Upload
imdcbiochem
View
224
Download
0
Embed Size (px)
Citation preview
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
1/99
Ck~g~tgxike lixmdgckql
D{
HT%QMHKM BMTGGEHI^MTXLIEX GJ DKGABILKQXT[
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
2/99
Ck~g~tgxikeq
~mtxkaciq jgyeh ke ~cmqlm xbmx xtmeq~gtxck~khq keacyhkef abgciqxitgc
ck~g~tgxike acmqqiq ab{cglkatgeq0 xmoi ck~khq jtgl qlmcc kexiqxkei
xbtgyfb c{l~b aiccq
zit{ cgv hieqkx{ ck~g~tgxikeq "ZCHC+
kexitlihkmxi hieqkx{ ck~g~tgxikeq "KHC+ cgv hieqkx{ ck~g~tgxikeq "CHC+
bkfb hieqkx{ ck~g~tgxikeq "BHC+
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
3/99
Ck~g~tgxikeacmqq
Hieqkx{"f'lC+
Hkmlixit "el+ ^tgxike ) gjht{ vx
^bgq~bgck~kh )
Xtkma{cfc{aitgc )gj ht{ vx
BHC =%>:1,=%4= 9 =9 11 4; 2
CHC =%>=; =%>:1 =2 42 49 4= 8
KHC =%>>:,=%>=; 49 , 9> =2 44 1=
ZCHC >%;9 =%>>: 1> , 2> => =2 9>
ab{cglkatgeq 3 >%;9 =>> , 9>> = , 4 6 28
Agl~gqkxkge meh ~tg~itxkiq gj bylme ck~g~tgxikeq
lgqx ~tgxikeq bmzi hieqkxkiq gj mdgyx =%1 =%8 f'lC meh ck~kh mfftifmxiq yqymcc{
bmzi hieqkxkiq gj mdgyx >%2 f'lC
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
4/99
Ck~g~tgxike qxtyaxyti
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
5/99
CHC lgciayci
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
6/99
Xbi m~gck~g~tgxikeq
lm`gt agl~geiexq gj ck~g~tgxikeq
gjxie tijittih xg mq m~tgxikeq
acmqqkjkih d{ mc~bmdixkamc hiqkfemxkge "M xbtyI+
xbi yqi gj tglme eylitmc qyjjkr hiqatkdiq xbigthit ke vbkab xbi m~gck~g~tgxike ilitfi jtgl
m abtglmxgftm~bka agcyle tiq~geqkdci jgt tiagfekxkge gj ~mtxkaci d{
tiai~xgtq
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
7/99
BICKAMC VBIIC ^TG@IAXKGE GJ M
^GTXKGE GJ M^GCK^G^TGXIKE M,K
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
8/99
CK^G^TGXIKEQ
q~bitkamc ~mtxkaciq vkxb m b{htg~bgdka
agti "XF meh iqxitkjkih abgciqxitgc+
m~gck~g~tgxikeq ge xbi qytjmai cmtfi0 m~gD "d,82 meh D,=>>+ mxbitgfieka
qlmccit0 m~gM,K# m~gA,KK# m~gI
acmqqkjkih ge xbi dmqkq gj hieqkx{ mehiciaxtg~bgtixka lgdkckx{ "ZCHC? CHC?
KHC?BHC? C~"m+
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
9/99
M~g~tgxikeq gj bylme
ck~g~tgxikeq M,K "42#1>>+, ~tkeak~mc ~tgxike ke BHC
;> =4> lf) ke ~cmqlm? maxkzmxiq CAMX
M,KK "2#6>>+ gaaytq mq hklit lmkec{ ke BHC 1> 9> lf )? iebmeaiq bi~mxka ck~mqi maxkzkx{
D,82 "48>#>>>+ jgyeh gec{ ke ab{cglkatge 39 lf )? hitkzih jtgl m~g,D,=>> fiei d{ TEM
ihkxkef? cmaoq xbi CHC tiai~xgt,dkehkef hglmke gjm~g,D,=>>
D,=>> "9>>#>>>+ ~tkeak~mc ~tgxike ke CHC 2> =>> lf )? dkehq xg CHC tiai~xgt
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
10/99
A,K "6#>>>+ jgyeh ke ab{cglkatge# ZCHC# BHC 8 6 lf )? lm{ mcqg maxkzmxi CAMX
A,KK "2#2>>+ , jgyeh ke ab{cglkatge# ZCHC# BHC 1 2 lf )? maxkzmxiq ck~g~tgxike ck~mqi
A,KKK "2#2>>+ , jgyeh ke ab{cglkatge# ZCHC# KHC# BHC 2 =9 lf )? kebkdkxq ck~g~tgxike ck~mqi
