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Safety Data SheetAccording to 1907/2006/EC, Article 31
01 Identification of the substance/mixture and of the company/undertaking
LAXMI ORGANIC INDUSTRIES
Revision: 11.09.2014
Product details: Trade name: ethyl 4-chloroacetoacetate Pre-registration number: 17-2119897496-15-0000
Relevant identified uses of the substance or mixture and uses advised
against
Application of the substance / the preparation
Used as medicine and pesticide intermediates
02 Hazards Identification
Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008 Classification according to Directive 67/548/EEC
or Directive 1999/45/EC
Acute Tox. 3 H301 Toxic if swallowed
GHS05 corrosion
Skin Corr. 1B H314 Causes severe skin burns and eye damage
GHS06 skull and crossbones
T: Toxic
R25: Toxic if swallowed
C: Corrosive
R35: Causes severe burns
Information concerning particular hazards for human
and environment: Not applicable
Manufacturer / Supplier
Laxmi Organic Industries Ltd.
Chandermukhi, 3rd Floor,
Nariman Point, Mumbai 400 021
Tel No. : +91 22 49104444
Fax No. : +91 22 22853752
Email :
Contact details of European importer
Laxmi Organic Industries (Europe) B.V. Burgemeester Feithplein 11, 2273 BZ Voorburg, The Netherlands
Tel No. : +31(0)70 20 40 600
Fax No. : +31 (0)70 20 40 604
Email :
Emergency telephone numbers:
+31 646159978 (for EU)
+91 7738092735 (for other regions)
Other Comments (e.g. language(s) of the phone service): English
Label elementsThe substance is classified and labelled according to the CLP regulation
Labelling according to Regulation (EC) No 1272/2008
Hazard pictograms:
GHS05 GHS06
SIGNAL WORD Danger
Hazard statements
H301 Toxic if swallowed.
H314 Causes severe skin burns and eye damage.
Precautionary statements
P301+P310 IF SWALLOWED: Immediately call a POISON
CENTER or doctor/physician
P303+P361+ IF ON SKIN (or hair): Remove/Take off immediately
P353 all contaminated clothing. Rinse skin with
water/shower.
P305+P351+ IF IN EYES: Rinse cautiously with water for several
P338 minutes. Remove contact lenses, if present and easy
to do. Continue rinsing
P310 Immediately call a POISON CENTER or doctor/
physician
P405 Store locked up.
P501 Dispose of contents/container in accordance with
local/regional/national/international regulations
Other Hazards:
Results of PBT and vPvB assessment
PBT : Not applicable
vPvB : Not applicable
03 Composition/Information on Ingredients
Chemical characterization: Substances
CAS No.: Description: ethyl 4-chloroacetoacetate
Identification number(s) Additional information:
EC number : 211-317-0 Molecular Formula : C6H9ClO3
Molecular Weight : 164.59
638-07-3
04 First Aid Measures 05 Firefighting Measures 06 Accidental Release Measures
General information:
Immediately remove any clothing soiled
by the product.
In case of irregular breathing or
respiratory arrest provide artificial
respiration.
After inhalation:
Supply fresh air. If required, provide
artificial respiration. Keep patient warm.
Consult doctor if symptoms persist.
In case of unconsciousness place patient
stably in side position for transportation.
After skin contact: Immediately wash
with water and soap and rinse thoroughly.
After eye contact: Rinse opened eye for
several minutes under running water.
Then consult a doctor.
After swallowing:
Do not induce vomiting; call for medical
help immediately.
Drink plenty of water and provide fresh
air. Call for a doctor immediately.
Information for doctor: Treat
symptomatically and supportively.
Most important symptoms and effects,
both acute and delayed:
No further relevant information available.
Indication of any immediate medical
attention and special treatment
needed:
No further relevant information available.
Extinguishing media
Suitable extinguishing agents:
CO2, powder or water spray. Fight
larger fires with water spray or alcohol
resistant foam.
Special hazards arising from the
substance or mixture:
May produce carbon mono-oxide and
carbon dioxide.
Advice for firefighters
Protective equipment: Wear self
contained breathing apparatus for fire
fighting if necessary.
Personal precautions, protective
equipment and emergency
procedures:
Wear protective equipment. Keep
unprotected persons away.
Environmental precautions: Do not
allow to enter sewers/ surface or ground
water.
Methods and material for containment
and cleaning up:
Use neutralizing agent.
Keep in suitable, closed containers for
disposal.
Dispose contaminated material as waste
according to item 13.
Reference to other sections:
See Section 7 for information on safe
handling.
See Section 8 for information on personal
protection equipment.
07 Handling and Storage
Handling
Precautions for safe handling
Ensure good ventilation/exhaustion at the workplace.
Information about fire - and explosion protection:
Keep ignition sources away - Do not smoke.
