet on cardiovascular performance in mice. 43rd annual meeting of the society for the study of reproduction. Milwaukee, WI, August 2010.

65. Martinez-Lemus, L.A., and Guiling Zhao, 2010. The role of reactive oxygen species and matrix

metalloproteinases in small artery remodeling. 9th World Congress for Microcirculation, Paris, France, September 2010.

66. Meininger, G.A., T.Y. Jackson, Z. Sun, L.A. Martinez-Lemus, and M.A. Hill. Inhibition of arteriolar myogenic responsiveness but not stretch-induced increases in intracellular Ca2+ after N-cadherin and integrin blockade. 9th World Congress for Microcirculation, Paris, France, September 2010.

67. Clifford P.S., S.R. Ella, L.A. Martinez-Lemus, K.A. Dora, Y. Yang, M.J. Davis, G.A. Meininger, and

M.A. Hill. 2010. Adventitial elastin fibers longitudinally constrain arteriolar smooth muscle cells in vessels from skeletal muscle but not the cerebral circulation. Integrin Signaling in Physiology and Disease Symposium. University of Missouri, Columbia, Missouri, October 17-18, 2010.

68. Galiñanes E.L., and Martinez-Lemus, L.A. Visualization of actin dynamics in isolated arterioles. Cardiovascular Day XVIII, University of Missouri-Columbia, Columbia, MO, February 2011

69. Stupica, A. P.S. Clifford, S.R. Ella, Z. Nourian, Y. Yang, K.A. Dora, L.A. Martinez-Lemus, M.J.

Davis, G.A. Meininger and M.A. Hill. Regional Heterogeneity in the Mechanical Environment of the Arteriolar Wall Due to Differences in Adventitial Matrix. Annual Meeting of the Societies for Experimental Biology. Washington D.C., April 2011. Published in FASEB J., 2011.

70. Galiñanes E.L., and Martinez-Lemus, L.A. Prolonged Vasoconstriction of Small Resistance

Arteries Involves Actin Polymerization Causing Cytoskeletal Remodeling Within the Vascular Smooth Muscle Cells (VSMC). Annual Meeting of the Societies for Experimental Biology. Washington D.C., April 2011. Published in FASEB J., 2011.

71. Beig, M.I., A. Dolan, G. Zhao, E. Hoover, E.L. Galiñanes, and L.A. Martinez-Lemus. Role of actin

cytoskeleton and microtubules in passive diameter and viscoelastic characteristics of rat cremaster arterioles. Annual Meeting of the Societies for Experimental Biology. Washington D.C., April 2011. Published in FASEB J., 2011.

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72. Dolan A., M.I. Beig, G. Zhao, E. Hoover, E. Galiñanes, L.A. Martinez-Lemus. The role of the

cytoskeleton on vascular remodeling and the viscoelastic characteristics of small resistance arteries. Life Sciences Undergraduate Research Spring Forum, University of Missouri, April, 2011.

73. Martinez-Lemus, L.A., E.L. Galiñanes and G.A. Meininger. Evidence for altered actin-

polymerization during vasoconstriction induced remodeling of resistance arteries. 10th International Symposium on Resistance Arteries, Rebild, Denmark May 8–12, 2011.

74. Meininger, Gerald A., Z. Sun, L.A. Martinez-Lemus and M.A. Hill. Integrins and matricryptins in

the control of microvascular tone and structural adaptation, Physiology, Oxford, July 2011.

75. Meininger, G.A., Z. Sun, L.A. Martinez-Lemus and M.A. Hill. The role of integrins and extracellular matrix in the control of microvascular tone and structural adaptation. The 1st Intenational Symposium on Microvascular Medicine, at the founding ceremony of International Center of Microvascular Medicine, CAMS, October 21, 2011.

76. Staiculescu, M.C., E.L. Galiñanes, G. Zhao, M. Li, U. Ulloa, M. Jin and L.A. Martinez-Lemus. Smooth Muscle Actin Polymerization and Vasoconstriction-Induced Inward Remodeling of Resistance Arteries. Cardiovascular Day XIX, University of Missouri-Columbia, Columbia, MO, February 2012.

