28
LDRC Member at Large Volunteer Form 1 / 1 Q1 Your contact information. Full Name Ziyad Ayyoub Institution Rancho losAmigos National Rehab Center Title Chief of Medical Staaff, medical Director inpatient Rehab services, Professor of PMR Email Address [email protected] Phone Number 5623856073 Q2 I am interested in serving as a Member at Large for the AAP Leadership Development and Recognition Committee. Yes Q3 Please explain the relevant experience, knowledge and skills you possess. I have experience in leadership, management and recognition Q4 Please explain other association and industry involvement/leadership positions. Leadership role in my organization, residency training, community and teaching institutions Q5 Please provide a brief statement of why you want to volunteer for this committee: It is a distinguished honor to volunteer and contribute to AAP in any way possible. This invitation is appreciated. Q6 Please submit a current copy of your CV. ZIYADAyyoubrevised cv.pdf (837.2KB) #10 #10 COMPLETE COMPLETE Collector: Collector: Web Link 1 Web Link 1 (Web Link) (Web Link) Started: Started: Wednesday, January 29, 2020 5:01:13 PM Wednesday, January 29, 2020 5:01:13 PM Last Modified: Last Modified: Wednesday, January 29, 2020 5:08:08 PM Wednesday, January 29, 2020 5:08:08 PM Time Spent: Time Spent: 00:06:54 00:06:54 IP Address: IP Address: 159.83.252.213 159.83.252.213 Page 1

L D R C M em ber at L arge Vol unt eer F orm€¦ · Full Name Ziyad Ayyoub Institution Rancho losAmigos National Rehab Center Title Chief of Medical Staaff, medical Director inpatient

  • Upload
    others

  • View
    1

  • Download
    0

Embed Size (px)

Citation preview

Page 1: L D R C M em ber at L arge Vol unt eer F orm€¦ · Full Name Ziyad Ayyoub Institution Rancho losAmigos National Rehab Center Title Chief of Medical Staaff, medical Director inpatient

LDRC Member at Large Volunteer Form

1 / 1

Q1 Your contact information.

Full Name Ziyad Ayyoub

Institution Rancho losAmigos National Rehab Center

Title Chief of Medical Staaff, medical Director inpatient Rehabservices, Professor of PMR

Email Address [email protected]

Phone Number 5623856073

Q2 I am interested in serving as a Member at Large forthe AAP Leadership Development and RecognitionCommittee.

Yes

Q3 Please explain the relevant experience, knowledge and skills you possess.

I have experience in leadership, management and recognition

Q4 Please explain other association and industry involvement/leadership positions.

Leadership role in my organization, residency training, community and teaching institutions

Q5 Please provide a brief statement of why you want to volunteer for this committee:

It is a distinguished honor to volunteer and contribute to AAP in any way possible. This invitation is appreciated.

Q6 Please submit a current copy of your CV.

ZIYADAyyoubrevised cv.pdf (837.2KB)

#10#10COMPLETECOMPLETE

Collector:Collector: Web Link 1 Web Link 1 (Web Link)(Web Link)Started:Started: Wednesday, January 29, 2020 5:01:13 PMWednesday, January 29, 2020 5:01:13 PMLast Modified:Last Modified: Wednesday, January 29, 2020 5:08:08 PMWednesday, January 29, 2020 5:08:08 PMTime Spent:Time Spent: 00:06:5400:06:54IP Address:IP Address: 159.83.252.213159.83.252.213

Page 1

Page 2: L D R C M em ber at L arge Vol unt eer F orm€¦ · Full Name Ziyad Ayyoub Institution Rancho losAmigos National Rehab Center Title Chief of Medical Staaff, medical Director inpatient

CURRICULUM VITAE

ZIYAD AYYOUB, M.D.

Physical Medicine and Rehabilitation, Board Certified, Spinal Cord Injury Medicine, Board Certified, Brain Injury Medicine, Board Certified, Addiction Medicine, Certified. Pain Management, Neurological and Orthopedic Rehabilitation.

ADDRESS:

Rancho Los Amigos National Rehabilitation Center, Dept. of Physical Medicine and Rehabilitation. 7601 E. Imperial Hwy Downey, Ca 90242

E mail: [email protected] Office: (562) 385-6073 Pager: (562) 466-0976

PERSONAL

Citizenship: U.S.

EDUCATION: 1980-1986, Minsk State Medical Institute, Minsk, Belarus Doctor of Medicine

1979-1980, Belarus University, Minsk, Belarus Diploma in Russian Language and Sciences

INTERNSHIP/ RESIDENCY:

7/1/1995-6/30/98, UCLA Multicampus Physical Medicine and Rehabilitation Residency Program West LA Veteran Affairs Center (VAMC), Los Angeles, California, Physical Medicine and Rehabilitation

1993-1994, Harbor- UCLA Medical Center, Torrance, California, Preliminary General Surgery, Completed 2nd Year 1987-1989, King Hussein Medical Center, Amman, Jordan. Rotations in General Surgery, Internal & Emergency Medicine, Pediatrics. 1986-1987, Irbid Medical Center, Irbid, Jordan. Transitional Internship

Page 3: L D R C M em ber at L arge Vol unt eer F orm€¦ · Full Name Ziyad Ayyoub Institution Rancho losAmigos National Rehab Center Title Chief of Medical Staaff, medical Director inpatient

2

EXPERIENCE & EMPLOYMENT: 8/1/98-present, Rancho Los Amigos National Rehabilitation Center, Downey, California, Department of Neurosciences, Chief Adult Brain Injury Service, and Senior Physician. 2005 to Present Rancho Research Institute, formerly Rancho Los Amigos Research and Education Institute (LAREI), Principle investigator 1994-1995, Per Diem primary care work

PM&R CLINICAL EXPERIENCE:

Stroke, spinal cord injuries, brain injuries, and various CNS disorders rehabilitation , management of musculoskeletal disorders and Orthopedic rehabilitation , spasticity and joints contractures management, pain management, prosthetics and orthotics, EMG/NCS. Procedures: Lumbar epidural, caudal blocks, joint, bursa, tendon, and trigger points injections, Peripheral nerve blocks, nerve root blocks and muscle chemodenervation with Toxins and Phenol

ADMINISTRATIVE EXPERIENCE:

2018- Vise Chief Inpatient Services Rancho Los Amigos National Rehabilitation Center, Downey, California

July 2017 -Vice Chairman Medical Executive Committee, Rancho Los Amigos National Rehabilitation Center, Downey, California

July 2017-, Chairman Risk Management committee Rancho Los Amigos National Rehabilitation Center, Downey, California July 2017-, Chairman of Credentials Committee, Rancho Los Amigos National Rehabilitation Center, Downey, California

July 2017-, Chairman bylaws committee Rancho Los Amigos National Rehabilitation Center, Downey, California

July 01, 2017-June 30 2019, President elect Professional Staff Association -Chief of Staff Rancho Los Amigos National Rehabilitation Center, Downey, California July 2011- 2013 Immediate Past President Professional Staff Association Rancho Los Amigos National Rehabilitation Center, Downey, California July 01, 2009-June 30 2011, President Professional Staff Association -Chief of Staff Rancho Los Amigos National Rehabilitation Center, Downey, California

Page 4: L D R C M em ber at L arge Vol unt eer F orm€¦ · Full Name Ziyad Ayyoub Institution Rancho losAmigos National Rehab Center Title Chief of Medical Staaff, medical Director inpatient

3

July 2009- May 2011, chairman Peer review committee Rancho Los Amigos National Rehabilitation Center, Downey, California July 2009-2013, chairman bylaws committee Rancho Los Amigos National Rehabilitation Center, Downey, California July 10, 2009-June 30 2011 Chairman MEC Rancho Los Amigos National Rehabilitation Center, Downey, California January, 2008- Present, Chairman M&M, Department of Neurorehabilitation at Rancho Los Amigos National Rehabilitation Center, Downey, California September 2007-2011, Chairman Committee on Failure Modes Effects& Criticality Analysis on: Deep Vein Thrombosis Prophylaxis and Treatment, Rancho Los Amigos National Rehabilitation Center, Downey, California July 2007- June 30, 2009 President-Elect, Professional Staff Association Rancho Los Amigos National Rehabilitation Center August 2007—July 2015 Institutional Review Board Member, Rancho Los Amigos National Rehabilitation Center, Downey, California Jan, 2006-Present: Co Chair, Department of Neurorehabilitation at Rancho Los Amigos National Rehabilitation Center, Downey, California May, 2007-2011: Rehabilitation Council at Rancho Los Amigos National Rehabilitation Center, Downey, California

2006- 2016, Research Committee Member Rancho Los Amigos National Rehabilitation Center, Downey, California 12/1/2000 - Present Chief Adult Brain Injury Service at Rancho Los Amigos National Rehabilitation Center, Downey, California 2001-Present Director of Spasticity Management Program at Rancho Los Amigos National Rehabilitation Center, Downey, California Jan/2001- May 2011, Chairman of Credentials Committee, Rancho Los Amigos National Rehabilitation Center, Downey, California 2000-Present, Chairman Clinical Managers Team, Rancho Los Amigos National Rehabilitation Center, Downey, California Jan/2000-2013, Chairman Performance Improvement Team on Restraints Use, Rancho Los Amigos National Rehabilitation Center, Downey, California