H "14#9>>+ , jgyeh ke BHC 2 => lf )? mcqg amccih abgciqxitgc iqxit xtmeqjit ~tgxike "AIX^+
I "18#=>>+ , jgyeh ke ab{cglkatge# ZCHC# KHC BHC 1 : lf )? dkehq xg CHC tiai~xgt
B "9>#>>>+ jgyeh ke ab{cglkatge? mcqg oegve mq ,4,fc{ag~tgxikeK "kezgczih ke XF lixmdgckql+
M~g~tgxikeq gj bylme
ck~g~tgxikeq
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
11/99
Lm`gt ck~g~tgxike acmqqiq
Ab{cglkatgeq "hitkzih jtgl hkix+
hieqkx{ 33=%>>:
hkmlixit 2> , 9>> el
hkixmt{ xtkfc{aitkhiq
m~gD,82# m~gM,K# m~gM,KK# m~gM,KZ# m~gA,
KK'A,KKK# m~gItilmkeq mx gtkfke ke iciaxtg~bgtixka jkich
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
12/99
Ab{cglkatge
jgtlih xbtgyfb irxtyqkge gj tiq{exbiqkpihxtkfc{aitkhiq jtgl xbi lyagqmc aiccq kexg xbikexiqxkemc cmaximcq
jcgv xbtgyfb xbi xbgtmaka hyaxq kexg xbiqyacmzkme zikeq
hiftmhih xg tilemexq d{ xbi maxkge gjck~g~tgxike ck~mqi "C~C+ vbkab kq cgamxih ge
am~kccmt{ iehgxbickmc aicc qytjmai tilemexq mti xmoie y~ d{ ckzit ~mtieab{lmc
aiccq hyi xg m~gI,KKK meh m~gI,KZ kqgjgtltiagfekxkge qkxiq
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
13/99
A
b{
cgl
katge
lixm
dg
c kql
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
14/99
Lm`gt ck~g~tgxike acmqqiq
ZCHC
hieqkx{ 5=%>>:
hkmlixit 1> , 2>eliehgfiegyq xtkfc{aitkhiq
m~gD,=>># m~gI# m~gA,KK'A,KKK
~tidixm ke iciaxtg~bgtiqkq
jgtlih ke xbi ckzit mq emqaiex ZCHC "agexmkeq gec{
xtkfc{aitkhiq# m~gI meh m~gD+
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
15/99
ZCHC
emqaiex ZCHCq xbie kexitmax vkxb BHCxg fieitmxi lmxyti ZCHCq "vkxb mhhih
abgciqxitgc# m~gA,KK meh m~gA,KKK+ lmxyti ZCHCq mti maxih y~ge d{ C~C xg
fieitmxi ZCHC tilemexq "KHC+
KHC mti jytxbit hiftmhih d{ bi~mxkaxtkfc{aitkhi ck~mqi "BXFC+ xg fieitmxiCHCq
Z
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
16/99
ZCHCl
ixmdgckq l
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
17/99
Lm`gt ck~g~tgxike acmqqiq
KHC "kexitlihkmxi hieqkx{ ck~g~tgxikeq+
hieqkx{0 =%>>: , =%>=;
hkmlixit0 49 , 19el
abgciqxit{c iqxitq meh xtkfc{aitkhiq
m~gD,=>># m~gI# m~gA,KK'A,KKK
qcgv ~ti,dixm
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
18/99
Lm`gt ck~g~tgxike acmqqiq
CHC "cgv hieqkx{ ck~g~tgxikeq+
hieqkx{0 =%>=; , =%>:1
hkmlixit0 =2,49el
abgciqxit{c iqxitq
m~gD,=>>
dixm "iciaxtg~bgtiqkq+
3 =1> CHC abgciqxitgc kq hiqktmdci# =1>,=9;
kq dgthitckei bkfb meh 5=:> kq bkfb
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
19/99
Lm`gt ck~g~tgxike acmqqiq
BHC "bkfb hieqkx{ ck~g~tgxikeq+
hieqkx{0 =%>:1,=%4=>
hkmlixit0 9,=4el
abgciqxit{c iqxitq meh ~bgq~bgck~khq
m~gM,K# m~gM,KK# m~gA,KK'A,KKK meh m~gI
mc~bm "iciaxtg~bgtiqkq+
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
20/99
BHCq
Qizitmc qydjmlkckiq irkqx
Hkqagkhmc BHC 0
agexmkeq abgciqxitgc# ~bgq~bgck~kh# m~gM,K# m~gM,KK# m~gI meh kq hkqa qbm~ih?