77. Kim, D.J., L.A. Martinez-Lemus and G.E. Davis. EB1, p150Glued and Clasp1 control apical polarization of acetylated tubulin during vascular tube formation in 3D matrices. Cardiovascular Day XIX, University of Missouri-Columbia, Columbia, MO, February 2012.

78. Staiculescu, M.C., E.L. Galiñanes, G. Zhao, M. Li, U. Ulloa, M. Jin and L.A. Martinez-Lemus.

Smooth Muscle Actin Polymerization and Vasoconstriction-Induced Inward Remodeling of Resistance Arteries. Annual Meeting of the Societies for Experimental Biology. San Diego CA, April 2012. Published in FASEB J., 2012.

79. Martinez-Lemus, L.A., K. Stockard, M. Jin, M.C. Staiculescu, G. Zhao, M.A. Hill and G.A.

Meininger. Characteristics of the internal elastic lamina in inwardly remodeled arteries. Joint meeting of The British Microcirculation Society and The Microcirculatory Society. Keble College, University of Oxford, U.K., July 4-6, 2012. Published in Microcirculation.

80. Nourian Z., M. Li, A. Stupica, M. Krenz, C. Baines, L.A. Martinez-Lemus, P. Clifford, G.A. Meininger and M.A. Hill. Age-dependent changes in arterial wall expression of extracellular matrix proteins. Meeting of the British Microcirculation Society and the Microcirculatory Society, Keeble College, Oxford, UK, July 4-6, 2012.

81. Schenewerk, A., S.R. Huffman, G. Zhao, L.A. Martinez-Lemus, and R.M. Rivera. The effect of

maternal high-fat diet and ART on cardiovascular outcome in offspring. Presented at the 45th annual meeting of the Society for the Study of Reproduction and the 18th Ovarian Workshop. State College, PA. August, 2012. Published in Reproduction.

82. Castorena-Gonzalez, J.A., M.C. Staiculescu, G. Zhao and L.A. Martinez-Lemus. Contribution of the Actin Cytoskeleton to the Viscoelastic Characteristics of Inwardly Remodeled Arterioles. Cardiovascular Day XX, University of Missouri-Columbia, Columbia, MO, February 2013.

83. Staiculescu M.C., Z. Hong, Z. Sun, F.I. Ramirez-Perez, G.A. Meininger and L.A. Martinez-Lemus. Production of Reactive Oxygen Species is Required for the Lysophosphatidic Acid-Induced Integrin Activation in Vascular Smooth Muscle Cells. Cardiovascular Day XX, University of Missouri-Columbia, Columbia, MO, February 2013.

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84. Foote, C.A., F.I. Ramirez-Perez, M.A. Hill, G.A. Meininger and L.A Martinez-Lemus. Topical

application of 5-HT + L-NAME in vivo induces inward remodeling of the rat cremasteric 1A arteriole via a mechanism that is antagonized by the addition of Cystamine, a competitive inhibitor of Transglutaminase II. Cardiovascular Day XX, University of Missouri-Columbia, Columbia, MO, February 2013.

85. Schenewerk, A., C. Foote, L.A. Martinez-Lemus, and R.M. Rivera. The effect of maternal high fat

diet and ART on cardiovascular health and body weight in offspring. Presented at the Rocky Mountain Reproductive Sciences Symposium. Loveland, CO, April 19, 2013.

86. Staiculescu, M.C., Z. Hong, Z. Sun, F. Ramirez-Perez, G.A. Meininger, L.A. Martinez-Lemus.

Lysophosphatidic acid-induced integrin activation in vascular smooth muscle cells requires production of reactive oxygen species. Annual Meeting of the Societies for Experimental Biology. Boston, MA, April 2013. Published in FASEB J., 2013.

