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ISSUE YEAR VOLUME

Newsletter Pharmacy

News and Views:

No. 1 Dec 2017

School of Pharmacy wins Postgraduate Course of the Year in Health Science at the gradireland Higher Education Awards in November 2016. UCC’s MSc in Clinical Pharmacy has won Postgraduate Course of the Year in the Health Sciences category

at the gradireland Higher Education Awards in 2016. The win was announced at a gala lunch in the Crowne Plaza, Blanchardstown, Dublin. The gradireland Higher Education Awards were created in partnership with the HEA and recognise and celebrate excellence in postgraduate course provision. These Awards are now widely recognised and firmly established with Higher Education Institutes and other stakeholders across Ireland and internationally. Courses are judged on criteria such as employability, the student experience, innovation, research record of academic staff, reputation and recognition of the programme.

Pharmacy & Pharmacology ranked in the top 100 in the QS World Rankings by Subject UCC School of Pharmacy is delighted to be ranked in the top 100 disciplines by subject in the latest QS World University Rankings. Pharmacy was one of two disciplines (along with the School of Nursing & Midwifery) in UCC to be ranked in the top 100 by subject area worldwide. The rankings are based upon measures of research impact and academic and employer reputation. Professor Stephen Byrne, Head of School of Pharmacy and Chair in Clinical Pharmacy Practice

said in reaction to the Rankings: “I am happy that yet again we feature so highly in the QS

world rankings and to see the influence that Pharmacy and Pharmacology in UCC have on a

global basis. I am also pleased to see the research endeavours of colleagues and collaborators

within UCC being recognised for their dedication and commitment. It is even more welcome

to the School, as it is implementing it five- year integrated MPharm degree which started in

September 2015.”

Research & Teaching Excellence

School of Pharmacy Researchers publish in New England Journal of Medicine as part of a major European Study entitled “Thyroid Hormone Replacement for Subclinical Hypo-Thyroidism Trial (TRUST)” in 2017. This collaborative European research project included experts in ageing, thyroid problems and vascular disease, investigating current treatment practices for people who suffer from a mildly underactive thyroid gland. The study was led by Professor David Stott from Scotland with major input from researchers in Ireland including Prof. Patricia Kearney (Dept. of Epidemiology & Public Health), Prof. Stephen Byrne, Maria Kelly and Kieran Walsh (School of Pharmacy) as well as colleagues from Dept. of Epidemiology & Public Health, School of Nursing & Midwifery and the Dept. of General Practice, UCC and Health research Board Clinical Research Facility, Mercy Hospital. The study was funded by the European Union.

Stott et al. 2017. Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism. New Eng J Med. 376(26):2534-2544

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The 5th general meeting of Trans-Int, an EU Framework 7 Consortium,

took place in the School of Pharmacy in April 2016. Over 45 scientists,

postdoctoral researchers and PhD students took part in discussions relating

to formulation of nanomedicines for oral administration. The program also

included a training session for PhD students, where talks by Prof John

F Cryan, UCC and Dr Niamh Curran, HPRA, and a workshop on ‘transitioning

to the workplace’ by Elizabeth Cox and Deirdre Parker, Student

Development and Employability UCC, were presented. The meeting was also

attended by representatives from the Industry partners, Sanofi, Paris and

Sigmoid Pharma Ireland.

Students of Postgraduate Certificate in (Bio)Pharma Processing graduated in November 2016. The PG Cert was designed by School of Pharmacy staff, Drs Abina Crean, Katie Ryan and Eoin Fleming in conjunction with the Adult Education Centre and Careers Services, UCC to facilitate science or engineering graduates to transition into employment in the (Bio)Pharma sector. The programme was funded through the government initiative Springboard (www.springboardcourses.ie). During the programme the students were provided with a practical and theoretical understanding of the processes involved in (Bio)Pharma manufacture. Practical sessions were delivered in the state of the art pilot scale facilities in the School of Pharmacy and National Institute for Bioprocessing Research and Training (NIBRT), Dublin. A key element of the programme was supporting participants with career coaching and job readiness.

Dr Christian Waeber received HRB funding for preclinical stroke studies. A

preclinical study aimed at establishing the potential of fingolimod as an acute

stroke therapeutic agent was recently funded by the Health Research Board.

Stroke is the third most common cause of death and the most common cause of

acquired physical disability in Ireland. The only available drug, recombinant

tissue plasminogen activator (tPA), can only be used in a small minority of

patients. Thus, the need for an effective and easily administered treatment

remains paramount. Dr Waeber and others have found that fingolimod is

effective in several rodent stroke models. Such findings and the fact that

fingolimod is already licensed for another neurological indication (multiple

sclerosis) suggest that fingolimod is one of the most compelling candidates ever

characterized in stroke models. But hundreds of drugs effective in animals have

failed to show efficacy in humans; this has greatly raised the bar to justify the

considerable expenses and risks of a clinical trials. In his project, Dr Waeber

therefore proposes to implement recommendations issued by stroke experts to

decrease the gap between preclinical and clinical studies.

Gold for UCC team at International Synthetic Biology Competition in November 2016. Pharmacy student Brandon Malone (pictured centre) recently led an undergraduate research team to win a gold medal at a prestigious international synthetic biology competition. The academic mentors on the project were Dr Cormac Gahan (from the School of Pharmacy) and Dr Mark Tangney (Cork Cancer Research Centre) and the team also included pharmacy students Kevin Ryan and Donnacha Fitzgerald (pictured standing centre-left). The “Limited Lactis” team focused upon the development of novel vaccines and competed in the prestigious iGEM (international Genetically Engineered Machine) Jamboree in Boston. More than 600 teams from the top universities in the world, including MIT, Harvard, Stanford, Cambridge and Oxford took part in the competition which is held up as the gold standard for “research-led education”.