kx kq jgtlih ke ckzit meh kexiqxkei
Kx kexitmaxq vkxb ab{cglkatm tilemexq meh
ciakxbke,abgciqxitgc ma{c xtmeqjitmqi "CAMX+ xgjgtl BHC1
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
21/99
BHCq
BHC1
agl~gqih gj abgciqxitgc# abgciqxitgc iqxit# ~bgq~bgck~kh
meh m~gM meh m~gI
kexitmaxq vkxb xbi aicc ~cmqlm lildtmeiq xg tilgzi jtiiabgciqxitgc
timaxkge vkxb CAMX agezitxq BHC1xg BHC
4m"me BHC vkxb
m bkfb m~gI meh abgciqxitgc iqxit agexiex+
abgciqxitgc iqxit,tkab BHC4m
kq xbie agezitxih xg
xtkfc{aitkhi,tkab BHC4dd{ ageaglkxmex xtmeqjit gj BHC
abgciqxitgc iqxitq xg ZCHC meh ZCHC xtkfc{aitkhiq xg
BHC
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
22/99
BHC
lix
md
gckql
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
23/99
Jyeaxkgeq gj BHC
xtmeqjitq ~tgxikeq xg gxbit ck~g~tgxikeq
~kaoq y~ ck~khq jtgl gxbit ck~g~tgxikeq
~kaoq y~ abgciqxitgc jtgl aicc lildtmeiq
agezitxq abgciqxitgc xg abgciqxitgc iqxitq zkm xbi
CAMX timaxkge
xtmeqjitq abgciqxitgc iqxitq xg gxbitck~g~tgxikeq# vbkab xtmeq~gtx xbil xg xbi ckzit
"tijittih xg mq tizitqi abgciqxitgc xtmeq~gtx+
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
24/99
Ck~g~tgxikeq "m+, C~"m+
megxbit mxbitgfieka jmlkc{ gj ck~g~tgxikeq"mxcimqx =; hkjjitiex mcciciq+
xbi{ ageqkqx gj CHC meh m ~tgxike hiqkfemxih mq
"m+ xbi m~gM kq agzmciexc{ ckeoih xg m~gD,=>> d{ m
hkqycjkhi ckeomfi yeyqymc ke xbmx kx agexmkeq m otkefci ~tgxike
lgxkj'hglmke "xtk,cgg~ih qxtyaxyti vkxb 1
kextmlgciaycmt hkqycjkhi dgehq tiqildckef mHmekqb ~tixpic+
bkfb tkqo mqqgakmxkge vkxb ~tilmxyti agtgemt{mtxit{ hkqimqi meh qxtgoi
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
25/99
Abgciqxitgc meh ck~kh xtmeq~gtx d{
ck~g~tgxikeq
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
26/99
Abgciqxitgc meh ck~kh xtmeq~gtx d{
ck~g~tgxikeq
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
27/99
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
28/99
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
29/99
Xbi CHC tiai~xgt
abmtmaxitkpih d{ Lkabmic Dtgve meh @gqi~bFgchqxike "Egdic ~tkpi vkeeitq ke =;29+
dmqih ge vgto ge jmlkckmc b{~itabgciqxitgcilkm
tiai~xgt mcqg amccih D'I tiai~xgt diamyqi gj kxqmdkckx{ xg tiagfekpi ~mtxkaciq agexmkekef dgxb m~gqD meh I
maxkzkx{ gaaytq lmkec{ ke xbi ckzit
tiai~xgt tiagfekpiq m~g I lgti timhkc{ xbme m~gD,=>>
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
30/99
Ti~tiqiexmxkge gj xbiCHC tiai~xgt "21; mm+
irxtmaiccycmt hglmke kq
tiq~geqkdci jgt m~g,D,
=>>'m~g,I dkehkef
kextmaiccycmt hglmke kq
tiq~geqkdci jgt
acyqxitkef gj CHCtiai~xgtq kexg agmxih
~kx tifkge gj ~cmqlm
lildtmei
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
31/99
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
32/99
Abgciqxitgc qgytaiq# dkgq{exbiqkq
meh hiftmhmxkge hkix
gec{ jgyeh ke meklmc jmx
dkgq{exbiqkq ~tklmtkc{ q{exbiqkpih ke xbi ckzit jtgl maix{c AgM
dkgq{exbiqkq kq kebkdkxih d{ CHC y~xmoi d{ xbi ckzit
hiftmhmxkge
gec{ gaaytq ke xbi ckzit
abgciqxitgc kq agezitxih xg dkci makhq
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
33/99
Dkgq{exbiqkq gj abgciqxitgc
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
34/99
Dkgq{exbiqkq gj abgciqxitgc
, q{exbiqkq gj lizmcgemxi
tmxi,cklkxkef qxi~
meh qxi~ qyd`iax xgkebkdkxkge d{ qxmxkeq
Dkgq{exbiqkq gj abgciqxitgc
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
