The 4th Sabah Medical Research and Scientific Confer-ence (Sabah Research Day 2016) took place at Queen Elizabeth Hospital on 25 Oct 2016. Four speakers were invited to deliver keynote lectures before kicked the oral presentation competi-tion. Among the speakers were:

Dr Akmal Yusof (CEO of Clinical Research Malaysia)

- Spoke on current ISR status in Malaysia.

Dr Sheamini (Head of Health

Statistics Unit, CRC)

- Spoke on Malaysian Health Sys-tem Research (MHSR). It is an ongoing MOH collaborative re-search with The University of Har-vard to improve Malaysia health system. It was a great insight as Dr Sheamini shared us some yet-to-be published results of her ongoing work.

Associate Prof. Dr Ayub (Statistician from Universiti Brunei Darusalam)

- Delivered a lecture on research methodology. A short and sweet introductory lecture on research methodology to pro-mote awareness among the healthcare workers.

Ms Lim Wei Yin (Deputy Head of CRC Perak)

- A pharmacist and a clinical epidemiologist, Ms Lim shared her journey in research. Her story was inspiring, with a hint of “the road not taken” by Robert Frost!

S a b a h r e s e a r c h d a y 2 0 1 6

I N S I D E T H I S

I S S U E :

Highlights 1

Tuesday CME

NMRR and research registration

2

A visit from Director General of health

2

Budget Impact

Analysis Workshop 3

Introduction to

clinical research 4

Research update 5

Upcoming

Workshops 5

H O S P I T A L Q U E E N E L I Z A B E T H I I

CRC Newsletter PAGE 1 Issue 4,SEPT-OCT 2016

Su Lan happily receives her cash prize from Dr Ayub.

(From left ) 1st row :Su Lan, Roslin, Kartinah, Fatrinah, Dr Eunice, Bing Ling, Dr

Liau Siow Yen. 2nd row: Irene, Dr.Stephanie, Juhana, Dr.Yen Chia How

Congratulations to Su Lan! Congratulations to our very own QEH2 CRC pharmacist Su Lan for winning the third prize in oral presentation! Her research entitled “Transcultural adaptation and vali-dation of Atlanta Heart Failure Knowledge Test”. It was her first attempt to participate in oral presentation and this will definitely be a great motivation for her.

Next year, CRC QEH2 will be the main organizer of Sabah Research Day 2017. We encourage healthcare workers who are interested in research to kick start their pro-jects now. We shall see you in 2017!

2

P a g e 2 I s s u e 4 , S E P T - O C T 2 0 1 6

C o n t i n u i n g m e d i c a l e d u c a t i o n ( T u e s d a y

c m e C o n n e r )

29th of September was a memorable day where we received

warm visit from Malaysia’s Director General of Health Datuk

Dr Noor Hisham bin Abdullah. In conjunction with World Heart

Day 2016 celebration at hospital level. He visited cardiology

and Cardiothoracic Ward and Outpatient Clinic in QEH2. We

displayed 17 posters and he was very glad that a lot of

research was conducted in this hospital. He later posted this in

his facebook “This state of art facility and world class

personnel has made a tremendous difference to the public of

Sabah. I have heard this first hand from the patient I visited in

QEH2 ward.Thank you Sabah State Health Department and

Queen Elizabeth Hospital 2 for the hospitality“

Director General of Health’s visit to Queen Elizabeth Hospital II

Continuous medical education (Tuesday CME Corner)

NMRR Research Registration

Guidance

Dr.Liew is presenting CRC research poster to DG at Leve 8,QEH2

1. Creating An User Account 2. Accessing NMRR System

3. Purpose of Submission 4. Research Submission for Registra-

tion, Approval & Notification

Adopted from http://blogs.plos.org/absolutely-

maybe/2016/03/17/how-to-spot-research-spin-the-case-of-the-

not-so-simple-abstract/

Adopted from http://nih.gov.my/web/nmrr-research-registration-guidance/

Cardiac Care Unit, QEH 2

Written by, Dr. Fathiyah (CRC medical officer)

http://www.nih.gov.my/Registration%20Guidance_files/Registration%20Guidance.htmhttp://www.nih.gov.my/Registration%20Guidance_files/Registration%20Guidance.htm

3

This course will be organized 2 times in a year.

Speaker was Mr.James Ang, the QA and training manager

of World’s courier. He has more than 25 years’ experience

in International Transportation and Logistics from various

Multi-National Cooperations. 20 participants from all

around Malaysia took part in this course. Participants are

mainly from CRC, CRM, Clinical Research / Site Co-

coordinators.

We hope we can apply and practice all the

knowledge that we have learned here in our working envi-

ronment.

P a g e 3 I s s u e 4 , S E P T - O C T 2 0 1 6

On 20th October 2016, World’s Courier organized

course of Dangerous Goods in Sunway Lagoon Club. The

objectives of this course were:

To increase awareness and knowledge regarding

safety in transporting Dangerous Goods.

To learn local and international law related to trans-

porting dangerous goods.

Per IATA (International Air Transport Association) –

Anyone handling a Dangerous Goods must be

trained.

Shippers must be audited by local regulators – keep

records on file.

To equip with an understanding of

the issues considered when planning and prepar-

ing bio specimens that is going to be shipped.

Dangerous goods

Adopted http://www.asp-cargo.com/dangerous-goods/

Adopted http://www.glship.com/services/air-freight/dangerous-goods-by-air/

Budget Impact Analysis (BIA) Workshop In Malaysia, government health expenditure is about 10%

GDP and for the past few years healthcare costs are on the rise. The rising healthcare costs are stifling economic growth. Public hospital resources are limited but patient volume is rising. The question is, how can we utilize scarce resources to practice best medicine?

In search of the solution to this issue, we have invited Asso-ciate Prof. Dr. Asrul Akmal Shafie. the health economics expert from USM to conduct budget impact analysis workshop. This workshop was held from 22nd to 23rd October 2016 had attracted 23 participants from various institutions. Among them comprised of policymakers, hospital directors, clinicians and pharmacists.

In this one and a half days course, Prof. Asrul used humorous way to teach basic concept of economic evaluation and BIA. He also discussed how economic evaluation and BIA can be applied in decision making. Besides lectures, exercise ques-tions were also given to help participant in better understanding the calculation part of BIA.

This workshop was a success, everyone went home happy with new knowledge. The feedbacks from the participants were overwhelming. In future, we hope to invite Prof. Asrul to give lecture regarding health economic to Sabah-based healthcare provider.

Written by, Dr. Yen (CRC medical officer)

Written by, Dr. Fathiyah (CRC medical officer)

4

How to conduct

a good clinical

research?

Introduction to clinical research

P a g e 4 I s s u e 4 , S E P T - O C T 2 0 1 6

Research is "creative work undertaken on a systematic basis in order to increase the stock of knowledge, including

knowledge of humans, culture and society, and the use of this stock of knowledge to devise new applications” [1].

What is clinical research?

Clinical research is a branch of healthcare science that de-

termines the safety and effectiveness (efficacy) of medica-

tions, devices, diagnostic products and treatment regimens

intended for human use. These may be used for prevention,

treatment, diagnosis or for relieving symptoms of a disease.

It is an important tool to improve medical knowledge and

patient care.

What is Industrial Sponsored Research (ISR)?

Drug or device development are part of clinical research, the

research development are funded by industrial, in another

words we call it as industrial sponsored research (ISR). Drug

development can divided into 3 stages: pre-clinical, clinical

and post marketing development (refer to Figure 1).

What is Investigator initiated research (IIR)?

Unlike ISR, this type of research is developed based on the investigator interested or the problem they face during their clinical practice.

How to develop own research?

1. Identifying & prioritising problem:

- Identify the problem during clinical practice. Every problem in your

clinical practice is your potential research idea.

- To get research idea from clinical experience, recurrent problem facing

during clinical, and reading article.

- Communicate with expert is another good way to get your research idea.

It helps to prevent repetitive research of what have been done.

2. Literature review:

- to read more literature and get more information regarding the gap of

research.

3. Protocol development:

- Systematically plan a research.

4. National Medical Research Register (NMRR) registration and

authority approval (MREC).

-Must get approval from authority before recruitment.

5. Data analysis & interpretation

6. Publication:

- Publication is part of the responsibility of a researcher, even if

the research produces a negative result.

-Do no harm to subject (patient)

-Provides Benefit to the human subject

-Obeys GCP (good clinical practice)

IMPORTANT

Figure 2: Process of development of IIR

Figure 1: Stage of drug development

Reference: 1.OECD (2002) Frascati Manual: proposed standard practice for surveys on research and experimental development, 6th edition. Retrieved 27 May 2012 fromwww.oecd.org/sti/

frascatimanual.

Written by,

Dr. Yen (CRC Medical officer)

Hospital CME (14.09.16)

http://www.oecd.org/sti/frascatimanualhttp://www.oecd.org/sti/frascatimanual

UPCOMING WORKSHOPS

Research Camp

19-20th November 2016

Scientific Writing Workshop

5—6th November 2016

Introduction to clinical audit

28-29th November 2016

RESEARCH CONSULTATION CLINIC (RCC)

RCC aimed to assist researchers in :

1. Literature review search

2. NMRR registration

3. Protocol development and methodology

4. Protocol review

and many more.

Please do not hesitate to contact us for more information.

I s s u e 4 S E P T - O C T 2 0 1 6

P a g e 5

Research Update

COMING ISR:

1. ACOSYM

IIR STUDY

1 BIA fibrinolytic therapy

2 Heart failure cost analysis

3 Heart failure self care behaviour

4 TOE audit

5 HF Ramadhan

6 CRHD

7 BIA of platelet function test

IIR MONTHLY UPDATE:

THE EFFECT OF FASTING AMONG HEART FAILURE (HF) PATIENTS

DURING RAMAHDAN MONTH: A SINGLE-CENTRE COHORT STUDY

It is a non-randomization, open-labeled single-center study done with convenient sampling of muslim faith patients. The objective of this study is to assess clinical effect of Ramadan month in HF patients whom medication regime were adjusted in term of frequency and dosing. Study Population: Age > 18 years old, Muslim faith patients with documented LVEF < 40% within 6 months. This study will take 8 months to complete. It is to be carried out from 20th May until 20th November 2016. The stages of the study are as below:

Please visit our website eCRC for more details

Scan here to register our workshop and book

research consultation clinic

Contact:

Tel: 088-324600(ext2019)

Email: crcenquiry@gmail.com

NO ISR STUDY

1 RELAX ASIA 9 ODDYSSEY

2 COMMANDER 10 FOURIER

3 LIMUS-DEB 11 DEB

4 ASIA HF 12 QUALIFY

5 DSE ISAR 13 MIRAGE

6 STENTYS 14 REDUCE

7 PAN ASIA BOD 15 MASCOT

8 VICTORIA 16 VERIFY NOW

Adopted from http://www.skillproindia.com/

research_analytics.html

Stage 1,prescreening April 2016

Stage 2,Data collection May-June 2016

Stage 3,Data Analysis July August 2016

Stage 3, Presentation and publication Sept-Nov 2016

SCAN ME