1999-2007. pCME program director -AMA PRA Category 1 CreditsTM Programs at RLANRC

Page 5: L D R C M em ber at L arge Vol unt eer F orm€¦ · Full Name Ziyad Ayyoub Institution Rancho losAmigos National Rehab Center Title Chief of Medical Staaff, medical Director inpatient

4

1998- 2000, Member of Medical Record Committee, Rancho Los Amigos National Rehabilitation Center, Downey, California

1999- 2000, Member of Credentials Committee, Rancho Los Amigos National Rehabilitation Center, Downey, California Nov/2000- 2002, CALS Committee member, at Rancho Los Amigos National Rehabilitation Center, Downey, California

ACADEMIC EXPERIENCE: May18, 2015 Clinical Professor of Physical Medicine & Rehabilitation, Western University of Health Sciences

July 1, 2012 Associate Clinical Professor of Medicine David Geffen School of Medicine at UCLA 2015-2016 Director UCLA Anesthesiology Pain Management Fellowship Program at Rancho Los Amigos National Rehabilitation Center, Downey, California

2013-Present Director UCI, SCI medicine fellowship Program at Rancho Los Amigos National Rehabilitation Center, Downey, California May19, 2011-2015 Associate Clinical Professor of Physical Medicine and Rehabilitation, Western University of Health Sciences 2008- June 30, 2012, Assistant Professor of PM&R, Loma Linda University October, 07- 2011 Clinical Assistant Professor of Physical Medicine and Rehabilitation, Western University of Health Sciences 1999-2012 Clinical Assistant Professor of Medicine David Geffen School of Medicine at UCLA 1998- 1999 Clinical Instructor of Medicine UCLA of Medicine. 1998- Present Co director UCLA/VA GLAHS Multicampus Physical Medicine and Rehabilitation Residency Training Program at Rancho 2003-Present Director UCLA/VA GLAHS Multicampus Physical Medicine and Rehabilitation Residency Training Program at Rancho July 2007-2012, Director Loma Linda Physical Medicine and Rehabilitation Residency training program at Rancho Los Amigos National rehabilitation Center

RESEARCH: A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Parallel Group, Dose-

Ranging, Multi-Center Trial to Evaluate the Efficacy and Safety of DaxibotulinumtoxinA

Injection for the Treatment of Upper Limb Spasticity (ULS) in Adults After Stroke or

Traumatic Brain Injury Pending

Page 6: L D R C M em ber at L arge Vol unt eer F orm€¦ · Full Name Ziyad Ayyoub Institution Rancho losAmigos National Rehab Center Title Chief of Medical Staaff, medical Director inpatient

5

Double-Blind, Controlled Phase 2B Study of the Safety and Efficacy of Modified Stem Cells (SB623) in Patients with Chronic Motor Deficit from Ischemic Stroke Protocol No. SB-STR02, PI- Principle Investigator, Rancho Los Amigo National Rehabilitation Center (RLANRC) Downey, California- In submission to IRB

A Phase 2, Randomized, Double-Blind, 6-Sequence, Placebo-Controlled, 2-Period

Multicenter Crossover Study to Evaluate the Safety and Efficacy of CTP-354 in Subjects

with Spasticity due to Spinal Cord Injury co- Investigator, Rancho Los Amigo National Rehabilitation Center (RLANRC) Downey, California–submitted to IRB

Prospective, multicenter, randomized, double-blind, parallel-group, dose-response study of three doses Xeomin® (incobotulinumtoxinA, NT 201) for the treatment of upper limb spasticity alone or combined upper and lower limb spasticity in children and adolescents (age 2 - 17 years) with cerebral palsy” Principle Investigator, Rancho Los Amigo National Rehabilitation Center (RLANRC) Downey, California

191622-127: BOTOX® Treatment in Adult Patients with Upper Limb Spasticity Multicenter, double-blind, randomized, placebo-controlled, parallel-group single treatment cycle, Principle Investigator, Rancho Los Amigo National Rehabilitation Center (RLANRC) Downey, California

Allergan 191622-116 BOTOX, Adult Post-Stroke Lower Limb Spasticity.

BOTOX Treatment in Pediatric Lower Limb Spasticity: Double-Blind Study, Study Number: 191622-111,

BOTOX Treatment in Pediatric Lower Limb Spasticity: Open-Label Study, Study Number: 191622-112

BOTOX Treatment in Pediatric Upper Limb Spasticity: Open-label Study, Study Number: 191622-105 PI, Rancho Los Amigo National Rehabilitation Center (RLANRC) Downey, California

BOTOX® Treatment in Pediatric Upper Limb Spasticity: Double-blind Study

STUDY NUMBER: 191622-101 PI for these studies, Rancho Los Amigo National Rehabilitation Center (RLANRC) Downey, California

Prospective, double-blind, placebo-controlled, randomized, multi-centre study with an

open-label extension period to investigate the efficacy and safety of NT 201 in the

treatment of post-stroke spasticity of the upper limb”, Protocol No. “MRZ 60201/SP/300

Prospective, double-blind, placebo-controlled, randomized, multi-center study with an

open-label extension period to investigate the efficacy and safety of NT 201 in the

treatment of post-stroke spasticity of the lower limb.

A PHASE III, MULTICENTRE, PROSPECTIVE, DOUBLE BLIND, RANDOMISED, PLACEBO CONTROLLED STUDY, EFFICACY AND SAFETY OF DYSPORT INTRAMUSCULAR INJECTIONS USED FOR THE REATMENT OF UPPER LIMB SPASTICITY IN ADULT SUBJECTS WITH SPASTIC

Page 7: L D R C M em ber at L arge Vol unt eer F orm€¦ · Full Name Ziyad Ayyoub Institution Rancho losAmigos National Rehab Center Title Chief of Medical Staaff, medical Director inpatient

6

HEMIPARESIS DUE TO STROKE OR TRAUMATIC BRAIN INJURY Ipsen Clinical Protocol Y-52-52120-145

A PHASE III, MULTICENTRE, PROSPECTIVE, OPEN LABEL EXTENSION STUDY TO ASSESS THE LONG TERM SAFETY AND EFFICACY OF REPEATED TREATMENT OF DYSPORT INTRAMUSCULAR INJECTIONS USED FOR THE TREATMENT OF UPPER LIMB SPASTICITY IN ADULT SUBJECTS WITH SPASTIC HEMIPARESIS DUE TO STROKE OR TRAUMATIC BRAIN INJURY Ipsen Clinical Protocol Y-52-52120-148:

A phase III, multicentrre, double blind, prospective, randomized, placebo controlled

study, assessing the efficacy and safety of dysport used for the treatment of lower limb

spasticity in adult subjects with hemiparesis due to stroke or traumatic brain injury.

STUDY PROTOCOL Study number Y-55-52120-140

A phase III, prospective, multicentre, open label, extension study, to assess the long term

safety and efficacy of repeated treatment of disport intramuscular injection in the

treatment of lower limb spasticity in adult subjects with spastic

Hemiparesis due to stroke or traumatic brain injury STUDY PROTOCOL Study number:

Y-55-52120-142

Nov 2010, Severe Traumatic Brain Injury: Neurological Outcomes Associated with Amantadine, Erythropoiesis Stimulating agents, and Beta-blockers Administration PI, Rancho Los Amigo National Rehabilitation Center (RLANRC) Downey, California

2010- Present Baroreceptor Sensitivity during Position Changes in Patients with

Traumatic Brain Injury, co-investigator, Rancho Los Amigo National Rehabilitation Center (RLANRC) Downey, California October, 2010 Stroke Inpatient Rehabilitation Reinforcement of ACTivity

(SIRRACT) PI, Rancho Los Amigo National Rehabilitation Center (RLANRC) Downey, California August 2010, Functional ambulation: Standard treatment vs. Electrical stimulation therapy(FASTEST) Trial in Chronic Post-Stroke Subjects with foot Drop, clinical protocol, CP-L300-0801,Rev. B , PI, Rancho Los Amigo National Rehabilitation Center (RLANRC) Downey, California 2009-A 17-Week, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multi-Center Trial of Pregabalin for the Treatment of Chronic Central Neuropathic Pain after Spinal Cord Injury. Feasibility Study of the Bioness Battery-Powered Microstimulator (BBPM) to Treat Chronic Shoulder Pain In Chronic Post-Stroke Subjects, 12/08, PI Rancho Los Amigo National Rehabilitation Center (RLANRC) Downey, California

October 2008-Present Spasticity and Pain in Spinal Cord Injury (SCI): Optimizing Pharmacotherapy Enhance Residual Gait and Motor Function LAREI-SCI Pain & Spasticity Study 071608 co investigator, submitted to IRB under review

Page 8: L D R C M em ber at L arge Vol unt eer F orm€¦ · Full Name Ziyad Ayyoub Institution Rancho losAmigos National Rehab Center Title Chief of Medical Staaff, medical Director inpatient