35/99
Dkgq{exbiqkq gj abgciqxitgc
,q{exbiqkq gj kqg~iexie{c,~{tg~bgq~bmxi
M lgegxit~iei
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
36/99
Q{e
xbiqkqg
jjm
teiq{c
~{tg~
gq~b
mxi
Dkgq{exbiqkq gj abgciqxitgc
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
37/99
Dkgq{exbiqkq gj abgciqxitgc
, q{exbiqkq gj q}ymciei
m qiq}ykxit~iei
m xtkxit~iei
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
38/99
Q{e xb
iqkqgj
q}y
mci
ei
Dkgq{exbiqkq gj abgciqxitgc
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
39/99
Dkgq{exbiqkq gj abgciqxitgc
, q{exbiqkq gj cmegqxitgc
xbi mcc{cmlkei mexkjyefmcq
kexitjiti vkxb xbi i~grkhmxkge
qxi~ "emjxkhkei# xitjkemdkei+
l
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
40/99
Jgtlmxk
gegj
xbi
qxit
gctk e
fq{qxil
Dkgq{exbiqkq gj abgciqxitgc
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
41/99
Dkgq{exbiqkq gj abgciqxitgc
Xbi hilixb{cmxkge
gj cmegqxitgc kq mcqg
m yqijyc qxi~ jgt htyf
hiqkfe k%i% mpgci mexkjyefmcq
MAMX kebkdkxgtq maxbiti
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
42/99
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
43/99
Dkgq{exbiqkq qyllmt{
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
44/99
Dkci makhq jtgl abgciqxitgc
jgtlih jtgl abgciqxitgc ke xbi ckzit
qxgtih ke xbi fmcc dcmhhit ke dkci mq dkci
qmcxq "qghkyl meh ~gxmqqkyl+ yxkckpih hytkef hkfiqxkge gj jmxq meh gxbit
ck~kh qydqxmeaiq "max mq hixitfiexq+
tmxi cklkxkef qxi~ kq xbi agezitqkge gjabgciqxitgc xg 6,mc~bm abgciqxitgc d{ 6, ,b{htgr{cmqi
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
45/99
BG BG GB6m,b{htgr{cmqi
EMH^B / B / EMH^
abgciqxitgc 6m,b{htgr{abgciqxitgc
BG GB
GB
A Q
G
AgM
B
BG GB
A Q
G
AgM
Babieghigr{abgc{c, AgM
abgc{c,AgM
=4m,b{htgr{cmqiG4? EMH^B / B
/
4 AgM,QBG4
EMH^B / B/
4 AgM,QB
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
46/99
BG
A Q
G
A gM
B
abgc{c,AgM
B G
A
G
B
E A B4 A G G B
fc{akeiAgM,QB
Agezitqkge gj abgc{c,AgM xg
fc{agabgcka makh
fc{agabgcka makh
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
47/99
BG
A Q
G
AgM
B
abgc{c,AgM
BG
A
G
B
AB4 AB4 QG1B
B
xmytgabgcka makh "~tklmt{ dkci makh+
xmytkei
AgM,QB
Agezitqkge gj
abgc{c AgM xg
xmytgabgcka makh
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
48/99
Xmytkei
Xmytkei kq jgtlih d{ xbi hiamtdgr{cmxkge
gj a{qxika makh# vbkab ke xyte kq lmhi d{
grkhmxkge gj a{qxikei
A
AGG
BB1E
AB4
QB
A
AGG
BB1E
AB4
QG4
a{qxikei a{qxikei qycjkemxi
AB4B1E
AB4
QG1
xmytkei
/ G4 / G4 , AG4
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
49/99
BG GB
A Q
G
AgM
B
abieghigr{abgc{c, AgM
xmytg, meh fc{ag,abieghigr{abgcka ma"~tklmt{ dkci makhq+
BGB
AGGB
ckxbgabgcka makh "qiagehmt{ dkci makh+
hiage`yfmxkge /
6m,hib{htr{cmxkge
"amxmc{pih d{ lkatgdkmc
iep{liq+
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
50/99
BG
A
G
B
E AB4 AGGB
fc{agabgcka makh "~tklmt{ dkci makh+
BG
B
AGGB
hiage`yfmxkge /6,hib{htgr{cmxkge
"amxmc{pih d{ lkatgdkmc
iep{liq+
Higr{abgcka makh "qiagehmt{ dkci makh
Agezitqkge gj fc{agabgcka
makh xg higr{abgcka makh
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
51/99
Dkci makhq
abgcka makh kq xbi dkci makh jgyeh ke xbicmtfiqx mlgyex ke dkci
abgcka makh meh abieghigr{abgcka makh mtitijittih xg mq ~tklmt{ dkci makhq
dkci makhq mti agezitxih xg ikxbit fc{akei gtxmytkei age`yfmxiq "ke bylmeq xbi tmxkg gj
