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U.S. Department of Energy. Office of Science. Life and Medical Sciences Program. Biological Facilities Support of biological stations at world-class synchrotron & neutron sources, JGI, and ORNL mouse house. Genomics: GTL - PowerPoint PPT Presentation
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Life and Medical Sciences Program
Biological Facilities Support of biological stations at world-class synchrotron & neutron sources, JGI, and ORNL mouse house.
Genomics: GTL Systems biology research in bioenergy, bioremediation and carbon sequestration; development of bioenergy research centers.
Health Effects Research- Low Dose Radiation Program
- Nuclear Medicine
- Advanced bio-medical instrumentation
- ELSI, Human Subjects Protection Program
Office of Science
U.S. Department of Energy
Shewenella FederationShewenella Federation
• Comparative genomic and physiological analysis of Shewenella species.
• Functional genomics energy flow and electron transport.
• Genetic and functional characterization of c-type cytochromes
• Characterization and modeling of metabolic and regulatory networks.
PNL, ANL,ORNL,USC,UCLA,MSU,BU. OU,MBL,DRI,BIATECH,GEONOMATICA
Federation Integrated ApproachFederation Integrated Approachto Shewanella Biologyto Shewanella Biology
ImagingAFM, EM, CLSM
Immuno-EM
ProteomicsMS
2-D gel
MR-1 GenomeSequence,
Bioinformatics
Information Synthesis & Interpretation
Linked measurements
Concepts &Hypotheses
Cellular networks,Modeling
Gene ExpressionMicroarraysReporters
Physiology &Metabolism
Computational Biology
Data Analysis &Integration
▲Perturbation:
•mutation•cultivation
ControlledControlledCultivationCultivation
DOE Imaging InstrumentationDOE Imaging Instrumentation
Clinical PET
MicroPET
Mobile PET
Office of Science
U.S. Department of Energy
Awake Animal Project :The Rat CAP
•Miniaturized, novel electronics which allows the signals from the RatCAP to be collected, amplified and analyzed
•LSO crystal arrays, backed to photodiodes and electronics board.
•Image resolution comparable to micro-PET
RatCAP
MicroPET
Schlyer, Vaska, Woody, 2006
Office of Science
U.S. Department of Energy
•Six 16-electrode devices implanted in humans. Longest implant in for 3 years.
•60 electrode device completing pre-clinical testing in dogs. Human study scheduled for 12/06.
•Component design for 250
electrode device completed.
ORNL, ANL, LANL, SNL, LLNL, BNL, USC, UC SC, CalTech,NC State, Second Sight