IsotopesIsOTOPEs for lAbEllED COmPOuNDs We provide a wide range of isotopic ma-terials for synthesis and manufacturing of labelled compounds. Main of them are deuterium gas, D 2 O,

Isotopesfor NuclearMedIcINe

CONTENT

AbOuT us 3

OXYGEN-18 (I.E. ≥ 98%) for PET 4

REAGENT KITs for FDG 5

sTAblE IsOTOPEs 6

sTAblE IsOTOPEs in GAs FORm 8

IsOTOPEs for lAbEllED COmPOuNDs 10

RADIOPhARmACEuTICAls 11

COlD KITs for Tc-99m Generator 12

RADIOACTIVE IsOTOPEs 14

OPhThAlmIC APPlICATORs 15

PACKAGING CONTAINERs for RADIOACTIVE subsTANCEs 16

lOGIsTIC sERVICE 17

CONTACT us 18

••• 2 www.isotope-cmr.com

AbOuT us

Center of Molecular Research known as CMR is a Russian isotope production company. CMR is a part of group of companies founded in 1993. By now, our company is one of the world’s largest manufacturers and suppliers of Oxygen-18 wa-ter, stable and radioactive isotopes worldwide.For more than twenty years, Center of Mo-lecular Research has been a reliable supplier of isotopes in different industries, mainly in nuclear medicine, science and industry. Our philosophy bases on client oriented ap-proach that is a cornerstone of our work and environment responsible vision, including clean technology production and recycling.

Briefly about our productsCMR is a manufacturer of GMP certified stable isotope Oxygen-18 water. Our goal is to sat-isfy all customers' needs therefore we offer a wide range of reagent kits, chemicals for PET-tomography and PET-precursors.All CMR reagents are produced in clean rooms and dispensed under high-level qual-ity control conditions. Materials and kits are sterile and non-pyrogenic. Vials are pack-

aged in a special vacuum bag within a com-pact carton box.Logistics services we provide are reliable at each stage from production release to the customers’ door. We ensure delivery on time and flexibility in shipping scheduling.The list of enriched stable isotopes we offer for cyclotron and reactor targets includes Xe-124, Te-124, Ni-64, Tl-203 and many others.CMR is ready to accept orders for almost full range of isotope elements of Periodic Table. Full Product List is always available on our web-site.Industrial isotopes are also on our Product List. There are Heavy Water, Depleted Zinc Oxide, Lithium-7 Hydroxide Monohydrate and others.We constantly expand assortment of prod-ucts and now are ready to organize supplies of radioactive isotopes. We have experience of delivery Radiopharmaceuticals and Genera-tors Tc-99m all over the territory of the Rus-sian Federation.We offer high quality products since manu-facture process totally complies with appli-cable international standards as well as certi-fied by GMP authorities.

3 •••www.isotope-cmr.com

OXYGEN-18 (I.E. ≥ 98%) for PET

Product description: Enriched Oxygen-18 water is used as a target which is bom-barded with the help of cyclotron or linear accelerator in order to produce Flourine-18. Flourine-18 is synthesized into 2-deoxy-2-18F-β-D-glucopyranose (18F-FDG) which is a radiolabelled sugar molecule used in PET (Positron emission tomography) for determining sites of ab-normal glucose metabolism and for local-ization of many types of tumors. Today 18F-FDG is the most widespread and suc-cessful PET radiopharmaceutical. 18F-FDG is an analogue of glucose, it is injected in vivo and then 18F-FDG is transported from blood to tissues in a way similar to glu-

cose. Cells absorb FDG like glucose but it cannot be metabolized. A very important advantage of FDG-PET is that it helps ac-curately define stage and sites of recur-rent disease in many cancer types.

Packaging: we supply Oxygen-18 water in the borosilicate US standard glass vi-als with rubber-stoppers and aluminum crimp seals. The vials special sterilized prior to filling.

18F-FDG structure

HO

18F

OH OHHO

CAS number

Isotopic Enrichment

Molecular Weight

14314-42-2 ≥ 98 % 20,02

H218O

GMP certified


REAGENT KITs for FDG

CMR supplies a wide range of reagent kits, chemicals for PET-tomography and PET precursors.

All CMR reagents are produced in clean rooms and dispensed under controlled conditions. Materials and kits are ster-ile and non-pyrogenic. Vials are doubly packaged in a special vacuum bag within a compact carton box.We also supply other materials. Please contact us for more information.

