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JAWAHARLAL INSTITUTE OF POSTGRADUATE MEDICAL EDUCATION & RESEARCH, PUDUCHERRY-605006

(Institute of National Importance under Govt. of India)

MINUTES OF THE Tenth MEETING OF JIPMER SCIENTIFIC ADVISORY COMMITTEE, HELD ON 22.11.2013 2013 in the NTTC Hall – 1, JIPMER Academic centre, JIPMER, PUDUCHERRY

The Tenth Meeting of the JIPMER Scientific Advisory Committee was held on 22.11.2013 in the NTTC Hall – 1, JIPMER Academic centre under the Chairmanship of the Director, JIPMER. The following members of the JIPMER Scientific Advisory Committee were present. 1. Dr. T.S. Ravikumar, Director, JIPMER Chairperson

2 .Dr. S.C. Parija, Professor-in-charge & Vice-Chairperson

Head (Research), JIPMER

3. Dr. Santosh Kumar, Professor, Urology, JIPMER Member Secretary

4. Dr. Ajit Sahai, Professor & Head, Biometrics & Member

Medical Informatics, JIPMER

5. Dr. R. Raveendran, Professor, Pharmacology, JIPMER Member

6. Dr. G. K. Pal, Professor & Head, Physiology, JIPMER Member

7. Dr. Jambulingam, Director, VCRC, Puducherry External Member

8. Dr. Hannah Rachel Vasanthi, Associate Professor, External Member

Biotechnology, Pondicherry University

9. Dr.T.K Dutta, Professor & Head, Clinical Hematology Special Invitee

10. Dr Vikram Kate, Professor& Head, Surgical Gastroenterology Special Invitee

At the outset Dr.T.S. Ravikumar, Director and Chairman welcomed the members of JSAC. The Minutes of the last meeting of JSAC held on 01.11.2013 were approved. Then the research proposals listed on the agenda were taken up one by one for discussion.

After the deliberation, the following decisions were arrived.

No. of proposals received-22 No. of proposals discussed-20 No. of proposals to be resubmitted- 4 No. of proposals approved subject to modifications, if any, and ethical clearance - 16

N.B. The Investigators of the projects will be fully responsible for incorporating the suggested changes in their project proposals. The investigators whose proposals need modifications are required to submit one copy of revised proposals to the Professor-in-charge & Head (Research), JIPMER on or before 05.12.2013.

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Sl. No.

Names of Investigators and Co-investigators

Titles of the Research Projects Recommendation

1. Investigator: Dr. Laxmisha Chandrashekar, Assistant Professor, Dermatology Co-Investigators: Dr. Medha R., Assistant Professor, Biochemistry Dr. D.M. Thappa, Professor, Dermatology

Optimizing treatment regimen in pemphigus: utility of biomarkers and HLA status

Approved subject to:

change of title to “Assessment of biomarkers and HLA status in pemphigus”

inclusion of interim analysis

ethical clearance

2. Investigator: Dr. Rajesh NG, Assistant Professor, Pathology Co-Investigators: Dr. Debdatta Basu, Professor, Pathology Dr. Bhawana Ashok Badhe, Professor and Head, Pathology Dr. Biswajit Dubashi, Assistant Professor, Medical Oncology Dr. Suresh Chandra Pradhan, Senior Professor and Head, Pharmacology

Genetic mutations and their role in risk stratification and therapy in Acute Myeloid Leukemia

Approved subject to:

change of title to “Assessment of genetic mutations in Acute Myeloid Leukemia”

ethical clearance

3. Investigator: Dr. Pradipta Kumar Parida, Assistant Professor, ENT Co-Investigators: Dr. S. Gopalakrishnan, Professor, ENT Dr. Vishnu Bhat B, Professor and Head, Paediatrics Mr. Anuprasad, Tutor, ENT

Incidence of hearing loss among neonates in a tertiary health care hospital in south India

Approved subject to:

change of title to “Assessment of prevalence and risk factors of hearing loss among neonates in a tertiary health care hospital in south India”

ethical clearance

4.