Conditions for safe storage, including any incompatibilities
Storage
Requirements to be met by storerooms and receptacles:
Store in a cool, dry, well-ventilated area away from incompatible substances.
Information about storage in one common storage facility:
Store away from strong acids, alkali or oxidizing agents.
Store away from reducing agents.
Further information about storage conditions:
Keep container tightly sealed.
Specific end use(s)
Used as medicine and pesticide intermediates.
08 Exposure Controls/ Personal Protection
Additional information about design of technical facilities:
Local exhaust ventilation required plus good work practise.
Safety shower. Eye fountain.
Control parameters
Ingredients with limit values that require monitoring at the workplace: Not required.
Exposure controls
Personal protective equipment:
General protective and hygienic measures:
Keep away from foodstuffs, beverages and feed.
Immediately remove all soiled and contaminated clothing
Wash hands before breaks and at the end of work.
Avoid contact with the eyes and skin.
Respiratory protection:
In case of brief exposure or low pollution use respiratory filter device. In case of intensive or longer exposure
use self-contained respiratory protective device.
Protection of hands Eye Protection
The glove material has to be impermeable and resistant to
the product/ the substance/ the preparation. Selection of
the glove material on consideration of the penetration
times, rates of diffusion and the degradation.
Material of gloves
Butyl rubber, BR Nitrile rubber, NBR
The selection of the suitable gloves does not only depend
on the material, but also on further marks of quality and
varies from manufacturer to manufacturer.
Penetration time of glove material
Full Contact:
Glove material: Butyl rubber
Glove thickness: 0.7 mm
Breakthrough time: > 480 min
Splash Contact:
Glove material: Nitrile rubber
Glove thickness: 0.40 mm
Breakthrough time: > 30 min
Body protection:
Protective work clothing
Tightly sealed gogglesProtective gloves
09 Physical and Chemical Properties
Information on basic physical and chemical properties
General Information
Appearance:
Colour: Yellow
Odour: Characteristic
pH-value (10 g/l) at 20°C: 2.9
Change in condition
Melting point/Melting range: -8°C
Boiling point/Boiling range: 220°C (1.013 hPa)
Flash point: 106°C
Flammability (solid, gaseous): Not applicable.
Ignition temperature: 320°C
Danger of explosion: Product does not present an explosion hazard
Explosion limits:
Lower: 1.8 Vol %
Upper: Not determined.
Vapour pressure at 20°C: 0.1 hPa
Density at 20°C: 1.21 g/cm³
Solubility in / Miscibility with 47 g/l
water at 20°C:
Segregation coefficient (n-octanol/water): 0.05 log POW (calculated)
Viscosity:
Dynamic at 20°C: 4.72 mPas
Other information: No further relevant information available.
Form: Liquid
10 Stability and reactivity
Reactivity :
Chemical stability :
Thermal decomposition / conditions to be avoided :
No decomposition if used according to specifications.
Possibility of hazardous reactions :
Violent reactions possible with Strong oxidising agents, strong reducing agents, alkalines, acids
Conditions to avoid :
Extreme heat
Incompatible materials :
Strong oxidising agents, strong reducing agents, alkalines, acids
Hazardous decomposition products:
May produce carbon mono-oxide and/or carbon dioxide
11 Toxicological information
LD/ LC 50 values relevant for classification
Oral LD 50 150 mg/kg (mouse)
200 mg/kg (rat)
Primary irritant effect:
On the skin: Strong caustic effect on skin and mucous membranes.
On the eye: Strong caustic effect.
Sensitization: No sensitizing effects known
Additional toxicological information:
Swallowing will lead to a strong caustic effect on mouth and throat and to the danger of perforation of
esophagus and stomach.
CMR effects (carcinogenity, mutagenicity and toxicity for reproduction)
Not listed as a carcinogen by ACGIH, IARC, NIOSH, NTP, OSHA, or CA Prop 65
Mutagenicity: The substance was found to be non-mutagenic as per Ames test.
Information on toxicological effectsAcute Toxicity
12 Ecological Information
Toxicity
Acquatic toxicity:
Quantitative data on the ecological effect of this product are not available.
Persistence and degradability:
No further relevant information available.
Behaviour in environmental systems:
Bioaccumulative potential
Behaviour in environmental systems:
Bioaccumulation Estimates from Log Kow (BCFWIN v2.17):
Log BCF from regression-based method = 0.500 (BCF = 3.162)
log Kow used: 0.05 (estimated)
Mobility in soil
Soil Adsorption Coefficient (PCKOCWIN v1.66):
Koc : 10
Log Koc : 1.000
Additional ecological information:
General notes:
Water hazard class 3 (German Regulation) (Self-assessment): extremely hazardous for water.
Do not allow product to reach ground water, water course or sewage system, even in small quantities.
Must not reach sewage water or drainage ditch undiluted or unneutralized.
