Learning Task Cellular Intervention

7/30/2019 Learning Task Cellular Intervention

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BY : SGD 4


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1.Learn the term :- Receptor- Effector- Agonist drug- Full agonist- Partial agonist- Pharmcologic antagonist- Competitive antagonist- Irreversible antagonist- Physiologic antagonist- Chemical antagonist- Graded dose response curve- Quantal dose response curve- ED 50- LD 50- Therapeutic Index- Efficacy- Potency


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2.Compare the efficacy and the potency of twodrugs on the basis of their dose response

curves


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3. Describe about tolerance,hyperreactive,hyporeactive, and idiosyncrasy


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Hyper reactive : If a drug produces its usualeffect at unexpected low dosage

Hyporeactive : If a drug produces its usualeffect only at unsually large dosageTolerance : Decreased sensitivityIdiosyncracy : An usual effect of a drug thatoccurs in only small percentage of individuals


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Dosage Percentage responding to drug A Percentage responding to drug B

12.5 mg 1 1025 mg 10 50

37.5 mg 50 7050 mg 90 100

Define : Efficacy of drug A and BED 50 of drug A and BLD 50 of drug A and B

Therapeutic index of drug A and BPotency of drug A and B


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Efficacy : Increasing the dose, increasing theresponse until sometime the response can

not increase although the dose is increased

Drug A and drug B :50 mg


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ED50 ( EFFECTIVE DOSE ) : The dose of drugrequired to produce a specified intensity of effect in 50% individuals

Drug A: 37.5Drug B : 25

LD50 (LETHAL DOSE) : If death is the end point

Drug A : 0Drug B : 0


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Therapeutic index : Ratio of LD50 to the ED 50LD50ED 50

Answer :Drugs A : Drugs B :LD50 = 0 LD50 : 0ED50= 37.5 ED50 : 25

LD50 LD50ED50 ED50

0 037.5 25

0 0


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Therapeutic index : Ratio of LD50 to the ED 50LD50ED 50

Answer :Drugs A : Drugs B :LD50 = 0 LD50 : 0ED50= 37.5 ED50 : 25

LD50 LD50ED50 ED50

0 037.5 25

0 0


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Potency : Amount of drug neded to produceto given effect

Drug A and Drug B: 12.5 mg


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1. Blocker with intrinsic sympathogeneticactivity (ISA)

2. Space reseptor3. Cardioselective Blocker4.Morphine + Nalorphine5. 2 selective agonist6. Physiologic antagonist7. Chemical antagonist


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this term is used particularly with beta blockers that canshow both agonism and antagonism at a given betareceptor, depending on the concentration of the agent(beta blocker) and the concentration of the antagonizedagent (usually an endogenous compound, such asnorepinephrine). See partial agonist for a more generaldescription.

Some beta blockers (e.g. oxprenolol, pindolol, penbutolol

and acebutolol) exhibit intrinsic sympathomimetic activity(ISA). These agents are capable of exerting low levelagonist activity at the -adrenergic receptor whilesimultaneously acting as a receptor site antagonist.


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Receptors thatdo not have to bind order forto be the maximum effect to be produced


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beta blockers are categorized in a few different ways. Some are"cardioselective" (meaning they are more likely to affect the heart andblood vessels rather than other parts of the body), some have "intrinsicsympathomimetic activity" (meaning they slightly stimulate betareceptors while also blocking them), and some are alpha blockers as well

