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Life Science Competitiveness Indicators March 2015

Life Science Competitiveness Indicators - GOV UK · 2016-11-23 · Life Science Competitiveness Indicators 4 Overview: Performance of UK Life Science Sector and Contribution to UK

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  • Life Science Competitiveness Indicators 1

    Life Science Competitiveness Indicators

    March 2015

  • Life Science Competitiveness Indicators 2

    Preface

    This report brings together in one place a set of competitiveness indicators covering a range of aspects of the life science environment in the UK and other countries. They are intended to give a broad understanding of the UK sector, and how it compares internationally.

    The choice of these indicators was informed by Technical and Steering Groups made up of a range of life science sector stakeholders. These included representatives from trade associations, life science sector companies, research organisations, regulators and government bodies. Comparator countries have been selected on the basis of data availability, and advice from the Technical and Steering Groups as to the most appropriate comparators. In some instances where a comparison was considered desirable, it has not been possible as data for particular countries was not available or was not considered reliable.

    There are a range of other UK specific data sources that were not used because internationally comparable data could not be identified. These limitations mean that, whilst this is the fullest picture we are currently able to provide, the set of indicators cannot be looked at in aggregate to provide an overall country ranking. Each indicator should be considered on its own merits and the caveats relating to data sources (which may be constantly updated) should be considered in each case. This report does not make any assessment of the relative importance of different factors for competitiveness, which is at least partly a subjective judgement.

    For the most part, the data on which these indicators are based is drawn from already published data. Wherever possible a link is provided to the data, or to the publication from which the chart has been reproduced. In a few instances it has been necessary for data to be sourced commercially or obtained directly from the organisation holding it. In these cases the supplier is clearly credited against relevant charts. In cases where the data is from a proprietary source, we have not been able to reproduce the underlying data tables.

    This is the first publication of these indicators. The intention is to further develop the indicator content and data sources for future publications.

    We would like to thank all those who have contributed to these indicators, or supplied data for this publication.

  • Life Science Competitiveness Indicators 3

    Table of contents

    Overview: Performance of UK Life Science Sector and Contribution to UK Economy 4

    Overview: Competitiveness of UK Life Science Environment 5

    Indicators for UK industry 6

    Chart 1A: Number of people employed in manufacture of basic pharmaceutical products and pharmaceutical preparations 7

    Chart 1B: Number of people employed in manufacture of medical technology products 8

    Chart 2A: Gross Value Added for pharmaceutical manufacturing in European competitor countries 9

    Chart 2B: Gross Value Added for pharmaceutical manufacturing in UK 10

    Chart 3A: Exports of pharmaceutical products 11

    Chart 3B: Exports of medical technology products 12

    Chart 4A: Imports of pharmaceutical products 13

    Chart 4B: Imports of medical technology products 14

    Chart 5A: Life sciences foreign direct investment projects 15

    Chart 5B: Life sciences foreign direct investment – capital expenditure 16

    Chart 6A: Share of global life science Initial Public Offerings (IPOs) – 2014 17

    Chart 6B: Initial Public Offerings (IPOs) in life sciences – amount raised in 2014 (where known) 18

    Chart 7A: Private equity investment – total investment 19

    Chart 7B: Number of companies receiving private equity investment 20

    Chart 8: Number of science graduates 21

    Research and Development Indicators 22

    Chart 9: Government spend on health research and development 23

    Chart 10: 2013 non-industry spend on research and development 24

    Chart 11: Pharmaceutical industry spend on research and development in the UK 25

    Chart 12A: Share of life science academic citations 26

    Chart 12B: Share of top 1% (most cited) life science citations 27

    Regulatory Indicator 28

    Chart 13: Instances where MHRA is in lead role in EU regulatory procedure 29

    Clinical Research Indicators 30

    Chart 14: Share of patients recruited to global studies (all trial phases) 31

    Chart 15: Time from core package received to first patient enrolled in country (all trial phases) 32

