CAS No.

50-00-0

50-32-8

52-24-4

55-98-1

56-53-1

58-89-9

62-44-2

64-17-5

71-43-2

75-01-4

75-07-0

75-21-8

78-87-5

79-01-6

91-59-8

92-67-1

92-87-5

95-53-4

101-14-4

106-99-0

148-82-3

Agents Classified by the IARC Monographs, Volumes 1113

50-18-06055-19-2

298-81-7

299-75-2

305-03-3

313-67-7

313-67-7

446-86-6

494-03-1

505-60-2

1336-36-3

1402-68-2

1746-01-6

7440-07-57440-29-1

7440-38-2

7440-41-7

7440-43-98007-45-2

10043-92-2

10540-29-1

13233-32-4

13909-09-6

13982-63-314596-37-3

542-88-1107-30-2

1332-21-413768-00-812172-73-517068-78-912001-29-512001-28-4

14567-73-8

14808-60-7

15262-20-1

18540-29-9

33419-42-0

57117-31-4

57465-28-8

65996-93-2

66733-21-9

68308-34-9

16543-55-864091-91-4

33419-42-015663-27-1

11056-06-7

59865-13-379217-60-0

Agent

Formaldehyde

Cyclophosphamide

Thiotepa

Busulfan

Diethylstilbestrol

Lindane (see also Hexachlorocyclohexanes)

Phenacetin

Ethanol in alcoholic beverages

Benzene

Vinyl chloride

Acetaldehyde associated with consumption of alcoholic beverages

Ethylene oxide

1,2-Dichloropropane

Trichloroethylene

2-Naphthylamine

4-Aminobiphenyl

Benzidine

4,4'-Methylenebis(2-chloroaniline) (MOCA)

1,3-Butadiene

Melphalan

Agents Classified by the IARC Monographs, Volumes 1113

Benzo[a]pyrene

ortho-Toluidine

Methoxsalen (8-methoxypsoralen) plus ultraviolet A radiation

Treosulfan

Chlorambucil

Aristolochic acid

Aristolochic acid, plants containing

Azathioprine

Chlornaphazine

Sulfur mustard

Bis(chloromethyl)ether; chloromethyl methyl ether (technical-grade)

Asbestos (all forms, including actinolite, amosite, anthophyllite, chrysotile, crocidolite, tremolite)

Polychlorinated biphenyls

Aflatoxins

PlutoniumThorium-232 and its decay products

Arsenic and inorganic arsenic compounds

Beryllium and beryllium compounds

Cadmium and cadmium compoundsCoal-tar distillationRadon-222 and its decay products

Tamoxifen

Radium-224 and its decay products

Semustine [1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea, Methyl-CCNU]

Radium-226 and its decay productsPhosphorus-32, as phosphate

2,3,7,8-Tetrachlorodibenzo-para-dioxin

Silica dust, crystalline, in the form of quartz or cristobalite

Radium-228 and its decay products

Chromium (VI) compounds

Etoposide

Etoposide in combination with cisplatin and bleomycin

2,3,4,7,8-Pentachlorodibenzofuran

3,4,5,3,4-Pentachlorobiphenyl (PCB-126)

Cyclosporine

Coal-tar pitch

Erionite

Shale oils

Acheson process, occupational exposure associated withAcid mists, strong inorganicAlcoholic beverages

Aluminium production

Areca nut

Auramine production

Benzidine, dyes metabolized to

Betel quid with tobacco

Betel quid without tobacco

Coal gasification

Coal, indoor emissions from household combustion of

Coke production

N'-Nitrosonornicotine (NNN) and 4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK)

Clonorchis sinensis (infection with)

Engine exhaust, dieselEpstein-Barr virusEstrogen therapy, postmenopausalEstrogen-progestogen menopausal therapy (combined)

Estrogen-progestogen oral contraceptives (combined)

Fission products, including strontium-90Fluoro-edenite fibrous amphibole

Haematite mining (underground)

Hepatitis B virus (chronic infection with)Hepatitis C virus (chronic infection with)Human immunodeficiency virus type 1 (infection with)

Human papillomavirus types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59

Human T-cell lymphotropic virus type IIonizing radiation (all types)

Iron and steel founding (occupational exposure during)

Isopropyl alcohol manufacture using strong acidsKaposi sarcoma herpesvirusLeather dust

Magenta production

Mineral oils, untreated or mildly treated

MOPP and other combined chemotherapy including alkylating agents

Neutron radiation

Nickel compounds

Outdoor air pollutionOutdoor air pollution, particulate matter inPainter (occupational exposure as a)Phenacetin, analgesic mixtures containing

