Inpharma 1462 - 6 Nov 2004

■ Low-dose unfractionated heparin preventscatheter-related thrombosis in patients with haemato-oncological disease, report researchers from Tunisia.Before central venous line (CVL) insertion, 111 suchpatients were randomised to receive a continuous IVinfusion of unfractionated heparin 100 IU/kg/day ornormal saline (control group). There were128 evaluable CVLs (65 in the heparin group). Theincidence of catheter-related thrombosis wassignificantly lower in the heparin group than thecontrol group (1.5% vs 12.6% of CVLs). Furthermore,there was a significantly lower rate of catheterdysfunction in the heparin group than the controlgroup (16.9% vs 52%).Abdelkefi A, et al. Prevention of central venous line-related thrombosis bycontinuous infusion of low-dose unfractionated heparin, in patients withhaemato-oncological disease: a randomized controlled trial. Thrombosis andHaemostasis 92: 654-661, No. 3, Sep 2004 800990246

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Inpharma 6 Nov 2004 No. 14621173-8324/10/1462-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved