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Vol. 28, No. 2, February, 2017

ISSN 0103-5053JBCSJournal of the Brazilian Chemical Society

Basic biology research shows that the haemostatic components and the cancer biology are interlinked in multiple ways. Nonetheless, it is noteworthy that while a group of cancer cells is capable of activating the clotting system, haemostatic factors play a role in tumor progression. In this research a novel 4-S lactam derivative was obtained through microwave assisted methodology as a promising leader for the development of new antitumor drugs. Moreover this original compound was selectively toxic to the HCT-116 cell line with low inhibitory Factor Xa (FXa) effect. Details are presented in the Communication Microwave Assisted Synthesis of Novel Six-Membered 4-C, 4-O and 4-S Lactams Derivatives: Characterization and in vitro Biological Evaluation of Cytotoxicity and Anticoagulant Activity by Nicolás E. Núñez-Navarro, Gerardine F. Segovia, Renato A. Burgos, Carlos F. Lagos, Nataly Fuentes-Ibacache, Mario A. Faúndez and Flavia C. Zacconi on page 203.

Contents

Communication203 Microwave Assisted Synthesis of Novel Six-Membered 4-C,

4-O and 4-S Lactams Derivatives: Characterization and in vitro Biological Evaluation of Cytotoxicity and Anticoagulant ActivityNicolás E. Núñez-Navarro, Gerardine F. Segovia, Renato A. Burgos, Carlos F. Lagos, Nataly Fuentes-Ibacache, Mario A. Faúndez and Flavia C. Zacconi

Graphical AbstractNovel six-membered lactam derivatives were synthesized using

microwave methodology. Cytotoxicity of products on cell lines and FXa activity assays are also reported.

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J. Braz. Chem. Soc.iv

Articles

217 Ultrasound-Promoted Synthesis of 3-(Thiophen-2-yl)-4,5-dihydro-1H-pyrazole-1-carboximidamides and Anticancer Activity Evaluation in Leukemia Cell LinesEric F. S. dos Santos, Nathália M. Cury, Tainara A. do Nascimento, Cristiano Raminelli, Gleison A. Casagrande, Claudio M. P. Pereira, Euclésio Simionatto, José A. Yunes and Lucas Pizzuti Graphical Abstract3-(Thiophen-2-yl)-4,5-dihydro-1H-pyrazole-1-carboximidamides were

efficiently synthesized through a cyclocondensation reaction between aminoguanidine hydrochloride and thiophenylchalcones under ultrasonic conditions employing KOH and ethanol in short reaction times and good yields. All compounds produced were evaluated against three leukemia

cell lines.

236 Validation of a Chromatographic Analytical Method for Quantification of Benznidazole Incorporated in Nanostructured Lipid FormulationsOsmar P. Almeida, Sara P. S. Marcial, Florena P. P. Gouveia and Guilherme Carneiro

Graphical AbstractA new chromatographic method was developed and validated for the determination of benznidazole incorporated within nanoemulsions or

nanostructured lipid carriers.

225 Ion Exchange Chromatography and Mass Bias Correction for Accurate and Precise Zn Isotope Ratio Measurements in Environmental Reference Materials by MC-ICP-MSDaniel F. Araújo, Geraldo R. Boaventura, Jerôme Viers, Daniel S. Mulholland, Dominik Weiss, Débora Araújo, Bárbara Lima, Izabel Ruiz, Wilson Machado, Marly Babinski and Elton Dantas Graphical AbstractZinc isotope ratios were determined in soil, plant, rock and sediment

reference materials by multi-collector inductively coupled plasma mass spectrometry (MC-ICP-MS). The procedure encompassed an improved ion

exchange chromatography protocol for fast and simple Zn separation, investigations into the instrumental mass bias processes and its

correction using different approaches.

208 Smectite Clay Modified with Quaternary Ammonium as Oil RemoverCarlos A. Lira Junior, Domingos S. A. Silva, Arão P. da Costa Filho, Elizabete F. Lucas and Sirlane A. A. Santana

Graphical AbstractSmectite clay modified with cetyltrimethylammonium bromide surfactant

and its ability to remove oil from aqueous effluents.

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vVol. 28, No. 2, 2017

250 Determination of Moxidectin in Serum by Liquid Chromatography-Tandem Mass Spectrometry and Its Application in Pharmacokinetic Study in LambsRafaela C. Baptista, Maria A. M. Fernandes, Susana Gilaverte, Sonia C. N. Queiroz, Marcia R. Assalin, Vera L. Ferracini, Alda L. G. Monteiro and Felix G. R. Reyes

Graphical AbstractDetermination of moxidectin in serum by liquid chromatography-tandem

mass spectrometry and its application in pharmacokinetic study in lambs.

257 Development of Molecularly Imprinted Polymers for Solid Phase Extraction of Parabens in Plasma Samples and Analysis by UHPLC-MS/MSMariane V. Roldão, Lidervan P. Melo, Luis Felippe C. Miranda, Marcos G. Resende and Maria Eugênia C. Queiroz

Graphical AbstractDevelopment of molecularly imprinted polymers for solid phase

extraction of parabens in plasma samples and analysis by UHPLC-MS/MS.

242 Structural Analysis of High-Spin States of S0-S4 at OEC Complex: A Theoretical Approach of Small ModelsEduardo W. Castilho-Almeida, Diego Paschoal, Hélio F. dos Santos, Patrick J. O’Malley and Wagner B. de Almeida

Graphical AbstractSmall model of oxygen evolving complex (OEC) cluster.

266 Speciation of Chromium in Water Samples after Dispersive Liquid-Liquid Microextraction, and Detection by Means of High-Resolution Continuum Source Atomic Absorption SpectrometryDaniele S. Porto, Naomi Akiba, Marcone Augusto L. de Oliveira and Ivanise Gaubeur

Graphical AbstractSpeciation and determination of Cr after liquid-liquid microextraction

combined with high-resolution continuum source atomic absorption spectrometry. Different pH value allowed speciation of CrIII and CrVI.

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285 New Multicomponent Reaction for the Direct Synthesis of β-Aryl-γ-nitroesters Promoted by Hydrotalcite-Derived Mixed Oxides as Heterogeneous CatalystCaroline R. M. D’Oca, Fabricio F. Naciuk, Jéssica C. Silva, Esthéfani P. Guedes, Celso C. Moro, Marcelo G. M. D’Oca, Leonardo S. Santos, Fabiane M. Natchigall and Dennis Russowsky

Graphical AbstractMulticomponent synthesis of b-aryl-g-nitroesters promoted by

hydrotalcite-derived mixed oxides.

299 Graphene Oxide/Zinc Oxide (GO/ZnO) Nanocomposite as a Superior Photocatalyst for Degradation of Methylene Blue (MB)-Process Modeling by Response Surface Methodology (RSM)Seyed A. Hosseini and Shabnam Babaei

Graphical AbstractThe scanning electron microscopy (SEM) results revealed the

nanostructure of the particles. Under optimum conditions the photocatalytic removal of methylene blue (MB) was 99% by experimental

testing.

277 Electrochemiluminescence Sensor for the Detection of Tiapride Hydrochloride with Chitosan-Ru(bpy)3

2+-SiO2NPs/MCNT/Nafion Modified ElectrodeXuemei Fan, Shumin Wang, Zhejian Li, Ping Liu, Yan Yu, Liangliang Chang, Kaibin Li and Xingwang Zheng

Graphical AbstractThe principle diagram of electrochemical luminescence sensor of

chitosan-Ru(bpy)32+-SiO2 NPs/MCNT/Nafion for tiapride hydrochloride.

308 Proximate Composition, Mineral Contents and Fatty Acid Composition of the Different Parts and Dried Peels of Tropical Fruits Cultivated in BrazilDamila R. Morais, Eliza M. Rotta, Sheisa C. Sargi, Elton G. Bonafe, Rúbia M. Suzuki, Nilson E. Souza, Makoto Matsushita and Jesuí V. Visentainer

Graphical AbstractData food composition knowledge is very important. Avocado, pineapple,

banana, papaya, passion fruit, watermelon and melon different parts (pulp, peel and seed) cultivated in Brazil have nutrients.

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viiVol. 28, No. 2, 2017

328 PhotoMetrix: An Application for Univariate Calibration and Principal Components Analysis Using Colorimetry on Mobile DevicesGilson A. Helfer, Vinícius S. Magnus, Fernanda C. Böck, Aline Teichmann, Marco F. Ferrão and Adilson B. da Costa

Graphical AbstractSchematic representation of PhotoMetrix, which employs techniques for

univariate analysis and multivariate exploratory analysis.

336 Acidity and Characterization of 12-Tungstophosphoric Acid Supported on Silica-AluminaFlávia C. G. de Mattos, Eduardo N. C. B. de Carvalho, Elon F. de Freitas, Mateus F. Paiva, Grace F. Ghesti, Julio L. de Macedo, Sílvia C. L. Dias and José A. Dias

Graphical Abstract12-Tungstophosphoric acid supported on silica-alumina is a stable

catalyst with interaction occurring on isolated and aluminic pseudo-bridging silanols. The most active catalyst for acetic acid and ethanol

esterification was 30 wt.% H3PW/SiO2-Al2O3, which showed 79 ± 3% yield and 100% selectivity for ethyl acetate after 2 h reaction time.

319 Strontium and Nickel Heterogeneous Catalysts for Biodiesel Production from Macaw OilWiury C. de Abreu, Carla V. R. de Moura, Jean C. S. Costa and Edmilson M. de Moura

Graphical AbstractStrontium and nickel oxides have shown effectiveness for production of

biodiesel of macaw oil. The catalyst can be used in many reaction cycles.

348 Physicochemical Properties and Field Evaluation of Monolithic Wax Formulations for the Controlled Release of a Forest Pest PheromoneMariel P. Slodowicz, Esteban Ceriani-Nakamurakare, Cecilia Carmarán and Paola A. González-Audino

Graphical AbstractDevelopment of monolithic dispensers for the controlled release of the

pheromone components of a forest pest and study of its physicochemical properties.

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367 A New Furanoheliangolide Sesquiterpene Lactone from Calea pinnatifida (R. Br.) Less. (Asteraceae) and Evaluation of Its Trypanocidal and Leishmanicidal ActivitiesTamires Cardoso Lima, Rafaela de Jesus Souza, Milene Hoehr de Moraes, Mário Steindel and Maique Weber Biavatti

Graphical AbstractIsolation and characterization of a new sesquiterpene lactone of the

furanoheliangolide type named 11,13-dihydroxy-calaxin, in addition to seven known compounds from Calea pinnatifida leaves.

376 Multielement Determination of Macro and Micro Contents in Medicinal Plants and Phytomedicines from Brazil by ICP OESAníbal de F. Santos Júnior, Rafael A. Matos, Eberson M. J. Andrade, Walter N. L. dos Santos, Hemerson I. F. Magalhães, Fernanda do N. Costa and Maria das Graças A. Korn

Graphical AbstractThe metal content of nine medicinal plants and phytomedicines from Brazil was evaluated by inductively coupled plasma optical emission

spectrometry (ICP OES).

360 Analysis of Xanthine Oxidase Inhibitors from Puerariae flos Using Centrifugal Ultrafiltration Coupled with HPLC-MSLiangliang Liu, Aiping Xiao, Lei Ma and Defang Li

Graphical AbstractFour compounds were successfully screened and identified as xanthine

oxidase inhibitors from Puerariae flos extract with centrifugal ultrafiltration coupled with high performance liquid chromatography-

mass spectrometry (CU-LC-MS).

385 Non-Invasive Detection of Adulterated Olive Oil in Full Bottles Using Time-Domain NMR RelaxometryPoliana M. Santos, Flávio Vinicius C. Kock, Maiara S. Santos, Carlos Manuel S. Lobo, André S. Carvalho and Luiz Alberto Colnago

Graphical AbstractA new procedure to detect the authenticity of commercial olive oils,

commonly adulterated with polyunsaturated oils, employing low-field nuclear magnetic resonance (LF-NMR) directly in the sealed bottles is

proposed.

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