fc{akei xg xmytkei age`yfmxiq kq 10=+
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
52/99
M~~tgrklmxi agl~gqkxkge gj dkci qmcxq
Fc{agabgcmxi 48)
Fc{agabieghigr{abgcmxi 48)
Xmytgabgcmxi =4) Xmytgabieghigr{abgcmxi =4)
Fc{aghigr{abgcmxi, =:)
Xmytghigr{abgcmxi 2) Zmtkgyq ckxbgabgcmxi 8)
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
53/99
Dkci makhq
jmx hkfiqxkge ~tghyaxq mti mdqgtdih ke xbi jktqx=>> al gj qlmcc kexiqxkei
xbi ~tklmt{ meh qiagehmt{ dkci makhq mtitimdqgtdih mclgqx iracyqkzic{ ke xbi kciyltixytekef xg xbi ckzit d{ vm{ gj xbi ~gtxmcaktaycmxkge ";2 xg ;;)+
xbkq kq oegve mq xbi iexitgbi~mxka aktaycmxkge
ciqq xbme 9>> lf m hm{ iqam~iq timdqgt~xkgemeh kq iratixih ke xbi jiaiq
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
54/99
Dkci qmcxq
hixitfiex abmtmaxit gj dkci qmcxq kq hyi xgxbi b{htg~bgdka,b{htg~bkcka emxyti gj
xbi lgciayciq xbi ~tiqieai gj b{htgr{c "gt qycjmxi+ meh
xbi xitlkemc amtdgr{c ftgy~ ge xbi xmkcfkziq xbi lgciayci kxq b{htg~bkcka jmai
xbi qxitgkh tkef vkxb kxq ~yaoitih ~cmei~tgzkhiq xbi b{htg~bgdka jmai
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
55/99
Jyeaxkge gj dkci qmcxq
ilycqkjkamxkge gj jmxq hyi xg hixitfiex maxkzkx{
mkh ke xbi mdqgt~xkge gj jmx,qgcydci zkxmlkeq
"iq~iakmcc{ zkxmlke O+ maaicitmxi xbi maxkge gj ~meatimxka ck~mqi
bmzi abgcitixka maxkge qxklycmxi xbi ckzit xg
qiatixi dkci
qxklycmxi kexiqxkemc lgxkckx{
oii~ abgciqxitgc ke qgcyxkge "mq lkaicciq+
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
56/99
Lkrih lkaicci jgtlih d{ dkci qmcxq# xtkma{cfc{aitgcq mehj ~meatimxka
ck~mqi
DKCI MAKHQ
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
57/99
AB1
AB1
AB1
AGGB
B
B
B
B
ABGCMEKA MAKH
AB1
AB1
AB1
AGGB
B
B
B
B
BG GB
BG
AB1
AB1
AB1
AGGB
B
B
B
B
BG GB
AB1
AB1
AB1
AGGB
B
B
B
B
BG GB
ABGCKA MAKH
ABIEGHIGR[ABGCKA MAKH "ABIEGHKGC+YTQGHIGR[ABGCKA MAKH "YTQGHKGC+
"MAXKFMCC+"ABIEKR+
1 6
=4
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
58/99
FMCCQXGEI XBITM^IYXKA MFIEXQ
abieghigr{abgcka makh "abieghkgc? Abiekr+
ytqghigr{abgcka makh "ytqghkgc? Maxkfmcc+
LMG0
tihyai bi~mxka qiatixkge gj abgciqxitgc kexgdkci
kebkdkxkge gj BLFAgM tihyaxmqi0 kebkdkxabgciqxitgc dkgq{exbiqkq
keatimqi abgciqxitgc qgcydkckx{
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
59/99
Abieghkgc meh ytqghkgc
dgxb mti ijjiaxkzi ke hkqqgczkefabgciqxitgc qxgeiq ke qgli ~mxkiexq
ytqghkgc kq xbi 6,dixm i~klit gj abieghkgc lgqx ijjiaxkzi ke hkqqgczkef qlmcc "39
ll+ jcgmxkef qxgeiq ke m jyeaxkgekeffmccdcmhhit
ameegx hkqqgczi qxgeiq xbmx mti lgti xbme8) amcakyl d{ vikfbx
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
60/99
Mxbitgqacitgqkq
bmthiekef gj xbi mtxitkiq hyi xg xbi
hi~gqkxkge gj mxbitglmq
bimtx hkqimqi kq xbi cimhkef amyqi gj himxb
amyqih d{ xbi hi~gqkxkge gj abgciqxit{c
iqxitq ge xbi vmccq gj mtxitkiq
mxbitgqacitgqkq kq agtticmxih vkxb bkfbCHC meh cgv BHC
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
61/99
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
62/99
Jtihitkaoqge ,VBG acmqqkjkamxkge
X{~i KX{~i K0 keat% ab{cglkatgeq# tihyaih BHC# mdqieai gjck~g~tgxike ck~mqi? hijkakiea{ gj m~g AKK
"b{~itab{cglktgeilkm+
X{~i KK,MX{~i KK,M0 tmkqih CHC? hiatimqih amxmdgckql gj CHC
"tiai~xgt hijkakiea{ gt ~gc{fieka+X{~i KK,DX{~i KK,D0 tmkqih ZCHC / CHC? gjxie tihyaih BHC?