7

July, 2008, AV650-014: A Four Week, Prospective, Randomized, Double Blind, Placebo-controlled Trial to Assess Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of AV650 in Patients with Spasticity due to Spinal Cord Injury, A Multi-Center, Double-Blind, Placebo-Controlled Parallel Approved by the IRB Rancho Los Amigo National Rehabilitation Center (RLANRC) Downey, California October, 2007 Multiple-Dose Efficacy and Safety Study of XP19986 in Subjects with Spasticity Due to Spinal Cord Injury, Rancho Los Amigo National Rehabilitation Center (RLANRC) Downey, California A Multi-Center, Double-Blind, Placebo-Controlled Parallel, Rancho Los Amigo National Rehabilitation Center (RLANRC) Downey, California 12/2005-Present, Rancho Los Amigo National Rehabilitation Center (RLANRC) Downey, California a Multi-Center, Double-Blind, Placebo-Controlled Parallel Group Safety Study of Pulmonary Function in Patients with Reduced Lung Function Treated with BOTOXPP® PP (Outline Toxin Type A) Purified Neurotoxin Complex for Focal Upper Limb Post-Stroke Spasticity. Allergan Protocol 191622-057 7/2007 Multicenter, Retrospective Chart Review of Adult patients Treated with Myobloc for Spasticity, protocol Number SN-SPAS-602

Research Studies during residency: 1995-1997, University of California Los Angeles, West LA Veteran Affairs Medical Center (VAMC), Department of PM&R “Comparison of Insulin Requirements before and After Below Knee Amputation in Diabetic Patient” “Evaluation of Effect of Exercise on Cerebral Blood Flow by PET Scan in Controls and in Stroke Patients” Research Associate volunteer: 1990-1993 Rancho Los Amigo Medical Center (RLAMC) Downey, California, Volunteer research associate, participants in projects: “The Use of Methicillin Vs

Oxacillin against Methicillin Sensitive and Methicillin Resistant Staphylococcus Aureus” “Comparative Studies of Quinolones against Aminoglycoside Resistant Bacteria” “Spectral Analysis and Modulation of Diabetic Cardiac Autonomic Neuropathy” Research studies during Medical school student volunteer 1982-1986 Minsk State Medical Institute, Minsk, Belarus Research Associate in Research Projects

Page 9: L D R C M em ber at L arge Vol unt eer F orm€¦ · Full Name Ziyad Ayyoub Institution Rancho losAmigos National Rehab Center Title Chief of Medical Staaff, medical Director inpatient

8

PUBLICATIONS:

Safety and Stability of Pulmonary Function in Patients Treated for Spasticity with OnabotulinumtoxinA: Ziyad Ayyoub,1 Allison Brashear,2 Marta Banach,3 Robert Schoene,4 William Stringer,5 Terry Boodhoo,6 Irina Yushmanova,6 Rozalina Dimitrova,6 Mitchell F Brin6,7 In submission

Dosing of abobotulinumtoxinA (Dysport®) injections for adults with lower limb spasticity Authors: Salvatore Napoli,1 Regina Berkovich,2 Theodore Brown,3 Ziyad Ayyoub,4,5,6 Gustavo Suarez,7 Philippe Picaut,8 Peter Hedera,9 Poster CMSC 2018 congress, and, 80 th Annual Assembly American Academy of Physical Medicine and Rehabilitation Orlando, Florida October 25-19,2018

Complete Bilateral Elbow Ankylosis Due to Heterotopic Ossification in a Major Flame Burn: A Case Report with Discussion, Josphen Collins, Ziyad Ayyoub, Michael Scott

Manuscript, " OnabotulinumtoxinA for Lower-Limb Spasticity:

Guidance from a Delphi Panel Approach". PM&R February 2017

Dose-dependent effects of abobotulinumtoxinA (Dysport®) on MUSCLE TONE, spasticity and active movements in adults with upper limb spasticity: Secondary analysis of a Phase 3 study Michael W. O’Dell1, Allison Brashear2, Robert Jech3, Thierry Lejeune4, Philippe Marque5, Djamel Bensmail6, Ziyad Ayyoub7, David Simpson8, Anne Sophie Grandoulier9, Claire Vilain9, Philippe Picaut9 and Jean Michel Gracies10 . Journal of PM&R The journal of injury, function and rehabilitation January 2018Volume 10, Issue 1, Pages 1–10

Manuscript: OnabotulinumtoxinA injection for post-stroke upper-limb spasticity:

Guidance for early injectors from a Delphi panel process David M. Simpson,

MD1 Atul T. Patel, MD2 Abraham Alfaro, PhD3 Ziyad Ayyoub, MD4–6 David

Charles, MD7 Khashayar Dashtipour, MD, PhD8 Alberto Esquenazi, MD9, IB

Odderson,MD,PhD, Journal of PM&R The journal of injury, function and

rehabilitation volume 9 issue 2(February 2017) 136-148

OnabotulinumtoxinA to Treat Common Postures in Post-Stroke Lower Limb

Spasticity: Identification of a Treatment Paradigm” has been accepted

as a poster at AAPM&R (2016) American Academy of Physical Medicine &

Rehabilitation - 77th Annual Assembly (October 20-23, 2016 in New

Orleans, Louisiana).

Page 10: L D R C M em ber at L arge Vol unt eer F orm€¦ · Full Name Ziyad Ayyoub Institution Rancho losAmigos National Rehab Center Title Chief of Medical Staaff, medical Director inpatient

9

Dosing of abobotulinumtoxinA in adult upper limb spasticity treatment:

Secondary analysis of a Phase III studyMichael W. O’Dell1, Allison Brashear2,

Robert Jech3, Thierry Lejeune4, Philippe Marque5, Djamel Bensmail6, Ziyad

Ayyoub7, David Simpson8, Anne Sophie Grandoulier9, Claire Vilain9 and

Philippe Picaut9, Jean Michel Gracies10

Improvement of spasticity, active movements and active function after

repeated injections of abobotulinumtoxinA (Dysport) in adults with spastic

paresis in the upper limb: Results of a Phase III open-label extension

study, Accepted by American Academy of Physical Medicine and

Rehabilitation Annual Assembly and Technical Exhibition in New

Orleans, Louisiana on October 20-23, 2016.

Acute Onset of Right Lower Extremity Weakness in a Patient with Iliopsoas Hematoma

and Diabetic Amyotrophy Resulting In Severe Lumbosacral Plexopathy: A Case Report.

David H. Nguyen, MD, Ryan H. Lee, MD, Aliss Markosian, DO, Michael Scott, MD,

Ziyad Ayyoub, MDAAPM&R's 2016 Annual Assembly, being held October 20-23, 2016

in New Orleans, LA

Efficacy and Safety of Repeated incobotulinumtoxinA Injections for Upper-

Limb Post-Stroke Spasticity Ziyad Ayyoub, Atul Patel, Michael Munin, Petr

KaňovskýAngelika Hanschmann, Reinhard Hiersemenzel, Christina Marciniak,

Elie Paul Elovic,

OnabotulinumtoxinA to Treat Common Postures in Post-Stroke Lower Limb

Spasticity: Identification of a Treatment Paradigm Alberto Esquenazi,1

Abraham Alfaro,2 Ziyad Ayyoub,3-5 David Charles,6 Khashayar Dashtipour,7 Glenn D. Graham,8,9 John R. McGuire,10 Ib R. Odderson11

Atul T. Patel,12 David M. Simpson,13 has been accepted for an oral

presentation at ISPRM (2016) International Society of Physical &

Rehabilitation Medicine - 10th World Congress (May 29-June 2,

2016 in Kuala Lumpur, Malaysia

Sustained Benefit with Repeated Treatments of OnabotulinumtoxinA in Post-

Stroke Lower Limb Spasticity: 1-Year Open-Label Final Results from a Double-

Blind, Placebo-Controlled, Phase 3 Trial, Carolyn Geis, MD,1 Theodore H

Wein, MD, FRCPC,2 Ziyad Ayyoub, MD,3 Stanislaw Ochudlo, MD, PhD,4

Lynn James, MPH,5 Grace Pan, MS,5 Andrzej Bogucki, MD, PhD,6 Rozalina

Dimitrova, MD, MPH5.

Improvement of spasticity, active movements and active function after repeated injections of abobotulinumtoxinA (Dysport) in adults with spastic

Page 11: L D R C M em ber at L arge Vol unt eer F orm€¦ · Full Name Ziyad Ayyoub Institution Rancho losAmigos National Rehab Center Title Chief of Medical Staaff, medical Director inpatient

10

paresis in the upper limb: Results of a Phase III open-label extension study, in submission.Max. 8 authors: Marciniak, Gul, Ayyoub, Simpson, Walker, Wimmer, Vilain, Gracies

Efficacy and safety of repeated incobotulinumtoxin A injections for upper-limb post-stroke spasticity Ziyad Ayyoub;1 Atul T Patel;2 Elie Paul Elovic;3 Michael C Munin;4 Petr Kaňovský;5 Angelika Hanschmann, MSc;6 Reinhard Hiersemenzel;6 Christina Marciniak7

Delphi Panel on Common Postures in Lower Limb Spasticity David M.

Simpson,1 Atul T. Patel,2 Abraham Alfaro,3 Ziyad Ayyoub,4–6 David Charles,7

Khashayar Dashtipour,8 Alberto Esquenazi,9 Glenn D. Graham,10,11 John R.

McGuire,12 Ib Odderson13

OnabotulinumtoxinA for post-stroke upper-limb spasticity: A Delphi panel approach,

Manuscript, David M. Simpson,1 Atul T. Patel,2 Abraham Alfaro,3 Ziyad Ayyoub,4–6

David Charles,7 Khashayar Dashtipour,8 Alberto Esquenazi,9 Glenn D. Graham,10,11

John R. McGuire,12 Ib Odderson13.

