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Linda Marie Brzustowicz, M.D.Address:Rutgers University, Department of Genetics145 Bevier Road, Room 231Piscataway, NJ 08854(732) 445-3331 (732) 445-1636 (FAX) [email protected]
Education:• Columbia University, New York, NY
Department of Psychiatry, Presbyterian Hospital and New York State Psychiatric InstitutePsychiatric Residency Training, July 1991 - June 1994
• Columbia University, New York, NYDepartment of Psychiatry, New York State Psychiatric Institute Research Fellow andKeck Scholar in Molecular Genetics, July 1988 - June 1991
• Brown University, Providence, RIDepartment of Pediatrics, Rhode Island HospitalPediatric Internship, July 1987 - June 1988
• Columbia University, New York, NYCollege of Physicians and Surgeons, M.D. May 1987Alpha Omega Alpha Honor Society
• Harvard University, Cambridge, MAHarvard-Radcliffe Colleges, A.B. Cum Laude in Biochemical Sciences, June 1982Elizabeth Cary Agassiz Scholar, John Harvard Scholarship
Medical Licenses:New York : 185889; New Jersey: MA61727
Certifications:ABPN Certified in Psychiatry, 5/95; Recertified 8/06
Faculty Positions:• Professor I, Rutgers University, Department of Genetics, Piscataway, NJ: July 2005 - present• Associate Professor (with tenure), Rutgers University, Department of Genetics, Piscataway, NJ: July
2000 – June 2005• Assistant Professor, Rutgers University, Center for Molecular and Behavioral Neuroscience, Newark, NJ:
July 1994 - June 2000• Clinical Professor, New Jersey Medical School, Department of Psychiatry, Newark, NJ: July 2007 -
Present• Associate Professor (co-terminus), New Jersey Medical School, Department of Psychiatry, Newark, NJ:
July 2001 – June 2007• Assistant Professor (co-terminus), New Jersey Medical School, Department of Psychiatry, Newark, NJ:
July 1994 - June 2001• Lecturer, Columbia University, Department of Psychiatry, New York, NY: July 1994 - present
September 1, 2007
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Scientific Advisory Boards:Motif BioSciences Scientific Advisory Board, 2004 - presentAstraZeneca Schizophrenia Genetics Advisory Board, 2003New Jersey Tourette Center of Excellence, Scientific Advisory Board, 2005 – presentFragile Families (Princeton University) DNA Advisory Group, 2007 – presentDepartment of Defense Autism Spectrum Disorder Research Program Integration Panel, 2007
Professional Societies:• American Association for the Advancement of Science• American Psychiatric Association• American Society of Human Genetics• International Genetic Epidemiology Society• New York Academy of Sciences
Prizes and Awards:2005 NARSAD Staglin Family Music Festival Schizophrenia Research Award2000 NARSAD Independent Investigator Award1996 New York State Psychiatric Institute, Centennial Award, Alumna of the Decade, 1990s1994 New York State Psychiatric Institute Alumni Award for Research1994 Mead Johnson Travel Fellow to the American College of Neuropsychopharmacology1993 Ginsberg Fellow to the Group for the Advancement of Psychiatry1990 NARSAD Young Investigator Award1987 Alpha Omega Alpha Medical Honor Society1987 Lange Medical Award for pre-clinical excellence in medical school1987 Merck Award for overall academic excellence in medical school
Research Interests:My research group applies the techniques of molecular and statistical genetics to approach clinicallyrelevant problems in neuroscience, with the ultimate goal of understanding gene function in both thepathologic and normal states. We are currently studying schizophrenia, autism, and specific languageimpairment (SLI). Work directly conducted by my group includes development of phenotype definitions,subject recruitment and assessment (for autism and SLI), genotyping and statistical analysis for linkage andassociation studies, comparative genomic analysis, and gene expression studies. Other areas of particularinterest include the role of microRNAs in the control of gene expression in the human brain andenhancements to moderately high throughput genotyping technologies. Our primary collaborators outsideof Rutgers/UMDNJ are Dr. Anne Bassett at the University of Toronto, who works on phenotypedefinition, subject recruitment and assessment for schizophrenia, and Dr. Veronica Vieland at theUniversity of Ohio, who works on the development of advanced statistical genetics methods.
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Active Grants (as Principal Investigator):• NIH – NIMH, R01 MH080429
Elucidating the Role of miRNA Dysregulation in Schizophrenia and Bipolar Disorder4/1/07 – 3/31/12: $2,748,613 total direct costs
• NIH – NIMH, R01 MH076435Identification and Functional Assessment of Autism Susceptibility Genes9/30/05 – 7/31/10: $1,652,474 total direct costs
• NARSADStaglin Family Music Festival Schizophrenia Research Award7/1/05 – 6/30/08, $250,000 total costs
• New Jersey Governor’s Council on AutismGenetic Analysis of an Autism Susceptibility Locus on Chromosome 1q23-257/1/05 – 6/30/07, $189,380 total direct costs
• NIH - NIMH, R01 MH62440Molecular Genetics of Schizophrenia Susceptibility2/01/04 - 1/31/09: $1,666,330 total direct costs
• NIH - NIMH, R01 MH70366Genetic Components of Autism Spectrum Disorders9/29/03 - 6/30/08: $3,064,398 total direct costs
• March of Dimes Research Award, 12-FY02-107Genetic Studies of Language and Reading Impairment in Canadian Families6/1/02 - 9/30/07: $255,239 total direct costs
Active Grants (as Co-Investigator):• NIH - NIMH, U24 MH068457 (Tischfield)
NIMH Center for Collaborative Genetic Studies on Mental Disorders7/1/03 - 06/30/08: $14,654,462 total direct costs
Completed Grants (as Principal Investigator):• New Jersey Governor’s Council on Autism
Mentor-Based Postdoctoral Fellowship7/1/04 – 6/30/06, $50,000 total direct costs
• March of Dimes Research Award, 12-FY02-110Candidate Gene Analysis in Autistic Families6/1/02 - 5/31/05: $233,662 total direct costs
• Rutgers University Busch GrantIdentification of the Simpson-Golabi-Behmel Syndrome Type II Gene on Chromosome Xp227/1/02 - 6/30/04: $20,000 total direct costs
• National Alliance for Autism ResearchLocalization of Genes Negatively Influencing Language Acquisition07/01/01 - 06/30/03: $81,460 total direct costs
• New Jersey Governor’s Council on AutismFamily-Based Approaches for Determining Autism Susceptibility Genes in the AGRE Sample6/1/01 - 5/31/03: $95,000 total direct costs
• NIH - NIMH, R01 MH62440Molecular Genetics of a Schizophrenia Locus on 1q21-222/01/01 - 1/31/04: $575,000 total direct costs
• NARSAD Independent Investigator AwardMolecular Genetics of a Schizophrenia Locus on 1q21-229/15/00 - 9/14/02: $92,592 total direct costs
• March of Dimes Research AwardGenetic Studies of Language and Reading Impairment in Canadian Families withSchizophrenia6/1/97 - 5/31/01: $46,580 total direct costs
• NIH - NIMH, K08 MH01392Phenotype Definition in Familial Schizophrenia2/1/97 - 1/31/02: $686,339 total direct costs
• Medical Research Council of Canada
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Genetic Linkage and Anticipation in Familial Schizophrenia7/1/96 - 6/30/98: C$163,328 total direct costs
• EJLB Foundation Scholar Research ProgrammePhenotype Definition and Gene Linkage in Familial Schizophrenia1/1/96 - 12/31/98: C$300,000 total costs
• March of Dimes Research AwardGenetic Linkage Study of Language Impairment4/1/95 - 3/31/97: $107,246 total direct costs
• Hoechst Celanese Innovative Research AwardGenetic Polymorphism Analysis of Dopamine and Serotonin Receptors3/1/95 - 2/29/96: $20,000 total direct costs
• American College of NeuropsychopharmacologyMead Johnson Travel Award, 12/94
• NARSAD Young Investigator AwardFine Genetic Mapping of a Possible Schizophrenia-Associated Region, 5q11.2-13.31/1/90 - 6/30/91: $30,000 total direct costs
Completed Grants (as Co-Investigator):• Canadian Institutes of Health Research (Bassett)
Delineating a High Risk Phenotype in Familial Schizophrenia4/1/02 - 3/31/07: C$878,255 total direct costs
• March of Dimes Research Award (Matise)Genomic Characterization of Schizophrenia Candidate Gene Regions6/1/02 - 5/31/05: $134,214 total direct costs
• Medical Research Council of Canada, MOP-38099 (Bassett)A Screening Strategy for a Genetic Subtype of Schizophrenia4/1/00 - 3/31/03: C$338,496 total direct costs
• Medical Research Council of Canada, MT-1225 (Bassett)Localizing Genes for Familial Schizophrenia10/1/98 - 9/30/01: C$301,092 total direct costs
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• NIH-NCRR Shared Instrumentation Grant (Siegel)IBM SP2 Computer for Experimental Neurocomputation Studies4/1/98 - 3/31/99: $327,994 total direct costs
• Scottish Rite Schizophrenia Research Program (Bassett)Deletion 22q11 and Velocardiofacial Syndrome: The Delineation of a Distinct Genetic Subtypeof Schizophrenia?8/1/97 - 7/31/99: $69,000 total direct costs