keatimqih ~tghyaxkge gj ZCHC / kl~mktih CHC
amxmdgckql
X{~i KKKX{~i KKK0 tmkqih KHC "h{qdixmck~g~tgxikeilkm+? mdegtlmcm~gck~g~tgxike I? kl~mktih amxmdgckql gj KHC? icizmxih
abgciqxitgc meh xtkfc{aitkhiq "jgtlitc{ oegve mq dtgmh
dixm hkqimqi+
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
63/99
Jtihitkaoqge ,VBG acmqqkjkamxkge
X{~i KZX{~i KZ0 tmkqih ZCHC? gjxie tihyaih BHC?
kl~mktih ZCHC amxmdgckql? hkixmt{
kehkqatixkge " jgtlitc{ oegve mq
b{~it~tidixmck~g~tgxikeilkm+
X{~i ZX{~i Z0 tmkqih ab{cglkatgeq / ZCHC? tihyaih
BHC? tihyaih ck~g~tgxike ck~mqi / ZCHCb{~itqiatixkge "jgtlitc{ oegve mq lkrih
ck~ilkm+
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
64/99
Jmaxgtq ~tglgxkef icizmxih dcggh
ck~khq mfi
lie 589 {imtq gj mfi? vglie 5 99 {imtq gj mfi
jmlkc{ bkqxgt{ gj AMH
qlgokef b{~itxieqkge 5=8>';> ll Bf
cgv BHC abgciqxitgc
gdiqkx{ 51>) gzitvikfbx
hkmdixiq licckxyq kemaxkzkx{' cmao gj iritakqi
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
65/99
Liabmekqlq gj maxkge gj htyfq
dkeh xg dkci makhq'abgciqxitgckebkdkx mdqgt~xkge'timdqgt~xkge
keatimqi ~itgrkqglmc JM grkhmxkge qxklycmxi ck~g~tgxike ck~mqi
kebkdkx xtkfc{aitkhi ck~mqi
kebkdkx BLF AgM tihyaxmqi qxklycmxiq lkatgqglmc 6,mc~bm
b{htgr{cmqi
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
66/99
Htyf Acmqqkjkamxkge
q{qxilka'ege,q{xilka
abgciqxitgc cgvitkef mfiexq
dkci makh qi}yiqxtmexq
qkxgqxitgcq*
~tgdyagc*
h,xb{tgrke*BLF Ag,M tihyaxmqi kebkdkxgtq
* Eg cgefit mzmkcmdci agllitakmcc{ ke xbi Y%Q
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
67/99
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
68/99
Dkci qi}yiqxitkef tiqkeq
BA
B4A
BA
B4A
ABB4A
E"AB1+1
e
ABGCIQX[TMLKEI
B4E
BE
BE
BE
"AB4+:E"AB1+1
BE
"AB4+;,AB1
GB
BE
"AB4+:E"AB
1+1
BE
"AB4+;AB1
B4E% e BAc
% e BAc
% e BAc
% e BAc % e BAc % e BAc
% e BAc% e BAc
AGCIQIZICML
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
69/99
Dkci qi}yiqxitkef tiqkeq
AB4BE
AB4
AB4 E AB4 AB4 E
AB4 AB4
AB4
AGB AGB AGBB
AB4
AB4 E AB4
AB4
AGB
AB4
B B
AB4
E
AB4
B
E EAB4 AB4,AB4AB4 E
AB4 EB
AB4
AGB
AB4
EB AB4 AB4 B AB4,AB4,
e
AGCIQXK^GC "AGCIQXKH+
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
70/99
Dkci makh qi}yiqxtmexq
~g# qmjiqx# ege q{qxilka dkeh xg dkci makhq meh kebkdkx timdqgt~xkge keatimqi 6,mc~bm b{htgr{cmqi maxkzkx{ cimhkef xg
abgciqxitgc hiftmhmxkge hiatimqiq ~cmqlm CHC ~tgdcilq0
mdhglkemc hkqagljgtx# dcgmxkef# ageqxk~mxkge
hiatimqiq htyf mdqgt~xkge? vmkx 8 btq mjxitmhlkekqxtmxkge gj DMQ xg fkzi htyfq
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
71/99
Agciqizicml "VicAbgc+
~gc{mco{cmlkei b{htgabcgtkhi+ atgqq ckeoih
vkxb i~kabcgtgb{htke meh mco{cmxih vkxb =,
dtglghiamei meh ":,dtglgbir{c+
xtklixb{cmllgekyl dtglkhi
mzmkcmdci mq m :49 lf xmdcix
qmli liabmekql gj maxkge mq agciqxk~gc meh
abgciqx{tmlkei
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
72/99
Dkci qi}yiqxitkef tiqkeq
htyf kexitmaxkgeq"hiatimqih qitylcizic+
mq~ktke ackehml{ake
acgjkdtmxi
jytgqilkhi
fck~pkhi
xgcdyxmlkhi
~bie{xgke
klk~tmlkei
lixb{chg~m
ekagxkeka makh
~iekakccke F
~tg~tmegcgc
xixtma{ackei
xbkmpkhi hkytixkaq
hkfgrke