An Analysis of Early and Late Response to Foot Drop

Stimulation in Persons with Stroke Poster accepted by AAPM&R

2015

OnabotulinumtoxinA to Treat Common Postures in Post-Stroke Upper Limb Spasticity:

Application of a Delphi Panel to Identify a Treatment Paradigm” Atul T. Patel, David M.

Simpson, Abraham Alfaro, Ziyad Ayyoub, David Charles, Khashayar Dashtipour, Alberto

Esquenazi, Glenn D. Graham, John McGuire, Ib Odderson has been accepted by

AAPM&R 2015

Using a Delphi Panel to Identify a Treatment Paradigm for Injecting Botulinum Toxin to

Treat Common Postures in Post-Stroke Upper Limb Spasticity David M. Simpson Atul T.

Patel, Abraham Alfaro, Ziyad Ayyoub, David Charles, Khashayar Dashtipour, Alberto

Esquenazi, Glenn D. Graham, John McGuire, Ib, abstract at the annual American

Academy of Neurology Meeting 2015

Feasibility Study of the Bioness, Battery-Powered Microstimulator (BBPM) to Treat Post-Stroke Shoulder Pain in Chronic Post-Stroke Subjects, Duc Chung, Ziyad Ayyoub MD, , Journal of Neurological Disorders & Stroke. 10/23, 2013

Efficacy and safety study of arbaclofen placarbil in patients with spasticity due to spinal

cord injury Patricia W. Nance, MD1, F. Jacob Huff, MD, FAAN*,2, Alberto Martinez-

Arizala, MD, FAAN3, Ziyad Ayyoub, MD4, Dan Chen, MD, PhD2, Amy Bian, ME2,

David Stamler, MD2, Spinal Cord (2011), 1–7 & 2011 International Spinal Cord Society All rights reserved 1362-4393/11

Levetiracetam and Speech Therapy in Aphasia from Penetrating Brain Injury. Could it be

the Way to Recovery? Z Ayyoub, R Ben-YoussefI JPMR 2010; 21 (2): 51-55

Page 12: L D R C M em ber at L arge Vol unt eer F orm€¦ · Full Name Ziyad Ayyoub Institution Rancho losAmigos National Rehab Center Title Chief of Medical Staaff, medical Director inpatient

11

The Evolving Role of Occupational Therapists in the Evaluation and Management of

Patients Receiving OnabotulinumtoxinA Injections for Spasticity Remy Chu, OTR/L,

Ziyad Ayyoub, MD,

Effective Treatment Inhibits the Progression of Carotid Artery Intima-Media Thickness in Women with SCI Yaga Szlachcic, M.D., Rodney H. Adkins, Ph.D., Ziyad Ayyoub, M.D, Florence Yee, and D. Pharm. Howard N. Hodis M.D.S

Case report and review of literature, Ziyad Ayyoub MD, Douglas Garland MD, Mohmmad Khan, MD, Breda Caroll MS IV, Heterotopic Ossification (HO)

Within the Temporomandibular Joint (TMJ) in a Stroke Victim: Indian Journal of

Physical Medicine and Rehabilitation, October 2009; 20(2): 55-57. Metabolic Correlates of 5-Year Longitudinal Changes in Fat Distribution in Persons with Chronic Spinal Cord Injury: accepted by Congress on Spinal Cord Medicine and Rehabilitation Yaga Szlachcic, M.D.; Charles A. Stewart, M.D.; Ziyad Ayyoub, M.D.; Rodney H. Adkins, Ph.D.

Case report and review of literature, Michael S. Hewitt, MD, Garland DE, Ziyad Ayyoub MD. Heterotopic Ossification complicating prolonged intubations, The Journal of Spinal Cord Medicine, Volume 25 number 1 spring 2002

Chapters: Ziyad Ayyoub, M.D., Fatima Badawi, M.A., C.C.C., S.L.P, Ann Vasile M.D,.Deborah Azaga, R.N., Amy Cassedy,M.D.and Vance Shaw, R.N. Dual Diagnosis: Spinal Cord Injury and Brain Injury, Textbook: Spinal Cord Medicine Principles and Practice, Editor in Chief Vernon W. Lin, M.D., PH.D. 2005 Ziyad Ayyoub, M.D. Aragaki, Dixie , Dual Diagnosis: Spinal Cord Injury and Brain Injury, Spinal Cord Medicine Principles and Practice, Editor in Chief Vernon W. Lin, M.D., PH.D. Second Edition 2013

Published Oral and Poster Presentations

1. Right Lower Extremity weakness in a patient with iliopsoas Hematoma and Diabetic

Amyotrophy Resulting in severe Lumbosacral Plexopathy: A Case Report. David H. Nguyen;

MD, Ryan H Lee, Aliss Markosian,, DO, Michael Scott, MD, Ziyad Ayyoub, MD. April

30,2016 at CSPMR annual meeting, Long Beach California

2. OnabotulinumtoxinA to Treat Common Postures in Post stroke Lower Limb Spasticity: Identification of a Treatment Paradigm Alberto Esquenazi,1 Abraham Alfaro,2 Ziyad

Ayyoub,3-5 David Charles,6 Khashayar Dashtipour,7 Glenn D. Graham,8,9 John R.

McGuire,10 Ib R. Odderson,11 Atul T. Patel,12 David M. Simpson13. 10th

International Society of Physical Me and Rehabilitation Medicine ISPRM World

Congress, 8th Malaysian Rehabilitation Medicine Conference, Kuala Lumpur

Malaysia, May 29-June 2th , 2016

3. Ramzi Ben-Youssef, Ziyad Ayyoub, Murray Brandstater, Ake Evans, Ken Hsin, Mallikarjuna

Nallegowda, Henry A. Richardson, Phuong Q. Tien. TTLevetiracetam and Speech Therapy in

Aphasia from Penetrating Brain Injury: A Case Report. AAPMR 71PPstPP Annual Assembly

Meeting, TT November 4-7, 2010, STTeatlle, WA, United States.

Page 13: L D R C M em ber at L arge Vol unt eer F orm€¦ · Full Name Ziyad Ayyoub Institution Rancho losAmigos National Rehab Center Title Chief of Medical Staaff, medical Director inpatient

12

4. Ken Hsin, Ziyad Ayyoub, Ramzi Ben-Youssef, Murray Brandstater, Ake Evans, Mallikarjuna

Nallegowda, Henry A. Richardson, Phuong Q. Tien. Atypical Presentation of Pediatric Multiple

Sclerosis: A Case Report. AAPMR71PPstPP Annual Assembly Meeting, November 4-7, 2010,

Seattle, WA, United States.

5. Henry A. Richardson, Ziyad Ayyoub, Ramzi Ben-Youssef, Murray Brandstater, Ake Evans,

Ken Hsin, Mallikarjuna Nallegowda, Phuong Q. Tien. Miller Fisher Syndrome—Response to

Intravenous Immunoglobulin: A Case Report. AAPMR 71PPstPP Annual Assembly Meeting,

November 4-7, 2010, Seattle, WA, United States.

6. Phuong Q. Tien, Ziyad Ayyoub, Ramzi Ben-Youssef, Murray Brandstater, Ake Evans, Ken

Hsin, Mallikarjuna Nallegowda, Henry A. Richardson. Transverse Myelitis with Atypical

Findings: A Case Report. AAPMR 71PPstPP Annual Assembly Meeting, November 4-7, 2010,

Seattle, WA, United States.

7. Ake Evans, Ziyad Ayyoub, Ramzi Ben-Youssef, Vance Eberly, Ken Hsin, Mallikarjuna

Nallegowda, Henry A. Richardson, Phuong Q. Tien. Proximal and Distal Patellar Realignment

for Chronic Patellar Dislocation in Ectrodactyly and Congenital Type 2 Deficiency of the Tibia:

A Case Report. AAPMR 71PPstPP Annual Assembly Meeting, November 4-7, 2010, Seattle,

WA, United States.

8. Recurrent Esophagocutaneous Fistula in a SCI Patient: A Case Report. Mallikarjuna

Nallegowda, Ziyad Ayyoub, Murray Brandstater, Jared Myers, an Ngo, Henry A. Richardson,

Michael Scott, Jiangnan Wang. AAPMR 71PPstPP Annual Assembly Meeting, November 4-7,

2010, Seattle, WA, United States.

9. Arbaclofen Placarbil is Efficacious and Safe in Subjects with Spasticity Due to Spinal Cord

Injury: F. Jacob Huff, Patricia W Nance, Alberto Martinez-Arizala, Ziyad Ayyoub, Dan Chen,

Amy Bian, David Stamler , Abstract at the 62PPndPP American Academy of Neurology Annual

MeetingApril10-April17, 2010 at the Metro Toronto Convention Center in Toronto, ON,

Canada

10. Cryptogenic Stroke in a young Woman with Patent Stroke in a young Woman with Patent

Foramen Ovale and May-Thunrner Cockett Syndrome, AAP 2011 Annual Meeting, April 12-

16, 2011, Sheraton Wild Horse Pass, Chandler, Arizona.