• NARSAD Independent Investigator Award (Bassett)Characterizing a Genetic Subtype of Schizophrenia7/1/97 - 6/30/99: $100,000 total direct costs
• NIH – NIDCD, R01 DC01654 (Tallal)Family Genetic Studies of Language Impairment7/1/96 - 6/30/03: $975,205 total direct costs
• NIH – NIDCD, R01-DC01854 (Tallal)Twin and Family Genetic Studies of Language Impairment4/1/93-3/31/96: $411,312 total direct costs
Teaching:• Human Genetics
Rutgers University, Cell and Developmental Biology Graduate Program, Piscataway, NJCourse Director/Sole Instructor, Fall 2001, Fall 2003, Fall 2005, Fall 2007
• Seminar in GeneticsRutgers University, Department of Genetics, Piscataway, NJCourse Director/Sole Instructor, Fall 2006
• Topics in Human GeneticsRutgers University, Department of Genetics, Piscataway, NJLecturer, Spring 2001 - 2007
• Medical GeneticsUniversity of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School,Piscataway, NJLecturer, Fall 2001-2007, Associate Course Director, Fall 2001, Fall 2002
• Child & Adolescent Psychiatry Fellow SeminarUniversity of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School,Piscataway, NJLecturer, Fall 2005, Fall 2007
• Microbial and Molecular GeneticsRutgers University/University of Medicine and Dentistry of New Jersey, Microbiology and MolecularGenetics Graduate Program, Piscataway, NJLecturer, Spring 2001 - 2003
• Evolutionary Genetics of Humans and Other PrimatesRutgers University, Departments of Genetics and Anthropology, Piscataway, NJLecturer, Fall 2002
• Seminar in Problems in Experimental Psychology: AutismRutgers University, Department of Psychology, Piscataway, NJLecturer, Fall 2002
• Genetics in EpidemiologyColumbia University, School of Public Health, New York, NYLecturer, Spring 1995 - 2001; Fall 2002
• Foundations in Neuroscience and BehaviorRutgers University, Center for Molecular and Behavioral Neuroscience, Newark, NJLecturer, Fall 1991 - 1994; Fall 1997 - 1999; Spring 1992 - 1996; Spring 1998 - 2000; Spring 2002;Spring 2003Course Director, Fall 1996
• Medical GeneticsSarah Lawrence College, Human Genetics Program, Bronxville, NYLecturer, Spring 1995 - 2000
• Human Molecular Genetics
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Rutgers University, Graduate Program in Behavioral and Neural Sciences and Graduate Program inBiology, Newark, NJCourse Director/Sole Instructor, Spring 1997, Spring 1999, Fall 1999
• Neuroscience MethodsRutgers University, Center for Molecular and Behavioral Neuroscience, Newark, NJLecturer, Fall 1994 - 1999
• Biological PsychiatryColumbia University, Psychiatric Epidemiology Training Program, New York, NYLecturer, Fall 1998
• Neurochemistry and NeuropharmacologyRutgers University, Center for Molecular and Behavioral Neuroscience, Newark, NJLecturer, Spring 1993, Spring 1995, Fall 1997
• Ethical Issues in MedicineNew Jersey Medical School, Behavioral Science Workshop, Newark, NJWorkshop Leader, Spring 1996, Spring 1997
• Issues in Human GeneticsRutgers University, Freshman Seminar Program, Newark, NJCourse Director/Sole Instructor, Spring 1996
• Psychopathology IINew School for Social Research, Department of Psychology, New York, NYLecturer, Spring 1996
• Advanced Human GeneticsSarah Lawrence College, Human Genetics Program, Bronxville, NYCourse Director, Fall 1994, Fall 1995
• Molecular Methods in Human GeneticsRutgers University/Essex County College, Newark, NJBridges to the Baccalaureate Degree Mini-CourseCourse Director/Sole Instructor, Summer 1995
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• Genetic Epidemiology in Child PsychiatryColumbia University, Child Psychiatry Clinical Research Center, New York, NYLecturer, Spring 1993, Spring 1994
• Medical GeneticsColumbia University, College of Physicians and Surgeons, New York, NYLecturer, Spring 1992, Spring 1993, Fall 1993
• Genetic Epidemiology in PsychiatryColumbia University, School of Public Health, New York, NYLecturer, Summer 1990, Summer 1991, Fall 1992, Fall 1993
• Mammalian GeneticsColumbia University, Department of Genetics and DevelopmentLecturer, Spring 1990
University and Departmental Committees:• Rutgers University, Institutional Review Board for the Use of Human Subjects in Research, 8/94 - present; Chair 9/00 - present• Rutgers/UMDNJ Molecular Biosciences Graduate Program Academic Review Committee,
4/01 – present• Rutgers/UMDNJ Molecular Biosciences Graduate Program Executive Committee, 9/02 – present• Rutgers/UMDNJ NJ Stem Cell Institute Director Search Committee, 4/05 - present• Rutgers University, Research Advisory Board, 9/02 – present• Rutgers University, RAB Conflict of Interest Review Subcommittee, 10/04 – present• Rutgers University, Department of Genetics, Faculty Mentoring Committee, 9/01 – present (for Chiu,
Singson, Matise, Gordon, Shumyatsky)• Rutgers/UMDNJ-RWJMS Barriers Reduction Committee, Human Subjects Protection Subcommittee,
12/06 - present• Rutgers University Priorities Committee, 2/07 – 6/07• Rutgers University, ORSP Director Search Advisory Committee, 10/06-12/06• Rutgers/UMDNJ Clinical & Translational Pilot Awards Review Committee, 5/07• Rutgers University, Committee on Bylaws and Governance, 7/06 – 5/07• Rutgers University, Faculty of Arts and Sciences Advisory Committee on Appointments and Promotions,
9/00 - 6/02• Rutgers University, Ethics in Teaching and Research Conference Planning Committee, 7/95 - 6/00• Rutgers University, Behavioral and Neural Science Program Comprehensive Examination Committee,
9/96 - 6/00• Rutgers/UMDNJ , Executive Committee, The Graduate Center at Newark Program in Neuroscience, 6/99
- 6/00• Rutgers University, Department of Genetics/Center of Alcohol Studies, Chair of Faculty Search
Committee, 9/02 – 5/04• Rutgers University, Department of Genetics, Chair of Faculty Search Committee, 9/04 – 5/05• Rutgers University, Department of Genetics, Faculty Search Committee, 9/05 – 5/07
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Grant Review Committees:• NIH Mammalian Genetics Study Section, Regular Member, 9/01 - 6/04• NIH Mammalian Genetics Study Section, Temporary Member, 10/99, 6/00, and 6/01 Meeting• NIH Genome Study Section, Temporary Member, 10/97, 6/98, 10/98, and 2/00 Meetings• NIH Genetics of Health and Disease Study Section, Temporary Member, 10/06 Meeting• NIH Special Emphasis Panels, 5/99, 3/01, 3/02, 3/03, 11/04, 7/05, 2/06 (chair), 7/06, 6/07• NIH SBIR Genetic Sciences Review Group, 3/99• National Alliance on Autism Research, Special Review, 5/06• March of Dimes Birth Defects Foundation, Social and Behavioral Sciences Research Advisory
Committee, 1993 – 2002; 2006 – 2010• American Heart Association - New Jersey Affiliate, Study Section B, 1995 - 1997
External Grant Reviewer:Medical Research Council (U.K.), Medical Research Council of Canada, Ontario Mental HealthFoundation, Scottish Hospital Endowments Research Trust, The Hospital for Sick Children Foundation,Veteran's Administration
Journal Editor:• Human Heredity, Associate Editor 11/96 – present• American Journal of Psychiatry, Associate Editor 1/07 – present• NeuroMolecular Medicine, Editorial Board 3/01 – 7/04• Journal of Molecular Medicine, Editorial Board, 4/01 – 7/04
Journal Referee:American Journal of Human Genetics, American Journal of Psychiatry, Archives of General Psychiatry,Biological Psychiatry, Clinical Genetics, European Journal of Human Genetics, Genes, Brain and Behavior,Human Genetics, Molecular Psychiatry, Neuropsychiatric Genetics, Neuropsychopharmacology,Neuroscience Letters, PLoS Medicine
Invited Presentations/Participation: National and International Meetings &Workshops• International Meeting for Autism Research Annual Meeting Scientific Program Committee London, UK May 15-17, 2008• Autism Spectrum Disorder: Recent Advances in Infantile Origins, Early Childhood Detection, and
Intervention“Genetic Studies of Autism Susceptibility”Providence, RI, October 12-14, 2007
• Kennedy Krieger Institute/Autism SpeaksAutism WorkshopBaltimore, MD, June 21-22, 2007
• NIH – National Institute of Mental HealthConte Centers Working GroupRockville, MD, April 4, 2007
• NIH – Center for Scientific ReviewNeurotechnology Working GroupTeleconference, March 12, 2007
• International Meeting for Autism Research Annual Meeting Educational Symposium, “Genetics of Autism” Montreal, Quebec, June 1, 2006• NIH – National Institute of Mental Health
The Genetics of Mood Disorders: Future Directions in the Post-Genomic EraLaguna Beach, CA, May 9-10, 2005
• NIH - National Institute of Environmental Health SciencesWorkshop on Research Priorities in AutismNew Brunswick, NJ, October 4, 2002
• NIH - National Institute of Mental Health, Clinical Neurosciences Branch