87. Foote, C., F.I. Ramirez-Perez, M.A. Hill, G.A. Meininger, L.A. Martinez-Lemus. Topical application

of serotonin + L-NAME in vivo induces inward remodeling of the rat cremasteric 1A arteriole via a mechanism that is antagonized by the addition of cystamine, a competitive inhibitor of transglutaminase II. Annual Meeting of the Societies for Experimental Biology. Boston, MA, April 2013. Published in FASEB J., 2013.

88. Ramirez-Perez, F.I., A. Schenewerk, C. Foote, G. Zhao, R.M. Rivera, L.A. Martinez-Lemus. Mice

produced by the use of assisted reproductive technologies from dams provided a high-fat and –fructose diet have reduced arterial vasodilation responses to acetylcholine. Annual Meeting of the Societies for Experimental Biology. Boston, MA, April 2013. Published in FASEB J., 2013.

89. Zhao, G., J.A. Castorena-Gonzalez, J.R. Sowers, L.A. Martinez-Lemus. Differential remodeling

characteristics of femoral and mesenteric arteries from mice with diet-induced obesity. Annual Meeting of the Societies for Experimental Biology. Boston, MA, April 2013. Published in FASEB J., 2013.

90. Castorena-Gonzalez, J.A., M.C. Staiculescu, G. Zhao, L.A. Martinez-Lemus. Contribution of the

actin cytoskeleton to the viscoelastic characteristics of inwardly remodeled arterioles. Annual Meeting of the Societies for Experimental Biology. Boston, MA, April 2013. Published in FASEB J., 2013.

91. Martinez-Lemus, L.A., R.A. de la Torre, E.L. Galiñanes, M.J. Perna, G. Zhao, J.A. Castorena-

Gonzalez. Arterioles from bariatric patients with diabetes have blunted responses to insulin but not acetylcholine. Annual Meeting of the Societies for Experimental Biology. Boston, MA, April 2013. Published in FASEB J., 2013.

92. Ramirez-Perez, F.I., A.L. Schenewerk, C.A. Foote, G. Zhao, R.M. Rivera and L.A. Martinez- Lemus. The Use of Assisted Reproductive Technologies and High-Fat and High-Fructose Diet Induces a Impaired Arterial Vasodilation Response to Acetylcholine in Female Mice. Cardiovascular Day XXI, University of Missouri-Columbia, Columbia, MO, February 2014.

93. Tong, X., M.C. Staiculescu and L.A. Martinez-Lemus. Identification of the elastin receptor in rat smooth muscle cells using Western blot. Cardiovascular Day XXI, University of Missouri-Columbia, Columbia, MO, February 2014.

94. Foote, C.A., M.C. Staiculescu, F.I. Ramirez-Perez, M.A. Hill, G.A. Meininger and L.A. Martinez-Lemus. Topical application of serotonin + L-NAME in vivo induces inward remodeling of the rat cremasteric 1A arteriole via a mechanism that is antagonized by the addition of cystamine, a

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competitive inhibitor of transglutaminase II. Cardiovascular Day XXI, University of Missouri-Columbia, Columbia, MO, February 2014.

95. Staiculescu M.C., F.I. Ramirez-Perez, J.A. Castorena-Gonzalez, Z. Hong, Z. Sun, G.A. Meininger3 and L.A. Martinez-Lemus. Effects of lysophosphatidic acid in vascular smooth muscle cells and resistance arteries. Cardiovascular Day XXI, University of Missouri-Columbia, Columbia, MO, February 2014.

96. Castorena-Gonzalez J.A., M.J. Perna, R.A. DeLa Torre and L.A. Martinez-Lemus. Arterioles from bariatric patients with diabetes have blunted-responses to insulin but not to acetylcholine. Cardiovascular Day XXI, University of Missouri-Columbia, Columbia, MO, February 2014.

97. Aroor, A.R., V. DeMarco, G. Jia, Z. Sun, M. Garro, L.A. Martinez-Lemus, G.A. Meininger, and

James R. Sowers. Increased Endothelial Cell Stiffness and Impaired Diastolic Function in Western Diet Fed Female Mice. ICE/ENDO 2014, June 21-24 in Chicago, Illinois.

