Healing wounds

naturally

Antibacterial (incl MRSA)

Debrides and reduces malodour

Anti-inflammatory

Stimulates wound healing

Easy to apply, safe to use and cost effective

References Boekema B et al. (2013) The effect of a honey based gel and silver sulphadiazine on bacterial infections of in vitro burn wounds. Burns 39(4):754-759

Brackman G et al. (2013) Biofilm inhibitory and eradicating activity of wound care products (..). J Applied Microbiol-ogy 114:1833-1842

Cooper R, Gray D (2005) The control of wound malo-dour with honey based wound dressings and ointments.Wounds UK 1(3):26-31

Chatzoulis G et al. (2012) Salvage of an infected titanium mesh in a large incisional ventral hernia using medicinal honey and VAC. Hernia 16(4):475-9

Du Toit D, Page B (2009) An in vitro evaluation of the cell toxicity of honey and silver dressings. Journal of Wound Care 18(9):383-389

Overgaauw P, Kirpensteijn J (2006) Honey in treatment of skin wounds. EJCAP 16(1):17-19

Postmes T et al. (1993) Honey for wounds, ulcers, and skin graft preservation. The Lancet 341(8847):756-7

Postmes T et al. (1995) The sterilization of honey with cobalt 60 gamma radiation. Experientia 51(9-10):986-9

Postmes T (1999) Recombinant growth factors or honey? Burns 25(7):676-8

Rossiter K et al. (2010) Honey promotes angiogeneic ac-tivity in the rat aortic ring assay. Journal of Wound Care 19(10):440, 442-6

Smaropoulos E (2011) Honey-based therapy for paediatric burns, dermal and other wounds. Wounds UK 7(1):33-40

Tellechea O et al. (2013) Efficacy of honey gel in the treatment of chronic lower leg ulcers: a prospective study. EWMA Journal 13(2):35-39

White R (2005) The benefits of honey in wound manage-ment. Nursing Standard 20(10):57-64

L-Mesitran OintmentAntibacterial ointment with 48% medical grade honey, hypoallergenic medical grade lanolin, aloë, calendula, ZnO and antioxidant vitamins C and E. Indicated for the removal of necrosis and debris. Cover with alginate, hydrofiber, foam or compress. Replace the ointment after 1-3 days.

L-Mesitran SoftAntibacterial gel with 40% medical grade hon-ey, hypoallergenic medical grade lanolin, PEG and vitamins C and E as antioxidants. Indicated for all superficial and deep wounds. Cover with foam, alginate, hydrofiber or compress. Replace the gel after 1-3 days.

L-Mesitran TulleHydro-active antibacterial synthetic sheet with L-Mesitran Soft. Does not adhere to the wound. Indicated for wounds with none to moderate exudates. Cover with absorbent dressing, fix-ate with regular adhesive gauzes. Replace the dressing after 3-5 days.

L-Mesitran HydroHydro-active antibacterial dressing with 30% medical grade honey, polymers and water. In-dicated for superficial wounds. Self adhering, must be fixated with regular gauze or (adhesive) tape. Replace the dressing after 3-5 days.

L-Mesitran Border Hydro-active antibacterial dressing with 30% medical grade honey, polymers, water and an adhesive border. Indicated for superficial wounds. Self-adhesive, showering or swimming is possible. Replace the dressing after 3-5 days.

L-Mesitran ActiveHydro-active antibacterial dressing with 30% medical grade honey, polymers, water and an adhesive border. Indicated for smaller superficial wounds. Self adhesive, showering/swimming is possible. Replace the dressing after 3-5 days.

L-Mesitran NetHydro-active antibacterial wound contact layer with 20% medical grade honey, polymers and water. Indicated for wounds with moderate to heavy exudates. Cover with absorbent dressings or compresses and fixate with regular adhesive gauzes. Replace the dressing after 3-5 days.