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Workshop on Fostering Translational Research in PsychiatryWashington, DC, September 10 - 11, 2002
• National Association for Research on Schizophrenia and Affective Disorders (NARSAD)Symposium, An Odyssey Through the Genetics of Brain DisordersPresentation "Genetics of Schizophrenia"Philadelphia, PA, March 17, 2001
• The Rockefeller UniversityNIMH - Sponsored Workshop on Phenotypes and Genetic Analysis of Complex TraitsPresentation "Linkage Analysis Using Components of the Schizophrenia Phenotype"New York, NY, September 30, 1999
• EJLB Scholars RetreatPresentation "Phenotype Definition and Gene Linkage in Familial Schizophrenia"Quebec City, Quebec, September 26, 1998
• American Academy of Child & Adolescent Psychiatry Annual Review CoursePresentation “Genetics of Mental Disorders in Children and Adolescents”New York, NY, June 24, 1998
• American Medical Women’s Association, Interim MeetingPresentation “Genetics and the Future of Women’s Health Care”Washington, DC, June, 1997
• NIH - National Institute on Deafness and Other Communication DisordersWorkshop on Research Opportunities in Molecular Biology and Genetics in Voice, Speech, andLanguagePresentation "Genetic Studies of Language Impairment"Bethesda, MD, April, 1997
• NIH - National Institute of Mental Health Genetics WorkgroupWorkshop on Genetics and Mental DisordersBethesda, MD, March, 1997
• 25th Annual Meeting of the International Neuropsychological SocietyPresentation “Genetic Linkage Studies: The Special Challenges of Behavioral Disorders”Orlando, Fl, February, 1997
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• 29th Annual Gatlinburg Conference on Research and Theory in Mental Retardation and DevelopmentalDisabilities - Genetics, Behavior & Developmental DisabilitiesPresentation "Genetics of Developmental Language Disability"Gatlinburg, TN, March, 1996
• University of Kansas Conference, Towards a Genetics of LanguagePresentation "Looking for Language Genes: Lessons from Complex Disorder Studies"Lawrence, KS, November, 1993
• American Speech-Language and Hearing Association ConferenceKeynote Address "Genetics: Progress and Promise for Communication Sciences and Disorders"Atlanta, GA, November, 1991
Invited Presentations/Participation: Regional Meetings• Cold Spring Harbor Laboratories: New York Psychiatric Genetics Meeting
Meeting Co-OrganizerCold Spring Harbor, NY, July 27, 2007
• The New Jersey Center for Outreach and Services for the Autism Community Annual Conference “Genetic Factors in Autism: An Overview” Atlantic City, NJ May 4, 2007• The New Jersey Center for Outreach and Services for the Autism Community Annual Conference “The Potential Causes of Autism: A State of the Research in Genetics” (keynote) “More From a Geneticist’s Perspective” (workshop) Atlantic City, NJ May 19, 2006• National Alliance for the Mentally Ill – Middlesex County
“Genetics and Mental Illness”Piscataway, NJ, April 4, 2005
• National Alliance for Autism Research - New Jersey, Autism Research Update“New Jersey Language and Genetics Autism Study”Piscataway, NJ, July 15, 2004
• New Jersey Center for Outreach and Services for the Autism Community Annual Conference“Genetic Components of Autism Spectrum Disorders: An Innovative New Jersey Study”Atlantic City, NJ, May 7, 2004
• National Alliance for the Mentally Ill, New Jersey Annual Conference“Genetics and Mental Illness: Implications for Prevention and Recovery” (keynote)“Recent Advances in the Genetics of Schizophrenia” (workshop)Somerset, NJ, May 19, 2001
• Columbia University Seminar in Genetic Epidemiology“Evidence for Schizophrenia Locus on Chromosome 1: Follow-Up Studies”New York, NY, May 10, 2001
• New Jersey Medical School, University of Medicine and DentistryFifth Annual Symposium on Medicine in the 21st Century: Psychiatry & Neurobiology“Localization of Multiple Genes for Schizophrenia Susceptibility”Newark, NJ, June 11, 1999
• Columbia University Seminar in Genetic Epidemiology“The Use of Quantitative Symptom Measures in the Linkage Analysis of Familial Schizophrenia”New York, NY, May 14, 1998
• New Jersey Neuroscience Symposium“Localization of a Gene Contributing to the Positive Symptoms of Schizophrenia”Newark, NJ, May 19, 1998
Invited Presentations: Departmental Grand Rounds and Seminars• Columbia University, Genetic Epidemiology Seminar Series
“Searching for Schizophrenia Risk Alleles in NOS1AP”New York, NY, May 10, 2007
• Children’s Specialized Hospital“Genetic Components of Autism”Mountainside, NJ, May 3, 2007
• Institute of Advanced Studies“Genetic Components of Autism”
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Princeton, NJ, November 20, 2006• New Jersey Medical School, University of Medicine and Dentistry
Department of Psychiatry Grand Round“Identifying the 1q22 Schizophrenia Susceptibility Locus”Newark, NJ, September 20, 2006
• Columbia University, Sergievsky Center “Identifying the 1q22 Schizophrenia Susceptibility Locus”New York, NY, January 10, 2006
• New Jersey Neuroscience Institute“Mapping the 1q22 Schizophrenia Susceptibility Locus”Edison, NJ, June 29, 2005
• Johns Hopkins University, Department of PsychiatryPsychiatric Genetics Seminar Series“Mapping the 1q22 Schizophrenia Susceptibility Locus”Baltimore, MD, January 26, 2005
• University of Pennsylvania Medical School, Department of Psychiatry Research Seminar"Fine Mapping of the Schizophrenia Susceptibility Locus on Chromosome 1q22"Philadelphia, PA, November 11, 2002
• Robert Wood Johnson Medical School, University of Medicine and Dentistry of New JerseyDepartment of Psychiatry Grand Rounds"Evidence for a Schizophrenia Susceptibility Locus on Chromosome 1q22"Piscataway, NJ, January 10, 2002
• Rutgers University, Department of Genetics1999-2000 Seminar Series"Localizing Multiple Genes for Schizophrenia Susceptibility"Piscataway, NJ, May 15, 2000
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• Rutgers University, Center for Molecular and Behavioral Neuroscience1999-2000 Colloquium Series"Localizing Multiple Genes for Schizophrenia Susceptibility"Newark, NJ, September 23, 1999
• New Jersey Medical School, University of Medicine and DentistryDepartment of Psychiatry Research Day“Linkage of Familial Schizophrenia to Chromosome 13q32 and 8p21”Newark, NJ, April 28, 1999
• Center for Inherited Disease Research“The Use of Quantitative Symptom Measures in the Linkage Analysis of Familial Schizophrenia”Baltimore, MD, June 9, 1998
• New Jersey Medical School, University of Medicine and DentistryDepartment of Psychiatry Grand Round“Genetic Linkage of the Severity of Positive Symptoms of Schizophrenia to Chromosome 6p”Newark, NJ, April, 1997
• Hillside Hospital, Department of Psychiatry Research Seminar“Genetic Linkage of the Severity of Positive Symptoms of Schizophrenia to Chromosome 6p”Glen Oaks, NY, April, 1997
• Elmhurst Hospital, Department of Psychiatry Grand Rounds“Update on Schizophrenia Genetics”Elmhurst, NY, April, 1996
• New Jersey Medical School, University of Medicine and DentistryDepartment of Psychiatry Grand Rounds"The Challenges of Psychiatric Genetics"Newark, NJ, November, 1994
• Elizabeth General Medical Center, Department of Psychiatry Grand Rounds"Psychiatric Genetics: What Can We Learn from Other Complex Disease Studies?"Elizabeth, NJ, September, 1993
• Kansas Mental Retardation Center Lecture Series“The Present State of Psychiatric Genetics”Kansas City, KS, February, 1993
Invited Presentations: Special Programs• Rutgers/UMDNJ Summer Undergraduate Research Program in Neuroscience
Career Choices ForumPiscataway, NJ, July 25, 2007
• Princeton University, PRISM/PCCM's Research Experience for UndergradsDiscussion of the Social Implications of the Film “GATTACA”Princeton, NJ, July 13, 2007
• Biology Teachers Association of New Jersey, Science in the Cinema seriesDiscussion of the Social Implications of the Film “GATTACA”Princeton Junction, NJ, March 11, 2006
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• Rutgers University, Rutgers Honors College"Genetically Engineering the Good Life"Newark, NJ, April, 1998
• Rutgers University, Howard Hughes Medical Institute Seminar"Genetic Studies of Behavioral Disorders"Newark, NJ, April, 1997
• Rutgers University, Howard Hughes Medical Institute Seminar"The Revolution in Human Genetics"Newark, NJ, February, 1994
Publications:1. Costanzo M, Hannett N, Brzustowicz L, Pero J. Bacteriophage SPO1 Gene 27: Location and
Nucleotide Sequence. Journal of Virology 1983; 48:555-560.2. Costanzo M, Brzustowicz L, Hannett N, Pero J. Bacteriophage SPO1 Genes 33 and 34. Location
and Primary Structure of Genes Encoding Regulatory Subunits of Bacillus subtilis RNAPolymerase. Journal of Molecular Biology 1984; 180:533-547.