98. Aroor A.R., V.G. DeMarco, G. Jia, J. Habibi, Z. Sun, M. Garro, L.A. Martinez-Lemus, G.A. Meininger and J.R. Sowers. 1,2,3,4DPP-4 inhibitor MK0626 decreases cardiac and vascular stiffness and improves diastolic and vascular relaxation in western diet fed mice, HBPR meeting 2014, Published in HBPR Council meeting abstracts.

99. Martinez-Lemus, L.A., M.C.Staiculescu, J.A. Castorena-Gonzalez, Z. Hong, M.A. Hill, and G.A. Meininger. Role of the vascular smooth muscle cytoskeleton on vasoconstriction-induced inward remodeling of resistance arteries. 11th International Symposium on Resistance Arteries. Banff, CA, September, 2014. Published in JVR.

100. Meininger G.A., Z. Hong, Z. Sun, M. Li, Z. Li, F. Bunyak, I. Ersoy, J.P. Trzciakowski, M.C. Staiculescu, L.A. Martinez-Lemus, M.A. Hill, K. Reeves, and K. Palaniappan. Dynamic effects of vasoactive agonists on vascular smooth muscle cell elasticity, cytoskeletal remodeling and adhesion. XVI Annual Linz Winter Workshop. Linz, Austria, February 2014.

101. Pennington, K.A., K.E. Pollock, O.O. Esangbedo, C.A. Foote, F.I. Ramirez-Perez, L.A. Martinez-Lemus, and L.C. Schulz. Role of Maternal Leptin in Programming of Offspring Cardiovascular Disease. SSR 2015 Annual Meeting, July 19-23, Grand Rapids, Michigan.

102. Tong X., M.C. Staiculescu, M. Li, F.I. Ramirez-Perez, C.A. Foote, M.A. Hill, G.A. Meininger and L.A. Martinez-Lemus. Elastin-derived Peptides Activate Vascular Smooth Muscle Cells via the Neuraminidase Subunit of the Elastin Receptor Complex. Cardiovascular Day XXII, University of Missouri-Columbia, Columbia, MO, February 2015.

103. Castorena-Gonzalez, J.A., M.A. Hill, G.A. Meininger, L.A. Martinez-Lemus. Functional and Mechanical Modifications Associated with Essential Hypertension and Aging in the Resistance Vasculature. Cardiovascular Day XXII, University of Missouri-Columbia, Columbia, MO, February 2015.

104. Foote, C.A., J.A. Castorena-Gonzalez, M.C. Staiculescu, M.A. Hill, G.A. Meininger and L.A. Martinez-Lemus. Transient serotonin exposure induces arteriolar inward remodeling in vivo via a mechanism contingent on transglutaminase activation and actin cytoskeleton reorganization. Cardiovascular Day XXII, University of Missouri-Columbia, Columbia, MO, February 2015.

105. Ramirez-Perez, F.I., K.A. Pennington, K.E. Pollock, O.O. Esangbedo, H. Wu, C.A. Foote, T. Ji, L.C. Schulz and L.A. Martinez-Lemus. Effects of Maternal Leptin and an Obesogenic Environment in Programming of Offspring Cardiovascular Function. Cardiovascular Day XXII, University of Missouri-Columbia, Columbia, MO, February 2015.

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106. Meininger, G.A., G. Jia, J. Habibi, A. R. Aroor, Z. Sun, L. Ma, V.G. DeMarco, L.A. Martinez-

Lemus, I.Z. Jaffe, and J.R. Sowers. Endothelial Cell Mineralocorticoid Receptor Knockout Prevents Western Diet - Induced Aortic Stiffness in Female Mice. XVII. Annual Linz Winter Workshop, Linz, Austria, January 30-February 2, 2015.