b{htgagtxkqgei
~bgq~bmxi qy~~ciliexq
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
73/99
AB1
AB1
B1A
AB4AB1
AB1
AB1
BG
QXKFLMQXMEGC
AB1
AB1
B1A
AB4AB1
AB1
AB1
BG
DIXM QKXGQXITGC
^CMEX QXITGCQ
B1A
AB1
A
AB1
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
74/99
AB1
AB1
B1A
AB4AB1
AB1
BG
QXKFLMQXITGC
AB1
AB1
B1A
AB1
BG
AB1
AML^IQXTGC
AB1
AB1
B1A
AB1
AB1
BG
AB1
AB1
MC^BM=,QKXGQXITGC
Lgti ~cmex qxitgcq
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
75/99
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
76/99
BLF AgM tihyaxmqi
1 hkjjitiex tifycmxgt{ liabmekqlq mtikezgczih0
agzmciex lghkjkamxkge0 ~bgq~bgt{cmxkge d{aML^,hi~iehiex ~tgxike okemqiq kemaxkzmxi xbitihyaxmqi% Xbkq kemaxkzmxkge ame di tizitqih d{ 4q~iakjka ~bgq~bmxmqiq
hiftmhmxkge gj xbi iep{li bmcj ckji gj 1 bgytq
meh xbi bmcj,ckji hi~iehq ge abgciqxitgc cizicq fiei ir~tiqqkge0 abgciqxitgc cizicq agextgc xbi
mlgyex gj lTEM
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
77/99
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
78/99
G
AGGB
AB1
GB
QAgM
GB
AGGB
AB1
GB
B B
4 EMH^B 4 EMH^
, AgMQB
GB
AGGB
AB1
GB
B
QAgM
G
AGGB
AB1
GB
B
EMH^B EMH^B
G GBG
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
79/99
G
AB1
B1A
G
B1A
B
B B
G
AB1
B1A
AB1
B
AB1
E
^
G
AGGB
^b
G,
BG
Ix
J
G
G
B
BG
Ac
AcBG
Ok < =>,=>
Ok < =>,==
Ok < =>,=>
Cgzmqxmxke
BG G
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
80/99
AB1
BG
G
BB1A
G
LIZMQXMXKE
AB1
B
G
G
BG G
BB1A
B1A
G
CGZMQXMXKE "LIZMAGT+
AB1
BG
G
BG G
AB1B1A
G
QKLZMQXMXKE "PGAGT+
AB1
BG
AGGB
BG
BB1A
G
BG
GB
^TMZMQXMXKE "^TMZMABGC+
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
81/99
E
GB
AG4Em
BG
J
AB"AB1+4
JCYZMQXMXKE
E
B1AG
"B1A+4BA AB"AB1+4
J
AG4Em
GB GB
AITKZMQXMXKE
Q{exbixka qxmxkeq
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
82/99
BLF AgM tihyaxmqi kebkdkxgtq
^tiamyxkge0 lkch icizmxkge gj qityl mlkegxtmeqjitmqi
"qbgych di limqytih mx 4 xg 8 lgexb kexitzmcq+
lkegt keatimqiq ke atimxkei okemqi "l{g~mxb{#
lyqaci ~mke meh xiehiteiqq+
hg egx fkzi hytkef ~tifemea{
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
83/99
Qiciaxih b{~gck~khilka ~tghyaxq
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
84/99
JKDTKA MAKH HITKZMXKZIQ
AB1
B1A
G "AB4+1 A
AB1
AB1
AGGB
FILJKDTGQKC "CG^KH+
Ac G A
AB1
AB1
AGGIx
ACGJKDTMXI "MXTGLKH,Q+
Ac
GA
AB1
AB1
k^tG4A
G
JIEGJKDTMXI "XTKAGT+
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
85/99
Acgjkdtmxi "Mxtglkh,Q+
^tiamyxkgeq
iebmeaiq agylmtke maxkzkx{
tiemc'bi~mxka ke`yt{ agextmkehkamxkge
~tifemea{'eytqkef
abgcickxbkmqkq
lgqx agllgec{ ti~gtxih MHT mti FK ticmxih
ckzit lmckfemeakiq "egx zit{ agllge? dyx bmq cih xgqamex yqmfi+
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
86/99
ACGJKDTMXI
^tklmt{ maxkzkx{ ge xtkfc{aitkhiq
LGM0 keatimqiq ck~g~tgxike ck~mqi
cgvitq ZCHC
keatimqiq ~itgrkqglmc JJM grkhmxkge
kebkdkxq abgciqxitgc dkgq{exbiqkq
keatimqiq dkckmt{ qiatixkge gj abgciqxitgc
meakccmt{0 hiatimqiq ~cmxicix mhbiqkzieiqq'jkdtkegfie
Filjkdtgqkc "Cg~kh+
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
87/99
Filjkdtgqkc "Cg~kh+