11. Osmotic Demyelination Syndrome: A Case Report, Daniel T. Saint-Elie, MDZiyad A. Ayyoub, MD Henry A. Richardson, MD, MBA AAPMR 72PPsecd Annual Assembly

Meeting, November 17-20, 2011, Orlando, FL, United States.

12. Acquired Central Hypoventilation—Ondine's Curse: A Case Report Henry

A. Richardson,MD,MBA,Ziyad Ayyoub,MDMurray Brandstater, MDKen Hsin, MDDaniel

T. Saint-Elie, MD Phuong Q. Tien, MD AAPMR 72PPsecd Annual Assembly Meeting,

November 17-20, 2011, Orlando, FL, United States.

13. Moyamoya Disease and Rehabilitation Outcomes: A Case Series

Mallikarjuna Nallegowda, MD, DNB, MNAMS Ziyad Ayyoub, MD, Murray Brandstater, MDJared Myers, BAJiangnan Wang, MDXiao Ling Zhang, MD AAPMR 72PPsecd Annual

Assembly Meeting, November 17-20, 2011, Orlando, FL, United States.

14. HETEROTOPIC OSSIFICATION IN TWO PATIENTS WITH PROLONGED INTUBATION

- A CASE REPORT Ziyad Ayyoub, BA, MD; Breda W Carroll, DO, AAP 2012 March 3

15. OnabotulinumtoxinA to Treat Common Postures in Post-Stroke Lower

Limb Spasticity: Identification of a Treatment Paradigm” has been

Page 14: L D R C M em ber at L arge Vol unt eer F orm€¦ · Full Name Ziyad Ayyoub Institution Rancho losAmigos National Rehab Center Title Chief of Medical Staaff, medical Director inpatient

13

accepted as a poster at AAPM&R (2016) American Academy of

Physical Medicine & Rehabilitation - 77th Annual Assembly (October 20-

23, 2016 in New Orleans, Louisiana

16. Improvement of spasticity, active movements and active function after repeated

injections of abobotulinumtoxinA (Dysport) in adults with spastic paresis in the

upper limb: Results of a Phase III open-label extension study, Accepted by

American Academy of Physical Medicine and Rehabilitation Annual Assembly

and Technical Exhibition in New Orleans, Louisiana on October 20-23, 2016.

17. Development of Heterotopic Ossification in the Setting of Burn

Rehabilitation, Punit Patel, Thomas Pham, Desi Barroga, MD, Michael D.

Scott, MD, Ziyad Ayyoub, MD, Association of Academic Physiatrists annual

meeting February 07-11, 2017 Las Vegas, Nevada accepted

COURSES & CONFERENCES:

October 25-29, 2018, 80th Annual Assembly American Academy of Physical Medicine and Rehabilitation Orlando , Florida July 21, 2018 Botulinum Toxin for Spasticity: Transforming Science into Clinical Success in Van Nuys, CA October 18-21 2017, Xeoforum conference, Tbilisi Georgia

October 11-15, 2017, 79th Annual Assembly American Academy of Physical Medicine and Rehabilitation Denver, Colorado October 20-22, 2016, 78th American Academy of Physical Medicine and Rehabilitation Annual Assembly Meeting, New Orleans, Louisiana.

September 29 October 1, 2016 , Xeoforum conference, Baku, Azerbaijan 2016 California Society of PM&R Annual meeting, April 29-May1, 2016, Long Beach California 2016 AAP Annual meeting, February 17-21, 2016 Sacramento Ca, Office Based treatment for Opioid Use Disorders Oct 28, 2015 November13-16, 2014, 76th American Academy of Physical Medicine and Rehabilitation Annual Assembly Meeting, San Diego, California May 3, 2014 Van Der Meulen Symposium, Neurorestorarion, expanding the Landscape for the treatment of nervous system disease through engineering and medicine, Keck School of Medicine of USC, Los Angeles California. October 3, 2013, Ultrasound Guidance for Chemodenervation Procedures: Lower Limb at 75PPthPP American Academy of Physical Medicine and Rehabilitation Annual Assembly Meeting, Washington DC

Page 15: L D R C M em ber at L arge Vol unt eer F orm€¦ · Full Name Ziyad Ayyoub Institution Rancho losAmigos National Rehab Center Title Chief of Medical Staaff, medical Director inpatient

14

October 3, 2013, Ultrasound Guidance for Chemodenervation Procedures: Upper Limb/Neck at 75PPthPP American Academy of Physical Medicine and Rehabilitation Annual Assembly Meeting, Washington DC October 1-2, 2013, Diagnostic and interventional Ultrasound Applications in Physiatry at 75PPthPP American Academy of Physical Medicine and Rehabilitation Annual Assembly Meeting, Washington DC October 3-6, 2013, 75PPthPP American Academy of Physical Medicine and Rehabilitation Annual Assembly Meeting, Washington DC March 9-10, Third Global summit on Neurotoxin, Milan Italy 2011 AAP Annual meeting, Feb 28-March3, 2012, Las Vegas Nevada Residency programs director workshop Feb 28-29 AAP Annual meeting, Las Vegas Nevada, Faculty development and mentoring, developing academic leadership course March 1- 3, 2012, AAP Annual meeting, Las Vegas Nevada November 17-20, 2011, 72ndPP American Academy of Physical Medicine and Rehabilitation Annual Assembly Meeting, Orlando FL 2011 AAP Annual meeting, April 12-16, 2011, Phoenix, AZ Virtual Reality in Neurorehabilitation, Review of the Equipment options an Hand-on Experience November 5, 2010, 71PPthPP American Academy of Physical Medicine and Rehabilitation Annual Assembly Meeting, Seattle, Washington Virtual Reality in Neurorehabilitation, Review of the Equipment options an Hand-on Experience November 5, 2010, 71PPthPP American Academy of Physical Medicine and Rehabilitation Annual Assembly Meeting, Seattle, Washington Coding and billing Workshop November 2-3, 2010, at 71PPthPP American Academy of Physical Medicine and Rehabilitation Annual Assembly Meeting, Seattle, Washington November 4-7, 2010, 71PPthPP American Academy of Physical Medicine and Rehabilitation Annual Assembly Meeting, Seattle, Washington May26-may 27, 2010 Physician Leadership Training , Health Services Administration, Quality Improvement and Patient Safety, Los Angeles, Ca. October 16-17, Management of Severe Spasticity with ITB Therapy, Newport Beach, California August 18, 2009 improving Physician and Clinical Documentation Educational Program, Hospital association of Southern California February 24-28, 2009 Residency Program& Fellowship Directors Workshop, Colorado Springs, Colorado February 24-28, 2009 Association of Academic Physiatrists annual meeting, Colorado Springs, Colorado

Page 16: L D R C M em ber at L arge Vol unt eer F orm€¦ · Full Name Ziyad Ayyoub Institution Rancho losAmigos National Rehab Center Title Chief of Medical Staaff, medical Director inpatient

15

November 20-23, 2008, 69PPthPP American Academy of Physical Medicine and Rehabilitation Annual Assembly Meeting, San Diego, California November 18-19, 2008 Advanced Assessment and Management Skills for Spasticity, Dystopia, and Related Motor Disorders: An interactive, Hands –On Workshop San Diego, California

Association of Academic Physiatrist Annual Meeting, Feb19-23, 2008, Anaheim, California

November 2-3, Spasticity Management National Symposium, Pediatric and Adult: Patient and Practice Management, Denver CO Myobloc Peer Educators Network Speaker training, October 12-13West Palm, FL September 27-30, 2007, 68PPthPP American Academy of Physical Medicine and Rehabilitation Annual Assembly Meeting, Boston, MA

July 12-13, 2007 Engaging with Physicians in a Shared Quality Agenda, Institute For Health Care Improvement, San Francisco , California Advanced Management of Spasticity in Pediatrics, challenging Cases in Patients and Practice Management, January 26-27, 2007, Newport Beach, CA Emerging Concepts in the Diagnosis and treatment of Pain, Nov 7-8, 67PPthPP Annual Assembly Pre conference Course, Honolulu, Hawaii June 10-11, 2006 CME course, Apportionment- Industrial Medicine Seminar, Santa Ana, California Nov9-12, 2006, 67PPthPP American Academy of Physical Medicine and Rehabilitation Annual Assembly Meeting, Honolulu, Hawaii

Nov, 2005 66PPth PPAmerican Academy of Physical Medicine and Rehabilitation Annual Assembly Meeting, Philadelphia, PA June 10-11, 2006 CME course, Apportionment- Industrial Medicine Seminar, Santa Ana, California October 7-10, 2005 65PPth PPAmerican Academy of Physical Medicine and Rehabilitation Annual Assembly Meeting, Phoenix, Arizona March 19-25, 2004 CME course, Costa Rica March 6, 2004 CME course, Workers Compensation-related medical dispute evaluations October 9-12, 64PPth PPAmerican Academy of Physical Medicine and Rehabilitation Annual Assembly Meeting, Chicago, Illinois June16-21 CARF Annual Conference, Tucson, Arizona

Page 17: L D R C M em ber at L arge Vol unt eer F orm€¦ · Full Name Ziyad Ayyoub Institution Rancho losAmigos National Rehab Center Title Chief of Medical Staaff, medical Director inpatient

16

April 11-12, 2003 Pre-CALS/ Medical Staff Leadership Conference, Universal City, California

November 21-24, 2002 American Academy of Physical Medicine and Rehabilitation 63PPrdPP Annual Assembly Meeting, Orlando, Florida