    Demand-side Indicators 33

    Chart 16: Dashboard of NICE Technology Appraisal publication timeframes 34

    Chart 17: Uptake of new medicines 35

  • Life Science Competitiveness Indicators 4

    Overview: Performance of UK Life Science Sector and Contribution to UK Economy

    Chart 5B: Life sciences foreign direct investment – capital expenditure

    2013

    2012

    2011

    2010

    2009

    ItalySwitzerlandJapanFranceIrelandGermanyUKUnited States

    0

    0.2

    0.4

    0.6

    0.8

    1.0

    1.2

    1.4

    1.6

    1.8

    2.0

    Sp

    end

    in b

    illio

    ns o

    f p

    oun

    ds

    (£b

    n)

    Source: fDi Markets, from The Financial Times Ltd.

    Notes: Values are for the year that projects were announced. Data is in current prices.

    Chart 1A: Number of people employed in manufacture of basic pharmaceutical products and pharmaceutical preparations

    0

    20,000

    40,000

    60,000

    80,000

    100,000

    120,000

    140,000

    2012

    2011

    2010

    2009

    2008

    United KingdomNetherlandsItalyFranceSpainGermany

    Num

    ber

    of

    peo

    ple

    em

    plo

    yed

    Source: Eurostat – Data Explorer, Annual detailed enterprise statistics for industry, http://appsso.eurostat.ec.europa.eu/nui/show.do?dataset=sbs_na_ind_r2&lang=en

    Notes: Selected Category in NACE_R2 “C21 Manufacture of basic pharmaceutical products and pharmaceutical preparations”. Data not available for some countries in certain years.

    Chart 1B: Number of people employed in manufacture of medical technology products

    20132012

    2011

    2010

    2009

    0

    50,000

    100,000

    150,000

    200,000

    250,000

    Num

    ber

    of

    peo

    ple

    em

    plo

    yed

    SwitzerlandUnitedKingdom

    NetherlandsItalyFranceSpainGermany

    Source: Eurostat – Data Explorer, Annual detailed enterprise statistics for industry, http://ec.europa.eu/eurostat/data/database

    Notes: Categories in NACE_ R2 “C266 Manufacture of irradiation, electromedical and electrotherapeutic equipment” plus “C325 Manufacture of medical and dental instruments and supplies”. Data not available for some countries in certain years.

    Chart 2B: Gross Value Added for pharmaceutical manufacturing in UK

    0

    5

    10

    15

    201320122011201020092008200720062005

    Gro

    ss V

    alue

    Add

    ed in

    bill

    ions

    of p

    ound

    s (£

    bn)

    Source: : UK data from ONS National Accounts, The Blue Book 2014 Edition dataset time series “KKF7: mGDP manufacture of basic pharmaceutical products and pharmaceutical preparations” http://www.ons.gov.uk/ ons/rel/naa1-rd/united-kingdom-national-accounts/the-blue-book--2014-edition/index.html

    Notes: UK data (Chart 2B) has been taken from a separate source from the comparator countries as it is not currently available broken down at this level through Eurostat. The medical technology sector is defined by two three-digit categories (C266 and C325) and National Accounts data is not available at this level. Data is in current prices.

    http://www.ons.gov.uk/ons/rel/naa1-rd/united-kingdom-national-accounts/the-blue-book--2014-edition/index.htmlhttp://www.ons.gov.uk/ons/rel/naa1-rd/united-kingdom-national-accounts/the-blue-book--2014-edition/index.htmlhttp://appsso.eurostat.ec.europa.eu/nui/show.do?dataset=sbs_na_ind_r2&lang=enhttp://ec.europa.eu/eurostat/data/database

  • Life Science Competitiveness Indicators 5

    Overview: Competitiveness of UK Life Science Environment

    Chart 8: Number of science graduates

    2012

    2011

    2010

    2009

    2008

    2012

    2011

    2010

    2009

    2008

    0

    25,000

    50,000

    75,000

    100,000

    250,000

    300,000

    Uni

    ted

    Sta

    tes

    Uni

    ted

    Kin

    gdom

    Sw

    itzer

    land

    Spa

    in

    Net

    herla

    nds

    Japa

    n

    Italy

    Irela

    nd

    Ger

    man

    y

    Fran

    ce

    Bel

    gium

    Num

    ber

    of

    gra

    dua

    tes 200,000

    Source: United Nations Educational, Scientific and Cultural Organisation (UNESCO) http://data.uis.unesco.org/Index.aspx?DataSetCode=EDULIT_DS

    Notes: Data not available for some countries in certain years.

