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Maryland Neuroimaging Center
Jonathan SimonBiology / Electrical & Computer Engineering
University of Maryland, College Park
Thanks to Luiz Pessoa for MNC slides
Maryland Neuroimaging Center
NSF grant by NACS faculty
3 Tesla Siemens MRI machine
Maryland Neuroimaging Center
Funds from the campus: $2-3 million• Broad support across several colleges
(BSOS, ENGR, CMNS, etc.)
Northeast of campus• Across route 193• Off Metzerott road
Maryland Neuroimaging Center
Multiple modalities for brain research• MRI• EEG: Electroencephalography (soon)• MEG: Magnetoencephalography (~ 1 year)
http://uuhsc.utah.edu/uumsi/images/sensor_array.jpg
http://ling.umd.edu/assets/photos/2011/06/07/KIT_MEG_350x350.jpeg
Research at the MNC Basic studies of perception,
cognition, and emotion Clinically relevant research
• Autism, Dyslexia, Anxiety, Addiction, etc.
Work with adults and children• Not yet with animals (only barrier is $$)
Functional MRI analysis Determine “activations” to task
conditions
http://t2.gstatic.com/images?q=tbn:ANd9GcTu4yd12HA97oU222KOoUrVELjAE5kVdhVS_71JOAYq2woSjJGr
Region does X!e.g. , V1 “does” orientation processing
Sensory processing example
Ocular dominance columns• Because of the connectivity from eye to
cortex, eye-of-origin related columns exist in early visual cortex
Horton
Sensory processing example
Ocular dominance columns with fMRI• In-plane resolution:
470 x 470 µm• Column width: 1.1
mm
session 1
session 2
SA
Horton
Many other approaches… Machine learning to “decode” brain
statesWhat is the person seeing?
Many other approaches…
Graph-theoretic analysis• How are brain regions organized as a
function of condition, population (autism vs. control), etc.?
Nodes: brain regions
Edges: “functional connectivity” between regions• Correlation
Structural MRI data Reconstructing physical connection
paths
http://3.bp.blogspot.com/XaZAD5nhhH4/TVbUkY0aJjI/AAAAAAAAHis/dZXN82sE03o/s1600/Fiber_Tractography.JPG
http://www.epicareflorida.com/images/Hippocampal_sclerosis.jpg
Combining techniques Run the same experiment with
functional MRI and MEG Integrating the two modalities
• Spatial resolution of functional MRI• Temporal resolution of MEG
t = 32 ms t = 38 ms From Ou et al (2009)
New projects $600/hour Seed funding available
• Faculty• Students + Faculty• Idea is that pilot data will be used for grant
application to support research
Journal club Meets every other Friday from noon-1
• Focus on MRI, MEG, and EEG related work• Open to all techniques that study the brain!
Thanks Come visit sometime!
http://www.thecnnh.org/ACEC/images/jimmysmile_phan.jpg