3. Brzustowicz LM, Lehner T, Castilla L, Penchaszadeh GK, Wilhelmsen K, Daniels R, Davies KE,Leppert M, Ziter F, Wood D, Dubowitz V, Zerres K, Hausmanowa-Petrusewicz I, Ott J, Munsat T,Gilliam TC. Genetic Mapping of Chronic Childhood-Onset Spinal Muscular Atrophy toChromosome 5q11.2-13.3. Nature 1990; 344:540-541.
4. Gilliam TC, Brzustowicz LM, Castilla L, Lehner T, Penchaszadeh GK, Wilhelmsen K, Dubowitz V,Thomas N, Regev R, Hislop J, Daniels R, Shapiro H, Munsat T, Ott J, Davies KE. GeneticHomogeneity Among Severe (SMA I) and Chronic (SMA II, III) Spinal Muscular Atrophy.Nature 1990; 345:823-825.
5. Munsat TL, Skerry L, Korf B, Pober B, Shapira Y, Gason GG, Al- Rajeh SM, Dubowitz V, Davies KE,Brzustowicz LM, Penchaszadeh GK, Gilliam TC. Phenotypic Heterogeneity of Spinal MuscularAtrophy Mapping to Chromosome 5q11.2-13.3 (SMA 5q). Neurology 1990; 40:1831-1836.
6. Weeks DE, Brzustowicz LM, Squires-Wheeler E, Cornblatt B, Lehner T, Stephanovich M, Bassett AS,Gilliam TC, Ott J, Erlenmeyer- Kimling L. Report of a Workshop on Genetic Linkage Studies inSchizophrenia. Schizophrenia Bulletin 1990; 16:673-686.
7. Brzustowicz LM, Wilhelmsen KC, Gilliam TC. Genetic Analysis of Childhood-Onset SpinalMuscular Atrophy. in Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases (Advancesin Neurology:56); Lewis P. Rowland, Editor. Raven Press, NY, NY; 1991.
8. Lien LL, Boyce FM, Kleyn PW, Brzustowicz LM, Menninger J, Ward DC, Gilliam TC, Kunkel LM.Mapping of Human Microtubule-Associated Protein 1B in Proximity to the Spinal MuscularAtrophy Locus at 5q13. Proceedings of the National Academy of Science, USA 1991; 88:7873-7876.
9. Kleyn PW, Brzustowicz LM, Wilhelmsen KC, Freimer NB, Miller JS, Munsat TL, Gilliam TC. SpinalMuscular Atrophy is Not the Result of Mutations at the Beta-Hexosaminidase or GM2 Loci.Neurology 1991; 41:1418-1422.
10. Daniels RJ, Thomas NH, MacKinnon RN, Lehner T, Ott J, Flint TJ, Dubowitz V, Ignatius J, Donner M,Zerres K, Rietschel M, Cookson WOC, Brzustowicz LM, Gilliam TC, Davies KE. Linkage Analysisof Spinal Muscular Atrophy. Genomics 1992; 12:335-339.
11. Brzustowicz LM, Kleyn PW, Boyce FM, Lien LL, Monaco AP, Penchaszadeh GK, Das K, Wang CH,Munsat TL, Ott J, Kunkel LM, Gilliam TC. Fine-Mapping of the Spinal Muscular Atrophy Locusto a Region Flanked by MAP1B and D5S6. Genomics 1992; 13:991-998.
12. Gilliam TC and Brzustowicz LM. The Molecular and Genetic Basis of Spinal MuscularAtrophies. in The Molecular and Genetic Basis of Neurological Disease 1992; R. Rosenberg, Editor.Butterworth/Heinemann Press, Stoneham, MA; pp 883-889.
13. Soares VM, Brzustowicz LM, Kleyn PW, Knowles JA, Palmer PA, Penchaszadeh GK, Munsat TL,Gilliam TC. Refinement of the Spinal Muscular Atrophy Locus to the Interval betweenD5S435 and MAP1B. Genomics 1993; 15:365-371.
14. Bernard LE, McPherson JD, Wasmuth JJ, Kreklywich CN, Brzustowicz LM, Wood S. LinkageMapping Detects Two Secondary Microdeletions in Cell Hybrid HHW1064, Used to IsolateDNA Probes from within 5q11.2-13.3. Cytogenetics and Cell Genetics 1993; 64:46-48.
15. Kleyn PW, Wang CH, Lien LL, Vitale E, Pan J, Ross BM, Grunn A, Palmer DA, Warburton D,Brzustowicz LM, Kunkel LM, Gilliam TC. Construction of a Yeast Artificial Chromosome
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Contig Spanning the Spinal Muscular Atrophy Disease Gene Region. Proceedings of theNational Academy of Science, USA 1993; 90:6801-6805.
16. Brzustowicz LM, Mérette C, Xie X, Townsend L, Gilliam TC, Ott J. Molecular and StatisticalApproaches to the Detection and Correction of Errors in Genotype Databases. AmericanJournal of Human Genetics 1993; 53:1137-1145.
17. Petrukhin K, Fischer SG, Pirastu M, Tanzi RE, Chernov I, Devoto M, Brzustowicz LM, Cayanis E,Vitale E, Russo JJ, Matseoane D, Boukhgalter B, Wasco W, Figus AL, Loudianos J, Cao A, Sternlieb I,Evgrafov O, Parano E, Pavone L, Warburton D, Ott J, Penchaszadeh GK, Scheinberg IH, Gilliam TC.Mapping, Cloning, and Genetic Characterization of the Region Containing the WilsonDisease Gene. Nature Genetics 1993; 5:338-343.
18. Tanzi RE, Petrukhin K, Chernov I, Pellequer JL, Wasco W, Ross B, Romano DM, Parano E, Pavone L,Brzustowicz LM, Devoto M, Peppercorn J, Bush AI, Sternlieb I, Pirastu M, Gusella JF, Evgrafov O,Penchaszadeh GK, Honig B, Edelman IS, Soares MB, Scheinberg IH, Gilliam TC. Identification ofthe Wilson's Disease Gene; A Copper Transporting ATPase with Homology to the MenkesDisease Gene. Nature Genetics 1993; 5:344-350.
19. Brzustowicz LM, Lehner T, Castilla LH, Penchaszadeh GK, Das K, Kleyn PW, Dubowitz V, MunsatTL, Ott J, Gilliam TC. Assessment of Non-Allelic Genetic Heterogeneity of Chronic (Types II &III) Spinal Muscular Atrophy. Human Heredity 1993; 43:380-387.
20. Brzustowicz LM, Allitto BA, Matseoane D, Penchaszadeh GK, Sugarman E, Chatkupt S, Suslak L,Koenigsberger MR, Gilliam TC, Handelin BL. Paternal Isodisomy for Chromosome 5 in a Childwith Spinal Muscular Atrophy. American Journal of Human Genetics 1994; 54:482-488.
21. Mérette C, Brzustowicz LM, Daniels RJ, Davies KE, Gilliam TC, Melki J, Munnich A, Pericak-VanceMA, Siddique T, Voosen B, Wirth B, Ott J. An Investigation of Genetic Heterogeneity andLinkage Disequilibrium with 161 Families with Spinal Muscular Atrophy. Genomics 1994;21:27-33.