February 22, 2002 QME course, Cedars Sinai Medical Center, Los Angeles, California November 02-05, 2000 American Academy of Physical Medicine and Rehabilitation 62PPndPP Annual Assembly, San Francisco, California November 03, 2000 Chemical Neurolysis with phenol for spasticity control, San Francisco, California November 04, 2000 Electrodiagnosis of carpal tunnel syndrome: The Latest, San Francisco, California October 04-07, 2000 CARF Surveyor training, Tucson, Arizona November 16-19, 1999 the international conference 1999: Basic and therapeutic Aspects of Outline and Tetanus Toxins. Orlando, Florida November 10-14, 1999 American Academy of Physical Medicine and Rehabilitation 61st Annual Assembly and 13th World Congress of international Federation of Physical Medicine and Rehabilitation. Washington, DC

June23, 98 PM&R Annual Research Day, West LA VA Medical Center Los Angeles, California

3-6/1998 EMG/NCS Review Course at UCLA Medical Center, Department of Neurology, Los Angeles, California

Nov/1997 Interdisciplinary team training program, Sepulveda VA Medical Center, Sepulveda, California Nov/1997 American Academy of Physical Medicine and Rehabilitation Annual Conference, Atlanta, Georgia Oct/1997 Common Musculoskeletal Problems-Update 1997, Sepulveda VA Medical Center, Sepulveda, California Sep/1997 Bayer Workshop on Clinician-Patient Communication, West LA VA Medical Center, Los Angeles, California

Dec/1996 Functional Independence Measure Training, West Los Angeles VA Medical Center, Los Angeles, California

May/1996 Art and Science of Cancer pain management, West Los Angeles VA Medical Center, Los Angeles, California

Page 18: L D R C M em ber at L arge Vol unt eer F orm€¦ · Full Name Ziyad Ayyoub Institution Rancho losAmigos National Rehab Center Title Chief of Medical Staaff, medical Director inpatient

17

March/96 Arm and leg: Prosthetic Conference, West Los Angeles VA Medical Center, Los Angeles, California

Sep/1995 Resident Advancement Counsel, California PM&R Association Annual Meeting, Los Angeles, California

PRESENTATIONS:

Botulinum Toxin use for Spasticity CME course Van Nuys, CA July 21, 2018

Brain injury: epidemiology, facts& figures, etiology, pathophysiology, classification, acute management, and Rehabilitation at UCI residency program June 21/2018 at Long Beach VA , Long Beach California

April 27, 2018 Brain Injury Epidemiology, facts and figures, and gait abnormalities in TBI California Society of Physical Medicine & Rehabilitation ANNUAL MEETING April 27-29, 2018 Long Beach California 1998-current, regular lecture series on various topics including Brain injury medicine, stroke, SCI, spasticity and other topics for ever new residents per quarter October 21 2017, Keys for effective spasticity management with Botulinum Toxins Xeoforum conference, Tbilisi Georgia

Injection and Anatomy cadaver Lab Workshop at North American Neurotoxin Association, 2016 Botulinum toxin Therapy Update: Focus on Limb dysfunction, October 14, 2016 New Port Beach, CA

Brain injury, etiology, pathophysiology, classification, acute management, and Rehabilitation at Annual conference “Comprehensive Care of Persons with a Brain Injury Symposium” October 6, 2016 and 4/2017: Rancho Los Amigos National Rehabilitation Center, Downey, California IncobotulinmToxinA dosing for adult spasticity management from Research and clinical persepctive’ October 29, 2016, Xeoforum conference, Baku, Azerbaijan

Spasticity Review in Adults August 1 2016, National Medical Association, 114th Annual convention & Scientific Assembly July 30- August 3, Los Angeles Convention Center, CA

Spasticity in Adults at 2016 California Society of PM&R Annual meeting Long Beach California April 30, 2016

Cervical Dystonia at 2016 California Society of PM&R Annual meeting Long Beach California April 29, 2016 Efficacy and Safety of Repeated incobotulinumtoxinA Injections for Upper-Limb Post-

Stroke Spasticity Oral Research Scientific Paper presentation at 2016 AAP Annual meeting, February 19 2016 Sacramento Ca

Page 19: L D R C M em ber at L arge Vol unt eer F orm€¦ · Full Name Ziyad Ayyoub Institution Rancho losAmigos National Rehab Center Title Chief of Medical Staaff, medical Director inpatient

18

Brain injury, etiology, pathophysiology, classification, acute management, and Rehabilitation at Annual conference “Comprehensive Care of Persons with a Brain Injury Symposium” November 2, 2015: Rancho Los Amigos National Rehabilitation Center, Downey, California November14, 2014, Emerging Trends in Therapy for Your Practice and Patients at 76PPthPP American Academy of Physical Medicine and Rehabilitation Annual Assembly Meeting, San Diego, California

November12, 2014, Residents Injection training at 76PPthPP American Academy of Physical Medicine and Rehabilitation Annual Assembly Meeting, San Diego , California Anatomical and physiological consideration, lesion localization: UCLA/VA LAHS residents, medical students Western University of Health Sciences at Rancho Los Amigos National Rehabilitation Center, Downey, California April 7,14, 2014 Cranial nerves Anatomy, UCLA/VA LAHS residents, medical students Western University of Health Sciences at Rancho Los Amigos National Rehabilitation Center, Downey, California, and teaching course for every rotation Brain Anatomy lecture series UCLA/VA LAHS residents, medical students Western University of Health Sciences at Rancho Los Amigos National Rehabilitation Center, Downey, CaliforniaJan14,21,28-2413, April24,28, May5,8 2014 Brain Injury series lectures on: disorders of conscious, acute management, rehabilitation, outcome measures, consequences, complications. October _Dec. 2012 UCLA/VA LAHS residents, medical students Western University of Health Sciences at Rancho Los Amigos National Rehabilitation Center, Downey, California Teaching Cadaver course C spine and UE anatomy at UCI Oct 12-13, 2012 Comprehensive Care of Persons with a Brain Injury Symposium august 1, 2012: Brain injury types and complications Rancho Los Amigos National Rehabilitation Center, Downey, California April 16, 2012: Prognosis after Severe TBI, Evidence Based Approach residents, UCLA/VA LAHS residents, at Rancho Los Amigos National Rehabilitation Center, Downey, California

April 16, 2012: Electro physiologic Assessment Techniques in TBI residents, UCLA/VA LAHS residents, at Rancho Los Amigos National Rehabilitation Center, Downey, California

April 9, 2012 Pathobiology of TBI and Concepts of CNS Plasticity12 Loma Linda residents, UCLA/VA LAHS residents, medical students Western University of Health Sciences at Rancho Los Amigos National Rehabilitation Center, Downey, California

Page 20: L D R C M em ber at L arge Vol unt eer F orm€¦ · Full Name Ziyad Ayyoub Institution Rancho losAmigos National Rehab Center Title Chief of Medical Staaff, medical Director inpatient

19

Chronic Traumatic Encephalopathy 3/27/12 Loma Linda residents, UCLA/VA LAHS residents, medical students Western University of Health Sciences at Rancho Los Amigos National Rehabilitation Center, Downey, California

Traumatic Brain Injury in Military 3/22/12 Loma Linda residents, UCLA/VA LAHS residents, medical students Western University of Health Sciences at Rancho Los Amigos National Rehabilitation Center, Downey, California Return to play after Concussion 2/9/2012 Loma Linda residents, UCLA/VA LAHS residents, Rancho Los Amigos National Rehabilitation Center, Downey, California Concussion in sport 3/19/2012 Loma Linda residents, UCLA/VA LAHS residents, medical students Western University of Health Sciences at Rancho Los Amigos National Rehabilitation Center, Downey, California Postcuncussive Syndrome 3/12/2012 Loma Linda residents, UCLA/VA LAHS residents, medical students Western University of Health Sciences at Rancho Los Amigos National Rehabilitation Center, Downey, California

Pathophsiology of Concussion 3/8/2012 CLA/VA LAHS residents, medical students Western University of Health Sciences at Rancho Los Amigos National Rehabilitation Center, Downey, California Cranial nerves anatomy and function 3/5,2012 Loma Linda residents, UCLA/VA LAHS residents, medical students Western University of Health Sciences at Rancho Los Amigos National Rehabilitation Center, Downey, California

Return to play after Concussion 2/9/2012 Loma Linda residents, UCLA/VA LAHS residents, Rancho Los Amigos National Rehabilitation Center, Downey, California

Epidemiology of Concussion 2/8/2012 Loma Linda residents, UCLA/VA LAHS residents, Rancho Los Amigos National Rehabilitation Center, Downey, California Rehabilitation in TBI 2/6/2012 Loma Linda residents, UCLA/VA LAHS residents, Rancho Los Amigos National Rehabilitation Center, Downey, California Spasticity, assessment, evaluation, management 01/25/2012 UCLA/VA LAHS residents, Rancho Los Amigos National Rehabilitation Center, Downey, California

Electrical stimulation, 11/09/2011, Loma Linda residents, at Rancho Los Amigos National Rehabilitation Center, Downey, California Spasticity in SCI patients, 11/09/2011, Loma Linda residents, at Rancho Los Amigos National Rehabilitation Center, Downey, California