Radioiodines, including iodine-131

Helicobacter pylori (infection with)

Opisthorchis viverrini (infection with)

Polychlorinated biphenyls, dioxin-like, with a Toxicity Equivalency Factor (TEF) according to WHO (PCBs 77, 81, 105, 114, 118, 123, 126, 156, 157, 167, 169, 189)

Radionuclides, alpha-particle-emitting, internally deposited

Radionuclides, beta-particle-emitting, internally deposited

Rubber manufacturing industry

Salted fish, Chinese-style

Solar radiation

Soot (as found in occupational exposure of chimney sweeps)

Tobacco smoke, second-handTobacco smoking

Tobacco, smokeless

Ultraviolet radiation (wavelengths 100-400 nm, encompassing UVA, UVB, and UVC)

Ultraviolet-emitting tanning devicesWood dustX- and Gamma-Radiation

Schistosoma haematobium (infection with)

Group Volume Year Additional information

1 2012

1 26, Sup 7, 100A 2012 anticanceroso

1 Sup 7, 92, 100F 2012

1 Sup 7, 50, 100A 2012 anticanceroso

1 4, Sup 7, 100A 2012 anticanceroso

1 21, Sup 7, 100A 2012 reemplazo hormonal1 113 In prep.

1 24, Sup 7, 100A 2012

1 96, 100E 2012

1 29, Sup 7. 100F 2012

1 Sup 7, 97, 100F 2012

1 100E 2012

1 2012

1 41, Sup 7, 71, 110 In prep.

1 Sup 7, 63, 106 2014

1 4, Sup 7, 99, 100F 2012

1 1, Sup 7, 99, 100F 2012

1 2012

1 2012

1 2012

1 2012

1 9, Sup 7, 100A 2012

Sup 7, 62, 88, 100F

NB: Overall evaluation upgraded to Group 1 based on mechanistic and other relevant data

NB: Overall evaluation upgraded to Group 1 with supporting evidence from other relevant data

Sup 7, 60, 97, 100F NB: Overall evaluation upgraded to Group 1 based

on mechanistic and other relevant data

29, Sup 7, 99, 100FSup 7, 77, 99, 100F

Sup 7, 57, 99, 100F NB: Overall evaluation upgraded to Group 1 based

on mechanistic and other relevant dataSup 7, 54, 71, 97, 100F

1 24, Sup 7, 100A 2012

1 26, Sup 7, 100A 2012

1 26, Sup 7, 100A 2012

1 82, 100A 2012

1 82, 100A 2012

1 26, Sup 7, 100A 2012

1 4, Sup 7, 100A 2012

1 9, Sup 7, 100F 2012

1 4, Sup 7, 100F 2012

1 14, Sup 7, 100C 2012

1 18, Sup 7, 107 In prep.

1 2012

1 Sup 7, 69, 100F 2012

1 78, 100D 20121 78, 100D 2012

1 23, Sup 7, 100C 2012

1 Sup 7, 58, 100C 2012

1 58, 100C 20121 92, 100F 20121 43, 78, 100D 2012

1 66, 100A 2012

1 78, 100D 2012

1 Sup 7, 100A 2012

1 78, 100D 20121 78, 100D 2012

NB: Overall evaluation upgraded to Group 1 based on mechanistic and other relevant data

NB: Mineral substances (e.g. talc or vermiculite) that contain asbestos should also be regarded as carcinogenic to humans

56, 82, 100F, Sup 7

NB: There is also conclusive evidence that tamoxifen reduces the risk of contralateral breast cancer in breast cancer patients

1 Sup 7, 68, 100C 2012

1 78, 100D 2012

1 Sup 7, 89, 100E 2012

1 Sup 7, 49, 100C 2012

1 76, 100A 2012

1 76, 100A 2012

1 100F 2012

1 100F 2012

1 50, 100A 2012

1 35, Sup 7, 100F 2012

1 42, Sup 7, 100C 2012

1 35, Sup 7, 100F 2012

1 111 In prep.1 54, 100F 20121 44, 96, 100E 2012

1 2012

1 85, 100E 2012

1 Sup 7, 99, 100F 2012

1 99, 100F 2012

1 Sup 7, 85, 100E 2012

1 Sup 7, 85, 100E 2012

1 61, 100B 2012

1 Sup 7, 92, 100F 2012

1 95, 100E 2012

1 Sup 7, 92, 100F 2012

NB: Overall evaluation upgraded to Group 1 based on mechanistic and other relevant data

NB: Overall evaluation upgraded to Group 1 based on mechanistic and other relevant data

NB: Overall evaluation upgraded to Group 1 based on mechanistic and other relevant dataSee Polychlorinated biphenyls, dioxin-like, with a TEF according to WHO

34, Sup 7, 92, 100F

NB: Overall evaluation upgraded to Group 1 based on mechanistic and other relevant data

1 46, 105 20131 70, 100B 20121 72, 100A 20121 72, 91, 100A 2012

1 72, 91, 100A 2012

1 100D 20121 111 In prep.