LGM qxklycmxiq ck~g~tgxike ck~mqi kexitmax vkxb ^^MT "~itgrkqgli ~tgckjitmxgt,maxkzmxih
tiai~xgtq+
kebkdkxq xtkfc{aitkhi ck~gc{qkq ke mhk~gqi xkqqyi hiatimqiq JJM y~xmoi d{ xbi ckzit
hiatimqiq bi~mxka ZCHC'XF q{exbiqkq
qckfbx abgciqxitgc cgvitkef ijjiax
~tiamyxkgeq qklkcmt xg acgjkdtmxi l{gqkxkq "zgcyexmt{ lyqaci kejcmllmxkge+ FK "kehkfiqxkge# mdhglkemc ~mke# hkmttbim+ abgcickxbkmqkq "keatimqih abgciqxitgc dkckmt{ qiatixkge+
bmcj ckji0 =%= bgytq
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
88/99
Jiegjkdtmxi "Xtkagt+
m ticmxkzic{ eiv jkdtka makh hitkzmxkzi"lkatgekpih jgtl gj xbi htyf+
cgvitq ~cmqlm XF
kebkdkxq XF q{exbiqkq qxklycmxiq amxmdgckql gj ZCHC
kehkamxih ~tklmtkc{ jgt b{~itxtkfc{aitkhilkm
qmli qkhi ijjiaxq meh ~tiamyxkge mq ke gxbit
jkdtka makh agl~gyehq bmcj,ckji0 4> bgytq
Hgqi0 :6,4>= lf'hm{ vkxb limcq
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
89/99
Egv mcqg mzmkcmdci mq m 4>> lf xmdcix
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
90/99
EKAGXKEKA MAKH "Ekmake+
E
AGGB
EKAGXKEKA MAKH "EKMAKE+
M vmxit qgcydci zkxmlke gj xbi D jmlkc{?
ekagxkemlkhi kq egx maxkzi
Geai agezitxih xg xbi mlkhi# kx kq
keagt~gtmxih kexg EMH
Ke gthit xg di ijjiaxkzi# kx bmq xg di hgqih mx xbi tmxi gj =%9 xg 1%9
fl hmkc{%
M qyqxmkeih ticimqi hgqmfi jgtl kq mzmkcmdci
mhzitqi ijjiaxq0 FK hkqxytdmeaiq "itgqkge meh ycaitmxkge+
tih jcyqb iq~iakmcc{ ke xbi jmai meh eiao mtim
amyqih d{ zmqghkcmxkge gj am~kccmtkiq
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
91/99
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
92/99
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
93/99
Tgqyzmqxmxke "Atiqxgt+
Eiv qxmxkeq0 tgqyzmqxmxke "PH8944+
E
k^t
AGGB
B
Q
AB1
GG
GBGB
J
ekaoemlih qy~itqxmqxke' fgtkccm qxmxke diamyqi gj kxq ~gvitjyc
ijjiax ge CHC abgciqxitgc
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
94/99
Ipixklkdi "Pixkm+
E
GB
G
J
GB
J
IPIXKLKDI
Xbkq htyf dcgaoq xbi kexiqxkemc mdqgt~xkge gj abgciqxitgc% M hgqi gj => lf }h cimhq xg
m =;) tihyaxkge gj CHC? qbgvq timc ~tglkqi ke agldg ~tghyax vkxb qxmxkeq "Qabitkef,
^cgyfb meh Litao+
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
95/99
Keziqxkfmxkgemc htyfq
ma{cAgM0 abgciqxitgc ma{cxtmeqjitmqi
kebkdkxgtq
Gt~bme eyacimt tiai~xgtq0 CRT gr{abgciqxitgc tiai~xgt ,,, iebmeaih
abgciqxitgc ijjcyr
JRT dkci makh tiai~xgt ,,,, hiatimqih
abgciqxitgc agezitqkge xg dkci qmcxq
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
96/99
MAMX Kebkdkxgtq
Q
E
AJ1
G G
AJ1
AJ1
X>;>=1=6 ,, CRT mfgekqx
AG4B
GB
CF4:2 ,, TRT mfgekqx
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
97/99
MAMX Kebkdkxgtq
G
AB
AB1B1A
AB
AB1
AB1
Q
E
A
B4
A
G
B
G
AB
ABAB
B1A AB1
AB1
AB1AB1
B1A
G
MZMQILKDI "AK,=>==+
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
98/99
Q}ymciei q{exbmqi kebkdkxgtq
q}ymciqxke =# m jitliexmxkge ~tghyaxhitkzih jtgl ^bcglm q~iakiq"Agicgl{aixiq+
m ~gxiex kebkdkxgt gj q}ymciei q{exbmqi
~tghyaiq m lmtoih hiatimqi ke qitylabgciqxitgc meh m~gD cizicq
lm{ ti~tiqiex me mcxitemxkzi ackekamcxbitm~{ xg b{~itabgciqxitgcilkm
8/14/2019 Lipoprotein Metabolism Lecture for 2nd year MBBS by Dr Sadia Haroon
99/99