Name ofDrug ACTIONINDICA-TIONCONTRA- INDICATIONADVERSE
EFFECTNURSING COSIDERATION
KETOROLACThe primaryactionresponsible for ketorolac's
anti-inflammatory, antipyretic and analgesic effects is the
inhibition of prostaglandin synthesis by competitive blocking of
theenzymecyclo-oxygenase(COX). Ketorolac is a non-selective COX
inhibitor.Short term management of moderate to severe post-op
painKetorolac iscontraindicatedin patients with a previously
demonstrated hypersensitivityto ketorolac, and in patients with the
complete or partial syndrome ofnasal polyps,angioedema,
bronchospasticreactivity or other allergic manifestations to
aspirin or other non-steroidalanti-inflammatory drugs (due to
possibility of severeanaphylaxis. A post-marketing surveillance
study[]indicated a dose-response relationship with average daily
dose for both gastrointestinal bleeding and operative site
bleeding, and an association between gastrointestinal bleeding and
therapy for more than five days.Allergic reactions (anaphylactoid
reactions, asthma, bronchospasmFluid retention and edema have been
reported with the use of ketorolac.Observe patient , Medication may
make patient drowsy or dizzy .Insure about the safe use of alcohol
while taking ketorolac.
Store the medicine at room temperature and away from excess heat
and moisture .Throw away any medication that is out dated or no
longer needed .
