Lead Neurotoxicity: Intervention/Prevention did not significantly alter the concentrations or Uic or

  • View
    1

  • Download
    0

Embed Size (px)

Text of Lead Neurotoxicity: Intervention/Prevention did not significantly alter the concentrations or Uic or

  • Lead Neurotoxicity: Intervention/Prevention

    January 22, 2007

    Lead Neurotoxicity: Intervention/Prevention

    Joseph Graziano, PhD Associate Dean for Research

    Professor of Environmental Health Sciences and Pharmacology

    Mailman School of Public Health Columbia University

    January 22, 2007

    1

  • 2

  • 3

  • 4

  • 5

  • 6

  • 7

  • 8

  • The Development of DMSA (Succimer) as a Treatment for Childhood Lead Poisoning

    • 1974: Animal model of Pb poisoning developed; begin screening candidate drugs

    • 1977: DMSA identified as a potential antidote for Pb in an animal model

    • 1982: Clinical trials begin at Columbia Univ. • 1990: New Drug Application submitted • 1991: FDA approval for use in children • SEVENTEEN YEARS! • What could have expedited this process?

    What Could Have Expedited This Process?

    • Higher throughput drug screening models

    • Help in partnering with a pharmaceutical firm interested in an orphan drug

    • The development of a network of sites involved in studies of children’s environmental health, with access to potential study participants

    • Funding for additional clinical trial sites

    9

  • 10

  • 11

  • 1985 CDC guidelines

    12

  • Blood Lead Levels in the U.S. Population 1976–1999

    B lo

    od L

    ea d

    L ev

    el s (

    m g/

    dL )

    18

    16

    14

    12

    10

    8

    6

    4

    2

    lead NHANES II, III, 99+ paint Ban can solder 1976 phase-out

    Begins unleaded 1978 gasoline

    Introduced 1979 lead &

    copper Rule can 1991 solder

    ends leaded 1992 gas

    ends 1996

    2.7 2.0

    0 1974 1976 1978 1980 1982 1984 1986 1988 1990 1992 1994 1996 1998 2000

    Year

    Number 19May 10, 2001Volume 344:1421-1426

    13

  • Thank You!

    14

  • 15

  • 16

  • 17

    002t~~/23M~IO 'f'Nr; J~/llJ.L Otf)j.d.MJ.(:01.0(;t Al"D £xpt:a1~blt.-.I. 'T\ttaAnt1nca \'atm,NO.s CoPrrilhtC>l!l&5b,-'llw ~ricariSocitty Corf>ti.~-.nd~ri!DenuJTber~ ~£1\.U.$.A,

    Use pf 2,3-Dimercaptopropane-1-Sulfonate in Treatment of Lead Poisoning in Children 1

    J. J. CHISOLM, JR. and DAVID J. THOMAS The. Kennedy Institute 10< Handicapped Children and the ...,.,,....... ,,,...,,., ..,.. , ....,._. - · ..................... ,.,.....,,_ ..... , ,..., -··~ • ~N v1 H,.11',,,,,, BaNUnote, Maryland

    A