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Laura Daly, class of 2016, was awarded 3rd prize for her poster presentation at the

TOPRA annual symposium in September 2016. Laura presented research conducted

as part of her final year project entitled “Evolution of regulatory guidelines for

combination medical devices - current requirements, future directions”. Her project

was supervised by Dr Katie Ryan, School of Pharmacy, UCC. Laura is currently

undertaking her internship at the HPRA.

PhD students Aoife McGillicuddy and Carol McCarthy promoting science at the National

Ploughing Championships in 2016. They spent a busy day showing scientific 'magic' tricks

to young and old! As part of the SSPC team (www.sspc.ie) they were based in the SFI tent.

With over 283,000 attendees, the National Ploughing Championships is Europe's largest

outdoor exhibition and agricultural trade show and a great place to promote the wonders of

science to the public.

Continuing success for School of Pharmacy Postgraduate students in the University's ‘Science for All’ competition in which PhD students explain their work to the public in front of a large audience. The 2016 competition was won by Carol McCarthy from the School of Pharmacy (left), with her talk ‘Sense and Solubility; Using Silica to Make New Medicines for Patients’. In the 2017 competition School of Pharmacy PhD student Elaine Enright (right) made the grand final with her presentation on ‘Gut Bacteria and Medicines: “Bugging” you to Keep your Health “Afloat” ‘ . Wishing all contestants the best of luck in the 2018 competition…..

The School of Pharmacy hosted its Second Clinical Pharmacy Summer School in August 2017 The School of Pharmacy, UCC and Future University in Egypt (FUE) signed a co-operation agreement in 2014 which has led to the development of the Clinical Pharmacy Summer School, hosted in UCC for the second time this year. The two-week Summer School was attended by 26 undergraduate students from FUE who travelled to Cork to take part in the programme. The students were accompanied by three staff members from FUE, including Professor Nabila El Maraghy, Ms Dina Khaled Aboelfadl and Mr Mahmoud Fathy Ibrahim. The Summer School was led by Dr Margaret Bermingham and delivered by staff members in the School of Pharmacy in collaboration with colleagues from the Pharmacy Departments of Mercy University Hospital, Cork University Hospital and Boots Pharmacy. The Summer School taught clinical pharmacy through interactive workshops, small group teaching and experiential clinical visits to practice settings. The focus was on the role of the clinical pharmacist in caring for patients with chronic conditions such as cardiovascular and respiratory disease.

The School of Pharmacy, UCC hosts 39th All Ireland Schools of Pharmacy Research Conference in April 2017. Approximately 100 delegates attended the 39th All Ireland Schools of Pharmacy Research Conference hosted by The School of Pharmacy and supported by the IPU and Fáilte Ireland on 24 and 25 April 2017. The attendees comprised postgraduate students and faculty from all five Schools of Pharmacy in Ireland; UCC, Royal College of Surgeons in Ireland, Trinity College Dublin, Queen's University Belfast and Ulster University. A total of 64 abstracts were included in the conference programme, with 26 oral presentations from postgraduate students scheduled over the two days. This year's conference programme also included two keynote speakers; Professor Joe Eustace, H.R.B Clinical Research Facility, UCC; and Professor Patricia Kearney, Department of Epidemiology & Public Health, UCC.

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The School of Pharmacy hosts first Annual Meeting of PEARRL EU training network in June 2017. UCC’s School of Pharmacy and the PEARRL EU training network recently jointly organised the first Regulatory Science Symposium which provided attendees with a unique opportunity to discuss regulatory support of innovation in Europe’s pharmaceutical industry. The exciting programme included presentations from experts in industry, academia and regulatory bodies from all over Europe on the following topics:

Regulatory pathways adapting to innovation

Strategies of regulatory bodies to enhance support for the development of medicines

Innovation in clinical trials and drug manufacture. PEARRL (Pharmaceutical Education And Research with Regulatory Links) is a European Training Network (ETN) for innovative drug formulation strategies and biopharmaceutics tools with regulatory application. The PEARRL ETN brings together 18 leading European institutions and is co-ordinated by Dr Brendan Griffin from the School of Pharmacy, University College Cork (UCC). The programme is funded (€4 million) under the European Union’s Horizon 2020 research and innovation programme (Marie Sklodowska-Curie actions). The PEARRL project brings together European Pharma industry, academia and regulatory agency partners in a multi-sectorial team to deliver a unique research and training programme, enabling 15 early stage researchers to focus their efforts on this complex paradigm for the next four years.

2016/17 Energy Performance: Originally as part of the SEAI “Engaging People” program, now the Saver Saves scheme, the Cavanagh building was piloted for the transfer of the energy budget to the School. The SOP, with the assistance of the B&E department, is determined to be involved in reducing energy consumption. The energy saving projects already implemented in 2017 include:

Installation of new air compressor with an expected 3.5% saving of Cavanagh building’s energy consumption

Lighting control upgrade for 24 office areas

Successful trials completed on fumehood set back operation

Temperature setback for lab & lecture room areas, reducing the overnight energy requirement

The fumehood speed control roll out project is scheduled for the coming year.

Dr Waleed Faisal, a postdoctoral researcher at the School of Pharmacy, was awarded best poster prize at the 3rd Annual, Pharmaceutical Manufacturing Technology Centre (PMTC), Knowledge Day, University of Limerick, August 2017. His poster entitled Software to support formulation development detailed basic decision tools to aid formulation scientists identify appropriate tabletting approaches based on drug substance properties.