22. Brzustowicz LM, Wang CH, Matseoane D, Kleyn PW, Vitale E, Das K, Penchaszadeh GK, MunsatTL, Hausmanowa-Petrusewicz I, Gilliam TC. Linkage Disequilibrium and Haplotype AnalysisAmong Polish Families with Spinal Muscular Atrophy. American Journal of Human Genetics1995; 56:210-215.
23. Wang CH, Kleyn PW, Vitale E, Ross BM, Lien L, Xu J, Carter T, Brzustowicz LM, Selig S, Pavone L,Parano E, Penchaszadeh GK, Munsat TL, Kunkel LM, Gilliam TC. Refinement of the SpinalMuscular Atrophy Locus by Genetic and Physical Mapping. American Journal of HumanGenetics 1995; 56:202-209.
24. Brzustowicz LM. Genetics. in The Women's Complete Healthbook 1995; RP Epps and SC Stewart,Editors. Delacorte Press, NY; pp 173-187.
25. Brzustowicz LM. Looking for Language Genes: Lessons from Complex Disorder Studies. inTowards a Genetics of Language 1996, M Rice, Editor. Lawrence Erlbaum Associates, Inc, Mahwah,NJ; pp 3-25.
26. Brzustowicz LM. Genetics. in The American Medical Woman's Association Guide to Fertility andReproductive Health. 1996; RP Epps and SC Stewart, Editors. Dell Publishing, NY; pp 1-43.
27. Brzustowicz LM and Allitto BA. Clinical Molecular Genetic Testing. Journal of the AmericanMedical Women's Association 1997; 52:11-15.
28. Brzustowicz LM, Gardner JP, Hopp L, Jeanclos E, Ott J, Yang XY, Fekete Z, Aviv A. LinkageAnalysis Using Platelet Activating Factor Ca2+ Response in Transformed Lymphoblasts.Hypertension 1997; 29:158-164.
29. Scott WK, Speer MC, Leal SM, Brzustowicz LM, Haynes CS, Pericak-Vance MA. False PositiveRates in a Genomic Screen for Complex Quantitative Traits. Genetic Epidemiology 1997;14:891-896.
30. Brzustowicz LM, Honer WG, Chow EC, Hogan J, Hodgkinson K, Bassett AS. Use of a QuantitativeTrait to Map a Locus Associated with Severity of Positive Symptoms in FamilialSchizophrenia to Chromosome 6p. American Journal of Human Genetics 1997; 61:1388-1396.
31. Brzustowicz LM. Molecular Genetic Approaches to the Study of Language. Human Biology1998; 70:325-345.
32. Brzustowicz LM, Farrell S, Khan MB, Weksberg R. Mapping of a New SGBS Locus toChromosome Xp22 in a Family with a Severe Form of Simpson-Golabi-Behmel Syndrome.American Journal of Human Genetics 1999; 65:779-783.
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33. Brzustowicz LM, Honer WG, Chow EWC, Little D, Hogan J, Hodgkinson K, Bassett AS. Linkage ofFamilial Schizophrenia to Chromosome 13q32. American Journal of Human Genetics 1999;65:1096-1103.
34. Brzustowicz LM, Hodgkinson K, Chow EWC, Honer WG, Bassett AS. Location of a MajorSusceptibility Locus for Familial Schizophrenia on Chromosome 1q21-q22. Science 2000;288:678-682.
35. Bowen T, Williams N, Norton N, Spurlock G, Wittekindt OH, Morris-Rosendahl DJ, Williams H,Brzustowicz L, Hoogendoorn B, Zammit S, Jones G, Sanders RD, Jones LA, McCarthy G, Jones S,Bassett A, Cardno AG, Owen MJ, O’Donovan MC. Mutation Screening of the KCNN3 GeneReveals a Rare Frameshift Mutation. Molecular Psychiatry 2001; 6:259-260.
36. Hodgkinson K, Murphy J, O'Neill S, Brzustowicz LM, Bassett AS. Genetic Counselling forSchizophrenia in the Era of Molecular Genetics. Canadian Journal of Psychiatry 2001; 46:123-130.
37. Bassett AS, Chow EWC, Waterworth DM, Brzustowicz LM. Genetic Insights into Schizophrenia.Canadian Journal of Psychiatry 2001; 46:131-137.
38. Bassett AS, Chow EWC, Brzustowicz LM. The Genetics of Schizophrenia. NeuroScience News2001; 4:20-26.
39. Bassett AS, Chow EWC, O'Neill S, Brzustowicz LM. Genetic Insights into theNeurodevelopmental Hypothesis of Schizophrenia. Schizophrenia Bulletin 2001; 27:417-430.
40. Tallal P, Hirsch LS, Realpe-Bonilla T, Miller S, Brzustowicz LM, Bartlett C, Flax JF. FamilialAggregation in Specific Language Impairment. Journal of Speech, Language, and HearingResearch 2001; 44:1172-1182.
41. Waterworth DM, Bassett AS, Brzustowicz LM. Recent Advances in the Genetics ofSchizophrenia. Cellular and Molecular Life Sciences 2002; 59:331-348.
42. Bassett AS, Chow EW, Weksberg R, Brzustowicz LM. Schizophrenia and Genetics: New Insights.Current Psychiatry Reports 2002; 4:307-314.
43. Bartlett CW, Flax J, Logue M, Vieland VJ, Bassett AS, Tallal P, Brzustowicz LM. A MajorSusceptibility Locus for Specific Language Impairment is Located on 13q21. American Journalof Human Genetics 2002; 71:45-55.
44. Bassett AS, Chow EW, Vieland VJ, Brzustowicz L. Is Schizophrenia Linked to Chromosome 1q?Science 2002; 298:2277.
45. Brzustowicz LM, Hayter J, Hodgkinson KA, Chow EWC, Bassett AS. Fine Mapping of theSchizophrenia Susceptibility Locus on Chromosome 1q22. Human Heredity 2002; 54:199-209.
46. Flax JF, Realpe-Bonilla T, Hirsch LS, Brzustowicz LM, Bartlett CW, Tallal P. Specific LanguageImpairment in Families: Evidence for Co-occurrence with Reading Impairments. Journal ofSpeech, Language, and Hearing Research 2003; 46:530-543.
47. Lewis CM, Levinson DF, Wise LH, DeLisi LE, Straub RE, Hovatta I, Williams NM, Schwab SG,Pulver AE, Faraone SV, Brzustowicz LM, Kaufmann CA, Garver DL, Gurling HM, Lindholm E, CoonH, Moises HW, Byerley W, Shaw SH, Mesen A, Sherrington R, O'Neill FA, Walsh D, Kendler KS,Ekelund J, Paunio T, Lonnqvist J, Peltonen L, O'Donovan MC, Owen MJ, Wildenauer DB, Maier W,Nestadt G, Blouin JL, Antonarakis SE, Mowry BJ, Silverman JM, Crowe RR, Cloninger CR, TsuangMT, Malaspina D, Harkavy-Friedman JM, Svrakic DM, Bassett AS, Holcomb J, Kalsi G, McQuillin A,Brynjolfson J, Sigmundsson T, Petursson H, Jazin E, Zoega T, Helgason T. Genome Scan Meta-Analysis of Schizophrenia and Bipolar Disorder, Part II: Schizophrenia. American Journal ofHuman Genetics 2003; 73:34-48.
48. Bassett AS, Chow EWC, Weksberg R, Brzustowicz L: Unravelling the Mysteries ofSchizophrenia: Advances from Genetic Studies. In The Science and Culture Series, NuclearStrategy and Peace Technology, International Seminar on Nuclear War and Planetary Emergencies,Zichichi A (Series Ed), Ragaini R (Ed), pp 471-483, 2003.
49. Brzustowicz LM, Simone J, Mohseni P, Hayter JE, Hodgkinson KA, Chow EWC, Bassett AS.Linkage Disequilibrium Mapping of Schizophrenia Susceptibility to the CAPON Region ofChromosome 1q22. American Journal of Human Genetics 2004; 74:1057-1063.
50. Gharani N, Benayed R, Mancuso, V, Brzustowicz LM, Millonig JH. Association of the HomeoboxTranscription Factor, ENGRAILED 2, with Autism Spectrum Disorder. Molecular Psychiatry2004; 9:474-484.
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51. Bartlett CW, Flax JF, Logue MW, Smith BJ, Vieland VJ, Tallal P, Brzustowicz LM. Examination ofPotential Overlap in Autism and Language Loci on Chromosomes 2, 7, and 13 in TwoIndependent Samples Ascertained for Specific Language Impairment. Human Heredity 2004;57:10-20.
52. Wassink TH, Brzustowicz LM, Bartlett CW, Szatmari P. The Search for Autism Disease Genes.Mental Retardation and Developmental Disabilities Research Review 2004; 10:272-283.
