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Kelainan Metabolisme
Protein
disampaikan oleh :
Dr. Rimbawan(Koordinator MK. Metabolisme Zat Gizi)
MK. Metabolisme Zat Gizi, Program Studi Ilmu Gizi
Departemen Gizi Masyarakat, FEM!IP"
#$%&
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Spesi'isitas Substrat minotrans'erase
Sumber : Harvey R! "errier DR. #$%%. Lippincot’s
Illustrated Reviews: Biochemistry 5th ed.
Setia& aminotransferase bersi'at
spesi'ik untu %atau sebaian besar uus amino.
# reasi aminotrans'erase terpenting diatalisis
ole* enzim alanine aminotrans'erase ()*+ dan
aspartate aminotrans'erase (S*+.
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Enzim lanine minotrans'erase ()*+
Disebut +ua denan enzim glutamate piruvat
transaminase (GPT).
Ditemuan di banyak aringan.
"unsi : Mengatalisis &eminda*an uus amino
alanine e ,-etolutarat! se*ina terbentuk
piru-at dan glutamate.
ersi'ar e-ersibel.
Sumber : Harvey R! "errier DR. #$%%. Lippincot’s
Illustrated Reviews: Biochemistry 5th ed.
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Enzim lanine minotrans'erase ()*+
Sumber : Harvey R! "errier DR. #$%%. Lippincot’s
Illustrated Reviews: Biochemistry 5th ed.
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Enzim spartate minotrans'erase (S*+
Disebut +ua denan glutamate oksaloasetat
transaminase (GOT)
Selama atabolisme asam amino! S/ aan
meminda*an uus amino dari lutamate e
osaloasetat untu membentu as&artate! yan aan
diunaan sebaai sumber nitroen dalam silus
urea.
Reasi bersi'at e-ersibel.
Sumber : Harvey R! "errier DR. #$%%. Lippincot’s
Illustrated Reviews: Biochemistry 5th ed.
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Penyakit /ati
S/ dan 0/ &lasma aan &ada *am&ir semua
&enyait *ati! terutama &ada eadaan yan
menyebaban nerosis sel y sanat luas.
0/ lebi* s&esi'i untu &enyait *ati dari&ada S/.
/eta&i! S/ lebi* sensiti' arena *ati menandun
se+umla* besar S/.
Sumber : Harvey R! "errier DR. #$%%. Lippincot’s
Illustrated Reviews: Biochemistry 5th ed.
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Penyakit /ati
Sumber : Harvey R! "errier DR. #$%%. Lippincot’s
Illustrated Reviews: Biochemistry 5th ed.
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*es )aboratorium untuk Faal /ati
G1/ GP/ Gamma G/ "os'atase lali 2H3 ilirubin /otal ilirubin
Dire4t
Protein /otal lbumin Prealbumin
Sumber : 0aboratorium Klini Prodia
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KE)I00 ME*"1)IK PD ME*"1)ISME SM MI01
Sumber : Harvey R! "errier DR. #$%%. Lippincot’s
Illustrated Reviews: Biochemistry 5th ed.
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KE)I00 ME*"1)IK PD ME*"1)ISME SM MI01
Sumber : Harvey R! "errier DR. #$%%. Lippincot’s
Illustrated Reviews: Biochemistry 5th ed.
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KE)I00 ME*"1)IK PD ME*"1)ISME SM MI01
Sumber : Harvey R! "errier DR. #$%%. Lippincot’s
Illustrated Reviews: Biochemistry 5th ed.
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Sumber : Harvey R! "errier DR. #$%%. Lippincot’s
Illustrated Reviews: Biochemistry 5th ed.
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Sumber : Harvey R! "errier DR. #$%%. Lippincot’s
Illustrated Reviews: Biochemistry 5th ed.
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*EIM KSI/