    Chart 12B: Share of top 1% (most cited) life science citations

    2012

    2011

    2010

    2009

    2008

    UnitedStates

    RussianFederation

    JapanItalyUnitedKingdom

    FranceGermanyChinaCanada

    0%

    5%

    10%

    15%

    20%

    25%

    30%

    35%

    40%

    45%

    50%

    55%

    60%

    65%

    70%

    Sha

    re o

    f ci

    tatio

    ns

    Source: International Comparative Performance of the UK Research Base – 2013 https://www.gov.uk/government/publications/performance-of-the-uk-research-base-international-comparison-2013

    Notes: In cases of co-authorship, citations are allocated to all participating countries (so totals may be more than 100%).

    Chart 9: Government spend on health research and development

    USUKSpainJapanItalyGermany FranceBelgium

    2012

    2011

    2010

    2009

    2008

    Sp

    end

    in b

    illio

    ns o

    f U

    S d

    olla

    rs ($

    bn)

    – 2

    005

    pri

    ces

    0

    1

    2

    3

    4

    25

    30

    35

    40

    Source: OECD Research & Development statistics http://stats.oecd.org/index.aspx?r=227797

    Notes: Government budget appropriations or outlays on R&D in Health.

    Chart 7A: Private equity investment – total investment

    2013

    2012

    2011

    2010

    2009

    0

    0.2

    0.4

    0.6

    0.8

    1.0

    1.2

    1.4

    1.6

    1.8

    2.0

    UKSwitzerlandSpainItalyIrelandGermanyFrance

    Tota

    l pri

    vate

    eq

    uity

    inve

    stm

    ent

    in b

    illio

    ns o

    f E

    uro

    s (€

    bn)

    Source: European Private Equity & Venture Capital Association (EVCA) http://www.evca.eu/research/activity-data/annual-activity-statistics/]

    Notes: Data is based on country of portfolio company. Data is in current prices.

    http://www.evca.eu/research/activity-data/annual-activity-statistics/]http://data.uis.unesco.org/Index.aspx?DataSetCode=EDULIT_DShttps://www.gov.uk/government/publications/performance-of-the-uk-research-base-international-comparison-2013https://www.gov.uk/government/publications/performance-of-the-uk-research-base-international-comparison-2013http://stats.oecd.org/index.aspx?r=227797

  • Life Science Competitiveness Indicators 6

    Indicators for UK industry

  • Life Science Competitiveness Indicators 7

    Chart 1A: Number of people employed in manufacture of basic pharmaceutical products and pharmaceutical preparations

    0

    20,000

    40,000

    60,000

    80,000

    100,000

    120,000

    140,000

    2012

    2011

    2010

    2009

    2008

    United KingdomNetherlandsItalyFranceSpainGermany

    Num

    ber

    of

    peo

    ple

    em

    plo

    yed

    Source: Eurostat – Data Explorer, Annual detailed enterprise statistics for industry, http://appsso.eurostat.ec.europa.eu/nui/show.do?dataset=sbs_na_ind_r2&lang=en

    Notes: Selected Category in NACE_R2 “C21 Manufacture of basic pharmaceutical products and pharmaceutical preparations”. Data not available for some countries in certain years.

    http://appsso.eurostat.ec.europa.eu/nui/show.do?dataset=sbs_na_ind_r2&lang=en

  • Life Science Competitiveness Indicators 8

    Chart 1B: Number of people employed in manufacture of medical technology products

    20132012

    2011

    2010

    2009

    0

    50,000

    100,000

    150,000

    200,000

    250,000N

    umb

    er o

    f p

    eop

    le e

    mp

    loye

    d

    SwitzerlandUnitedKingdom

    NetherlandsItalyFranceSpainGermany

    Source: Eurostat – Data Explorer, Annual detailed enterprise statistics for industry, http://ec.europa.eu/eurostat/data/database