53. Bartlett CW, Gharani N, Millonig JH, Brzustowicz LM. Three Autism Candidate Genes: ASynthesis of Human Genetic Analysis with Other Disciplines. International Journal ofDevelopmental Neuroscience 2005; 23:221-234.
54. Saviouk V, Chow EWC, Bassett AS, Brzustowicz LM. Tumor Necrosis Factor Promoter HaplotypeAssociated with Schizophrenia Reveals a Linked Locus on 1q44. Molecular Psychiatry2005;10:375-383.
55. Benayed R, Gharani N, Rossman I, Mancuso V, Lazar G, Kamdar S, Bruse SE, Tischfield S, Smith BJ,Zimmerman RA, DiCicco-Bloom E, Brzustowicz LM, Millonig JH. Support for the HomeoboxTranscription Factor Gene ENGRAILED 2 as an Autism Spectrum Disorder SusceptibilityLocus. American Journal of Human Genetics 2005; 77:851-868.
56. Xu B, Wratten N, Charych EI, Buyske SG, Firestein BL, Brzustowicz LM. Increased Expression inDorsolateral Prefrontal Cortex of CAPON in Schizophrenia and Bipolar Disorder. PLoSMedicine 2005; 2:e263.
57. Talkowski ME, Seltman H, Bassett AS, Brzustowicz LM, Chen X, Chowdari KV, Collier DA, CordeiroQ, Corvin AP, Deshpande SN, Egan MF, Ferrell RE, Gill M, Kendler KS, Kirov G, Heston LL, LevittP, Lewis DA, Li T, Mirnics K, Morris DW, Norton N, O’Donovan MC, Owen MJ, Richard C, SemwalP, Sobell JL, St Clair D, Straub RE, Thelma BK, Vallada H, Weinberger DR, Williams NM, Wood J,Zhang F, Devlin B, Nimgaonkar VL. Evaluation of a Susceptibility Gene for Schizophrenia:Genotype Based Meta-Analysis of RGS4 Polymorphisms from Thirteen IndependentSamples. Biological Psychiatry, 2006;60:152-162.
58. Widom C, Brzustowicz LM. MAOA and the “Cycle of Violence”: Childhood Abuse andNeglect, MAOA Genotype, and Risk for Violent and Antisocial Behavior. BiologicalPsychiatry, 2006;60:684-689.
59. Logue MW, Brzustowicz LM, Bassett AS, Chow ECW, Vieland VJ. A Posterior Probability of Linkage(PPL) Based Re-Analysis of Schizophrenia Data Yields Evidence of Linkage to Chromosomes1 and 17. Human Heredity, 2006;62:47-54.
60. Brzustowicz LM. Size Matters: The Unexpected Challenge of Detecting Linkage in LargeCohorts. American Journal of Psychiatry, 2007;164:192-194.
61. Saviouk V, Moreau MP, Tereshchenko IV, Brzustowicz LM. Association of Synapsin 2 withSchizophrenia in Families of Northern European Ancestry. Schizophrenia Research, 2007 inpress.
Meeting Abstracts:1. Kaufman CA, Brzustowicz LM, Knowles J, Willick SA, Lehner T, Ott J, Gilliam TC. Physical and
Genetic Analysis of a Putative Schizophrenia Locus on Chromosome 5. First InternationalCongress on Schizophrenia, Oxford, England, August 1989.
2. Brzustowicz LM, Penchaszadeh G, Castilla L, Lehner T, Das K, Wilhelmsen KC, Ott J, Gilliam TC.Spinal Muscular Atrophy: Genetic Mapping and Characterization. Spinal Muscular AtrophyConference: Association Francaise Contre Les Myopathies, Ile des Embiez, France, September 1989.
3. Brzustowicz LM, Wilhelmsen KC, Knowles J, Kaufman CA, Willick SE, Bassett AS, Wasmuth JJ,Gilliam TC. Physical and Genetic Mapping of a Possible Schizophrenia Associated Region,5q11.2-13.3. American Society of Human Genetics, Baltimore, MD, November 1989.
4. Wilhelmsen K, Brzustowicz LM, Castilla LH, Ott J, Gilliam TC. Progress in the Search for theGene(s) for Spinal Muscular Atrophy. ALS Conference, Tuscon, AZ, December 1989.
5. Brzustowicz LM, Castilla LH, Lehner T, Penchaszadeh GK, Daniels R, Munsat T, Davies KE, Ott J,Gilliam TC. Linkage Analysis of Acute and Chronic Forms of Spinal Muscular Atrophy.Seventh International Congress on Neuromuscular Disease, Munich, West Germany, September, 1990.
6. Adams PB, Lish JD, Freimer N, Brzustowicz LM, Vieland VJ. Pedigree and DNA MarkerManagement: Integrated Data Management System for Molecular and Family-GeneticStudies. American Society of Human Genetics, Cincinnati, OH, October 1990.
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7. Brzustowicz LM, Castilla LH, Lehner T, Penchaszadeh GK, Kleyn PW, Munsat TL, Davies KE, Ott J,Gilliam TC. Genetic Homogeneity Between Acute and Chronic Forms of Spinal MuscularAtrophy. American Society of Human Genetics, Cincinnati, OH, October 1990.
8. Kleyn PW, Brzustowicz LM, Wilhelmsen KC, Freimer NB, Gilliam TC. Spinal Muscular Atrophy(SMA) is Not Caused by Defects at the HEXB Locus on Chromosome 5q. American Society ofHuman Genetics, Cincinnati, OH, October 1990.
9. Lehner T, Brzustowicz LM, Castilla LH, Penchaszadeh GK, Munsat TL, Davies KE, Gilliam TC, Ott J.Mapping of Acute Spinal Muscular Atrophy in Inbred Families. American Society of HumanGenetics, Cincinnati, OH, October 1990.
10. Boyce FM, Lien L, Monaco A, Kleyn P, Brzustowicz LM, Gilliam TC, Kunkel LM. Analysis ofYACs from the Vicinity of the Spinal Muscular Atrophy Locus. 8th International Congress ofHuman Genetics, Washington, D.C., October 1991.
11. Brzustowicz LM, Lehner T, Kleyn PW, Munsat TL, Ott J, Gilliam TC. Evaluation of Non-AllelicGenetic Heterogeneity Among the Childhood-Onset Spinal Muscular Atrophies. 8thInternational Congress of Human Genetics, Washington, D.C., October 1991.
12. Kleyn PW, Brzustowicz LM, Lehner T, Lien LL, Boyce FM, Miller JM, McPherson J, Thompson T,Wasmuth JJ, Munsat TL, Kunkel LM, Ott JM, Gilliam TC. Mapping the Disease Locus for theSpinal Muscular Atrophies. 8th International Congress of Human Genetics, Washington, D.C.,October 1991.
13. Lein LL, Boyce FM, Kleyn P, Brzustowicz LM, Menninger J, Ward DC, Gilliam TC, Kunkel LM.Mapping of a Gene Encoding a Dystrophin Cross-Reactive Protein in Close Proximity to theSpinal Muscular Atrophy Locus. 8th International Congress of Human Genetics, Washington,D.C., October 1991.
14. Penchaszadeh GK, Brzustowicz LM, Handelin B, Klinger K, Wood D, Das K, White P, Gilliam TC.Prenatal Diagnostic Testing of the Spinal Muscular Atrophies. 8th International Congress ofHuman Genetics, Washington, D.C., October 1991.
15. Brzustowicz LM, Townsend L, Asokan S, Gilliam TC, Ott J. Prevalence and Effects of Errors onGenotype Databases. American Society of Human Genetics, San Francisco, CA, October 1992.
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16. Kleyn PW, Brzustowicz LM, Soares V, Knowles J, Vitale E, Mérette C, Penchaszadeh G, Palmer D,Wang C, Jie P, Grunn A, Lien L, Yu M-T, Warburton D, Kunkel LM, Munsat T, Ott J, Gilliam TC.Physical and Genetic Mapping of the Spinal Muscular Atrophy Locus. American Society ofHuman Genetics, San Francisco, CA, October 1992.
17. Lien LL, Feener CA, Fishbach N, Kleyn P, Brzustowicz LM, Gilliam TC, Kunkel LM.Characterization of the Human Microtubule Associated Protein 1B Gene and Analysis of Itas a Marker for Spinal Muscular Atrophy. American Society of Human Genetics, San Francisco,CA, October 1992.
18. McPherson JD, Thompson T, Davies KE, Morrison KE, Kleyn P, Knowles J, Brzustowicz LM, GilliamTC, Burghes AHM, Didonato C, Huschenbett J, Moyzis RK, Grady DL, Wasmuth JJ. RadiationHybrid Mapping of the Spinal Muscular Atrophy Region (5q12-13.2) and Isolation ofRegion-Specific Clones. American Society of Human Genetics, San Francisco, CA, October 1992.