Pharmacy students win awards from National University of Ireland (NUI). Congratulations to Radek Zuk and Fiona O'Regan, winners of the Dr H H Stewart award in Pharmacy. The Dr H H Stewart Medical Scholarships and Prizes are awards are based on examination results in the Faculties and Schools of Medicine and Nursing of the constituent universities, the Royal College of Surgeons in Ireland and St. Angela’s College, Sligo.

Congratulations to our 2017 SoP UCC

Quercus Scholars. The Quercus Talented

Students’ Programme is aimed at

supporting and promoting excellence in

academia, sport, creative and performing

arts, active citizenship and innovation/

entrepreneurship for both prospective

undergraduate/level 8 students and

students already registered in UCC.

Photo (left to right) Ms Ciara O'Connell; Mr

Jack Murray; Ms Róisín Mc Carthy; Ms

Lauren Kennedy; Rebecca Sealy with Dr

Margaret Bermingham, School of

Pharmacy.

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Researchers Corner: Featured Researcher – Dr Habib Baghirov

POSITION: POSTDOCTORAL RESEARCHER SUPERVISORS: PROF. CAITRIONA O’DRISCOLL, PROF. JOHN CRYAN

Originally a medical doctor from Azerbaijan, I spent several years working in medical research in my home country before moving to Finland in 2010. There I enrolled in a MS Program in Biomedical Imaging and proposed to investigate nanoparticle transport across the blood-brain barrier. After graduating in 2012, I researched cell invasion in cancer, using a number of imaging techniques and high-content screening. In 2013, I moved to Norway, to do a PhD in brain nanomedicine. My project employed multiple imaging modalities and, at the final stage, advanced medical technology. I now continue investigating nanoparticle transport across the blood-brain barrier as a postdoctoral researcher in Ireland. My key research interest is nanocarrier-based drug delivery to the brain, and my main expertise is in biomedical imaging. In my postdoctoral project at UCC, I work on the delivery of cyclodextrin-based nanoparticles across the blood-brain barrier in

glioblastoma treatment. Glioblastoma is a primary brain cancer with dismal prognosis; its treatment is complicated by tumor

heterogeneity and restricted access to diseased cells due to the presence of the blood-brain barrier. Novel therapeutic

strategies and delivery methods are clearly needed. The nanoparticles I am using are loaded with nucleic acids intercepting

cancer cell signaling and targeted for crossing the blood-brain barrier and entering diseased cells. The project involves in vitro

and in vivo studies, and its ultimate goal is to deliver these biopharmaceuticals into the brain to improve therapeutic outcome

in glioblastoma.

Congratulations to the School of Pharmacy Graduating Class of 2017. Good luck to all the class for very bright futures at home and abroad. We will be watching your careers with pride.

Gary O’Brien awarded the title of “Perrigo Young Pharmacist of the Year 2017". Gary represented the School of Pharmacy at the Clanwilliam Pharmacist Awards, Mansion House, Dublin. The School was thrilled to have had a high number of nominee finalists in various categories.

Congratulations to Senior Camogie team All Ireland Champions 2017. Huge congratulations to Amy O'Connor, Niamh McCarthy, Keeva McCarthy, and the Senior Camogie team on their impressive win against Kilkenny in the 2017 O’Duffy Cup finals. The School was delighted to welcome the Cup to the Cavanagh Pharmacy Building last October.