Cryptand 222

CAS number Purity Molecular

Weight

23978-09-8 > 99 % 376,49

C18H36N2O6

Triflate Mannose

CAS number Purity Molecular

Weight

92051-23-5 > 99 % 480,37

C15H19F3O12S

Acetonitrile Anhydrous

CAS number Assay Molecular

Weight

75-05-8 > 99,8 % 41,05

CH3CNHydrochloric Acid

CAS number Appearance Bacterial

endotoxins

7647-01-0clear, colorless

liquid< 10,0 I.U./ml

HCL


sTAblE IsOTOPEs

CMR provides a wide range of stable iso-topes. We do our best in order to meet the needs of our customers most effectively.Stable isotopes offered by our company are produced by several methods includ-ing:

• the gas centrifuge method • electromagnetic separation • rectification separation• photo-chemical method• chemical exchange separation method

We provide stable isotopes which serve as a basis for the state-of-the-art technology in different spheres of human activities:

• the production of radiopharmaceuticals• fundamental and goal-oriented re-

searches• creation of high-precision measure-

ment instruments and devices for technical and medical diagnostics.

Ag 107, 109

ba 130, 132, 134, 135, 136, 137, 138

Ca 40, 42, 43, 44, 46, 48

Cd 106, 108, 110, 111, 112, 113, 114, 116

Ce 136, 138, 140, 142

Cr 50, 52, 53, 54

Cu 63, 65

Dy 156, 158, 160, 161, 162, 163, 164

Er 162, 164, 166, 167, 168, 170

Eu 151, 153

Fe 54, 56, 57, 58


Ga 69, 71

Gd 152, 154, 155, 156, 157, 158, 160

Ge 70, 72, 73, 74, 76

hf 174, 176, 177, 178, 179, 180

In 113

Ir 191, 193

K 39, 40, 41

la 138, 139

lu 175, 176

mg 24, 25, 26

mo 92, 94, 95, 97, 98, 100

Nd 142, 143, 144, 145, 146, 148, 150

Ni 58, 60, 61, 62, 64

Os 184, 186 187, 188, 189, 190, 192

Pb 204, 206, 207, 208

Pd 102, 104, 105, 106, 108, 110

Rb 85, 87

Re 185, 187

s 32, 33, 34, 36

sb 121, 123

se 76, 77, 78, 80, 82

si 28, 29, 30

sm 144, 147, 148, 149, 150, 152, 154

sn 112, 115, 116, 117, 118, 119, 120, 122, 124

sr 84, 86, 87, 88

Te 120, 122, 123, 124, 125, 126, 128, 130

Ti 46, 47, 48, 49, 50

Tl 203, 205

W 180, 182, 183, 184, 186

Yb 168, 170, 171, 172, 173, 174, 176

Zn 64, 66, 67, 68, 70

Zr 90, 91, 92, 94, 96


Ammonia (D3)

Argon 36, 38, 40

Carbon-13 Dioxide (13CO2)

Carbon-13 Monooxide (13CO)

Deuterium 2D

Ethylene (13C2 H4)

Ethylene (C2 D4)

Helium-3

Methane (13CH4)

Krypton 78, 80, 82, 83, 84, 86

Neon-20

Neon-22

Nitrogen-15 (15N2)

Oxygen-18 Carbon Dioxide (С 18O2)

Oxygen-18 Carbon Monooxide (C 18O)

Oxygen-18 (18O2)

Oxygen-17 (17O2)

Xenon 124, 126, 128, 129, 130, 131, 132, 134, 136

sTAblE IsOTOPEs in GAs FORm


OTHER ISOTOPIC GASES AND GAS MIXTURES ARE AVAILABLE

CylindersWe supply isotopic gases and gas mixtures in cylinders designed specially for high pure isotopic materials. Cylinders are available of different capaci-ties: 0,5 L, 1,0 L, 2,0 L or more, depending on customer's preferences.

ValvesOur cylinders can be equipped with any type of high pressure valves which are suitable for customer's usage: ¼ NPT, DIN-477, G ¾, G ⅝, CGA-580 and others.


IsOTOPEs for lAbEllED COmPOuNDs

We provide a wide range of isotopic ma-terials for synthesis and manufacturing of labelled compounds. Main of them are deuterium gas, D2O, Tritium, O-18, C-13,

C-14, Lu-177, Ga-68. These materials can be ordered from our warehouse for fast delivery. Many others isotopes can be pre-pared on a special request.

• D2O WATER • O-18

• DEuTERIum GAs • TRITIum

• C-13 • lu-177

• C-14 • Ga-68

and many others


RADIOPhARmACEuTICAls

Tс-99m generatorAreas of application Tc-99m generator is intended for multiple production of ste rile pyrogen-free sodium pertechnetate in physiological saline solution (0,9% NaCl).