107. Manrique C., G. Lastra, D. Haertling, V.G. DeMarco, A.R. Aroor, G. Jia, F. Ramirez, L.A. Martinez-Lemus and Jaffe IZ. Endothelial Estrogen Receptor Alpha Does Not Protect Female Mice Against High Fat/High Fructose Diet Induced Vascular Stiffness. Presented at Annual Meeting of the Endocrine Society. San Diego, CA, March 2015. Published in Endocrine Reviews, 2015.

108. Jia G., J. Habibi, A.R. Aroor, Z. Sun, L. Ma, V.G. DeMarco, L.A. Martinez-Lemus, G.A. Meininger, I.Z. Jaffe and J.R. Sowers. Endothelial Cell Mineralocorticoid Receptor Knockout Corrects Western Diet-Induced Aortic Stiffness and Cardiac Diastolic Dysfunction in Female Mice. Presented at Annual Meeting of the Endocrine Society. San Diego, CA, March 2015. Published in Endocrine Reviews, 2015.

109. Aroor, A.R., J. Habibi, V.G. DeMarco, G. Jia, C.M. Manrique, L.A. Martinez-Lemus, Z. Sun, M. Garro, G.A. Meininger and James R. Sowers. Sex Differences in Progression of Arterial Stiffness and Diastolic Dysfunction in Western Diet Fed Mice. Presented at Annual Meeting of the Endocrine Society. San Diego, CA, March 2015. Published in Endocrine Reviews, 2015.

110. Bender, S.B., J.A. Castorena-Gonzalez, M. Garro, C.C. Reyes-Aldasoro, J.R. Sowers, V.G. DeMarco and L.A. Martinez-Lemus. Regional Variation in Arterial Stiffening and Dysfunction in Western Diet-Induced Obesity. Annual Meeting of the Societies for Experimental Biology. Boston, MA, April 2015. Published in FASEB J., 2015.

111. Hill, M.A., Nourian Z., K. Hong, J. Castorena-Gonzalez, L.A. Martinez-Lemus, G.A. Meininger. Structural and Cellular Mechanisms Underlying Adaptive and Pathological Vascular Responses to Mechanical Forces. 10th World Congress for Microcirculation, Kyoto, Japan, September 25-27, 2015.

112. Jia, G., Javad Habibi, A.R. Aroor, Z. Sun, L. Ma, V.G. DeMarco, L.A. Martinez-Lemus, G.A. Meininger, I.Z. Jaffe, and J.R. Sowers. Endothelial Cell Mineralocorticoid Receptor: A Critical Player in Aortic Stiffness and Cardiac Diastolic Dysfunction in Female Mice. High Blood Pressure Research Council Meeting of American Heart Association, Orlando, FL November 7-11, 2015.

113. Aroor, A.R., G. Jia, V.G. DeMarco, J. Habibi, Z. Sun, M. Garro, L.A. Martinez-Lemus, R. Nistala, A.T. Whaley-Connell, G.A. Meininger and James R. Sowers. Uric acid promotes vascular stiffness and immune inflammatory response in western diet fed mice. High Blood Pressure Research Council Meeting of American Heart Association, Orlando, FL November 7-11, 2015.

114. Johnson, A.G., F.I. Ramirez-Perez, J.R. Sowers and L.A. Martinez-Lemus. Endothelial ENaC Inhibition Attenuates Western Diet-induced Endothelial Dysfunction in Female Mice. Health Sciences Research Day, School of Medicine University of Missouri, Columbia, MO, November 12 2015.

115. Restaino, R.M., L.K. Walsh, T. Morishimia, J.R. Vranish, L.A. Martinez-Lemus, P.J. Fadel, J.

Padilla. Endothelial Dysfunction following Prolonged Sitting is Mediated by a Reduction in Shear Stress. Cardiovascular Day XXIII, University of Missouri-Columbia, Columbia, MO, February 2016.