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Publications 2016 Tumwesigye K.S.; Peddapatla R.V. G.; Crean A.; Oliveira J.C. & Sousa-Gallagher M.J. (2016) 'Integrated process standardisation as zero-based approach to bitter cassava waste elimination and widely-applicable industrial biomaterial derivatives'. Chemical Engineering and Processing: Process Intensification, 108 :139-150 [DOI] [Details] Ji JF;Fitzpatrick J; Cronin K; Crean A; Miao S (2016) 'Assessment of measurement characteristics for rehydration of milk protein based powders'. Food Hydrocolloids, 54 :151-161 [DOI] [Details] Vrdoljak A; Allen EA; Ferrara F, Temperton NJ; Crean AM; Moore AC (2016) 'Induction of broad immunity by thermostabilised vaccines incorporated in dissolvable microneedles using novel fabrication methods'. Journal of controlled release : official journal of the Controlled Release Society [DOI][Details] McGillicuddy A; Kelly M; Sweeney C; Carmichael A; Crean AM; Sahm LJ (2016) 'Modification of oral dosage forms for the older adult: an Irish prevalence study'. International Journal of Pharmaceutics [DOI] [Details] Enright E.F.; Gahan C.G; Joyce M; S.A.; Griffin B.T. (2016) 'The Impact of the Gut Microbiota on Drug Metabolism and Clinical Outcome'. YALE JOURNAL OF BIOLOGY AND MEDICINE, 89 [CORA Link] [Details] Cushen SJ; Power DG; Murphy KP; McDermott R; Griffin BT; Lim M; Daly L; MacEneaney P; O'Sullivan K; Prado CM (2016) 'Impact of body composition parameters on clinical outcomes in patients with metastatic castrate-resistant prostate cancer treated with docetaxel'. Clinical Nutrition ESPEN, 13 [Details] Evans J.C.; Malhotra M.; Guo J.; O'Shea J.P.; Hanrahan K.; O'Neill A.; Landry W.D.; Griffin B.T.; Darcy R.; Watson R.W.; O'Driscoll C.M. (2016) 'Folate-targeted amphiphilic cyclodextrin.siRNA nanoparticles for prostate cancer therapy exhibit PSMA mediated uptake, therapeutic gene silencing in vitro and prolonged circulation in vivo'. Nanomedicine, 12 (8):2341-2351 [DOI] [Details] Niu Z; Conejos-Sánchez I; Griffin BT; O'Driscoll CM; Alonso MJ (2016) 'Lipid-based nanocarriers for oral peptide delivery'. Advanced Drug Delivery Reviews [Details] Griffin B.T; Guo J.; Presas E.; Donovan M.D.; O'Driscoll C.M. (2016) 'Pharmacokinetic, Pharmacodynamic and Biodistribution following oral administration of nanocarriers containing peptide and protein drugs'. Advanced Drug Delivery Reviews [DOI] [Details] Donovan MD; Boylan GB; Murray DMC; Ryan JF; Griffin BT; (2016) 'Treating disorders of the neonatal central nervous system: pharmacokinetic and pharmacodynamic considerations with a focus on antiepileptics'. British Journal of Clinical Pharmacology, 81 (1) [DOI] [Details] Donovan MD; Schellekens H; Boylan GB; Cryan JE; Griffin B.T. (2016) 'In vitro bidirectional permeability studies identify pharmacokinetic limitations of NKCC1 inhibitor bumetanide'. European Journal of Pharmacology, 770 :117-125 [DOI] [Details] Keohane K.; Rosa M.; Coulter I.S.; Griffin B. T. (2016) 'Enhanced colonic delivery of ciclosporin A self-emulsifying drug delivery system encapsulated in coated minispheres'. Drug Development and Industrial Pharmacy, 42 (22):245-253 [Details] Donovan, M.D.; Griffin, B.T.; Kharoshankaya, L.; Cryan, J.F.;Boylan, G.B. (2016) 'Pharmacotherapy for Neonatal Seizures: Current Knowledge and Future Perspectives'. Drugs, 76 (66):647-61 [CORA Link] [Details] O'Brien F.E.; O'Connor R.M.; Clarke G.; Dinan T.G.; Griffin B.T.; Cryan J.F. (2016) 'Effect of P-Glycoprotein Inhibition on the Brain Distribution and Antidepressant-Like Activity of Escitalopram in Rodents'. Irish Journal of Medical Science, 185 Donovan M.D.; Schellekens H.; Boylan G.B.; Cryan J.E.; Griffin B.T. (2016) 'In vitro bidirectional permeability studies identify pharmacokinetic limitations of NKCC1 inhibitor bumetanide'. European Journal of Pharmacology, 770 :117-125

Evin Allen (A Moore/A Crean) Shane Cullinan (S Byrne/D O’Mahony) Rena Creedon (S Byrne/S McCarthy) Maria Donovan (B Griffin/J Cryan/G Boylan) James Evans (C O’Driscoll) Kathleen Fitzgerald (C O’Driscoll) James Gallagher (S Byrne/S McCarthy) Maria Kelly (S McCarthy/L Sahm/R O’Sullivan/F Shiely)

