Limfosit b and T y Ppt

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LIMFOSIT BDAN

LIMFOSIT TOleh:

Noorma Paramitha 44114130

Novi Latifa 4411413033



SEL-SEL SISTEM IMUN





SEL-SEL SISTEM IMUN SPESIFIK

1. Sel T

•. Sel aal el T a!alah !ari "m"m t"la#$ mema"%i

tim" &er'roliferai !i re$io "&%a'"ler

•.Sel aal it" a!alah !ari (D4 !a# (D )

•. Ter!iri !ari &er&a$ai "&et :• Sel Th *T hel'er+

• Sel T *T "''reor+

• Sel T!h,T! *!ela-e! h-'ere#itivit-+

• Sel T *-toto/i+

• Sel limfoit #aif *vir$i#+

• Sel Th0

• Sel e$"lator !a# efe%tor



Activation of Lymphocytes inLymph Nodes



Pe#-e&ara# Limfoi! Pa!a T"&"h Ma#"ia



•F"#$i Sel T "m"m#-a :

•Mem&a#t" el B !alam mem'ro!"%ia#ti&o!i

•Me#$e#al !a# me#$ha#"r%a# el

-a#$ teri#fe%i vir"•Me#$a%tif%a# ma%rofa$ !alam

fa$oitoi

•Me#$o#trol am&a#$ !a# %"alita

item im"#



2. Sel B• Per%em&a#$a# Sel B !alam "m"mt"la#$ a!alah a#ti$e# i#!e'e#!e# teta'i

'er%em&a#$a# ela#"t#-a memerl"%a#

ra#$a#$a# !ari a#ti$e#• F"#$i "tama el B a!alah mem'ro!"%i

a#ti&o!i

• Ata 'e#$ar"h Sel T el B &er'loriferai!a# &er!ifere#iai me#a!i el 'lama

-a#$ mam'" mem&e#t"% I$ -a#$ 'eifi%







SIST2M IMN SP2SIFI

• SP2SIFI 5MOAL• Be#!a ai#$ el B &er'roliferai !a# &er%em&a#$ me#a!i el 'lama

mem&e#t"% a#ti&o!i me#tetraliir to%i# i#fe%i e%trael"ler

• SP2SIFI S2LL2

• Sel T

Pertaha#a# terha!a' i#fe%i i#trael"ler • SIST2M LIMFOID

• Tem'at 'emata#$a# el T !a# el B

B l-m'ho-te a#! 'lama ellT l-m'ho-te

5el'er,I#!"er *(D4+

S"''reor *(D)+



Pertaha#a# 5"moral

A. om'leme#

a. F"#$i %om'leme#

1. Me#$ha#"r%a# el mem&ra# &a#-a% &a%teri (lisis)

6. Mele'a &aha# %emota%ti% -a#$ me#$erah%a# ma%rofa$ %e

tem'at &a%teri (kemotaksis)3. Me#$e#!a' 'a!a 'erm"%aa# &a%teri mem"!ah%a# ma%rofa$

"#t"% me#$e#al (opsonisasi) lal" mema%a##-a

&. Lar"t !alam %ea!aa# #o# a%tif !ia%tivai oleh a#ti$e#7

%om'le% im"#7 !& me!iator *&iolo$i% a%tif ata"'"# m!

e#8im "#t"% rea%i ela#"t#-a+. 9al"r a%tivai i#i eri#$ '"la !iertai !e#$a# %er"a%a#

ari#$a#



Pertaha#a# Sel"ler

1. Fa$oit• Pa!a !aar#-a em"a el &erifat fa$oitoi

• No# 'eifi% mo#o#"%lier *mo#oit ma%rofa$+ !a#

'olimorfo#"%lier ata" $ra#"loit

• Al"r : %emota%i *a%tivai %om'leme#+ me#ela# mema%a#

*fa$oitoi+ mem&"#"h me#er#a *lii+

6. Ma%rofa$• Da'at hi!"' lama

• Mem'"#-ai &e&era'a $ra#"l !a# mele'a%a# &er&a$ai &aha# :

lio8im7 %om'leme#7 i#terfero#7 !a# ito%i# %o#tri&"i !alam SIN

!a# SIS

3. L;L *Large Granular Lymphocyte)• Me#$a#!"#$ &a#-a% ito'lama7 $ra#"l ito'lama a8"rofili%7

'e"!o'o!ia7 !a# #"%le" e%e#tri

• Berifat e'erti el N



B a#! T (ell Ativatio#i$#ali#$ overvie<

Scharenberg et al.

Nat Rev Immunol.

2007



(o#e="e#e of T>(ell Ativatio#

• Treme#!o" Proliferatio#• A#ti$e# 'l" o>tim"lator- i$#al *(D6)+ lea! to e#tr- i#to ell

-le a#! IL>67 IL>6 'ro!"tio#. IL>6,IL>6 lea! to 'ro$reio#

thro"$h ell -le.