19. Mérette C, Brzustowicz LM, Gilliam TC, Daniels RJ, Davies KE, Melki J, Siddique T, Pericak-VanceMA, Wirth B, Ott J. An International Linkage Analysis of Chronic Childhood-Onset SpinalMuscular Atrophy. American Society of Human Genetics, San Francisco, CA, October 1992.
20. Sugarman E, Shuber A, DiMaggio R, Munsat TL, Brzustowicz LM, Gilliam TC, Handelin B. PrenatalDiagnosis of Spinal Muscular Atrophy: Experience in the First 56 Families. American Societyof Human Genetics, San Francisco, CA, October 1992.
21. Allitto BA, Brzustowicz LM, Chatkupt S, Sugarman E, Michaud L, Silven B, Landes G, Theves R,Suslak L, Koenigsberger MR, Gilliam TC, Handelin BL. Paternal Isodisomy for Chromosome 5 ina Child Affected with Spinal Muscular Atrophy. American Society of Human Genetics, NewOrleans, LA, October 1993.
22. Brzustowicz LM, Matseoane D, Wang CH, Kleyn PW, Vitale E, Penchaszadeh GK, Hausmanowa-Petrusewicz I, Gilliam TC. Linkage Disequilibrium and Haplotype Analysis Among PolishFamilies with Spinal Muscular Atrophy. American Society of Human Genetics, New Orleans, LA,October 1993.
23. Kleyn PW, Wang CH, Vitale E, Carter TA, Ross BM, Jie P, Palmer DA, Grunn A, Bonaldo MF, ShahA, Penchaszadeh GK, Das K, Brzustowicz LM, Lien LL, Selig S, Perls KB, Parano E, Pavone L,Munsat T, Warburton D, Soares MB, Kunkel LM, Gilliam TC. Physical Mapping of the SpinalMuscular Atrophy Locus and Identification of Candidate Genes. American Society of HumanGenetics, New Orleans, LA, October 1993.
24. Mérette C, Brzustowicz LM, Daniels RJ, Davies KE, Gilliam TC, Melki J, Pericak-Vance MA, SiddiqueT, Wirth B, Ott J. An Investigation of Genetic Heterogeneity and Linkage Disequilibrium with161 Spinal Muscular Atrophy Families. American Society of Human Genetics, New Orleans, LA,October 1993.
25. Petruhkin K, Tanzi RE, Fischer S, Pirastu M, Chernov I, Boukhgalter B, Cyanis E, Wasco W,Brzustowicz LM, Matseoane D, Devoto M, Figlis AL, Lolidihnos J, Cao A, Chumakov I, Evgrafov G,Sternlieb I, Warburton D, Penchaszadeh G, Scheinberg IH, Gilliam TC. Mapping the Wilson'sDisease Gene. American Society of Human Genetics, New Orleans, LA, October 1993.
26. Pirastu M, Cossu P, Loi A, Nucaro AL, Deiana M, Loudianos J, Angius A, Dessi V, DeVirgilis S, CaoA, Figus AL, Farci G, Balestrieri A, Nurchi AM, Deplano A, Devoto M, Brzustowicz LM, PetrukhinKE, Chernov IP, Gilliam TC. A Founder Effect for Wilson's Disease in Sardinia Defined byLinkage Disequilibrium Mapping. American Society of Human Genetics, New Orleans, LA,October 1993.
27. Vitale E, Wang CH, Grunn A, Ross B, Lien LL, Cayanis E, Fisher SG, Wellington S, Das K, KleynPW, Brzustowicz LM, Warburton D, Kunkel LM, Gilliam TC. Contig and Fish Analysis of theSMA Region. American Society of Human Genetics, Montréal, Quebec, October 1994.
28. Wang CH, Carter TA, Kleyn PW, Ross BM, Vitale E, Lien LL, Xu J, Das K, Grunn A, BrzustowiczLM, Kunkel, Gilliam TC. Characterization of a Protein Kinase Gene in Allelic Association withthe Spinal Muscular Atrophy Gene. American Society of Human Genetics, Montréal, Quebec,October 1994.
29. Brzustowicz LM, Ricketts AH, Hausmanowa-Petrusewicz I. Extended Haplotype Analysis andDeletions in the SMN Gene in Polish Families with Spinal Muscular Atrophy. AmericanSociety of Human Genetics, Minneapolis, MN, October 1995.
30. Bassett AS, Honer WG, McAlduff J, Hodgkinson K, Ricketts AR, Kirkham SJ, Brenner N,Brzustowicz LM. No Evidence for a Schizophrenia Susceptibility Locus on Chromosomes 6,20, or 22 in Canadian Families of Celtic Ancestry. American Society of Human Genetics, SanFrancisco, October 1996.
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31. Brzustowicz LM, Gardner JP, Hopp L, Ott J, Jeanclos E, Yang XY, Fekete Z, Aviv A. Genetic LinkageStudies Using Cellular Phenotypes in Transformed Lymphoblasts: Mapping of a Locus forPlatelet Activating Factor-Evoked Calcium Response to Chromosome 16, and Its PossibleImplication for Essential Hypertension. American Society of Human Genetics, San Francisco,October 1996.
32. Brzustowicz LM, Honer WG, McAlduff J, Hodgkinson K, Ricketts AR, Bassett AS. Evidence for aLocus on Chromosome 6p Related to Positive Symptom Scores in Canadian Families withSchizophrenia. The International Society of Psychiatric Genetics, San Francisco, October 1996.
33. Bassett AS, McAlduff J, Hodgkinson KA, Brzustowicz LM. A Susceptibility Locus forSchizophrenia on Chromosome 6 Using Positive Symptom Scores as Quantitative Traits. VInternational Congress on Schizophrenia Research, Colorado Springs, April 1997.
34. Brzustowicz LM, Honer WG, Chow EWC, Hogan J, Hodgkinson K, Scutt L, Bassett AS.Quantitative Symptom Measures Linked to Chromosome 6p in Familial Schizophrenia.International Genetic Epidemiology Society, Baltimore, October 1997.
35. Brzustowicz LM, Honer WG, Chow EWC, Hogan J, Hodgkinson K, Scutt L, Bassett AS.Quantitative Symptom Measures Linked to Chromosome 6p in a Canadian Sample ofFamilial Schizophrenia. American Society of Human Genetics, Baltimore, October, 1997.
36. Rosario LA, Abercrombie ED, Brzustowicz LM. Direct Sequencing of the Tyrosine HydroxylaseGene in Inbred F344 and LEW Rat Strains: Relationship to Stress-Induced Differences inTyrosine Hydroxylation. Society for Neuroscience, New Orleans, October 1997.
37. Bassett AS, Lawrence J, Chow EWC, Hodgkinson K, Scutt L, Weksberg R, Brzustowicz LM.Molecular Assessment of 22q11.2 Deletions in Adults with Schizophrenia. American Society ofHuman Genetics, Denver, October 1998.
38. Brzustowicz LM, Farrell S, Khan M, Weksberg R. Mapping of an Infantile Lethal Variant ofSimpson-Golabi-Behmel Syndrome to Chromosome Xp22. American Society of HumanGenetics, Denver, October 1998.
39. Brzustowicz LM, Honer WG, Chow EWC, Roberts SA, Little D, Hayter J, Kahn M, Scutt L, Hogan J,Hodgkinson K, Bassett AS. Linkage of Familial Schizophrenia to Chromosome 13q.International Congress on Schizophrenia Research, Santa Fe, April 1999.
40. Brzustowicz LM, Honer WG, Chow EWC, Little D, Hayter J, Khan M, Scutt L, Hogan J, Hayden D,Hodgkinson K, Bassett AS. Linkage of Familial Schizophrenia to Chromosome 13q32.American Society of Human Genetics, San Francisco, October 1999.
41. Bartlett CW, Flax J, Yabut O, Hirsch L, Li W, Tallal P, Brzustowicz LM. A Genome-Scan forLinkage of Specific Language Impairment: Report on Chromosomes 1, 6, And 15. AmericanSociety of Human Genetics, Philadelphia, October 2000.
42. Shi A, Scutt L, Weksberg R, Chow EWC, Gatzoulis MA, Webb GD, Bassett AS, Brzustowicz LM.Molecular Assessment of 22q11.2 Deletion in Adults with Schizophrenia or Tetralogy ofFallot. American Society of Human Genetics, Philadelphia, October 2000.
43. Bartlett CW, Flax J, Yabut O, Hirsch L, Li W, Brzustowicz LM, Tallal P. Linkage Analysis ofChromosomes 1, 6, and 15 on Families Selected for Specific Language Impairment. Society forNeuroscience, New Orleans, November 2000.