    Notes: Categories in NACE_ R2 “C266 Manufacture of irradiation, electromedical and electrotherapeutic equipment” plus “C325 Manufacture of medical and dental instruments and supplies”. Data not available for some countries in certain years.

    http://ec.europa.eu/eurostat/data/database

  • Life Science Competitiveness Indicators 9

    Chart 2A: Gross Value Added for pharmaceutical manufacturing in European competitor countries

    0

    5.0

    10.0

    15.0

    20.0

    25.0

    Netherlands

    Italy

    France

    Spain

    Germany

    20122011201020092008200720062005

    Gro

    ss V

    alue

    ad

    ded

    in b

    illio

    ns o

    f E

    uro

    s (€

    bn)

    Source: Comparator countries’ data from Eurostat National Accounts data http://ec.europa.eu/eurostat/web/national-accounts/data/database

    Notes: UK data (Chart 2B) has been taken from a separate source from the comparator countries as it is not currently available broken down at this level through Eurostat. The medical technology sector is defined by two three-digit categories (C266 and C325) and National Accounts data is not available at that level. Data is in current prices.

    http://ec.europa.eu/eurostat/web/national-accounts/data/database

  • Life Science Competitiveness Indicators 10

    Chart 2B: Gross Value Added for pharmaceutical manufacturing in UK

    0

    5

    10

    15

    201320122011201020092008200720062005

    Gro

    ss V

    alue

    Ad

    ded

    in b

    illio

    ns o

    f p

    oun

    ds

    (£b

    n)

    Source: UK data from ONS National Accounts, The Blue Book 2014 Edition dataset time series “KKF7: mGDP manufacture of basic pharmaceutical products and pharmaceutical preparations” http://www.ons.gov.uk/ons/rel/naa1-rd/united-kingdom-national-accounts/the-blue-book--2014-edition/index.html

    Notes: UK data (Chart 2B) has been taken from a separate source from the comparator countries as it is not currently available broken down at this level through Eurostat. The medical technology sector is defined by two three-digit categories (C266 and C325) and National Accounts data is not available at this level. Data is in current prices.

    http://www.ons.gov.uk/ons/rel/naa1-rd/united-kingdom-national-accounts/the-blue-book--2014-edition/index.html

  • Life Science Competitiveness Indicators 11

    Chart 3A: Exports of pharmaceutical products

    20132012

    2011

    2010

    2009

    0

    10

    20

    30

    40

    50

    60

    70

    USUK SwitzerlandSpainJapanItalyIrelandGermanyFranceBelgium

    Exp

    ort

    s in

    bill

    ions

    of

    US

    Do

    llars

    ($b

    n)

    Source: UNCTAD STAT Data Center http://unctadstat.unctad.org/wds/ReportFolders/reportFolders.aspx?sCS_ChosenLang=en

    Notes: Categories used are [541] Medicinal and pharmaceutical products excluding 542, and [542] Medicaments including veterinary medicaments. Data is in current prices.

    http://unctadstat.unctad.org/wds/ReportFolders/reportFolders.aspx?sCS_ChosenLang=en

  • Life Science Competitiveness Indicators 12

    Chart 3B: Exports of medical technology products

    20132012

    2011

    2010

    2009

    USUK SwitzerlandSpainJapanItalyIrelandGermanyFranceBelgium

    0

    5

    10

    15

    20

    25

    30

    35E

    xpo

    rts

    in b

    illio

    ns o

    f U

    S D

    olla

    rs ($

    bn)

    Source: UNCTAD STAT Data Center http://unctadstat.unctad.org/wds/ReportFolders/reportFolders.aspx?sCS_ChosenLang=en

    Notes: Categories used are [774] Electro-diagnostic apparatus for medical science etc. and [872] Instruments and appliances, n.e.s, for medical, etc. Data in current prices.

    http://unctadstat.unctad.org/wds/ReportFolders/reportFolders.aspx?sCS_ChosenLang=en