Spasticity Upper Extremity, 10/24/2011, Loma Linda residents, UCLA/VA LAHS residents, medical students Western University of Health Sciences at Rancho Los Amigos National Rehabilitation Center, Downey, California

Page 21: L D R C M em ber at L arge Vol unt eer F orm€¦ · Full Name Ziyad Ayyoub Institution Rancho losAmigos National Rehab Center Title Chief of Medical Staaff, medical Director inpatient

20

Brain Injury: agitation maladaptive behavior, psychological and psychiatric consequences. September 26, 2011, Loma Linda residents, UCLA/VA LAHS residents, medical students Western University of Health Sciences at Rancho Los Amigos National Rehabilitation Center, Downey, California Brain Injury: disorders of conscious, acute management, rehabilitation, outcome measures, consequences, complications. October 20, 2011, UCI and UCLA/VA LAHS residents, medical students Western University of Health Sciences at Rancho Los Amigos National Rehabilitation Center, Downey, California

Brain Injury Incidence Mechanism of Injury, severity assessment, demographics, Etiology, Pathphysiology, and Imaging. October 17, 2011, Loma Linda and UCLA/VA GLAHS residents, medical students Western University of Health Sciences at Rancho Los Amigos National Rehabilitation Center, Downey, California

Brain Injury Incidence Mechanism of Injury, severity assessment, demographics, Etiology, Pathphysiology, and Imaging. October 06, 2011, UCI and UCLA/VA GLAHS residents, medical students Western University of Health Sciences at Rancho Los Amigos National Rehabilitation Center, Downey, California

Comprehensive Care of Persons with a Brain Injury Symposium august 2, 2001: Brain injury types and complications Rancho Los Amigos National Rehabilitation Center, Downey, California Brain Injury: acute Management, physiatrist assessment July 25, 2011, Loma Linda and UCLA/VA GLAHS residents, medical students Western University of Health Sciences at Rancho Los Amigos National Rehabilitation Center, Downey, California Brain Injury Etiology, Path physiology, definition, acute Management, consequences, and rehabilitation July 11, 2011, Loma Linda and UCLA/VA GLAHS residents, medical students Western University of Health Sciences at Rancho Los Amigos National Rehabilitation Center, Downey, California

Shoulder anatomy, physical examination, and injections techniques July 12, 2010, Loma Linda and UCLA/VA GLAHS residents, Students Westerns university of Health Sciences, at Rancho Los Amigos National Rehabilitation Center, Downey, California Spasticity , evaluation, management and injection techniques and April26,2010 Loma Linda and UCLA/VA GLAHS residents, Students Westerns university of Health Sciences, at Rancho Los Amigos National Rehabilitation Center, Downey, California Maladaptive behavior, psychiatric consequences, clinical decline in TBI patients November 9, 2009, Loma Linda and UCLA/VA GLAHS residents, Students Westerns university of Health Sciences, at Rancho Los Amigos National Rehabilitation Center, Downey, California Traumatic Brain Injury Model Systems, Brain injury: Demographics Classification, Path physiology, imaging September 29, 2009, Loma Linda and

Page 22: L D R C M em ber at L arge Vol unt eer F orm€¦ · Full Name Ziyad Ayyoub Institution Rancho losAmigos National Rehab Center Title Chief of Medical Staaff, medical Director inpatient

21

UCLA/VA GLAHS residents, Students Westerns university of Health Sciences, at Rancho Los Amigos National Rehabilitation Center, Downey, California Variability among Outline toxins August 27, 2009 Loma Linda and UCLA/VA GLAHS residents, Students Westerns university of Health Sciences, at Rancho Los Amigos National Rehabilitation Center, Downey, California Cervical Dystopia characteristics, treatment and diagnosis August 19, 2009 Loma Linda and UCLA/VA GLAHS residents, Students Westerns university of Health Sciences, at Rancho Los Amigos National Rehabilitation Center, Downey, California

Therapeutic uses of Neurotoxins August 12, 2009 Loma Linda and UCLA/VA GLAHS residents, Students Westerns university of Health Sciences, at Rancho Los Amigos National Rehabilitation Center, Downey, California

Skull and Brain Anatomy, Physiology, Brain Injury, epidemiology, classification, acute management, Rehabilitation, consequences, complications, Symposium Rancho Los Amigos National Rehabilitation Center, Downey, California, August 5,09 Brain: Anatomy, and Imaging June 1, 2009 Loma Linda and UCLA/VA GLAHS residents at Rancho Los Amigos National Rehabilitation Center, Downey, California Brain: Anatomy, physiology, lesion localization April 27, 2009 Loma Linda and UCLA/VA GLAHS residents at Rancho Los Amigos National Rehabilitation Center, Downey, California

Cranial Nerves: Anatomy, function, and Testing April 6, 2009 Loma Linda and UCLA/VA GLAHS residents at Rancho Los Amigos National Rehabilitation Center, Downey, California

Pediatric TBI, Etiology, Prevention 2/9/09, Loma Linda and UCLA/VA GLAHS residents at Rancho Los Amigos National Rehabilitation Center, Downey, California History of Development of Outline Toxins January 26, 09, Loma Linda and UCLA/VA GLAHS residents at Rancho Los Amigos National Rehabilitation Center, Downey, California

Brain Injury Model Systems Oct 1, 2008, Loma Linda and UCLA/VA GLAHS residents at Rancho Los Amigos National Rehabilitation Center, Downey, California

Brain Injury Rehab – Complication Outcomes Dec, 01, 2008, Loma Linda and UCLA/VA GLAHS residents at Rancho Los Amigos National Rehabilitation Center, Downey, California

Brain Injury Path physiology – Acute Management, Nov. 24, 2008, Loma Linda and UCLA/VA GLAHS residents at Rancho Los Amigos National Rehabilitation Center, Downey, California

Page 23: L D R C M em ber at L arge Vol unt eer F orm€¦ · Full Name Ziyad Ayyoub Institution Rancho losAmigos National Rehab Center Title Chief of Medical Staaff, medical Director inpatient

22

Brain Injury Classification, Imaging. Nov 10, 08, Loma Linda and UCLA/VA GLAHS residents at Rancho Los Amigos National Rehabilitation Center, Downey, California Brain Injury Incidence, Prevalence, Demographics, Oct 7, 2008 Loma Linda and UCLA/VA GLAHS residents at Rancho Los Amigos National Rehabilitation Center, Downey, California Blepharospasm, Strabismus, Hyperhydrosis , August 27, 2008, Loma Linda and UCLA/VA GLAHS residents at Rancho Los Amigos National Rehabilitation Center, Downey, California Cervical Dystopia Treatment, August 25, 2008, Loma Linda and UCLA/VA GLAHS residents at Rancho Los Amigos National Rehabilitation Center, Downey, California Pediatric TBI, TBI prevention, June 18, 2008, Loma Linda and UCLA residents Rancho Los Amigos National Rehabilitation Center, Downey, California

Mild TBI, June 16, 2008 Loma Linda and UCLA residents Rancho Los Amigos National Rehabilitation Center, Downey, California Clinical decline after TBI, Clinical competency June 09, 2008 Loma Linda and UCLA residents Rancho Los Amigos National Rehabilitation Center, Downey, California Injections Techniques training, June 04, 2008 Loma Linda and UCLA residents Rancho Los Amigos National Rehabilitation Center, Downey, California Injections Techniques training, June 04, 2008 Loma Linda and UCLA residents Rancho Los Amigos National Rehabilitation Center, Downey, California Adult Brain Injury, complications, June 04, 2008 Loma Linda and UCLA residents Rancho Los Amigos National Rehabilitation Center, Downey, California Adult Brain Injury, Physiatrist Assessment, consequences, complications, May 28, 2008 Loma Linda and UCLA residents Rancho Los Amigos National Rehabilitation Center, Downey, California Cervical Dystopia, symptoms, path physiology, evaluation and treatment, 5/14, 08 Loma Linda and UCLA residents Rancho Los Amigos National Rehabilitation Center, Downey, California Traumatic brain Injury: Evaluation and Treatment, Rancho Los Amigos National Rehabilitation Center, Downey, California May 7, 08 Brain Injury: Terminology, Path physiology Loma Linda and UCLA residents Rancho Los Amigos National Rehabilitation Center, Downey, California April 21. 08

Page 24: L D R C M em ber at L arge Vol unt eer F orm€¦ · Full Name Ziyad Ayyoub Institution Rancho losAmigos National Rehab Center Title Chief of Medical Staaff, medical Director inpatient

23

Brain Injury: Terminology, classification, consequences, complications and rehabilitation, Brain Injury Symposium, Rancho Los Amigos National Rehabilitation Center, Downey, California April 17, 08 Therapeutic use of Outline toxins Loma Linda and UCLA residents Rancho Los Amigos National Rehabilitation Center, Downey, California April1 16, 08 Brain Injury: Facts, Figures, Epidemiology, Terminology, Path physiology Loma Linda and UCLA residents Rancho Los Amigos National Rehabilitation Center, Downey, California April14. 08 Spasticity etiology, path physiology, evaluation and treatment, National Occupational Therapy association, annual meeting, Long Beach, Ca April 11, 08 Spasticity etiology, path physiology, evaluation and treatment, Loma Linda and UCLA residents Rancho Los Amigos National Rehabilitation Center, Downey, California April 9. 08 Skull: Embryology and Anatomy Loma Linda and UCLA residents Rancho Los Amigos National Rehabilitation Center, Downey, California April 7. 08 Cervical Dystopia, Multiple presentations on the topic , 9-6, 9-17, 9-18, 9-13,9-21, 9-27,10-11, 10-13,10-23, 10-26-07,12/05/07 Outline Toxins and Phenol Applications in Spasticity Management, April 25, 2007, Loma Linda medical enter, Department of PM&R, Loma Linda California