Parent Isotope activity

4 GBq, 6 GBq, 8 GBq, 11 GBq, 19 GBq

Appearance Colorless, transparent solution

Radioactive concentration

74–3700 MBq/ml

pH 4,0–7,0

Radiochemical purity

not less than 99.0%

Expiry 15 days from the production date

Generator weight

16 kg ( weight of generator including the package)

I-131 sodium IodideIndication: Diagnostics and thyroid gland treatment.

I-131 sodium o-Iodohippurate Indication: Diagnostics of kidneys diseases.

I-131 sodium Iodide in isotonic solution Indication: Diagnostics and thyroid gland treatment.

P-32 sodium phosphate for injections This preparation is intended for treatment of polycystemia, myeloma illnesses, chronic leucosis, diagnostics of malignant neoplasm.

pH 6,0 –7,0

Volume radioactivity 370–1110 MBq/ml

Radiochemical purity > 98,5%

Radionuclidic purity > 99,99%

Expiry 60 days

Sm-153 oxabiphorIntended to decrease intensity of painful syndrome of metastatic defeat of bones, for growth inhibition of metastatic tissues in bones.

pH 5,0 –7,0

Radioactive concentration

240 –1500 MBq/ml

Radiochemical purity > 90%

Radionuclidic purity > 99,99%

Expires after 4 days


COlD KITs for Tc-99m Generator

International Name Description Indications

Br-HIDAMebrofenin

Bromezida, Tc-99m

Bromezida, Tc-99m is a suitable agent for dynamic scintigraphy of the hepatobiliary system.

DTPACalcium trisodium pentetate

Pentatech,Tc-99m

Pentatech, Tc-99m is a suitable agent for dynamic scintigraphy of the kidneys, for glomerular filtration rate measurements, for radionuclide angiocardiography, for visualization of the brain tumours.

MAG3—

Technemag,Tc-99m

Technemag, Tc-99m is a suitable agent for evaluation of renal function radionuclide measurements.

DMSATechnetium (99mTc)

succimer

Technemek,Tc-99m

Technemek, Tc-99m is a suitable agent for scintigraphy of the kidneys, has proven valuable in the detection of the size, shape, position and presence of the damage of the kidneys and its function.

PHYTATE—

Technephyte,Tc-99m

Technephyte, Tc-99m is a suitable agent for liver scintig-raphy, has proven valuable in the detection of the shape, size and presence of the damage of the liver and spleen at tumours, cirrhosis, hepatitis and others diseases.


International Name Description Indications

analog MDPOxabiphore

(oxa-bis (ethylennitrilo) tetramety-lenephosphonic acid)

Technephor,Tc-99m

Technephore, Tc-99m is a suitable agent for bone scintigraphy, has proven valuable in the detection of primary and metastatic tumours, osteomyelitics, bone-joint tuberculosis etc.

HEDPEtidronic acid (Xydiphon)

Phosphotech,Tc-99m

Phosphotech, Tc-99m is a suitable agent for bone scintigraphy, has proven valuable in the detection of primary and metastatic tumours, osteomyelitics, bone-joint tuberculosis etc.

HMPAOTechnetium (99mTc) with

hexcamethylpropylenaminoxime

Teoxim,Tc-99m

Teoxim, Tc-99m is a suitable agent for regional cerebral blood flow scintigraphy and for white blood cell label-ling in vitro.

PYPTechnetium (99mTc) with

pyrophosphate

Pyrphotech,Тс-99m

Pyrphotech, Tc-99m is a suitable agent for bone scin-tigraphy, detection of acute myocardial infarctions and malignant tumours of the ovaries, for the red blооd cells (АВС) labelling in vivo.

MIBITechnetium (99mTc) with

2-methoxy-isobutyl-isonitrile

Technetril,Тс-99m

Technetril, Tc-99m is a suitable agent for evaluation of the myocardial perfusion at its different pathological states and for the scintigraphy of the malignant tumors of the lung and breast.