  • Life Science Competitiveness Indicators 13

    Chart 4A: Imports of pharmaceutical products

    20132012

    2011

    2010

    2009

    USUK SwitzerlandSpainJapanItalyIrelandGermanyFranceBelgium

    0

    10

    20

    30

    40

    50

    60

    70Im

    po

    rts

    in b

    illio

    ns o

    f U

    S D

    olla

    rs ($

    bn)

    Source: UNCTAD STAT Data Center http://unctadstat.unctad.org/wds/ReportFolders/reportFolders.aspx?sCS_ChosenLang=en

    Notes: Categories used are [541] Medicinal and pharmaceutical products excluding 542, and [542] Medicaments including veterinary medicaments. Data is in current prices.

    http://unctadstat.unctad.org/wds/ReportFolders/reportFolders.aspx?sCS_ChosenLang=en

  • Life Science Competitiveness Indicators 14

    Chart 4B: Imports of medical technology products

    20132012

    2011

    2010

    2009

    USUK SwitzerlandSpainJapanItalyIrelandGermanyFranceBelgium

    0

    5

    10

    15

    20

    25

    30Im

    po

    rts

    in b

    illio

    ns o

    f U

    S D

    olla

    rs ($

    bn)

    Source: UNCTAD STAT Data Center http://unctadstat.unctad.org/wds/ReportFolders/reportFolders.aspx?sCS_ChosenLang=en

    Notes: Categories used are [774] Electro-diagnostic apparatus for medical science etc., and [872] Instruments and appliances, n.e.s, for medical, etc. Data is in current prices.

    http://unctadstat.unctad.org/wds/ReportFolders/reportFolders.aspx?sCS_ChosenLang=en

  • Life Science Competitiveness Indicators 15

    Chart 5A: Life sciences foreign direct investment projects

    2013

    2012

    2011

    2010

    2009

    0

    20

    40

    60

    80

    100

    120

    ItalySwitzerlandJapanFranceIrelandGermanyUKUnited States

    Num

    ber

    of

    fore

    ign

    dire

    ct in

    vest

    men

    t p

    roje

    cts

    Source: fDi Markets, from The Financial Times Ltd.

    Notes: Numbers are for the year that projects were announced.

  • Life Science Competitiveness Indicators 16

    Chart 5B: Life sciences foreign direct investment – capital expenditure

    2013

    2012

    2011

    2010

    2009

    ItalySwitzerlandJapanFranceIrelandGermanyUKUnited States

    0

    0.2

    0.4

    0.6

    0.8

    1.0

    1.2

    1.4

    1.6

    1.8

    2.0S

    pen

    d in

    bill

    ions

    of

    po

    und

    s (£

    bn)

    Source: fDi Markets, from The Financial Times Ltd

    Notes: Values are for the year that projects were announced. Data is in current prices.

  • Life Science Competitiveness Indicators 17

    Chart 6A: Share of global life science Initial Public Offerings (IPOs) – 2014

    US 71.7%

    China Hong Kong 7.6%

    China 6.7%

    UK 4.1%

    Sweden 2.7%

    France 2.2%

    Brazil 1.5%

    New Zealand 1.0%

    Other:Japan 0.9%South Korea 0.6%Singapore 0.5%Australia 0.2%Finland 0.2%Norway 0.1%

    Source: S&P Capital IQ

    Notes: Numbers refer to the country in which the IPO was launched, not the domicile of the IPO Company.

  • Life Science Competitiveness Indicators 18

    Chart 6B: Initial Public Offerings (IPOs) in life sciences – amount raised in 2014 (where known)

    Am

    ount

    rais

    ed in

    mill

    ions

    of p

    ound

    s (£

    m)

    0

    100

    200

    300

    400

    500

    3,000

    3,500

    4,500

    4,500

    5,000

    Norw

    ay

    Finlan

    d

    Austr

    alia

    Singa

    pore

    Sout

    h Kor

    eaJa

    pan

    New

    Zeala

    ndBr

    azil

    Franc

    e

    Swed

    enUKChina

    China

    Hon

    g Kon

    gUS

    Source: S&P Capital IQ

    Notes: Values refer to the country in which the IPO was launched, not the domicile of the IPO Company.

