Lowering the Histamine Burden Oct 2012 Mastocytosis Conference

Lowering the Lowering the Histamine BurdenHistamine Burden

Methods we used to lower our young son’s histamine burden,

to reduce the frequency and intensity of dangerous and painful

histamine mediated reactions.

The Mastocytosis Society Annual ConferenceOctober 2012

Copyright Tiffany Blackden 2012 All Rights Reserved


Max’s Daily MCAD Max’s Daily MCAD SymptomsSymptoms

Hives, dermatographia, flushing, swelling, stomach aches, headaches, leg pain, itching, anaphylaxis from:Food (too many to name!)FrictionHeatColdChange in tempAnimalsChemicalsSynthetic FabricsSkin Contact With Plants/GrassEtc…???


A few of his A few of his reactions:reactions:

Blisters on both lower legs after consuming olive oil.

Rolled around on synthetic rug…

taken after the hives calmed down a bit.

Really angry reaction from playing with a scratchy rope. This was after it was calm, we nearly went to the hospital, it covered a lot of his torso and most of his arm.


Max’s Health Team:Max’s Health Team:

Naturopathic DoctorsNationally Certified NutritionistsAcupuncturist - BioSet PractitionerChinese Medicine PractitionerOsteopathic DoctorChiropractorMD HomeopathBiomedical MDHis Mommy, Daddy and Sister, Ellie


What’s in a mast cell? Preformed mediators :

(from granules)-Serine proteases-Tryptase-Histamine-Serotonin-Proteoglycans-mainly heparin

Newly formed Lipid Mediators: (eicosanoids)-Thromboxane-Prostoglandins-Leukotreines-Platelet Activating Factor-Cytokines

Today we are focusing on HISTAMINE…Copyright Tiffany Blackden 2012 All Rights Reserved

Art by: Angela Canada Hopkinshttp://www.canadahopkins.com/

Histamine is a protective part Histamine is a protective part of our body’s natural of our body’s natural responses…responses…

Local Immune Response for Injury

Protective Mechanism in ‘Boundary’ Tissues

Regulates Smooth Muscle Contraction

Neurotransmitter


Histamine Affects Histamine Affects EveryEvery System of the Body System of the Body

NeurologicalCardiovascularMusculoskeletalGastrointestinalReproductiveRespiratoryCutaneous

It is produced in mast cells, basophils, platelets, neutrophils and some neurons…and stored intracellularly, then released when stimulated.


Histamine Receptors:Histamine Receptors:H1: Smooth Muscle, Endothelium, Central

Nervous System Tissue

H2: Gastrointestinal, Vascular Smooth Muscle Tissue

H3: Central Nervous System and Some Peripheral Nervous System

H4 (Just discovered in 2000): Bone Marrow, Basophils, Thymus, Small Intestine, Spleen, Colon


Dtsch Arztebl 2006; 103(51–52):A 3477–83.


Histamine Histamine Burden is Burden is cumulative over cumulative over the course of a the course of a day (sometimes day (sometimes more, if the more, if the burden is high).burden is high).

Control what you Control what you CAN, to keep the CAN, to keep the cup from cup from overflowing with overflowing with all the factors all the factors not in your not in your control.control.


Histamine Overload…Histamine Overload…

Histamine for Digestion

PineappleSodium Benzoate in Soda

Cat Dander

Ragweed

Hot Day

Chicken Leftover in Fridge


Sources of Histamine:Sources of Histamine:

Normal Metabolic Function Throughout Body

Dietary Histamine Foods That Release Histamine From

Mast CellsIgE (Allergy) Mast Cell Degranulation Non-IgE (Trigger)Mast Cell

DegranulationBacteria


Avoiding High Histamine Avoiding High Histamine Pitfalls:Pitfalls:

Fermented FoodsCured FoodsDyesPreservatives/AdditivesSulphitesRefrigerated Leftovers (freeze them)AlcoholHigh Histamine FoodsHistamine Releasing FoodsDAO Inhibiting Chemicals


How Does How Does HistamineHistamine

* *EXIT*EXIT* Our Bodies?Our Bodies?