Investigator Dr. P. Sakthi Rajan, Assistant Professor, Anesthesiology and Critical Care Co-Investigators Dr. Praveen Talawar, Assistant Professor, Anesthesiology and Critical Care Dr. Bidkar Prasanna Udupi, Assistant Professor , Anesthesiology and Critical Care

Comparison of nitroglycerin (NTG) and lignocaine subcutaneous perivascular infiltration for radial artery cannulation after failed attempts - Randomized controlled trial.

Approved subject to:

addition of use of ultrasound before cannulation

sample size recalculation and inclusion of sample size determination method

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Dr. S. Adinarayanan, Assistant Professor, Anesthesiology and Critical Care

ethical clearance

5 Investigator: Dr. P. Sakthi Rajan, Assistant Professor, Anesthesiology and Critical Care Co-Investigators Dr. Praveen Talawar, Assistant Professor , Anesthesiology and Critical Care Dr. S. Adinarayanan, Assistant Professor, Anesthesiology and Critical Care Dr. Zachariah Bobby, Additional Professor, Biochemistry Dr. Prasanna Bidkar, Assistant Professor , Anesthesiology and Critical Care

Evaluation of cerebrospinal fluid

(CSF) composition on spinal

anaesthesia characteristics in diabetic

patients with 0.5% hyperbaric

bupivacaine.

Approved subject to:

specification of CSF composition to be studied in title and methodology

inclusion of the element of comparison in title

ethical clearance

6 Investigator: Dr. Praveen Talawar, Assistant Professor, Anesthesiology Co-Investigators: Dr. Pankaj Kundra, Professor and Head, Anesthesiology and Critical Care

Comparison of post-operative pain scores in patients undergoing elective and emergency caesarian section - prospective observational study

Approved subject to:

addition of GA in exclusion criteria

inclusion of sample size determination method

inclusion of operative procedures and designations of surgeons in variables noted

ethical clearance

7. Investigators: Dr. T S Ravikumar, Director, JIPMER Dr. Sitanshu Sekhar Kar, Assistant Professor, PSM Co-Investigators Dr A K Das, Senior Professor and Head, Endocrinology TNHSP, IIT Chennai (confidentiality agreement;IP) Dr. Sadeesh@ Kamalnathan, Assistant Professor, Endocrinology

Creating Diabetes Care Continuum: Stratified Modes of Care & Use of Care – Bundle in Selected Population of Puducherry and Tamilnadu

Approved subject to:

ethical clearance

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Dr. Subitha L, Senior Resident, PSM

8. Investigators: Dr. T S Ravikumar, Director, JIPMER Dr. Sitanshu Sekhar Kar, Assistant Professor, PSM Co-Investigators Dr. Anita Rustogi, Additional Medical Superintendent Dr.J. Balachander, Medical Superintendent & Senior Professor, Cardiology Dr. KC Premarajan, Professor, PSM Dr. Subitha L, Senior Resident, PSM

Impact Evaluation of Chief Minister’s Comprehensive Health Insurance Scheme in Tamil Nadu

Approved subject to:

ethical clearance

9.

Investigator: Dr. Priyamvada P.S., Assistant Professor, Nephrology Co-Investigators Dr. Sreejith Parameswaran, Assistant Professor, Nephrology Dr. Sandeep Morkhanikar, Senior Resident, Nephrology Mr. K T Harichandrakumar, Lecturer, Statistics & Demography

Assessment of Health Related Quality of Life and its determinants in patients with Chronic Kidney Disease

Approved subject to:

inclusion of method of translation of questionnaire into Tamil

standardized administration of questionnaire

consultation with PSM department

ethical clearance

10. Investigator: Dr. Priyamvada P.S., Assistant Professor, Nephrology Co-Investigators: Dr. Sreejith Parameswaran, Assistant Professor, Nephrology Dr. Jayasurya, Senior Resident, Nephrology Dr. Sadish Kumar, Assistant Professor, Nephrology

Body composition analysis in predialysis Chronic Kidney Disease patients and its association with conventional markers of malnutrition in south Indian patients – A pilot study

Approved subject to:

considering inclusion of computerized body fat analysis as a companion study

ethical clearance

11. Investigator: Dr. Kalayarasan R. C., Assistant Professor, Surgical Gastroenterology Co-Investigators: Dr. Vikram Kate, Professor and Head, Surgical Gastroenterology

Can early estimation of drain fluid amylase predict pancreatic fistula following pancreatic surgery