  • Life Science Competitiveness Indicators 19

    Chart 7A: Private equity investment – total investment

    2013

    2012

    2011

    2010

    2009

    0

    0.2

    0.4

    0.6

    0.8

    1.0

    1.2

    1.4

    1.6

    1.8

    2.0

    UKSwitzerlandSpainItalyIrelandGermanyFrance

    Tota

    l pri

    vate

    eq

    uity

    inve

    stm

    ent

    in b

    illio

    ns o

    f E

    uro

    s (€

    bn)

    Source: European Private Equity & Venture Capital Association (EVCA) http://www.evca.eu/research/activity-data/annual-activity-statistics/]

    Notes: Data is based on country of portfolio company. Data is in current prices.

    http://www.evca.eu/research/activity-data/annual-activity-statistics/]

  • Life Science Competitiveness Indicators 20

    Chart 7B: Number of companies receiving private equity investment

    2013

    2012

    2011

    2010

    2009

    0

    20

    40

    60

    80

    100

    120

    140

    160

    180

    200

    220N

    umb

    er o

    f co

    mp

    anie

    s

    UKSwitzerlandSpain ItalyIrelandGermanyFrance

    Source: European Private Equity & Venture Capital Association (EVCA) http://www.evca.eu/research/activity-data/annual-activity-statistics/]

    Notes: Data is based on country of portfolio company.

    http://www.evca.eu/research/activity-data/annual-activity-statistics/]

  • Life Science Competitiveness Indicators 21

    Chart 8: Number of science graduates

    2012

    2011

    2010

    2009

    2008

    2012

    2011

    2010

    2009

    2008

    0

    25,000

    50,000

    75,000

    100,000

    250,000

    300,000

    Uni

    ted

    Sta

    tes

    Uni

    ted

    Kin

    gdom

    Sw

    itzer

    land

    Spa

    in

    Net

    herla

    nds

    Japa

    n

    Italy

    Irela

    nd

    Ger

    man

    y

    Fran

    ce

    Bel

    gium

    Num

    ber

    of

    gra

    dua

    tes 200,000

    Source: United Nations Educational, Scientific and Cultural Organisation (UNESCO) http://data.uis.unesco.org/Index.aspx?DataSetCode=EDULIT_DS

    Notes: Data not available for some countries in certain years.

    http://data.uis.unesco.org/Index.aspx?DataSetCode=EDULIT_DS

  • Life Science Competitiveness Indicators 22

    Research and Development Indicators

  • Life Science Competitiveness Indicators 23

    Chart 9: Government spend on health research and development

    USUKSpainJapanItalyGermany FranceBelgium

    2012

    2011

    2010

    2009

    2008

    Sp

    end

    in b

    illio

    ns o

    f U

    S d

    olla

    rs ($

    bn)

    – 2

    005

    pri

    ces

    0

    1

    2

    3

    4

    25

    30

    35

    40

    Source: OECD Research & Development statistics http://stats.oecd.org/index.aspx?r=227797

    Notes: Government budget appropriations or outlays on R&D in Health.

    http://stats.oecd.org/index.aspx?r=227797

  • Life Science Competitiveness Indicators 24

    Chart 10: 2013 non-industry spend on research and development

    National Institute of Health and Research – £959m

    Association of Medical ResearchCharities Member Charities – £1,294m

    Medical Research Council – £767m

    Source: Association of Medical Research Charities http://www.amrc.org.uk/sites/default/files/doc_lib/AMRC-annual-review-2013-14.pdf

    Notes: Expenditure by Medical Research Council and National Institute of Health Research will also be captured by Indicator 9.

    http://www.amrc.org.uk/sites/default/files/doc_lib/AMRC-annual-review-2013-14.pdf

  • Life Science Competitiveness Indicators 25

    Chart 11: Pharmaceutical industry spend on research and development in the UK

    Sp

    end

    in b

    illio

    ns o

    f p

    oun

    ds

    (£b

    n)