PhD Successes Since January 2016

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Publications continued Pereira-Fantini PM; Bines JE; Lapthorne S; Fouhy F; Scurr M; Cotter PD; Gahan CG; Joyce SA; (2016) 'Short bowel syndrome (SBS)-associated alterations within the gut-liver axis evolve early and persist long-term in the piglet model of short bowel syndrome'. Journal of gastroenterology and hepatology Nolan JA; Kinsella M; Hill C; Joyce SA; Gahan CG; (2016) 'Analysis of the Impact of Rosuvastatin on Bacterial Mevalonate Production Using a UPLC-Mass Spectrometry Approach'. Current Microbiology, 73 (1) Dowd GC; Bahey-El-Din M; Casey PG; Joyce SA; Hill C; Gahan CG; (2016) 'Listeria monocytogenes mutants defective in gallbladder replication represent safety-enhanced vaccine delivery platforms'. Human Vaccines & Immunotherapeutics Broaders E; O'Brien C; Gahan CG; Marchesi JR; (2016) 'Evidence for plasmid-mediated salt tolerance in the human gut microbiome and potential mechanisms'. Fems Microbiology Ecology, 92 (3) Govindarajan Kalaimathi; MacSharry John; Casey Patrick G.; Shanahan Fergus; Joyce Susan A.; Gahan Cormac G. M. (2016) 'Unconjugated bile acids influence expression of circadian genes: a potential mechanism for microbe-host crosstalk'. Plos One, 11 (1212):e0167319-1-e0167319-13 Joyce SA; Gahan CG; (2016) 'Bile Acid Modifications at the Microbe-Host Interface: Potential for Nutraceutical and Pharmaceutical Interventions in Host Health'. Annual Review Of Food Science And Technology, Vol 1, 7 Casey A; McAuliffe O; Fox EM; Leong D; Gahan CG; Jordan K; (2016) 'Draft Genome Sequences of Listeria monocytogenes Serotype 4b Strains 944 and 2993 and Serotype 1/2c Strains 198 and 2932'. Genome Announcements, 4 (3) Nzakizwanayo J; Hanin A; Alves DR; McCutcheon B; Dedi C; Salvage J; Knox K; Stewart B; Metcalfe A; Clark J; Gilmore BF; Gahan CG; Jenkins AT; Jones BV; (2016) 'Bacteriophage Can Prevent Encrustation and Blockage of Urinary Catheters by Proteus mirabilis'. Antimicrobial Agents and Chemotherapy, 60 (3) Rao Khandavilli U.B.; Lusi M.; Bhogala B.R.; Maguire A.R.; Stein M.; Lawrence S.E.; (2016) 'Diversity in a simple co-crystal: racemic and kryptoracemic behaviour'. Chemical Communications, 52 (53):8309-8312 Mccaw PG; Buckley NM; Collins SG; Maguire AR (2016) 'Generation, Reactivity and Uses of Sulfines in Organic Synthesis'. European Journal of Organic Chemistry, :1630-1650 Mullins ND; Maguire NM; Ford A; Das K; Arnold E; Balzarini J; Maguire AR (2016) 'Exploring the role of the alpha-carboxyphosphonate moiety in the HIV-RT activity of alpha-carboxy nucleoside phosphonates'. Organic & Biomolecular Chemistry, 14 (8):2454-2465 Deadman BJ; O'Mahony RM; Lynch D; Crowley DC; Collins SG; Maguire AR (2016) 'Taming tosyl azide: the development of a scalable continuous diazo transfer process'. Organic & Biomolecular Chemistry, 14 (13):3423-3431 Mullins Nicholas D.; Deadman Benjamin J.; Moynihan Humphrey A.; McCarthy Florence O.; Lawrence Simon E.; Thompson Jonathan; Maguire Anita R (2016) 'The impact of storage conditions upon gentamicin coated antimicrobial implants'. Journal of Pharmaceutical and Biomedical Analysis, Volume 6, December 2016 (Issue 6):374-381 Gooding M.; Malhotra M.; Evans JC.; Darcy R.; O’Driscoll CM (2016) Oligonucleotide conjugates – candidates for gene silencing therapeutics. European Journal of Pharmaceutics and Biopharmaceutics, 107:321-340. Fitzgerald KA.; Guo J.; Raftery RM.; Mencía Castaño I.; Curtin CM.; Gooding M.; Darcy R.; O’Brien FJ.; O’Driscoll CM (2016) Nanoparticle-mediated siRNA delivery in a 3D co-culture model simulating prostate cancer bone metastasis. Int. J. Pharmaceutics, 511(2):1058-1069. Evans JC.; Malhotra M.; Fitzgerald KA.; Guo J; Cronin MF.; Curtin CM.; O'Brien FJ.; Darcy R.; O'Driscoll CM. (2016) Formulation and Evaluation of Anisamide-Targeted Amphiphilic Cyclodextrin Nanoparticles To Promote Therapeutic Gene Silencing in a 3D Prostate Cancer Bone Metastases Model. Mol. Pharm., DOI: 10.1021/acs.molpharmaceut.6b00646 Guo J.; McKenna SL.; O’Dwyer ME.; Cahill MR.; O’Driscoll CM. (2016) RNA interference for multiple myeloma therapy: targeting signal transduction pathways. Expert Opinion On Therapeutic Targets, 20(1): 107-21. http://dx.doi.org/10.1517/14728222.2015.1071355

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Publications continued O’Reilly Kate; Gupta Manoj K.; Gandhi Hirenkumar; Kumar Vydyula P.; Eccles Kevin S.; Lawrence Simon E.; O’Sullivan Timothy P. (2016) 'Cinchona-catalysed, Enantioselective Synthesis of β-Peroxycarboxylic Acids, β-Peroxyesters and β-Peroxyalcohols'. Current Organic Chemistry, 20 (24):2633-2638 Marshall Sarah; Sahm Laura J.; Moore Anne C. (2016) 'Microneedle technology for immunisation: Perception, acceptability and suitability for paediatric use'. Vaccine, 34 (66):723-734 Gillicuddy Aoife; Kelly Maria; Sweeney Catherine; Carmichael Ann; Crean Abina; Sahm Laura J. (2016) 'Modification of oral dosage forms for the older adult: an Irish prevalence study'. International Journal of Pharmaceutics Klionsky DJ; Waeber C; et al (2016) 'Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)'. Autophagy, 12 (1):1-222 O'Mahony A. M.; Griffin B. T.; and O'Driscoll C. M. (2016) ''Oral delivery of macromolecules – highlighting the challenges to maximize opportunities'' In: Advances and challenges in the oral delivery of macromolecules. Unitec House, 2 Albert Place, London, N3 1QB, UK: Future Science Ltd Münzner M; Tappenbeck N; Gembardt F; Rülke R; Furkert J; Melzig MF; Siems WE; Brockmann GA; Walther T; (2016) 'Green Tea reduces body fat via upregulation of neprilysin'. International journal of obesity (2005) Sahr A; Wolke C; Maczewsky J; Krippeit-Drews P; Tetzner A; Drews G; Venz S; Gürtler S; van den Brandt J; Berg S; Döring P; Dombrowski F; Walther T; Lendeckel U (2016) 'The Angiotensin-(1-7)/Mas axis improves pancreatic ß-cell function in vitro and in vivo'. Endocrinology Meinert C; Gembardt, F; Bohme I; Tetzner A; Wieland T; Greenberg B; Walther T (2016) 'Identification of intracellular proteins and signaling pathways in human endothelial cells regulated by angiotensin-(1-7)'. Journal of Proteomics, 130 :129-139 Schouten LR; Helmerhorst HJ; Wagenaar GT; Haltenhof T; Lutter R; Roelofs JJ; van Woensel JB; van Kaam AH; Bos AP; Schultz MJ; Walther T; Wösten-van Asperen RM; (2016) 'Age-Dependent Changes in the Pulmonary Renin-Angiotensin System Are Associated With Severity of Lung Injury in a Model of Acute Lung Injury in Rats'. Critical Care Medicine Tetzner A; Gebolys K; Meinert C; Klein S; Uhlich A; Trebicka J; Villacanas O; Walther T (2016) 'G-Protein-Coupled Receptor MrgD Is a Receptor for Angiotensin-(1-7) Involving Adenylyl Cyclase, cAMP, and Phosphokinase A'. Journal of Hypertension, 68 :185-194 Gallego-Delgado J; Basu-Roy U; Ty M; Alique M; Fernandez-Arias C; Movila A; Gomes P; Weinstock A; Xu W;Edagha I; Wassmer SC; Walther T; Ruiz-Ortega M; Rodriguez A (2016) 'Angiotensin receptors and ß-catenin regulate brain endothelial integrity in malaria'. Journal of Clinical Investigation, 126 (10) Auer-Grumbach M; Toegel S; Schabhüttl M; Weinmann D; Chiari C; Bennett DL; Beetz C; Klein D; Andersen PM; Böhme I; Fink-Puches R; Gonzalez M; Harms MB; Motley W; Reilly MM; Renner W; Rudnik-Schöneborn S; Schlotter-Weigel B; Themistocleous AC; Weishaupt JH; Ludolph AC; Wieland T; Tao F; Abreu L; Windhager R; Zitzelsberger M; Strom TM; Walther T; Scherer SS; Züchner S; Martini R; Senderek J (2016) 'Rare Variants in MME, Encoding Metalloprotease Neprilysin, Are Linked to Late-Onset Autosomal-Dominant Axonal Polyneuropathies'. American Journal of Human Genetics, 99 (3) Khan A, Wang Y; Schultheiss HP; Moreira MD; Walther T (2016) 'Role of monokine induced by interferon-gamma (MIG) in discrimination and prognosis of patients with Chagas' disease and idiopathic dilated cardiomyopathy'. Journal of cardiovascular pharmacology Supe S; Kohse F; Gembardt F; Kuebler WM; Walther T (2016) 'Therapeutic time window for angiotensin-(1-7) in acute lung injury'. British Journal of Pharmacology, 173 :1618-1628 Fitzgerald KA; Malhotra M; Gooding M; Sallas F; Evans JC; Darcy R; O'Driscoll CM (2016) 'A novel, anisamide-targeted cyclodextrin nanoformulation for siRNA delivery to prostate cancer cells expressing the sigma-1 receptor'. International Journal of Pharmaceutics, 499 :131-145