• Ma#- ro"#! of 'roliferatio# *1 ell to tho"a#!+• Differe#tiatio# i#to effetor f"#tio#



T-cell Activation

Signaling





Stages of T lymphocyte development-I



Maturation of T lymphocytes in Thymus



Antigen Presenting Cells

•Macrophages/monocytes

•Dendritic cells (e.g., Langerhan’s cells)

•B cells



T cells require APCs to respond toa specific Ag



Selection of T lymphocytes in Thymus



T>ell "&'o'"latio#

1+ (D4 T hel'er l-m'ho-te *T5+

> T5 l-m'ho-te reo$#i8e a#ti$e# o# the "rfae of AP( i#

aoiatio# <ith la II M5( mole"le

> The- are ativate! a#! erete everal -to%i#e

> There are t<o mai# "&et of T5 ell *T5I a#! T56+

> The t<o "&et are !iffere#tiate! o# &ai of the -to%i#e the-

'ro!"e



1+ (D4 T hel'er l-m'ho-te S"&et

Th1 'ro!"e mai#l- :

> (-to%i#e of (MI a#! i#flammatio#

e.$. IFN>?7 TNF> @7 IL>3 a#! IL>6

T56 'ro!"e mai#l-:

> (-to%i#e that tim"late B>ell

> S"''reor -to%i#e

e.$. Il>47 IL>7 IL> a#! IL>10



6+ (D) (-toto/i T>l-m'ho-te *(TL+

C The- o#tit"te 3 0o 'eri'heral T>ell

C (TL reo$#i8e a#ti$e# o# ""rfae of tar$et ell *i#fete!

AP( or other i#fete! #"leoti! ell+ i# aoiatio# <ith M5(>I

C The- are ativate! a#! %ill the vir" i#fete! ell or t"mo"r ell



A#ti&o!ie 'ro!"e! &- B>ell of the imm"#e -tem

reo$#i8e forei$# a#ti$e# a#! mar% them for !etr"tio#



Ativatio# of hel'er T ell



Ativatio# of -toto/i T ell



T (ell eo$#itio# of A#ti$e#

• eo$#i8e a#ti$e# 'e'ti!e fra$me#t &o"#! to'eiali8e ell "rfae mole"le o# a#ti$e#>'ree#ti#$ell *AP(+.

• Mole"le are e#o!e! &- maor hitoom'ati&ilit-

om'le/• Pe'ti!e are !i'la-e! to T ell a 'e'ti!e:M5(om'le/e

• T ell a#ti$e# ree'tor reo$#i8e 'e'ti!e:M5(

om'le/e• 2ah M5( mole"le a# &i#! #"mero" !iffere#t'e'ti!e

• T<o lae of M5( mole"le



Maor 5itoom'ati&ilit- (om'le/

*M5(+ ;e#e Pro!"t

• (la I• A#ti$e# i ""all- e#!o$e#o" *e.$. viral 'rotei#+.

• (D)E -toto/i T l-m'ho-te *(TL+ reo$#i8e a#ti$e# i#

aoiatio# <ith la I M5( $e#e 'ro!"t o# AP(.

• (la II Mole"le• A#ti$e# i ""all- e/traell"lar .

• (D4E 5el'er T L-m'ho-te reo$#i8e a#ti$e# i# aoiatio# <ith

la II M5( $e#e 'ro!"t o# AP(.



(ell"lar (oo'eratio# a#! A#ti$e#

eo$#itio#

APC ExtracellularAntigen

CD4+ HelperTLymphocyte

Class IIMHC-associatedantigen

+



B (ell A#ti$e# eo$#itio#

• (ell "rfae imm"#o$lo&"li# ree'tor or B>ell ree'tor

*I$M a#! I$D+

• A#ti$e# o#tat i#itiate B>ell ativatio#7 lo#al e/'a#io#7

mat"ratio# to 'lama ell

• A#ti$e# ree'tor i i!e#tial to imm"#o$lo&"li# that <ill

"ltimatel- &e 'ro!"e!

Plasma ell

(!e"i#e$ %"om B-l m 'o te "o$es

B



P e # $ e # a l a #

a # t i $ e #

o l e h

e L B



B (2LL A(TIATION



B>ell ativatio#



Stages of lymphocyte development-I



Stages of lymphocyte development-II



Stages of lymphocyte development-III



The Phases of cell !esponses



-cell Activation Signaling



Interface "et#een T and -cells



(ell"lar (oo'eratio#

TH Ba#ti$e#

A#ti&o!- eretio#

&- 'lama ell

Plama (ell

A#ti$e# 'ree#ti#$ ell

A#ti$e# 'ree#tatio# to Ta#! B ell &- AP(

T ell ela&orate

-to%i#e to failitate B

ell 'roliferatio# a#!

mat"ratio#



2ffetor Meha#im

• Meha#im that are "e! &- the imm"#e -temto elimi#ate 'atho$e# *or other "&ta#e+from the &o!-

• (ell"lar effetor meha#im• Ativate! T ell• Nat"ral %iller ell

• 5"moral effetor meha#im *a#ti&o!-+

• Ne"trali8atio#• O'o#i8atio#• (om'leme#t ativatio#• A#ti&o!->!e'e#!e#t ell>me!iate! -toto/iit- *AD((+



2ffetor Ativit- A$ai#t Patho$e#



Per&e!aa# a#tara Limfoit B !a# Limfoit T

In$ikato" Lim%osit T Lim%osit B

1. F"#$i &er'era# !alami#flamai7 a%tifaima%rofa$ !alamfa$oitoi7 a%tivai

!a# 'roliferai el B!alam mem&e#t"%a#ti&o!i7 erta'e#$e#ala# !a#'e#$ha#"ra# el -a#$teri#fe%i vir"

mem'ro!"%ia#ti&o!i

6. Aal Th-m" Bo#e Marro<



o In$ikato" Lim%osit T Lim%osit B

. Str"%t"r !a#mar%er

ree'tor

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Limfosit b and T y Ppt