    0

    1

    2

    3

    4

    5

    201320122011201020092008200720062005200420032002

    Source: ONS BERD survey 2013 http://www.ons.gov.uk/ons/rel/rdit1/bus-ent-res-and-dev/2013/stb-berd-2013.html

    Notes: Data is not available for medical technology industry spend. Data is in current prices.

    http://www.ons.gov.uk/ons/rel/rdit1/bus-ent-res-and-dev/2013/stb-berd-2013.html

  • Life Science Competitiveness Indicators 26

    Chart 12A: Share of life science academic citations

    2012

    2011

    2010

    2009

    2008

    UnitedStates

    RussianFederation

    JapanItalyUnitedKingdom

    FranceGermanyChinaCanada

    0%

    5%

    10%

    15%

    20%

    25%

    30%

    35%

    40%

    45%

    50%S

    hare

    of

    cita

    tions

    Source: International Comparative Performance of the UK Research Base –2013 https://www.gov.uk/government/publications/performance-of-the-uk-research-base-international-comparison-2013

    https://www.gov.uk/government/publications/performance-of-the-uk-research-base-international-comparison-2013

  • Life Science Competitiveness Indicators 27

    Chart 12B: Share of top 1% (most cited) life science citations

    2012

    2011

    2010

    2009

    2008

    UnitedStates

    RussianFederation

    JapanItalyUnitedKingdom

    FranceGermanyChinaCanada

    0%

    5%

    10%

    15%

    20%

    25%

    30%

    35%

    40%

    45%

    50%

    55%

    60%

    65%

    70%S

    hare

    of

    cita

    tions

    Source: International Comparative Performance of the UK Research Base – 2013 https://www.gov.uk/government/publications/performance-of-the-uk-research-base-international-comparison-2013

    Notes: In cases of co-authorship, citations are allocated to all participating countries (so totals may be more than 100%).

    https://www.gov.uk/government/publications/performance-of-the-uk-research-base-international-comparison-2013

  • Life Science Competitiveness Indicators 28

    Regulatory Indicator

  • Life Science Competitiveness Indicators 29

    Chart 13: Instances where MHRA is in lead role in EU regulatory procedure

    0

    10%

    20%

    30%

    40%

    50%

    60%

    70%

    UK Decentralised Procedures - Reference Member State

    Scientific AdviceCo-ordinator

    Centralised ProceduresRapporteur/Co-rapporteur

    2014201320122011201020092008

    Pro

    po

    rtio

    n o

    f to

    tal c

    ases

    Source: Medicines and Healthcare Products Regulatory Agency

    Notes: The chart illustrates the proportion of work the UK has undertaken in three key areas of European regulatory activity. As the work of the Medicines and Healthcare Products Regulatory Agency (MHRA) within the areas covered by these indicators is collaborative, no direct comparison with the other 27 Member States is made and the UK’s position in the leading role is shown as a percentage of all work undertaken.

    Each new medicinal product seeking approval in Europe through the Centralised Procedure has a Rapporteur and a co-Rapporteur appointed by the European Medicines Agency (EMA) to lead the assessment process. The Decentralised Procedure requires the applicant company to select a Reference Member State (RMS) to lead the assessment of the medicine during the procedure.

  • Life Science Competitiveness Indicators 30

    Clinical Research Indicators

  • Life Science Competitiveness Indicators 31

    Chart 14: Share of patients recruited to global studies (all trial phases)

    2012

    2011

    2010

    2009

    2008

    Czech RepublicPolandFranceGermanyUSUK

    Sha

    re o

    f p

    atie

    nts

    recr

    uite

    d g

    lob

    ally

    0%

    5%

    10%

    15%

    20%

    25%

    30%

    35%

    40%

    Source: This material is reproduced under a licence from CMR International.

    Notes: You may not copy or re-distribute this material in whole or in part without the written consent of CMR International.

  • Life Science Competitiveness Indicators 32

    Chart 15: Time from core package received to first patient enrolled in country (all trial phases)

    2012

    2011

    2010

    2009

    2008

    Czech RepublicPolandFranceGermanyUSUK

    Day

    s

    0

    50

    100

    150

    200

    250

    300

    Source: This material is reproduced under a licence from CMR International.