RADIOACTIVE IsOTOPEs

Application

Card

iolo

gy

Onco

logy

Neur

olog

y

Rheu

mat

olog

y

Pulm

onol

ogy

Diag

nost

ic

Rese

arch

Ther

apeu

tic

Molybdenum-99 ⦁ ⦁ ⦁ ⦁ ⦁

Xenon-133 ⦁ ⦁

Lutetium-177 ⦁ ⦁ ⦁ ⦁

Iodine-131 ⦁ ⦁ ⦁ ⦁

Iodine -125 ⦁ ⦁ ⦁ ⦁

Phosphorus-33 ⦁ ⦁ ⦁ ⦁

Phosphorus-32 ⦁ ⦁ ⦁ ⦁

Thallium-201 ⦁ ⦁


OPhThAlmIC APPlICATORs Ru106 + Rh106

CMR provides ophthalmic applicators (OA) which are intended for contact radiation ther-apy of malignant tumors of eyes and append-ages of the eye, such as melanoma of the iris, retinoblastoma, melanoma and others.OA is a sealed radionuclide source of ionizing radiation. They are produced by an original technology – radionuclides Ruthenium-106 and Rhodium-106 are placed on the sub-strate, which makes it possible to distribute the activity on its surface uniformly.Advantages:• Application of ophthalmic applicators

is exceptional organ preserving and ef-ficient method of treatment.

• Outer surface is made of stainless steel that prevents the corrosion and allows under-going any multiple types of sterilization.

• Ophthalmic applicators are reusable as they are resistant to humidity, body and tissue fluids.

Ophthalmic applicators are supplied all over the world by CMR. Every applicator is produced by the SSC RF Institute for Phys-ics and Power.

Specifications

Isotope 106Ru – 106Rh

Decay mode Е (106Ru)=39,4 keVЕ (106Rh)=3540,0 keV

Half-life period Т ½ (106Ru)=373,59 daysТ ½ (106Rh)=29,9 sec

The absorbed dose rate (ADR) on the working surface

20–40 cGy/hour

Shelf Life 12 months

OA Type Diameter, mm Holder height Spheric radius, mm

P7 17 12–14P6 17 2 12–14P5 17 5 12–14P4 22 2 12–14P3 22 5 12–14P2 19 4 12–14


Our company has a pool of containers for the radioactive materials.

1. Model A65 type A container for transportation of radioactive material.

Radionuclide 99Mo 123I 67Ga

Max. activity [GBq] 598 600 300

Technical Data:

Height of the container 365 mm

Diameter of the container 310 mm

Total maximum weight of the packaging set 44 kg

2. Model UK 20 type B(U) tungsten container.

The type B (U) UK 20 packaging container is designed for transportation and stor-age of special forms or other radioactive substance than those of a special form, including liquids, up to the maximum ac-tivity values specified in the table below:

Radionuclide 99Mo 192Ir 131I 60Co 137Cs 227Ac

Max. activity [TBq] 55,5 148 9,25 0.06 70 20

Technical Data:

Height of the screening container 317 mm

Diameter of the screening container 210 mm

Height of the packaging set (including lid lugs) 451 mm

Diameter of the screening container 290 mm

Number of embedded compartments 1

Size of the embedded compartment

Ø 56x25 mm

Maximum weight of the screening container 158 kg

Total maximum weight of the packaging set 198 kg

3. Model CF18-T tungsten shielded container for vial transport.

The CF18-T shielded container made of tungsten and is used to transport radioactive FDG in vial.

Technical Data:

Weight 14 kg

Pit dimensions 33x57 (Øxh) mm

External dimensions 93x 130 (Øxh) mm

Shielding (W) 29,5 mm

PACKAGING CONTAINERs for RADIOACTIVE subsTANCEs


lOGIsTIC sERVICEIn order to ensure safety and delivery of our products CMR has organized logistic department with a large car park.

Transportation of Dangerous Goods Class 7 • Packing Group I – Low danger• Packing Group II – Medium danger• Packing Group III – High danger

Advantages:• Specially equipped vehicles• High qualified staff• ADR certificate• Accuracy and reliable time management• High professionalism in service delivery• Client-oriented approach


REPREsENTATIVEs WORlDWIDE

• Argentina• Australia• Austria• Belarus• Belgium• Brazil• Canada• Chile• China• Colombia• Finland• France• Germany

• Holland• India• Indonesia• Italy• Japan• Jordan• Kazakhstan• Kuwait• Malaysia• Mexico• New Zealand• Oman• Pakistan

• Saudi Arabia• South Korea• Sweden• Taiwan• Turkey• The UK• The United

Arab Emirates• The USA• Ukraine• Uruguay• Venezuela• Vietnam

Russia, Head officeTel : +7 495 662 9492info@isotope-cmr comwww isotope-cmr com


Russia Head officeTel : +7 495 662 9492info@isotope-cmr comwww isotope-cmr com

Documents

IsotopesIsOTOPEs for lAbEllED COmPOuNDs We provide a wide range of isotopic ma-terials for synthesis and manufacturing of labelled compounds. Main of them are deuterium gas, D 2 O,