1 1, Sup 7, 100D 2012

1 61, 100B 20121 59, 100B 20121 59, 100B 20121 67, 100B 2012

1 64, 90, 100B 2012

1 67, 100B 20121 100D 2012

1 34, Sup 7, 100F 2012

1 Sup 7, 100F 20121 70, 100B 20121 100C 2012

1 2012

1 33, Sup 7, 100F 2012

1 Sup 7, 100A 2012

1 75, 100D 2012

1 Sup 7, 49, 100C 2012

1 61, 100B 20121 109 In prep.1 109 In prep.1 47, 98, 100F 20121 Sup 7, 100A 2012

1 107 In prep.

1 78, 100D 2012

NB: There is also convincing evidence in humans that these agents confer a protective effect against cancer in the endometrium and ovary

NB: The HPV types that have been classified as carcinogenic to humans can differ by an order of magnitude in risk for cervical cancer

Sup 7, 57, 99, 100F

NB: Overall evaluation upgraded to Group 1 with supporting evidence from other relevant data

NB: Overall evaluation upgraded to Group 1 with strong supporting evidence from other relevant data

1 78, 100D 2012

1 78, 100D 2012

1 28, Sup 7, 100F 2012

1 56, 100E 20121 61, 100B 20121 55, 100D 2012

1 2012

1 83, 100E 20121 83, 100E 2012

1 Sup 7, 89, 100E 2012

1 55, 100D 2012

1 100D 20121 62, 100C 20121 75, 100D 2012

NB: Specific radionuclides for which there is sufficient evidence in humans are also listed individually as Group 1 agents

NB: Specific radionuclides for which there is sufficient evidence in humans are also listed individually as Group 1 agents

35, Sup 7, 92, 100F

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Last update 24 August 2015

CAS No. Agent Group

50-00-0 Formaldehyde 1

Cyclophosphamide 1

50-32-8 1

52-24-4 Thiotepa 155-98-1 Busulfan 156-53-1 Diethylstilbestrol 1

58-89-9 1

62-44-2 Phenacetin 1

64-17-5 Ethanol in alcoholic beverages 1

71-43-2 Benzene 175-01-4 Vinyl chloride 1

75-07-0 1

75-21-8 Ethylene oxide 1

78-87-5 1,2-Dichloropropane 179-01-6 Trichloroethylene 191-59-8 2-Naphthylamine 192-67-1 4-Aminobiphenyl 1

92-87-5 Benzidine 1

95-53-4 1

101-14-4 1

106-99-0 1,3-Butadiene 1

148-82-3 Melphalan 1

Agents Classified by the IARC Monographs, Volumes 1113

50-18-06055-19-2

Benzo[a]pyrene

Lindane (see also Hexachlorocyclohexanes)

Acetaldehyde associated with consumption of alcoholic beverages

ortho-Toluidine

4,4'-Methylenebis(2-chloroaniline) (MOCA)

298-81-7 1

299-75-2 Treosulfan 1305-03-3 Chlorambucil 1

313-67-7 Aristolochic acid 1

313-67-7 Aristolochic acid, plants containing 1

446-86-6 Azathioprine 1494-03-1 Chlornaphazine 1505-60-2 Sulfur mustard 1

1

1

1336-36-3 Polychlorinated biphenyls 1

1402-68-2 Aflatoxins 1

1746-01-6 1

7440-07-5 Plutonium 1

7440-29-1 Thorium-232 and its decay products 1

7440-38-2 1

7440-41-7 Beryllium and beryllium compounds 1

7440-43-9 Cadmium and cadmium compounds 1

8007-45-2 Coal-tar distillation 1

10043-92-2 Radon-222 and its decay products 1

Methoxsalen (8-methoxypsoralen) plus ultraviolet A radiation

542-88-1107-30-2

Bis(chloromethyl)ether; chloromethyl methyl ether (technical-grade)

1332-21-413768-00-812172-73-517068-78-912001-29-512001-28-4

14567-73-8

Asbestos (all forms, including actinolite, amosite, anthophyllite, chrysotile, crocidolite, tremolite)