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Publications continued Evans JC.; Malhotra M.; Cryan JF.; O’Driscoll CM. (2016). The therapeutic and diagnostic potential of the prostate specific membrane antigen/glutamate carboxypeptidase II (PSMA/GCPII) in cancer and neurological disease. Brit. J. Pharmacol. DOI; http://www.ncbi.nlm.nih.gov/pubmed/27526115. Fitzgerald KA; Rahme K; Guo JF; Holmes JD; O'Driscoll CM (2016) 'Anisamide-targeted gold nanoparticles for siRNA delivery in prostate cancer - synthesis, physicochemical characterisation and in vitro evaluation'. Journal of Materials Chemistry B, 4 :2242-2252 Russell EG; Guo JF; O'Sullivan EC; O'Driscoll CM; McCarthy FO; Cotter TG (2016) '7-formyl-10-methylisoellipticine, a novel ellipticine derivative, induces mitochondrial reactive oxygen species (ROS) and shows anti-leukaemic activity in mice'. Investigational new drugs, 34 :15-23 Reen M; O'Sullivan TP (2016) 'The Application of Molecular Tethers in Controlling Axial Chirality'. Mini-Reviews in Organic Chemistry, 13 (3):206-218 Fleming Aoife; Barry Louise; Byrne Stephen; Prentice Michael. (2016) 'Antimicrobial susceptibility of long term care facility and general practice urine samples in patients 65 years and older: an observational study'. European Journal of Public Health

2017

Mc Gillicuddy A; Kelly M; Crean AM; Sahm LJ (2017) ‘The knowledge, attitudes and beliefs of patients and their healthcare professionals around oral dosage form modification: A systematic review of the qualitative literature’. Research in Social and Administrative Pharmacy 13 (4), 717-726 O’Driscoll M; Byrne S; Mc Gillicuddy A; Lambert S; Sahm LS (2017) ‘The effects of mindfulness-based interventions for health and social care undergraduate students–a systematic review of the literature’. Psychology, health & medicine 22 (7), 851-865 [DOI] [Details] Marshall S; Fleming A; Moore AC; Sahm LS (2017) ‘Acceptability of microneedle-patch vaccines: A qualitative analysis of the opinions of parents’ . Vaccine [DOI] [Details] Kelly M; LJ Sahm Shiely F; O’Sullivan R; de Bont EG; Mc Gillicuddy A; … (2017) ‘Parental knowledge, attitudes and beliefs on fever: a cross-sectional study in Ireland’. BMJ open 7 (7), e015684 [DOI] [Details] Raae-Hansen CR; Walsh EK; Bradley CP; Sahm LJ (2017) ‘Teaching Prescribing: Just What the Doctor Ordered? A Thematic Analysis of the Views of Newly Qualified Doctors’. Pharmacy 5 (2), 32 [DOI] [CORA Link] [Details] Raae-Hansen C; Byrne S; O'Mahony D; Kearney PM; Sahm LJ;… (2017) ‘Challenges of deprescribing in older patients with multimorbidity, from healthcare professionals' perspectives-a narrative review’. PHARMACOEPIDEMIOLOGY AND DRUG SAFETY 26, 16-17 Kelly M; Sahm LJ; Shiely F; O’Sullivan R; de Bont E; McGillicuddyA … (2017) ‘Parental fever knowledge insufficient for effective care: Opportunities for healthcare professionals’. Archives of Disease in Childhood 102 (Suppl 1), A26-A27 Kelly M; McCarthy S; O’Sullivan R; Shiely F; McGillicuddy A; Dahly D… (2017) ‘Parental fever knowledge: A randomised controlled trial to assess the effectiveness of an educational intervention to increase parental knowledge’. Archives of Disease in Childhood 102 (Suppl 1), A19-A19 Walsh EK; Raae-Hansen C; Sahm LJ; Kearney PM; Doherty E; Bradley CP (2017) ‘Economic impact of medication error: a systematic review’. Pharmacoepidemiology and Drug Safety 26 (5), 481-497 [Details] Gavin C; Carr B; Sahm LJ (2017) ‘A clinical and cost analysis of medication reconciliation by pharmacists at discharge from the acute medical assessment unit (AMAU) of a large urban teaching hospital’. Eur J Hosp Pharm 24 (Suppl 1), A72-A73 Michaelson M; Walsh E; Bradley CP; McCague P; Owens R; Sahm; LS (2017) Prescribing error at hospital discharge: a retrospective review of medication information in an Irish hospital’. Irish Journal of Medical Science (1971-), 1-6 [DOI] [Details]