    Notes: You may not copy or re-distribute this material in whole or in part without the written consent of CMR International. “Core package received” refers to receipt of final documentation relating to the clinical study by the local operating company or their representative.

  • Life Science Competitiveness Indicators 33

    Demand-side Indicators

  • Life Science Competitiveness Indicators 34

    Chart 16 Dashboard of NICE Technology Appraisal publication timeframes

    Source: National Institute for Health and Care Excellence – Technology Appraisal Programme

    Notes: MA: Marketing AuthorisationACD: Appraisal Consultation DocumentFAD: Final Appraisal DeterminationDials address forecast and actual timeframes for different stages of the NICE Technology Appraisal process. Full details of the process, including descriptions of the separate stages can be found on the NICE website (http://www.nice.org.uk/About/What-we-do/Our-Programmes/NICE-guidance/NICE-technology-appraisal-guidance). Red and Green zones on dials relate to whether milestones have been attained within existing targets for NICE performance.

    http://www.nice.org.uk/About/What-we-do/Our-Programmes/NICE-guidance/NICE-technology-appraisal-guidancehttp://www.nice.org.uk/About/What-we-do/Our-Programmes/NICE-guidance/NICE-technology-appraisal-guidancehttp://www.nice.org.uk/About/What-we-do/Our-Programmes/NICE-guidance/NICE-technology-appraisal-guidancehttp://www.nice.org.uk/About/What-we-do/Our-Programmes/NICE-guidance/NICE-technology-appraisal-guidance

  • Life Science Competitiveness Indicators 35

    Chart 17 Uptake of new medicines

    Year 1

    11.4%

    UK

    up

    take

    per

    hea

    d/a

    ll co

    untr

    y up

    take

    per

    hea

    d

    0%

    50%

    100%

    150%

    200%

    250%

    300%

    350%

    Years from launch

    Year 2

    31.9%

    Year 3

    50.7%

    Year 4

    50.7%

    Year 5

    90.2%

    Source: IMS Health, courtesy of the Office of Health Economics

    Notes: The chart shows the per capita uptake of twenty-eight new medicines launched in the UK between 2007 to 2012 and approved (recommended or restricted) by NICE, compared to the average in a group of comparator countries (Australia, Austria, Belgium, Canada, Finland, France, Germany, Ireland, Italy, Japan, Netherlands, New Zealand, Spain, Sweden, Switzerland, and USA). The vertical lines represent uptake of the medicines in their 1st, 2nd etc. years after launch. Thus medicines launched in 2012 will only appear in the ‘Year 1 from launch’ group, those launched in 2011 will appear in both the ‘Year 1 from launch’ and ‘Year 2 from launch’ groups and so on. The medicines launched in 2007 will appear in all five year groups.

    The percentage number reported in each year is the median rate of uptake in the UK relative to the international average in that year; in other words half of the medicines have a higher UK relative rate of use, and half have a lower UK relative rate of use. A value below 100% means that the UK per capita consumption of the new medicine(s) is below the international average. For example, medicines in their 3rd year after launch (and subsequently approved by NICE) were used in the UK at a level which was on average 50.7% of the average usage in the comparator countries. Caution is required in the 5th year after launch as the median rate of uptake reported (90.2%) is based on only five data points (medicines) and is therefore highly sensitive to the choice of medicines included.

  • BIS/15/249

    Life Science Competitiveness IndicatorsPrefaceTable of contentsOverview: Performance of UK Life Science Sector and Contribution to UK EconomyOverview: Competitiveness of UK Life Science EnvironmentIndicators for UK industryChart 1AChart 1BChart 2AChart 2BChart 3AChart 3BChart 4AChart 4BChart 5AChart 5BChart 6AChart 6BChart 7AChart 7BChart 8

    Research and Development IndicatorsChart 9Chart 10Chart 11Chart 12AChart 12B

    Regulatory IndicatorChart 13

    Clinical Research IndicatorsChart 14Chart 15

    Demand-side IndicatorsChart 16Chart 17