Deactivation AND Liver Deactivation AND Liver MetabolismMetabolism

Enzymes that BREAK DOWN Histamine:

oDAO (Diamine Oxidase)oHMT (Histamine Methyltransferase)oMAO A (Monoamine Oxidase A)

Phase I & II Liver DetoxificationoMethylationo SulfationoOxidation


Histamine Liberating or Histamine Liberating or DAO Inhibiting MedicationsDAO Inhibiting Medications

Substance class Some Active agents Radiological Contrast media Muscle relaxants Pancuronium, Alcuronium, D-Tubocurarin Narcotics Thiopental Analgesics Morphine, pethidine, NSAR, ASS,

metamizole Local anesthetics Prilocaine Antihistamines Dyphenhydramine Antihypotensives Dobutamine Antihypertensives Verapamil, alprenolol, dihydralazine Antiarrhythmics Propafenon Diuretics Amiloride Motility agents Metoclopramide Antibiotics Cefuroxime, cefotiam,

isoniazid,pentamidine, clavulanic acid, chloroquine Mucolytics Acetylcysteine, ambroxol Broncholytics Aminophylline H2 receptor antagonists Cimetidine Cytostatics Cyclophosphamide Antidepressants Amitriptylline Copyright Tiffany Blackden 2012

All Rights Reserved

Ways to Help the Liver Flush Ways to Help the Liver Flush HistamineHistamine

Reduce overall chemical load.

Move lymph in our bodies.Lower your stress level.Drink lots of clean water.Get adequate nutrients for detoxification.


Some doctors in Europe treat Some doctors in Europe treat DAO deficiency as a DAO deficiency as a progressing disease progressing disease

process…process…

MastocytosisMCAD

Hypersensitivity DisorderHistaminosis

Histamine Intolerance


Our Low Histamine Our Low Histamine StrategiesStrategies


Mast Cell – Histamine Mast Cell – Histamine DiariesDiariesFoods (Sensitivities/Histamine/Glycemic

Index)Beverages (Hydration

Level/Dyes/Sweeteners)Exposures

(Pollen/Stores/Chemicals/Smells)Reactions (Type/Duration/Medication)Sleep (Amount/Quality)Emotional State

(Anxious/Depressed/Happy/Stressed)


Our High Quality NutritionOur High Quality Nutrition

Drink plenty of good quality water every day.Low Histamine/Tyramine, Organic Whole Foods

(locally grown when possible)Rotate FoodsNo Gluten/Dairy/Soy/Eggs/Nuts/Citrus/Dyes/Additives

Preservatives/Polyunsaturated FatsOnly grass fed beef and wild caught fishGood quality fats daily(No PUFAs) Digestive EnzymesSources of Trace Minerals (Pink Himalayan Salt,

Dulse Flakes, Superdupermineralpackedwheatgrass juice)

Some High Quality SupplementsRaw Leafy Greens (methylation support)


Daily Health SupportDaily Health SupportHydration, Hydration, HydrationDense NutritionEpsom Salt Baths Daily (Additional

Magnesium Chloride Spray as Needed)Moderate Exercise-Play, Mini

TrampolineClean AirGood Quality SleepLimit All Man-made Chemical Exposure

PossibleAyurvedic-Style Meal Preparation12 Hour Night FastLow Stress Copyright Tiffany Blackden 2012

All Rights Reserved

Get in touch, get Get in touch, get support…support…

Tiffany Blackden on Facebook or Twitter

[email protected]

Join Facebook Group: “Mastocytosis – Holistic Approach”

Our FB page for our medical journey & research:

www.Facebook.com/blackdenfamilyCopyright Tiffany Blackden 2012 All Rights Reserved

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Lowering the Histamine Burden Oct 2012 Mastocytosis Conference