Approved subject to:

making it a pilot study

ethical clearance

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Dr. Biju Pottakkat, Assistant Professor, Surgical Gastroenterology

12 Investigator: Dr. Ajith Ananthakrishna Pillai, Assistant Professor, Cardiology Co-Investigators: Dr.J. Balachander, Medical Superintendent & Senior Professor, Cardiology Dr Chandramohan R, Senior Resident, Cardiology

Intravascular Ultrasound and Virtual Histology Analysis of High Risk Atherosclerotic Plaques in Young Indian Patients with Acute Coronary Syndrome – Understanding Atherosclerosis in Young Indians (UAYI)

Approved subject to:

leaving out the phrase

“high risk” from title

considering inclusion of

correlation with suitable

markers of endothelial

inflammation

ethical clearance

13 Investigator: Dr. Sonali Sarkar, Assistant Professor, PSM Co-Investigators: Dr. KC Premarajan, Professor, PSM Dr. Dilip Maurya, Assistant Professor, Obs & Gyn Dr. Subitha L, Senior Resident, PSM

Morbidity Status of Women of the Reproductive Age Group in Pondicherry – A Follow – up Study

Approved subject to:

modification of title to match objectives

coordination with other groups/ agencies working in community

ethical clearance

14 Investigator: Dr. Balasubramaniyan Vairappan, Scientist D, Biochemistry

Investigation of Nostrin on the regulation of NO bioavailability in the pathogenisis of liver disease

Approved subject to:

replacement of the phrase “ liver disease” with specific conditions in title

inclusion of justification for use of two animal models

ethical clearance

15 Investigator: Dr. Balasubramaniyan Vairappan, Scientist D, Biochemistry Co-Investigators: Dr. Sridhar, Professor and Head, Biochemistry

Effect of Candesartan Cilexetil on the modulation of ADMA – DDAH axis in the pathogenesis of hepatorenal syndrome

To be resubmitted with:

revision of hypothesis

revision of objectives and

text in view of differences

between submitted and

presented version

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16 Investigator: Dr. Nataraj.A.R., Assistant Professor, Orthopedics Co-Investigators: Dr. Navin Kumar, Assistant Professor, PMR Mr.J. Mohanakrishnan, Junior Physiotherapist, PMRC Ms. Bhanumathy Mohanakrishnan, Junior Physiotherapist, PMRC Ms. Salaja, Junior Physiotherapist, PMRC

Short term effects of shortwave Diathermy versus therapeutic ultra sound in pain reduction and functional improvement in middle aged patients with Painful arc syndrome in Indian population

To be resubmitted with:

addition of patients requiring urgent surgical treatment in exclusion criteria

inclusion of sample size determination method

inclusion of randomization details, standardized analgesic therapy and outcome measures and clarification of therapy regimen

considering crossover in nonresponders

following CONSORT criteria

17 Investigator: Dr.Swaroop Kumar Sahu, Assistant Professor, PSM Co-Investigator: Dr,Gautam Roy, Professor and Head, PSM

Surveillance System for Injuries in Primary Care Settings in Pondicherry

To be resubmitted with:

inputs from organizers and experts of “Registry Workshop” of “International Summit on Emergency & Trauma”, JIPMER

18 Investigator: Dr.R.Soundravally, Assistant Professor, Biochemistry Co-Investigators: Dr.Rahul Dhodapkar, Assistant Professor, Microbiology Dr. T.Kadhiravan, Assistant Professor, Medicine Dr. P.Narayanan, Assistant Professor, Pediatrics

Assessment of Platelet membrane fluidity, its functional properties and early markers of coagulopathy in dengue/DHF patients for disease prognosis

Approved subject to:

ethical clearance

19 Investigator: Dr. R.Aravind, Associate Professor, Surgical Oncology Co-Investigator: Dr. Shyama Gopalakrishnan, Associate Professor, Radiotherapy

Feasibility of Video Assisted Thoracoscopic Esophagectomy Following Neoadjuvant Chemoradiotherapy for Carcinoma of the Esophagus

Not presented

20 Investigator: Dr. R.Aravind, Associate Professor, Surgical Oncology Co-Investigators:

Identification of biomarkers that predict lymph node metastasis in oral squamous cell carcinoma

Not presented