Living Donor Kidney Transplant April 15, 2012 Margaret Leid Transplant Community Liaison Penn Transplant Institute margaret.leid@uphs.upenn.edu

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<ul><li><p>Living Donor Kidney TransplantApril 15, 2012Margaret LeidTransplant Community LiaisonPenn Transplant Institutemargaret.leid@uphs.upenn.edu</p><p>*</p><p>Greater Philadelphia Region Kidney Transplant Centers Deceased &amp; Living Donor Transplants: Volume** Scientific Registry of Transplant Patients, January 2012.Time period 7/1/2010 6/30/2011. www.srtr.org</p><p>Chart1</p><p>163</p><p>105</p><p>81</p><p>74</p><p>60</p><p>39</p><p>33</p><p>31</p><p>25</p><p>22</p><p>17</p><p>14</p><p>Total Kidney Transplants</p><p>Sheet1</p><p>Transplant CenterTotal Kidney TransplantsDeceased Donor TransplantLiving Donor TransplantsTotal New Registrations</p><p>Hospital of the University of Pennsylvania16311944315</p><p>Albert Einstein Medical Center1059411444</p><p>Thomas Jefferson University815724192</p><p>Pinnacle Health744628128</p><p>Lehigh Valley604713123</p><p>Hahnemann University Hospital39355150</p><p>Penn State Hershey3324989</p><p>Geisinger Danvillle31121982</p><p>Lankenau2518757</p><p>Our Lady of Lourdes22121073</p><p>Geisinger Wyoming Valley179860</p><p>Temple University Hospital149568</p><p>Transplant CenterTotal Kidney TransplantsTransplant CenterTotal Kidney Transplants</p><p>Hospital of the University of Pennsylvania163PENN163</p><p>Albert Einstein Medical Center105A105</p><p>Thomas Jefferson University81B81</p><p>Pinnacle Health74D74</p><p>Lehigh Valley60E60</p><p>Hahnemann University Hospital39F39</p><p>Penn State Hershey33G33</p><p>Geisinger Danvillle31H31</p><p>Lankenau25I25</p><p>Our Lady of Lourdes22J22</p><p>Geisinger Wyoming Valley17K17</p><p>Temple University Hospital14L14</p><p>Sheet1</p><p>Total Kidney Transplants</p><p>Sheet2</p><p>Sheet3</p><p>*</p><p>Penn Transplant Institute3-Year Patient Survival</p><p>Penn Transplant InstituteBest 3-Year Graft Survival in Region</p><p>Penn Transplant Institute Highest Volume Center in the Region</p><p>SRTR Data 1/2012. For patients transplanted between 1/1/2006 and 6/30/2008</p><p>*</p><p>*Based on January 2012 SRTR data</p><p>Penn Transplant Institute Kidney Transplant ProgramEXPERIENCEFirst kidney transplant 1966VOLUMEHighest volume in Philadelphia RegionOUTCOMESBest 3-year graft survival rates in Philadelphia region*LIVING DONOR TEAMOne of countrys most experienced teams. Most living kidney donors in region*GUEST HOUSEFor transplant patients and their families traveling more than 50 milesEVAL CLINIC YARDLEY, PAReduces travel time by car from NYC by one hour each directionACCESSIBLEBy TrainAmtrak, NJ Transit By BusGreyhound Megabus, Bolt BusLOCATIONHistoric University of Pennsylvania Campus located in shopping/dining University City District</p><p>*</p><p>Clyde F. Barker Penn Transplant HouseFor Reservations and Additional Information: 215-662-4540</p><p>NEW GUESTHOUSEBuilt in June 2011For Penn transplant patients and families traveling more than 50 milesSUPPORT THROUGH ALL PHASES OF CARE EvaluationSurgeryFollow-upCONVENIENT LOCATION Five blocks from PennOn Septa bus line</p><p>INSURANCE COVERAGE Considered part of travel expense for transplant evaluation and follow-up.Check with insurance companyKIDNEY TRANSPLANT SUPPORT GROUPS Second Sunday of each month. Pre and post transplant patients and their familiesLight refreshments providedLONG TERM STAYSBeautiful common kitchen area with storage for each family. Common living and dining area for connection with other transplant patients and families.</p><p>*</p><p>Questions to Run On</p><p>Why does a kidney from a living donor sometimes last twice as long as a kidney from a deceased donor?</p><p>How do I know it is safe for my friends or family to donate a kidney to me?</p><p>How does someone interested in learning about donating a kidney get information before committing to the surgery?</p><p>What are the health requirements for someone thinking about donating a kidney?