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Publications continued Hansen CR;Byrne S;Cullinan S;O'Mahony D;Sahm LJ;Kearney PM; (2017) 'Longitudinal patterns of potentially inappropriate prescribing in early old-aged people'. European Journal of Clinical Pharmacology, [DOI] [Details] Ní Dhubhlaing C; Young A; Sahm LJ (2017) ‘Impact of Pharmacist Counselling on Clozapine Knowledge Schizophrenia’. Research and Treatment 2017 Kearney A; Halleran C; Walsh E; Byrne D; Haugh J; Sahm LJ; (2017) 'Medication Reviews by a Clinical Pharmacist at an Irish University Teaching Hospital'. Pharmacy (Basel, Switzerland), 5 (4) [DOI] [Details] Cullinan S; Raae-Hansen CR; Byrne S; O'Mahony D; Kearney P; Sahm LJ (2017) ‘Challenges of deprescribing in the multimorbid patient’. Eur J Hosp Pharm 24 (1), 43-46 1 [DOI] [Details] McCarthy CA; Faisal W; O'Shea JP; Murphy C; Ahern RJ; Ryan KB; et al. ‘In vitro dissolution models for the prediction of in vivo performance of an oral mesoporous silica formulation’. (2017) Journal of Controlled Release 250:86-95. [DOI] [CORA Link] [Details] Crowley ME; Hegarty A; McAuliffe MA; O'Mahony GE; Kiernan L; Hayes K; et al. (2017) ‘Near-infrared monitoring of roller compacted ribbon density: Investigating sources of variation contributing to noisy spectral data’. European Journal of Pharmaceutical Sciences 102:103-14 [DOI] [CORA Link] [Details] Keane SM; Culligan EP; Hoffmann RF; Gahan CG; Hill C; Snelling WJ; Sleator RD (2016) 'Shedding light on betL*: pPL2-lux mediated real-time analysis of betL* expression in Listeria monocytogenes'. Bioengineered, 7 Murphy KD; Lambert S;McCarthy S;Sahm LJ;Byrne S; (2017) 'You Don't Feel: The Experience of Youth Benzodiazepine Misuse in Ireland'. Journal of Psychoactive Drugs 1-8 [DOI] [Details] Riordan David O.; Byrne Stephen; Fleming Aoife; Kearney Patricia M.; Galvin Rose; Sinnott Carol (2017) 'GPs' perspectives on prescribing for older people in primary care: a qualitative study'. British Journal of Clinical Pharmacology, 83 (7):1521-1531 [DOI] [CORA Link] Walsh Kieran A.; Dennehy Rebecca; Sinnott Carol; Browne John; Byrne Stephen; McSharry Jennifer; Coughlan Eoin; Timmons Suzanne (2017) 'Influences on Decision-Making Regarding Antipsychotic Prescribing in Nursing Home Residents With Dementia: A Systematic Review and Synthesis of Qualitative Evidence'. Journal of the American Medical Directors Association, 18 (10) [DOI] [Details] Stott DJ; Rodondi N; Kearney PM; Ford I; Westendorp RG; Mooijaart SP; Sattar N; Aubert CE; Aujesky D; Bauer DC; Baumgartner C; Blum MR; Browne JP; Byrne S; Collet TH; Dekkers OM; den Elzen WP; Du Puy RS; Ellis G; Feller M; Floriani C; Hendry K; Hurley C; Jukema JW; Kean S; Kelly M; Krebs D; Langhorne P; McCarthy G; McCarthy V; McConnachie A; McDade M; Messow M; O'Flynn A; O'Riordan D; Poortvliet RK; Quinn TJ; Russell A; Sinnott C; Smit JW; Van Dorland HA; Walsh KA; Walsh EK; Watt T; Wilson R; Gussekloo J; TRUST Study Group (2017) 'Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism'. New England Journal of Medicine, [Details] Stott DJ; Gussekloo J; Kearney PM; Rodondi N; Westendorp RGJ; Mooijaart S; Kean S; Quinn TJ; Sattar N; Hendry K; Du Puy R;Den Elzen WPJ; Poortvliet RKE; Smit JWA; Jukema JW; Dekkers OM; Blum M; Collet TH; McCarthy V; Hurley C; Byrne S; Browne J; Watt T; Bauer D; Ford I (2017) 'Study protocol; Thyroid hormone Replacement for Untreated older adults with Subclinical hypothyroidism - a randomised placebo controlled Trial (TRUST)'. BMC Endocrine Disorders, 17 :1-17 [DOI] [Details] Muimhneachain; EO;Pardo; LM;Bateman; LM;Khandavilli; UBR;Lawrence; SE;McGlacken; GP (2017) 'Intramolecular Direct Arylation of 1,3-Diketone-Derived Enol Ethers in a Synthesis of Tricyclic Oxoisochromene Derivatives'. Advanced Synthesis and Catalysis, 359 :1529-1534 [DOI] [Details] O’Callaghan J; Bermingham M; Leonard M; Hallinan F; Morris JM; Moore U; Griffin BT. (2017) 'Assessing awareness and attitudes of healthcare professionals on the use of biosimilar medicines: A survey of physicians and pharmacists in Ireland'. Regulatory toxicology and pharmacology : RTP [Details] Geisler ME; Ledwidge M; Bermingham M; McAuliffe M; McMenamin MB; Waterstone J. (2017) 'Intrauterine insemination - No more Mr. N.I.C.E. guy?'. European Journal of Obstetrics & Gynecology and Reproductive Biology; (210):342-347 [Details]