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116. Ramirez-Perez F.I, K.A. Pennington, K.E. Pollock, O.O. Esangbedo, C.A. Foote, C.C. Reyes-Aldasoro, H. Wu, T. Ji, L.A. Martinez-Lemus, L.C. Schulz. Maternal Hyperleptinemia Increases Arterial Stiffening and Alters Vasodilatory Responses to Insulin in Adult Male Mice Offspring. Cardiovascular Day XXIII, University of Missouri-Columbia, Columbia, MO, February 2016.

117. Nourian, Z, J.A. Castorena-Gonzalez, L.A. Martinez-Lemus, G.A. Meininger and M.A. Hill. Age-related changes in small mesenteric arterial structure in spontaneously hypertensive rats. Cardiovascular Day XXIII, University of Missouri-Columbia, Columbia, MO, February 2016.

118. Foote, C.A., J.A. Castorena-Gonzalez, M.A. Hill1, J.R. Sowers, C.C. Reyes-Aldasoro, and L.A. Martinez-Lemus. A Western diet induces arterial stiffening in mouse mesenteric arteries, coincident with increased elastin deposition, decreased arterial fenestrations and increased plasma neuraminidase activity. Cardiovascular Day XXIII, University of Missouri-Columbia, Columbia, MO, February 2016.

119. Manrique-Acevedo, C., J. Padilla, V. Vieira-Potter, D. Haertling, F.I. Ramirez-Perez, J.R. Sowers and L.A. Martinez-Lemus. Loss of Endothelial Estrogen Receptor Alpha Reduces Vascular Stiffness in Western Diet-Fed Male Mice. Presented at Annual Meeting of the Endocrine Society. Boston, MA, April 2016. Published in Endocrine Reviews, 2016.

120. Ramirez-Perez F.I, K.A. Pennington, K.E. Pollock, O.O. Esangbedo, C.A. Foote, C.C. Reyes-Aldasoro, H. Wu, T. Ji, L.A. Martinez-Lemus, L.C. Schulz. Maternal Hyperleptinemia Increases Arterial Stiffening and Alters Vasodilatory Responses to Insulin in Adult Male Mice Offspring. Annual Meeting of the Societies for Experimental Biology. San Diego, CA, April 2016. Published in FASEB J., 2016.

121. Restaino, R.M., L.K. Walsh, T. Morishimia, J.R. Vranish, L.A. Martinez-Lemus, P.J. Fadel, J. Padilla. Endothelial Dysfunction following Prolonged Sitting is Mediated by a Reduction in Shear Stress. Annual Meeting of the Societies for Experimental Biology. San Diego, CA, April 2016. Published in FASEB J., 2016.

122. Padilla, J., F.I. Ramirez-Perez, B. Bostick, A.R. Aroor, C. Manrique, L.A. Martinez-Lemus, J.R. Sowers. Regular Exercise Reduces Endothelial and Whole Artery Stiffness in Western Diet-Fed Female Mice. Annual Meeting of the Societies for Experimental Biology. San Diego, CA, April 2016. Published in FASEB J., 2016.

123. Aroor, A., J. Habibi, G. Jia, C. Manrique, Z. Sun, L.A. Martinez-Lemus, G.A. Meininger, J.R. Sowers. Xanthine Oxidase Inhibition Decreases Vascular Stiffness in Western Diet-Fed Male and Female Mice. Annual Meeting of the Societies for Experimental Biology. San Diego, CA, April 2016. Published in FASEB J., 2016.

124. Foote, C.A., J.A. Castorena-Gonzalez, P.S. Clifford, M.A. Hill, G.A. Meininger, L.A. Martinez-Lemus. Transient exposure to Serotonin + L-NAME activates early processes mediating inward remodeling of cremasteric arterioles, in vivo. Annual Meeting of the Societies for Experimental Biology. San Diego, CA, April 2016. Published in FASEB J., 2016.

125. Martinez-Lemus, L.A., F.I. Ramirez-Perez, G. Jia, J. Habibi, A. Aroor, V. DeMarco, Z. Sun, G.

Meininger, I. Jaffe and J. Sowers. Amiloride Enhances Arterial Flow-Induced Dilation in Female Mice Fed a Western Diet. Annual Meeting of the Societies for Experimental Biology. San Diego, CA, April 2016. Published in FASEB J., 2016.

