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Lecture 12 – Second Messengers VI – Others BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy Last modified -13F

Lecture 12 – Second Messengers VI – Others BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy Last modified -13F

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Page 1: Lecture 12 – Second Messengers VI – Others BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy Last modified -13F

Lecture 12 – Second Messengers VI – Others

BIOL 5190/6190 Cellular & Molecular Singal TransductionPrepared by Bob Locy

Last modified -13F

Page 2: Lecture 12 – Second Messengers VI – Others BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy Last modified -13F

CSB Fig 02:01 Cell signalling pathways

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

Page 3: Lecture 12 – Second Messengers VI – Others BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy Last modified -13F

Transducers Second Messengers II

1. JAK/STAT signaling

2. Smad signaling3. Hedgehog signaling4. Wnt signaling5. Hippo signaling6. Notch signaling7. ER Stress signaling8. AMP signaling

Page 4: Lecture 12 – Second Messengers VI – Others BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy Last modified -13F

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

CSB Fig 2:72 JAK and STAT structure

Page 5: Lecture 12 – Second Messengers VI – Others BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy Last modified -13F

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

CSB Fig 2:73 STAT1/DNA complex

Page 6: Lecture 12 – Second Messengers VI – Others BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy Last modified -13F

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

CSB Fig 2:74 JAK/STAT heterogeneity

Page 7: Lecture 12 – Second Messengers VI – Others BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy Last modified -13F

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

CSB Fig 2:75 JAK/STAT function

Page 8: Lecture 12 – Second Messengers VI – Others BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy Last modified -13F

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

CSB Fig 2:76 Smad domain structure

Page 9: Lecture 12 – Second Messengers VI – Others BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy Last modified -13F

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

CSB Fig 2:77 TGF-βR activation

Page 10: Lecture 12 – Second Messengers VI – Others BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy Last modified -13F

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

CSB Fig 2:78 Smad signalling

Page 11: Lecture 12 – Second Messengers VI – Others BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy Last modified -13F

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

CSB Fig 2:79 Wnt signalling pathways

Page 12: Lecture 12 – Second Messengers VI – Others BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy Last modified -13F

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

CSB Fig 2:80 Wnt canonical pathway

Page 13: Lecture 12 – Second Messengers VI – Others BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy Last modified -13F

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

CSB Fig 2:81 Hedgehog signalling pathway

Page 14: Lecture 12 – Second Messengers VI – Others BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy Last modified -13F

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

CSB Fig 2:82 Hippo signalling pathway

Page 15: Lecture 12 – Second Messengers VI – Others BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy Last modified -13F

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

CSB Fig 2:83 Notch signalling

Page 16: Lecture 12 – Second Messengers VI – Others BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy Last modified -13F

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

CSB Fig 2:84 Notch modulation

Page 17: Lecture 12 – Second Messengers VI – Others BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy Last modified -13F

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

CSB Fig 2:85 ER stress signalling

Page 18: Lecture 12 – Second Messengers VI – Others BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy Last modified -13F

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

CSB Fig 2:86 Metabolic messengers

Page 19: Lecture 12 – Second Messengers VI – Others BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy Last modified -13F

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

CSB Fig 2:87 Metabolic signalling

Page 20: Lecture 12 – Second Messengers VI – Others BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy Last modified -13F

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

CSB Fig 2:88 Pyruvate and Ca2+ signalling

Page 21: Lecture 12 – Second Messengers VI – Others BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy Last modified -13F

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

CSB Fig 2:89 AMPK structure

Page 22: Lecture 12 – Second Messengers VI – Others BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy Last modified -13F

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

CSB Fig 2:90 AMPK control of metabolism

Page 23: Lecture 12 – Second Messengers VI – Others BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy Last modified -13F

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

CBS Fig 2:91 Omega-3 fatty acids