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J Infect Chemother 20 (2014) 231

Contents lists avai

Journal of Infection and Chemotherapy

journal homepage: http: / /www.elsevier .com/locate/ j ic

Announcement

JIC Award 2013

The Japanese Society of Chemotherapy and The Japanese Societyof Association for Infectious Diseases established the “JIC Award” tocommend high-quality papers published in the Journal of Infectionand Chemotherapy. In each volume of the Journal, one article isselected on the vote of the JIC Award Selection Committee. Forvolume 19, 2012, the following article was selected.

Dr. Yuta Nanjo

Effects of slow-releasing colistin microspheres on endo-toxin-induced sepsis

Authors: Yuta Nanjo, Yoshikazu Ishii, Soichiro Kimura, ToshiroFukami, Masahiro Mizoguchi, Toyofumi Suzuki, Kazuo Tomono,Yoshikiyo Akasaka, Toshiharu Ishii, Kazuhisa Takahashi, KazuhiroTateda, Keizo Yamaguchi

J Infect Chemother (2013) 19: 683e90

Abstract

Lipopolysaccharide (LPS) is a major contributing factor toendotoxic shock. Colistin specifically binds to LPS. However, it hasthe disadvantages that adverse reactions are common and it has ashort half-life. To overcome these disadvantages, we preparedslow-releasing colistin microspheres and examined the efficacy ofthese colistinmicrospheres in amousemodel of endotoxin-inducedsepsis. We prepared the colistin microspheres using poly-lactic-co-glycolic acid. For acute toxicity investigations, mice were overdosedwith colistin sulfate or colistin microspheres. The group adminis-tered with colistin microspheres was associated with less acute

http://dx.doi.org/10.1016/j.jiac.2014.03.0011341-321X/� 2014, Japanese Society of Chemotherapy and The Japanese Association for Infecti

toxicity and fewer nephrotoxic changes on histopathological ex-amination compared to the group administeredwith colistin sulfatealone. For pharmacokinetic analysis, mice were subcutaneouslyadministered with colistin microspheres or colistin sulfate alone.The plasma concentration of colistin was higher in the colistinmicrospheres group than in the colistin sulfate group at 12 and 24 hafter administration. Moreover, mice were intraperitoneally injec-ted with LPS and then immediately subcutaneously administeredwith blank microspheres, colistin microspheres or colistin sulfatealone. The levels of endotoxin in the sera and cytokine in thespleens were then measured. A significant reduction in the serumendotoxin level in the colistin microspheres group was observed at24 h. The reduced endotoxin levels in the sera were correlated withthe lower cytokine levels in the spleens ofmice treatedwith colistinmicrospheres. Our results suggest that the use of colistin micro-spheres may help to maintain a higher colistin concentration inblood, reduce the levels of endotoxin and cytokines in endotoxin-induced sepsis, and lead to decreased toxicity.

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