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Verma Vivek; Peddapatla Raghu V. G.; Crowley Clare M.; Crean Abina M.; Davern, Peter; Hudson Sarah; and Hodnett Benjamin K. (2017) 'An Experimental Study on the Influence of Excipients on the Heterogeneous Crystallisation and Dissolution Properties of an Active Pharmaceutical Ingredient'. Crystal Growth & Design, [DOI] [Details] Peddapatla RVG; Ahmed MR; Blackshields CA; Sousa-Gallagher MJ; McSweeney S; Krüse J; Crean AM; Fitzpatrick D; (2017) 'Broadband Acoustic Resonance Dissolution Spectroscopy (BARDS) - A novel approach to investigate the wettability of pharmaceutical powder blends'. Molecular Pharmaceutics, [DOI] [Details] Blackshields Caroline A.; Crean Abina M. (2017) 'Continuous powder feeding for pharmaceutical solid dosage form manufacture: a short review'. Pharmaceutical Development And Technology, :1-7 [DOI] [CORA Link] [Details] Howick K; Alam R; Chruscicka B; Kandil D; Fitzpatrick D; Ryan AM; Cryan JF; Schellekens H; Griffin BT; (2017) 'Sustained-release multiparticulates for oral delivery of a novel peptidic ghrelin agonist: Formulation design and in vitro characterization'. International Journal of Pharmaceutics, 536 (1) [DOI] [Details] Howick Ken; Griffin Brendan; Cryan John; Schellekens Harriët (2017) 'From Belly to Brain: Targeting the Ghrelin Receptor in Appetite and Food Intake Regulation'. International Journal of Molecular Sciences, 18 (2) [DOI] [CORA Link] [Details] Balzarini Jan; Menni Michael; Das Kalyan; van Berckelaer Lizette; Ford Alan; Maguire Nuala M.; Liekens Sandra; Boehmer Paul E.; Arnold Eddy; Götte Matthias; Maguire Anita R. (2017) 'Guanine a-carboxy nucleoside phosphonate (G-a-CNP) shows a different inhibitory kinetic profile against the DNA polymerases of human immunodeficiency virus (HIV) and herpes viruses'. Biochemical Pharmacology 136 :51-61 [DOI] [CORA Link] [Details] O'Reilly K.; Gupta M. K.; Gandhi H.; Kumar VP.; O'Sullivan T. P. . (2017) 'Asymmetric Peroxidation of α,β-Unsaturated Aldehydes under Diarylprolinol Ether Catalysis'. Current Organic Chemistry, 21 (19):2013-2016 [DOI] [Details] Jones David J.; O'Leary Eileen M.; O'Sullivan Timothy P. (2017) 'Synthesis of symmetrically and unsymmetrically substituted S,S-dialkyl phosphonodithioates'. Tetrahedron Letters, 58 (44):4212-4214 [DOI] [Details] Gandhi H.; O'Sullivan T. P. (2017) 'Preparation of γ,δ-unsaturated-β-ketoesters: Lewis acid-catalysed CH insertion of ethyl diazoacetate into α,β-unsaturated aldehydes'. Tetrahedron Letters, 58 (36):3533-3535 [DOI] [Details] Gandhi H.; O'Reilly Kate; Gupta M.K.; Horgan C.; O'Leary E.M.; O'Sullivan T.P. (2017) 'Advances in the synthesis of acyclic peroxides'. RSC Advances, 7 (32):19506-19556 [DOI] [CORA Link] [Details] Sartawi Ziad; Schipani Ernestina; Ryan Katie B.; Waeber Christian (2017) 'Sphingosine 1-phosphate (S1P) signalling: role in bone biology and potential therapeutic target for bone repair'. Pharmacological Research, [DOI] [CORA Link] [Details]

2016 ''Oral delivery of macromolecules – highlighting the challenges to maximize opportunities'' O'Mahony, A. M., Griffin, B. T., and O'Driscoll, C. M. (2016) ''Oral delivery of macromolecules – highlighting the challenges to maximize opportunities'' In: Advances and challenges in the oral delivery of macromolecules. Unitec House, 2 Albert Place, London, N3 1QB, UK: Future Science Ltd. [DOI] [Details] Klionsky, DJ, ... Waeber, C, et al (2016) 'Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)'. Autophagy, 12 (1):1-222 [DOI] [Details]

2017 Maguire AR; Gavin D (2017) 'Chirality related to biocatalysis and enzymes in organic synthesis' In: F R Keene (eds). Chirality in Supramolecular Assemblies - Causes and Consequences. Chichester: John Wiley & Sons. [Details]

Book Chapters

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