44. Bartlett CW, Flax J, Tallal P, Brzustowicz LM. Possible Genetic Overlap Between Autism andSpecific Language Impairment: Evidence from a Linkage Study of Chromosome 13. TheAutism Genetics Workshop, Pine Mountain, Georgia, March 2001
45. Brzustowicz LM and Bassett AS. Interactive Schizophrenia Susceptibility Loci onChromosomes 1 and 13. International Congress on Schizophrenia Research, Whistler, BritishColumbia, May, 2001
46. Bartlett CW, Flax J, Tallal P, Brzustowicz LM. Linkage Analysis of Chromosome 13 in FamiliesSelected for Specific Language Impairment. American Society of Human Genetics, San Diego,October 2001
47. Bartlett CW, Flax J, Tallal P, Brzustowicz LM. Auditory Temporal Processing Measures asMarker for Language Development: Evidence from Genetic Correlations in ExtendedPedigrees. Society for Neuroscience, San Diego, November 2001
48. Bartlett CW, Flax J, Tallal P, Brzustowicz LM. A Major Locus for Specific Language Impairmentis Located on 13q21-22: Implications for Autism Research. The Autism Genetics Workshop,Pine Mountain, Georgia, March 2002
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49. Bartlett CW, Flax JF, Logue MW, Vieland VJ, Tallal P, Brzustowicz LM. Further Evidence forLinkage of Specific Language Impairment to 13q21 From an American Sample. AmericanSociety of Human Genetics, Baltimore, October 2002
50. Saviouk V, Chow EWC, Bassett AS, Brzustowicz LM. Tumor Necrosis Factor Alpha (TNFA)Haplotypes Modify Susceptibility to Schizophrenia. American Society of Human Genetics,Baltimore, October 2002
51. Waterworth DM, Chow EWC, Bassett AS, Brzustowicz LM. Fine Mapping of a SchizophreniaSusceptibility Locus on 13q32 in a Canadian Sample. American Society of Human Genetics,Baltimore, October 2002
52. Xu B, Hart RP, Zhang Z, Weksberg R, Brzustowicz LM. Identification of the Simpson-Golabi-Behmel Syndrome Type 2 Gene Candidates on Chromosome Xp22. American Society of HumanGenetics, Baltimore, October 2002
53. Logue MW, Vieland VJ, Goedken RJ, Chow EWC, Bassett AS, Brzustowicz LM. PPL Based Re-analysis of a Genome Screen for Schizophrenia. International Genetic Epidemiology Society, NewOrleans, November 2002.
54. Bartlett CW, Flax JF, Li W, Reaple-Bonilla T, Hayter J, Hirsch LS, Logue MW, Zimmerman R,Vieland VJ, Tallal P, Brzustowicz LM. A Genome Scan of Specific Language Impairment Loci inFamilies from the United States. American Society of Human Genetics, Los Angeles, November2003.
55. Brzustowicz LM, Simone J, Mohseni P, Hayter JE, Chow EWC, Bassett AS. LinkageDisequilibrium Mapping of a Schizophrenia Susceptibility Locus on 1q22. American Societyof Human Genetics, Los Angeles, November 2003.
56. Gharani N, Benayed R, Brzustowicz LM, Millonig JH. Association of the HomeodomainTranscription Factor Engrailed 2 with Autism Spectrum Disorder. American Society of HumanGenetics, Los Angeles, November 2003.
57. Saviouk V, Chow EWC, Bassett AS, Brzustowicz LM. Rare Allele in Synapsin 2 Associated withDecreased Rate of Schizophrenia and Schizoaffective Disorder. American Society of HumanGenetics, Los Angeles, November 2003.
58. Xu B, Chow EWC, Bassett AS, Brzustowicz LM. Linkage Disequilibrium Analysis of G72 inCanadian Families with Schizophrenia. American Society of Human Genetics, Los Angeles,November 2003.
59. Brzustowicz LM, Simone J, Hayter JE, Chow EWC, Bassett AS. No Evidence of LinkageDisequilibrium between RGS4 and Schizophrenia in Canadian Linkage Families. AmericanSociety of Human Genetics, Toronto, October 2004.
60. Gharani N, Benayed R, Mancuso V, Brzustowicz LM, Millonig JH. Replication of Association ofENGRAILED 2 in 485 Autism Spectrum Disorder Families. American Society of HumanGenetics, Toronto, October 2004.
61. Saviouk V, Chow EWC, Bassett AS, Brzustowicz LM. Simulations to Evaluate SampleStratification Results – an Example Using TNFA and Schizophrenia. American Society ofHuman Genetics, Toronto, October 2004.
62. Vieland VJ, Huang X, Shi M, Bassett AS, Brzustowicz LM. Measurement of LinkageDisequilibrium (LD) Parameter D' for Complex Traits via the Posterior Probability of LD(PPL-LD) Changes the LD Picture within CAPON, a Large Candidate Gene forSchizophrenia. American Society of Human Genetics, Toronto, October 2004.
63. Wratten NS, Simone J, Chiu CH, Brzustowicz LM. A Comparative Genomics Approach to SNP-Hunting in Large Genes. American Society of Human Genetics, Toronto, October 2004.
64. Yang X, Brzustowicz LM, Bassett AS, Vieland VJ. LD-PPL: The Posterior Probability of Linkage(PPL) with Linkage Disequilibrium (LD). American Society of Human Genetics, Toronto,October 2004.
65. Xu B, Chow EWC, Bassett AS, Brzustowicz LM. Linkage Disequilibrium and Gene Expressionof PPP3CC in Schizophrenia. American Society of Human Genetics, Toronto, October 2004.
66. Benayed R, Gharani N, Mancuso V, Lazar G, Kamdar S, Brzustowicz LM, Millonig J. Support forENGRAILED 2 as an Autism Spectrum Disorder Susceptibility Gene. Society forNeuroscience, San Diego, October 2004.
67. Bruse S, Xu B, Zimmerman P, Buzaki L, Tereshchenko I, Zimmerman R, Brzustowicz LM.Multiplexed SNP Genotyping Uusing the LuminexTM 100 Flow Cytometry Platform. 2ndAnnual Planet xMAP Symposium, Austin, April 2005.
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68. Brzustowicz LM, Xu B, Wratten N, Charych EI, Buyske S, Firestein BL. Increased Expression inDorsolateral Prefrontal Cortex of CAPON in Schizophrenia and Bipolar Disorder. AmericanSociety of Human Genetics, Salt Lake City, October 2005.
69. Bruse SE, Azaro MA, Tereshchenko IV, Goff LA, Hart RP, Brzustowicz LM. Investigation ofDGCR8 and the miRNA Pathway in Schizophrenia. American Society of Human Genetics, SaltLake City, October 2005.
70. Wratten NS, Bruse SE, Azaro MA, Simone J, Hayter JE, Brzustowicz LM. IdentifyingSchizophrenia-Associated Non-Coding Variants in the CAPON Gene. American Society ofHuman Genetics, Salt Lake City, October 2005.
71. Benayed R, Gharani N, Rossman I, Kamdar S, Lazar G, DiCicco-Bloom E, Brzustowicz LM, MillonigJH. Support for the Homebox Transcription Factor, Engrailed 2, as an Autism SpectrumDisorder (ASD) Susceptibility Locus. International Meeting for Autism Research, Montreal,Quebec, June 2006.
72. Andriole BL, Schmidt H, Gray J, Brzustowicz LM, Cartwright C. Obsessive Compulsive Symptomsin Family Members of Individuals with Autism Spectrum Disorder. International Meeting forAutism Research, Montreal, Quebec, June 2006
73. Bruse SE, McGregor N, Azaro MA, Xu B, Brzustowicz LM. An Inexpensive Bead-BasedOligonucleotide Ligation Assay for SNP Genotyping. American Society of Human Genetics, NewOrleans, October 2006.
74. Wratten N, Memoli H, Azaro MA, Messenger J, Hayter J, Buyske S, Bassett A, Chow E, BrzustowiczLM. Identifying Schizophrenia-Associated Non-Coding Variants in the NOS1AP Gene.American Society of Human Genetics, New Orleans, October 2006.
75. Millonig JH, Benayed R, Matteson PG, Gharani N, Kamdar S, Lazar G, Rossman I, DiCicco-Bloom E,Brzustowicz LM. Support for the Homeobox Transcription Factor, ENGRAILED 2, as anAutism Spectrum Disorder Susceptibility Gene. American Society of Human Genetics, NewOrleans, October 2006.
76. Bruse SE, Moreau M, DiCicco-Bloom E, Azaro MA, Brzustowicz LM. Schizophrenia andmicroRNAs: Expression Profiling and Candidate Gene Study. microRNA in Human Disease,Boston, April 2007.