Spasticity Management in Stroke Patients, Nov 16, 06, at Rancho Los Amigos National Rehabilitation Center, Downey, California

CME program provider sponsored by the University of Wisconsin School of Medicine and Public Health and MDG Development Group, Las Vegas, Nevada, September 26, 2006

Spasticity Management in Stroke Patients, Oct 23, 06, Prague, Czech Republic

Overview of Spasticity and the role of Outline Toxins in Disease Management, CME program provider sponsored by the University of Wisconsin School of Medicine and Public Health and MDG Development Group, Las Vegas, Nevada, September 26, 2006 Overview of Spasticity and the role of Outline Toxins in Disease Management, CME program provider sponsored by the University of Wisconsin School of Medicine and Public Health and MDG Development Group, Las Vegas, Nevada, September 26, 2006

Overview of Spasticity and the role of Outline Toxins in Disease Management, CME program provider sponsored by the University of Wisconsin School of Medicine and Public Health and MDG Development Group, San Jose, California, September 23, 2006 Spasticity Management in Stroke Patients: CME program Achieving Excellence in Stroke Care and Treatment, Cedars Sinai Medical center, September 09, 2006

Page 25: L D R C M em ber at L arge Vol unt eer F orm€¦ · Full Name Ziyad Ayyoub Institution Rancho losAmigos National Rehab Center Title Chief of Medical Staaff, medical Director inpatient

24

Treatment options for patient with Spastic syndromes for UCI Residents And Faculty, August 31, 2006 Brain Injury Consequences and Rehabilitation, Kindred Hospital, Brea, May 30, 2006 Traumatic Brain Injury Rehabilitation, Grand Rounds, California Hospital, 4/ 11/06 Achieving Excellence in Rehabilitation Care and Treatment Course, Cedars Sinai Medical center May 7, 2005 Management of Spasticity in adults Focus on an Interdisciplinary, Continuing Education and Training Course, 2004, Downey Management of Spasticity in adults Focus on an Interdisciplinary, Continuing Education and Training Course, Nov. 2003, Whittier Approach, Rehabilitation Grand Rounds/CME program, Cedars Sinai Medical Center, September 23, 2004 Spasticity, Etiology, Assessment, and Management, Costa Rica 3/20/04 Focus on an Interdisciplinary Approach: Management of Spasticity in Adults,

Nerve Blocks and Botox injections, Rancho Los Amigos National Rehabilitation Center, 11/22/00, 6/21/2001, 1/16/2002, and 10/16/02 Brain Injury Rehabilitation, Trauma Care 2001: 14 PPthPP annual Anesthesia and critical Care Symposium and World Exposition, San Diego, California, May 18, 2001

Rehabilitation Process of Persons with Brain Injury. Rancho Los Amigos National Rehabilitation Center May 15, 2001 “Traumatic Brain Injury, Figures and Facts” Rancho Los Amigos National Rehabilitation Center, 10/11/2000, 07/19/2000, Jan 10, 2001, 8/14/02

“Spasticity” Rancho Los Amigos National Rehabilitation Center, 08/30/2000, Feb/14/2001, 5/2/2001, 2/6/2002 “Rehabilitation interventions for spasticity management” Rancho Los Amigos National Rehabilitation Center, 7/12/2000, 10/09/2002 “Joint Contracture” Rancho Los Amigos National Rehabilitation Center, 3/14/2001 “Post-Traumatic Seizures”, Rancho Los Amigos National Rehabilitation Center 7/19/00, 6/12/02

“Heterotropic Ossification”, Rancho Los Amigos Medical Center12/3/98, 4/11/2001

Page 26: L D R C M em ber at L arge Vol unt eer F orm€¦ · Full Name Ziyad Ayyoub Institution Rancho losAmigos National Rehab Center Title Chief of Medical Staaff, medical Director inpatient

25

“Aphasia”, Rancho Los Amigos Medical Center (RLAMC), 9/10/98, 11/17/98, 3/28/2001, 09/04/2002

“Reflex Sympathetic Dystrophy”, RLAMC, 8/27/98, 2/28/01 “Complications of Spinal Cord Injury”, West LA VAMC, 10/97, RLANRC 3/31/2001 “Comparison of Insulin Requirements before and After Below-Knee Amputation”, West LA VAMC, 6/97

“Ocular Movement Disorders in TBI”, Cedars Sinai Med. Center, 5/97, and RLAMC 1995, 1999 “Traumatic Brain Injury in Pediatrics”, West LA VAMC, 7/96

“Evaluation of Effect of Exercise on Cerebral Blood Flow by PET Scan in Controls and in Stroke Patients”, West LA VAMC, 6/96

“Stroke Rehabilitation Techniques”, West LA VAMC, 6/96, RLANRC 12/20/00

“Post-Traumatic Seizures in Pediatrics”, Rancho Los Amigos Medical Center (RLAMC), 6/96 “Rehabilitation in Geriatric Patient”, Sepulveda Nursing Home Care Unit Veteran Affairs Medical Center, 1/96 “Assistive Devices”, Sepulveda Nursing Home Care Unit Veteran Affairs Medical Center, 3/96 “Autonomic Dysreflexia”, Rancho Los Amigos Medical Center, 12/95, RLANRC 12/13/2000

CERTIFICATIONS:

ECFMG, 1992 Certificate Number 0-455-148-7, Valid May, 09, 1992 -indefinitely

FLEX, 1992 ID # 611215013

TOEFL Number 4322439

Medical Association of Jordan Examination, 1987 Belarus State Examination, 6/1986 ACLS, BLS

AAPM&R Board Certificate, 7/1999 expires 12/31/2019

Spinal Cord Injury Medicine, 12/2005 expires 12/31/2025 Spinal Cord Injury Medicine recertification 11/2014

Page 27: L D R C M em ber at L arge Vol unt eer F orm€¦ · Full Name Ziyad Ayyoub Institution Rancho losAmigos National Rehab Center Title Chief of Medical Staaff, medical Director inpatient

26

Brain Injury Medicine, 10/2014, expires 12/31/2024 Addiction Medicine 10,28,2015 American Osteopathic Academy of Addiction Medicine

Qualified Medical Evaluator, State of California Industrial Medical Council, 2000-2007

LICENSURE:

State of California 1994, License No. A53397 expires 12/31/2017 DEA Registration No. BA4172538 expires 6/30/2018

BOARD CERTIFICATION:

American Academy of Physical Medicine & Rehabilitation (AAPM&R), 7/1999, recertification 2/2008 Spinal Cord Injury Medicine, 12/2005, Subspecialty of AAPM&R, expires 12/31/2024. Brain Injury Medicine, 10/2014, Subspecialty of AAPM&, expires 12/31/2024

PROFESSIONAL AFFILIATIONS:

Association of Academic Physiatrists

American Academy of Physical Medicine and Rehabilitation Brain Injury Special Interest Group AAPM&R Spasticity Special Interest Group AAPM&R AAPM&R Musculoskeletal Medicine Council

AAPM&R Pain Medicine and Neuromuscular Medicine Council

AAPM&R Neurological Council HOSPITAL PRIVILEGES:

Rancho Los Amigos National Rehabilitation Center, 1998-Present, Downey, Ca

Suburban Medical Center, Paramount, March 2, 2000-Present Kindred Hospital, La Mirada, Sept 22, 2000-Present Kindred Hospital, Brea 3/3/2005- Present, 75 North Brae Blvd, Brea, Ca 92821 Kindred Hospital Santa Ana, Kindred Hospital, San Gabriel, Hawaiian Gardens, and South Bay

Page 28: L D R C M em ber at L arge Vol unt eer F orm€¦ · Full Name Ziyad Ayyoub Institution Rancho losAmigos National Rehab Center Title Chief of Medical Staaff, medical Director inpatient

27

HONORS & AWARDS: Top Doctors:

Ranked in the top 1% of physiatrists in USA by US News & world report newspaper multiple times, recognized by other news magazines

John E. Affeldt, MD Distinguished Physician Award 2011-2012 Ranked in the top 1% of physiatrists in USA by US News & world report newspaper July, 2011 Cerebral Palsy International Research Foundation, Grant review committee Amigos Fund, Board Member Rancho Los Amigos Foundation, Board Member June23, 1998 Riggler Award for Academic Excellence, Cedar - Sinai Medical Los Angeles, California June 23, 1998 Award “Most Reliable Physician”, UCLA Multi-Campus Program June 18, 1996 UCLA Multicampus PM&R Residency Training Program Award Best Research Proposal Aug, 1987 Irbid Medical Center Award

June 27, 1986 Minsk State Medical Institute, Honor student June 30, 1980 Belarus University Honor Graduation/Diploma July/1979 Ministry of Education of Jordan Scholarship

LANGUAGES:

English, Russian, Spanish, Arabic

REFERENCES: Available upon Request