2,3,7,8-Tetrachlorodibenzo-para-dioxin

Arsenic and inorganic arsenic compounds

10540-29-1 Tamoxifen 1

13233-32-4 Radium-224 and its decay products 1

13909-09-6 1

13982-63-3 Radium-226 and its decay products 1

14596-37-3 Phosphorus-32, as phosphate 1

14808-60-7 1

15262-20-1 Radium-228 and its decay products 1

1

18540-29-9 Chromium (VI) compounds 1

33419-42-0 Etoposide 1

1

57117-31-4 2,3,4,7,8-Pentachlorodibenzofuran 1

57465-28-8 1

Cyclosporine 1

65996-93-2 Coal-tar pitch 1

Semustine [1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea, Methyl-CCNU]

Silica dust, crystalline, in the form of quartz or cristobalite

16543-55-864091-91-4

N'-Nitrosonornicotine (NNN) and 4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK)

33419-42-015663-27-1

11056-06-7

Etoposide in combination with cisplatin and bleomycin

3,4,5,3,4-Pentachlorobiphenyl (PCB-126)

59865-13-379217-60-0

66733-21-9 Erionite 168308-34-9 Shale oils 1

1

Acid mists, strong inorganic 1Alcoholic beverages 1

Aluminium production 1

Areca nut 1Auramine production 1

Benzidine, dyes metabolized to 1

Betel quid with tobacco 1Betel quid without tobacco 1

1

Coal gasification 1

1

Coke production 1

Engine exhaust, diesel 1Epstein-Barr virus 1

Estrogen therapy, postmenopausal 1

1

1

1

Fluoro-edenite fibrous amphibole 1

Haematite mining (underground) 1

Acheson process, occupational exposure associated with

Clonorchis sinensis (infection with)

Coal, indoor emissions from household combustion of

Estrogen-progestogen menopausal therapy (combined)

Estrogen-progestogen oral contraceptives (combined)

Fission products, including strontium-90

11

1

1

1

1

Ionizing radiation (all types) 1

1

1

Kaposi sarcoma herpesvirus 1

Leather dust 1

Magenta production 1

1

1

Neutron radiation 1

Nickel compounds 1

1

Outdoor air pollution 1

1

Helicobacter pylori (infection with)Hepatitis B virus (chronic infection with)Hepatitis C virus (chronic infection with)Human immunodeficiency virus type 1 (infection with)

Human papillomavirus types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59

Human T-cell lymphotropic virus type I

Iron and steel founding (occupational exposure during)

Isopropyl alcohol manufacture using strong acids

Mineral oils, untreated or mildly treated

MOPP and other combined chemotherapy including alkylating agents

Opisthorchis viverrini (infection with)

Outdoor air pollution, particulate matter in

Painter (occupational exposure as a) 1

1

1

Radioiodines, including iodine-131 1

1

1

Rubber manufacturing industry 1

Salted fish, Chinese-style 1

1

Solar radiation 1

1

Tobacco smoke, second-hand 1

Tobacco smoking 1Tobacco, smokeless 1

1

Ultraviolet-emitting tanning devices 1

Phenacetin, analgesic mixtures containing

Polychlorinated biphenyls, dioxin-like, with a Toxicity Equivalency Factor (TEF) according to WHO (PCBs 77, 81, 105, 114, 118, 123, 126, 156, 157, 167, 169, 189)

Radionuclides, alpha-particle-emitting, internally deposited

Radionuclides, beta-particle-emitting, internally deposited

Schistosoma haematobium (infection with)

Soot (as found in occupational exposure of chimney sweeps)

Ultraviolet radiation (wavelengths 100-400 nm, encompassing UVA, UVB, and UVC)

Wood dust 1X- and Gamma-Radiation 1

QUIMICOS 70MEDICAMENTOS 22DROGAS 3FISICOS 7BIOLOGICOS 12LICOR 3

117

Volume Year Additional information

Sup 7, 62, 88, 100F 2012

26, Sup 7, 100A 2012 anticanceroso

Sup 7, 92, 100F 2012

Sup 7, 50, 100A 2012 anticanceroso4, Sup 7, 100A 2012 anticanceroso21, Sup 7, 100A 2012 reemplazo hormonal

113 In prep.

24, Sup 7, 100A 2012

96, 100E 2012

29, Sup 7. 100F 2012Sup 7, 97, 100F 2012

100E 2012

Sup 7, 60, 97, 100F 2012

41, Sup 7, 71, 110 In prep.Sup 7, 63, 106 20144, Sup 7, 99, 100F 20121, Sup 7, 99, 100F 2012