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SoftOintmentHydroTulleAquacel Ag

Fig. 1 Antibacterial activity against Staph. aureus (standard Pharmacopeia in vitro testing)

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Fig 1. Antibacterial activity against Staph. aureaus (standard Pharmacopeia in vitro testing)

SoftOintmentHydroTulleAquacel Ag

Control T=0 T=6hrs T=24hrs T=48hrs T=168hrs T=336hrs T=672hrs (7 days) (14 days) (28 days)

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SoftOintmentHydroTulleAquacel Ag

Fig. 1 Antibacterial activity against Staph. aureus (standard Pharmacopeia in vitro testing)

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T= 336hrs (14days)

T= 672hrs (28days)

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Pioneering wound careL-Mesitran is a pioneering product range, based on Medical Grade Honey and available worldwide since 2002 with excel-lent clinical results. These advanced wound care dressings from Holland were the first to receive the CE mark and FDA approval. They have been used on a variety of severe wounds, including antibiotic resistant (MRSA) infected wounds. The founding father of the products, dr. Theo Postmes, published in the renowned Lancet journal and since then the efficacy of the L-Mesitran products has been the subject of many publications. L-Mesitran is currently incorporated in many standard wound care protocols around the world.

Antibacterial activity (incl. MRSA)Test results show that the most common wound bacteria will be killed within 24-48 hours, like Staph. aureus (fig. 1), MRSA and ESBL producing bacteria. The antibacterial activity of L-Mesitran is based on its high osmolarity, its low pH and the ability to produce hydrogen peroxide (H2O2).

Debrides and reduces malodourOsmosis encourages lymphatic fluids to flow to devitalized tissue in the wound bed, debriding the wound. Bacteria preferably metabolize the glucose in honey to lactic acid (odourless), instead of amino acids from the wound bed into malodorous (sulphur/ammonia) compounds. The removal of malodour is quick and immediately enhances the quality of life of the patients.

Anti-inflammatoryProlonged inflammation is associated with delayed wound healing. Honey changes the wound bed environment posi-tively and surpresses bacterial and other particles present in the wound bed that induce inflammation. Honey ‘scavenges’ the free oxygen radicals by functioning as an anti-oxidant.

Stimulates wound healing, less scarringL-Mesitran promotes new tissue regeneration and healing. The unique ability to stimulate angiogenesis is important for treating delayed (chronic) wounds. L-Mesitran supplies nutrients to the wound bed, aiding in speeding up the healing process. It also creates a moist wound healing environment, important to minimize scarring.

Easy to apply, safe to use and cost effectiveTo date no adverse effects have been reported. The products are easy to apply with maximum patient comfort. Because only small amounts of product are necessary for an optimum effect, the products contribute to a cost effective approach in wound management.

BurnsA girl (18 months) had par-tial thickness burns, 35% TBSA (fig. c). Only her right leg was treated with L-Mes-itran, the rest of her body was treated with skin grafts, povidon iodine and paraffin gauzes. The L-Mesitran leg recovered swiftly, the wound (10X8x0,5cm) healed com-pletely (fig. d). Whilst the back underwent two skin transplants without accept-able results, tissue from the already healed leg was even-tually used for the skin grafts on the child’s back.

Debridement of a diabetic pressure soreAn 80-year-old woman (dia-betes, stroke, high blood pressure) with a reasonable health had a pressure ulcer on her left heel (fig. e). This was caused by her stroke and the numbness she had as a result in the foot. L-Mesitran was (bi-) daily applied after cleaning the wound with a saline solution. This was covered with an absorbent gauze dressing. In rough-ly four weeks the wound was completely debrided and stimulated to heal in 3 months (fig. f).The wound did not get infected and no anti-biotics were used, despite the underlying pathologies.

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Less scarring in antibiotic resistant wound infectionAn obese woman (48) had an E. clocae infected wound of 9.6x9.0x0.6cm (fig. a). Anti-biotics and povidone iodine had no effect. L-Mesitran was applied and on the 5th day, the malodour, debris, swelling and the wound exu-dates already dramatically reduced. The trauma epithe-lialized completely within two months with almost no scar-ring (fig. b).

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Infection, malodourA male (43) was brought to the hospital for a post-op infected right thigh wound (fig. g). The wound (30x12x4cm) produced malodour and lab results showed Ps. aeruginosa. L-Mesitran was applied on the wound and covered with reg-ular absorbent dressings for fixation. The severe infection was cleared and malodour controlled within three days without the use of antibiot-ics. Twenty days after the start with L-Mesitran the wound was clean and granulating (fig. h). Four weeks later the wound was completely healed.

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