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Low Cost Blood Analyzer for Malaria Detection. Project Advisors: Prof. William Tang, Gelareh Eslamian Project Team: Nadia Ahmed, Kevin Cho, Johnway Yih, Anna Grace Additional Help: Timothy Quang , Robert Diehl, Ling Kong, Transon Nguyen, Kun Qian. Background. - PowerPoint PPT Presentation
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Low Cost Blood Low Cost Blood AnalyzerAnalyzerfor Malaria Detectionfor Malaria Detection
Project Advisors: Prof. William Tang, Gelareh EslamianProject Team: Nadia Ahmed, Kevin Cho, Johnway Yih, Anna GraceAdditional Help: Timothy Quang, Robert Diehl, Ling Kong, Transon Nguyen, Kun Qian
BackgroundBackgroundMalaria affects 500 million people a yearThe most common and lethal of four different strains of malaria is Plasmodium Falciparum
www.sciencemag.org on June 1, 2010
PurposePurpose
• Avoid misdiagnosis (which leads to drug resistance)
• Provide cheap and reliable diagnosis
• Keep the device portable
• Create an alternative to slow and expensive microscopy blood analysis
Properly diagnose Malaria in a cheap and effective manner
Project TheoryProject Theory• Malaria targets red blood cells (RBC)
• Infected RBCs become more rigid and form a rough exterior
• Infected RBCs travel slower than non infected RBCs
• Infection can be quantified and measured based on flow speed of RBCs
www.pnas.orgcgidoi10.1073pnas.2433968100
Project DesignProject DesignCreate an optical sensor with a laser diode
and photodiode
Flowing RBCs will interrupt the laser beam
Disruption of the laser beam will be recorded by voltage output of photodiode
Use National Instruments DAQ to record information on a PC
Project DesignProject Design
Project DesignProject Design
DataDataPhotodiode readout of wire (~500 µm) test
DataDataPhotodiode readout of hair (~100 µm)
test
Microfluidic ChannelsMicrofluidic ChannelsShrinky dink mold methodPrint channel layout on
polystyreneOven at 160-170 degrees CelsiusProblems keeping them flatPour PDMS on top of shrinky
dinksAdhere PDMS to glass slides to
create permanent channels
PDMS ChannelPDMS Channel
Continued WorkContinued WorkFocus the laser
beam to the smallest spot size possible
Detect microbeads flowing through a microchannel (~10 µm)
Detect RBCs (~4-8 µm) in mouse blood
Ultimate GoalUltimate GoalReverse engineer common CD ROM drives
Use the internal optical system for our device
Optical sensors will already be sensitive enough
Cheap alternative to constructing our own materials
Thank YouThank You
Project Advisors: Prof. William Tang, Gelareh EslamianProject Team: Nadia Ahmed, Kevin Cho, Johnway Yih, Anna GraceAdditional Help: Timothy Quang, Robert Diehl, Ling Kong, Transon Nguyen, Kun Qian