29, Sup 7, 99, 100F 2012

Sup 7, 77, 99, 100F 2012

Sup 7, 57, 99, 100F 2012

Sup 7, 54, 71, 97, 100F 2012

9, Sup 7, 100A 2012

Agents Classified by the IARC Monographs, Volumes 1113

NB: Overall evaluation upgraded to Group 1 based on mechanistic and other relevant data

NB: Overall evaluation upgraded to Group 1 with supporting evidence from other relevant data

NB: Overall evaluation upgraded to Group 1 based on mechanistic and other relevant data

NB: Overall evaluation upgraded to Group 1 based on mechanistic and other relevant data

24, Sup 7, 100A 2012

26, Sup 7, 100A 201226, Sup 7, 100A 2012

82, 100A 2012

82, 100A 2012

26, Sup 7, 100A 20124, Sup 7, 100A 20129, Sup 7, 100F 2012

4, Sup 7, 100F 2012

14, Sup 7, 100C 2012

18, Sup 7, 107 In prep.

56, 82, 100F, Sup 7 2012

Sup 7, 69, 100F 2012

78, 100D 2012

78, 100D 2012

23, Sup 7, 100C 2012

Sup 7, 58, 100C 2012

58, 100C 2012

92, 100F 2012

43, 78, 100D 2012

NB: Overall evaluation upgraded to Group 1 based on mechanistic and other relevant data

NB: Mineral substances (e.g. talc or vermiculite) that contain asbestos should also be regarded as carcinogenic to humans

66, 100A 2012

78, 100D 2012

Sup 7, 100A 2012

78, 100D 2012

78, 100D 2012

Sup 7, 68, 100C 2012

78, 100D 2012

Sup 7, 89, 100E 2012

Sup 7, 49, 100C 2012

76, 100A 2012

76, 100A 2012

100F 2012

100F 2012

50, 100A 2012

35, Sup 7, 100F 2012

NB: There is also conclusive evidence that tamoxifen reduces the risk of contralateral breast cancer in breast cancer patients

NB: Overall evaluation upgraded to Group 1 based on mechanistic and other relevant data

NB: Overall evaluation upgraded to Group 1 based on mechanistic and other relevant data

NB: Overall evaluation upgraded to Group 1 based on mechanistic and other relevant data

See Polychlorinated biphenyls, dioxin-like, with a TEF according to WHO

42, Sup 7, 100C 201235, Sup 7, 100F 2012

111 In prep.

54, 100F 201244, 96, 100E 2012

34, Sup 7, 92, 100F 2012

85, 100E 2012Sup 7, 99, 100F 2012

99, 100F 2012

Sup 7, 85, 100E 2012Sup 7, 85, 100E 2012

61, 100B 2012

Sup 7, 92, 100F 2012

95, 100E 2012

Sup 7, 92, 100F 2012

46, 105 201370, 100B 2012

72, 100A 2012

72, 91, 100A 2012

72, 91, 100A 2012

100D 2012

111 In prep.

1, Sup 7, 100D 2012

NB: Overall evaluation upgraded to Group 1 based on mechanistic and other relevant data

NB: There is also convincing evidence in humans that these agents confer a protective effect against cancer in the endometrium and ovary

61, 100B 2012

59, 100B 2012

59, 100B 2012

67, 100B 2012

64, 90, 100B 2012

67, 100B 2012

100D 2012

34, Sup 7, 100F 2012

Sup 7, 100F 2012

70, 100B 2012

100C 2012

Sup 7, 57, 99, 100F 2012

33, Sup 7, 100F 2012

Sup 7, 100A 2012

75, 100D 2012

Sup 7, 49, 100C 2012

61, 100B 2012

109 In prep.

109 In prep.

NB: The HPV types that have been classified as carcinogenic to humans can differ by an order of magnitude in risk for cervical cancer

NB: Overall evaluation upgraded to Group 1 with supporting evidence from other relevant data

47, 98, 100F 2012

Sup 7, 100A 2012

107 In prep.

78, 100D 2012

78, 100D 2012

78, 100D 2012

28, Sup 7, 100F 2012

56, 100E 2012

61, 100B 2012

55, 100D 2012

35, Sup 7, 92, 100F 2012

83, 100E 2012

83, 100E 2012Sup 7, 89, 100E 2012

55, 100D 2012

100D 2012

NB: Overall evaluation upgraded to Group 1 with strong supporting evidence from other relevant data

NB: Specific radionuclides for which there is sufficient evidence in humans are also listed individually as Group 1 agents

NB: Specific radionuclides for which there is sufficient evidence in humans are also listed individually as Group 1 agents

62, 100C 201275, 100D 2012

CLASIFICACION

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IARC Classifications Vol 1-111Sheet2