</p><p>*</p><p>How Do Kidneys Become Available?Living Donors Do Not Need to Be in Your FamilyORLiving Kidney Donors4 to 6 Year Wait Deceased Donor KidneysUNITED NETWORK OF ORGAN SHARING (UNOS)</p><p>*</p><p>(UNITED NETWORK FOR ORGAN SHARING)Government contract to oversee the national system for U.S. organ procurement an transplantationOne Central DatabaseACUTE CARE HOSPITALSWork with OPOs to coordinate the organ donation processTransplant Waiting List:Updated Every Time A Family Says Yes to Donation and Every Time a Patient is Added to the ListWhere do deceased donor kidneys come from?TRANSPLANT CENTERSList patients for transplant Penn is 1 of 256 transplant centers in the U.S.Donor Data Sent to UNOSFamily Says Yes to DonationRecipient data sent to UNOS computer system</p><p>*</p><p> 112,637 OPTNU.S.TRANSPLANT WAITING LIST ALL ORGANS90,621 KIDNEY = 80%WAITING GIFT OF LIFE DONOR PROGRAMDONATION YEAR 2009-2010780 KIDNEY TRANSPLANTS </p><p>OPTN DATA 1/20/2012http://optn.transplant.hrsa.gov</p><p>Our Region5,335 </p><p> AVERAGE WAITING TIME35 YEARS(BASED ON BLOOD TYPE)</p><p>*</p><p>91,425 people in U.S. waiting for kidneyAn average of 16,000 people receive kidney transplants per yearGallup Poll of Americans93%Would Donate Their Loved Ones Organs If They Knew Their Wishes Ahead of Time</p><p>Donor DesignationPennsylvania45.2% Philadelphia County30%</p><p>*</p><p>*</p><p>How Many of Your Patients Understand:</p><p>Dialysis shortens life expectancy compared to transplant.</p><p>The less time on dialysis before transplant, the better the kidney will function and the longer it will last.</p><p>*</p><p>Optimum Strategies to Minimize Time On DialysisLiving Donors</p><p>Consider Kidneys from Expanded Criteria Donors(ECD)</p><p>*</p><p>Summary of OptionsOwn healthy kidneysLiving donor kidneyStandard criteria kidneyExpanded criteria kidneyDialysis</p><p>*</p><p>Why does a kidney from a living donor sometimes last twice as long as a kidney from a deceased donor?Kidney not impacted by brain death.</p><p>The time the kidney is without blood flow is dramatically reduced.</p><p>Living kidney donors are healthier than the average person.</p><p>Only very healthy people are accepted at Penn to be living kidney donors.</p><p>First living donor transplant at Penn more than 40 years ago. Donor and recipient still doing well.</p><p>*</p><p> Benefits of Living Kidney Donor TransplantationKidney lasts longer improved qualityAvoid dialysis completely or shorten time on dialysisBefore complications developImproved patient survivalAvoid 4-6 year wait for deceased donor kidneyTime of transplant operation is made at convenient time for donor and recipientMinimal delayed organ functionMedicines post-transplant may be less aggressive</p><p>Who can be a living donor?Family memberFriendStranger</p><p>*</p><p>*</p><p>Living Donor Evaluation ProcessExtensive and ThoroughDONOR EDUCATIONSESSIONDONOR SELECTION COMMITTEE REVIEW</p><p>*</p><p>Interested in Living Kidney Donation?Steps for Listed Patients</p><p>Complete all testing and attain status 1 on the transplant waiting list.</p><p>Share with your family and friends your experiences with chronic kidney disease and dialysis.</p><p>Invite interested potential donors to complete the Living Kidney Donation Referral Form.</p><p>Encourage friends and family members to support organ donation awareness initiatives through Gift of Life.Steps for Potential Donors</p><p>Submit request for private preliminary consultation with the Living Kidney Donor team.</p><p>Learn about the living kidney donor process through the evaluation process</p><p>Talk with the team about concerns and questions.</p><p>Decide if this is the right option for you at this time.</p><p>*</p><p> What Are the Top 5 Criteria to be a Living Kidney Donor?Free from diabetes, cancer, kidney disease, heart disease and substantial high blood pressure.Physically fit - Body Mass Index (BMI) </p></li></ul>

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