Danger to drinking water if even extremely small quantities leak into the ground.
Results of PBT and vPvB assessment :
PBT : Not applicable.
vPvB : Not applicable.
Other adverse effects : No further relevant information available
13 Disposal considerations
Waste treatment methods
Recommendation: Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed
professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent
and burn in a chemical incinerator equipped with an afterburner and scrubber.
Uncleaned packaging:
Recommendation: Disposal must be made according to official regulations.
14 Transport Information
UN-Number:
ADR, IMDG, IATA: UN2922
UN proper shipping name :
ADR 2922 CORROSIVE LIQUID, TOXIC, N.O.S. (ethyl 4-chloroacetoacetate)
IMDG, IATA CORROSIVE LIQUID, TOXIC, N.O.S. (ethyl 4-chloroacetoacetate)
Transport hazard class(es)
ADR
Class: 8 Corrosive substances
Label: 8+6.1
IMDG, IATA
Class: 8 Corrosive substances
Label: 8+6.1
Packing group:
ADR, IMDG, IATA II
Environmental hazards
Marine pollutant: No
Special precautions for user: Warning: Corrosive substances
Danger code (Kemler): 886
EMS Number: F-A, S-B
Transport in bulk according to Annex II
of MARPOL73/78 and the IBC Code : Not applicable
Transport/Additional information:
ADR
Tunnel restriction code: E
UN "Model Regulation": UN2922, CORROSIVE LIQUID, TOXIC, N.O.S. (ethyl 4- chloroacetoacetate), 8 (6.1), II
15 Regulatory Information
Hazard pictograms Please refer section 2
Single word Danger
Hazard statements Please refer section 2
Precautionary statements Please refer section 2
Chemical safety assessment:
A Chemical Safety Assessment has not been carried out and shall be available at the time of REACH registration.
Safety, health and environmental regulations/legislation specific for the substance or mixtureLabelling according to regulation (EC) No 1272/2008
16 Other Information
Abbreviations and acronyms
ADR : Accord européen sur le transport des marchandises dangereuses par Route (European Agreement
concerning the International Carriage of Dangerous Goods by Road)
RID : Règlement international concernant le transport des marchandises dangereuses par chemin de fer
(Regulations Concerning the International Transport of Dangerous Goods by Rail)
IMDG : International Maritime Code for Dangerous Goods
IATA : International Air Transport Association
ICAO : International Civil Aviation Organization
GHS : Globally Harmonized System of Classification and Labelling of Chemicals
EINECS : European Inventory of Existing Commercial Chemical Substances
CAS : Chemical Abstracts Service (division of the American Chemical Society)
LC50 : Lethal concentration, 50 percent
LD50 : Lethal dose, 50 percent
This information is based on our present knowledge. However, this shall not constitute a guarantee for any specific
product features and shall not establish a legally valid contractual relationship.
.
REGULATION (EC) No 1272/2008 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL on classification,
labelling and packaging of substances and mixtures, amending and repealing Directives 67/548/ EEC and
1999/45/EC, and amending Regulation (EC) No 1907/2006
Data is from MSDS of Merck KGaA
http://ecommerce-prod.merck.de/chemicals/en US/Merck-International-Site/USD/ViewProductDocuments- File?Produc
tSKU=MDACHEM-818571&DocumentType=MSD&DocumentId=& DocumentSource=&
Country=GLOBAL&Channel=Merck- International-Site&Language=EN
Data is from MSDS of Sigma Aldrich (Product ID: Aldrich - 690295)
http://www.sigmaaldrich.com/MSDS/MSDS/
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*Data compared to the previous version altered.
Section 2 : Hazard Identification
Section 4 : First-aid measures
Section 6 : Accidental Release Measures
Section 7 : Handling and Storage
Section 8 : Exposure Controls / Personal Protection
Section 10 : Stability and Reactivity
Section 11 : Toxicological Information
Section 12 : Ecological Information
Section 13 : Disposal Considerations
Section 14 : Transport Information
Section 15 : Regulatory Information
Sources
Ethyl-4-chloroacetoacetate
(E4CAAE)
CAS No. 638-07-3
HS Code 2918 30 90
EINECS No. 211-317-0
Synonyms 4-Chloro-3-oxobutanoic Acid ethyl ester Ethyl 3-oxo-4-chlorobutanoate Ethyl 4-chloro-3-oxobutanoate Molecular Formula C6H9ClO3
Chemical Structure
Molecular Weight 164
Quality
Parameter Specification
Colour Colourless to yellowish
Consistency Clear Liquid
Moisture Content %, max 0.1
Purity (by GC), % area, min 98
Packaging Bulk Tankers, 200kg HMHDPE Drums Application Medicine and pesticide intermediate Country of Origin India
For further information please visit www.laxmiorganic.co.in or send an enquiry to [email protected]
Issue Date :14.10.2014