as beta blockers. Some beta blockers fall into more than one category. Cardioselective beta blockers (that are more likely to block beta-1receptors rather than beta-2 receptors) include: Acebuto lol (Sectral )Atenolol (Tenormi n)Betaxolol (Kerlone , Betoptic )Bisoprolol (Zebeta )Esmolol (Brevibloc)Nebivolol (Bystolic)Metoprolol (Lopressor , Toprol-XL
http://heart.emedtv.com/acebutolol/acebutolol.htmlhttp://blood-pressure.emedtv.com/atenolol/atenolol.htmlhttp://heart.emedtv.com/acebutolol/acebutolol.htmlhttp://heart-disease.emedtv.com/tenormin/tenormin.htmlhttp://heart-disease.emedtv.com/tenormin/tenormin.htmlhttp://heart-disease.emedtv.com/tenormin/tenormin.htmlhttp://senior-health.emedtv.com/betaxolol/betaxolol.htmlhttp://senior-health.emedtv.com/betaxolol/betaxolol.htmlhttp://heart-disease.emedtv.com/tenormin/tenormin.htmlhttp://hypertension.emedtv.com/kerlone/kerlone.htmlhttp://heart-disease.emedtv.com/tenormin/tenormin.htmlhttp://eyes.emedtv.com/betoptic/betoptic.htmlhttp://hypertension.emedtv.com/bisoprolol/bisoprolol.htmlhttp://hypertension.emedtv.com/bisoprolol/bisoprolol.htmlhttp://blood-pressure.emedtv.com/zebeta/zebeta.htmlhttp://eyes.emedtv.com/betoptic/betoptic.htmlhttp://heart.emedtv.com/esmolol/esmolol.htmlhttp://hypertension.emedtv.com/bisoprolol/bisoprolol.htmlhttp://blood-pressure.emedtv.com/brevibloc/brevibloc.htmlhttp://blood-pressure.emedtv.com/brevibloc/brevibloc.htmlhttp://blood-pressure.emedtv.com/brevibloc/brevibloc.htmlhttp://hypertension.emedtv.com/nebivolol/nebivolol.htmlhttp://hypertension.emedtv.com/nebivolol/nebivolol.htmlhttp://blood-pressure.emedtv.com/brevibloc/brevibloc.htmlhttp://blood-pressure.emedtv.com/bystolic/bystolic.htmlhttp://heart-disease.emedtv.com/metoprolol/metoprolol.htmlhttp://heart-disease.emedtv.com/metoprolol/metoprolol.htmlhttp://blood-pressure.emedtv.com/bystolic/bystolic.htmlhttp://blood-pressure.emedtv.com/lopressor/lopressor.htmlhttp://blood-pressure.emedtv.com/lopressor/lopressor.htmlhttp://heart-disease.emedtv.com/metoprolol/metoprolol.htmlhttp://blood-pressure.emedtv.com/lopressor/lopressor.htmlhttp://blood-pressure.emedtv.com/toprol-xl/toprol-xl.htmlhttp://blood-pressure.emedtv.com/toprol-xl/toprol-xl.htmlhttp://blood-pressure.emedtv.com/toprol-xl/toprol-xl.htmlhttp://blood-pressure.emedtv.com/toprol-xl/toprol-xl.htmlhttp://blood-pressure.emedtv.com/toprol-xl/toprol-xl.htmlhttp://blood-pressure.emedtv.com/lopressor/lopressor.htmlhttp://heart-disease.emedtv.com/metoprolol/metoprolol.htmlhttp://blood-pressure.emedtv.com/bystolic/bystolic.htmlhttp://hypertension.emedtv.com/nebivolol/nebivolol.htmlhttp://blood-pressure.emedtv.com/brevibloc/brevibloc.htmlhttp://heart.emedtv.com/esmolol/esmolol.htmlhttp://blood-pressure.emedtv.com/zebeta/zebeta.htmlhttp://hypertension.emedtv.com/bisoprolol/bisoprolol.htmlhttp://eyes.emedtv.com/betoptic/betoptic.htmlhttp://hypertension.emedtv.com/kerlone/kerlone.htmlhttp://senior-health.emedtv.com/betaxolol/betaxolol.htmlhttp://heart-disease.emedtv.com/tenormin/tenormin.htmlhttp://blood-pressure.emedtv.com/atenolol/atenolol.htmlhttp://hypertension.emedtv.com/sectral/sectral.htmlhttp://heart.emedtv.com/acebutolol/acebutolol.html


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Morphine (full agonist) + Nalorphine (partialagonist) => the % response will follow the the

partial agonist


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Beta2-agonists are available in metered-dose inhaler(MDI), nebulizer, pill, injected, and syrup forms. Somebeta2-agonists may be available in multiple forms. Yourdoctor will help you decide which form is best for you.There are 2 types of beta2-agonists: short-acting andlong-acting. The short-acting type relieves symptoms andthe long-acting type helps prevent breathing problems.Short-acting beta2-agonists are used for treating stableCOPD in a person whose symptoms come and go

(intermittent symptoms). Long-acting beta2-agonists areeffective and convenient for preventing and treatingCOPD in a person whose symptoms do not go away(persistent symptoms).


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A drug that counters the beffects of anotherby binding to a different receptor and causing

opposing effects


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A drug that counters the effects of another bybinding the drug and preventing its action

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Learning Task Cellular Intervention