126. Jia, G., J. Habibi, A.R. Aroor, F.I. Ramirez-Perez, Z. Sun, V.G. DeMarco, L.A. Martinez-Lemus, G.A. Meininger, I.Z. Jaffe, J.R. Sowers. Endothelial Cell Mineralocorticoid Receptor Mediates

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Vascular Insulin Resistance and Stiffness in Female Mice Fed a Western Diet. 76th Annual American Diabetes Association Meeting, New Orleans, LA, June 10-14, 2016.

127. Aroor, A.R., V.G. DeMarco, G. Jia, J. Habibi, Z. Sun, L.A. Martinez-Lemus, G.A. Meininger, I.Z. Jaffe, J.R. Sowers. Epithelial sodium channel inhibition with amiloride prevents vascular stiffening in response to a western diet in female mice. 76th Annual American Diabetes Association Meeting, New Orleans, LA, June 10-14, 2016.

128. Sowers, J.R., A. Aroor, G. Jia, R. Nistala, M. Garro, G.A. Meininger, L.A. Martinez-Lemus, E. Mayoux, A. Whaley-Connell and V.G. DeMarco. Sodium Glucose Transporter Type-2 Inhibitor (SGLT-2i), Empagliflozin, Improves Vascular Stiffness in Female Diabetic db/db Mice Independent of Blood Pressure Reduction. 76th Annual American Diabetes Association Meeting, New Orleans, LA, June 10-14, 2016.

129. Meininger, G.A., Z. Sun, M.A. Hill, L.A. Martinez-Lemus. Rapid remodeling of vascular smooth muscle adhesion is coordinated with contraction. Joint Meeting of the Federation of European Societies of Physiology and the French Physiological Society, Paris, June 29-July 1, 2016.

130. Martinez-Lemus, L.A., C.A. Foote, J.A. Castorena-Gonzalez, M.C. Staiculescu, M.A. Hill, G.A. Meininger. Is tissue-type transglutaminase involved in smooth muscle cytoskeletal reorganization during vascular remodeling? Gordon Conference: Transglutaminases in Human Disease Processes. Girona, Spain, July 10-15, 2016.

131. Mayoux, E., J.R. Sowers, A. Aroor, G. Jia, R. Nistala, M. Garro, G.A. Meininger, L.A. Martinez-Lemus, A. Whaley-Connell and V.G. DeMarco. Sodium Glucose Transporter Type-2 Inhibitor (SGLT-2i), Empagliflozin, Improves Vascular Stiffness in Female Diabetic db/db Mice Independent of Blood Pressure Reduction. Chinese Society of Endocrinology August 31 to September 4, 2016.

132. Aroor, A.R., F.I. Ramirez-Perez, G. Jia, J. Habibi, V.G. DeMarco, M. Garro, B.J. Barron, Z. Sun,

G.A. Meininger, L.A. Martinez-Lemus, and J.R. Sowers. Endothelial Sodium Channel Activation Promotes Vascular Stiffness in Obese Female Mice. Presented at Annual Meeting of the Hypertension 2016 Scientific Sessions. Orlando, FL, September 14-17, 2016.

133. G.A. Meininger, Z. Sun, M.A. Hill, L.A. Martinez-Lemus. Dynamic Remodeling of the Cytoskeleton and Adhesion Coupled to Vascular Smooth Muscle Dilation. International Symposium on Mechanisms of Vasodiliataion. Mayo Clinic, Rochester, MN November 6-9, 2016.

134. DeClue, C.E., C. Manrique-Acevedo, F.I. Ramirez-Perez, J.R. Sowers, L.A. Martinez-Lemus. Loss of Estrogen Receptor Alpha Reduces Vascular Stiffness in Western Diet-Fed Male Mice Via Collagen and Elastin Hypertrophic Remodeling. Health Sciences Research Day, School of Medicine University of Missouri, Columbia, MO, November 17, 2016.