Isolated Central Nervous Glioma Signaling Introduction to ... · Introduction to Structural Chemistry A concise description of models and quantitative parameters in structural chemistry

Biomedicine springer.com/NEWSonline

12

K. Ballanyi, University of Alberta, Edmonton, AB, Canada (Ed)

Isolated Central Nervous System CircuitsContents Autonomic Nervous System In Vitro: Studying Tonically Active Neurons Controlling Vagal Outflow in Rodent Brainstem Slices.- Anatomi-cally ‘Calibrated’ Isolated Respiratory Networks from Newborn Rodents.- Physiological Properties of Human Fetal Cortex In Vitro.- Histological Characterization of Physiologically Determined Fast-Spiking Interneurons in Slices of Primate Dorsolateral Prefrontal Cortex.- Neural Circuits Underlying Circadian Oscillations in Mammals: Clocks in a Dish.- Osmoregulatory Circuits in Slices and En Bloc Preparations of Rodent Hypothalamus.- Establishing In Vivo-Like Activity in Rat Cerebellar Cells Maintained In Vitro.- Spontaneous Rhythmic Activity in the Adult Cerebral Cortex In Vitro.- Living Human Brain Slices: Network Analysis Using Voltage Sensitive Dyes.- Intact In Vitro Preparations of the Neonatal Rodent Cortex: Analysis of Cellular Properties and Network Activity.- Spontaneous Neural Network Oscillations in Hippocampus, Cortex, and Locus Coeruleus of Newborn Rat and Piglet Brain Slices.- Neuronal Networks in the In Vitro Isolated Guinea Pig Brain.- The Study of Respiratory Chemoreflexes Using a Novel Dual-Perfused Rodent Preparation.- Defined Medium Organotypic Cultures of Spinal Cord Put ‘Pain in a Dish’.- Rodent Isolated Spinal Cord Preparations to Examine Motor Output.

Fields of interestsNeurosciences; Human Physiology

Target groupsProfessional/practitioner

Discount groupProfessional Non-Medical

Due August 2012

2012. XV, 548 p. 125 illus., 53 in color. With online files/update. (Neuromethods, Volume 73) Hardcover7 $159.00ISBN 978-1-62703-019-9

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J. Barańska, Nencki Institute of Experimental Biology, Warsaw, Poland (Ed)

Glioma SignalingGlioma Signaling is a text reference on cellular signaling processes focused on the mechanism of nucleotide receptors activation by exogenic nuc-leotides and the formation of complex signaling cascades, including cytoplasmic transcription factors, induced by growth factors, cytokines and cannabinoids.

Features 7 Important topics concerning molecular mechanisms responsible for glioma physiology and pathology 7 Unique occasion to get an inside signaling induced by extracellular nucle-otides, growth factors and cytokines in glioma cells 7 New data concerning gliomas invasion and progression 7 Role of cytoplasmic transcrip-tion factors, as STAT and SMAD in glioma patho-genesis 7 Comparison of the nature of calcium signals in glioma cells with that in astrocytes and microglia

Contents 1.introduction to purinergic signaling in the brain. - 2. adenosine signaling in glioma cells. - 3. cross-talk in nucleotide signaling in glioma c6 cells. - 4. calcium signaling in glioma cells – the role of nucleotide receptors. - 5. purinergic signa-ling in glioma progression. - 6. cytoskeleton and nucleotide signaling in glioma cells. - 7. signaling determinants of glioma cell invasion. - 8. receptor tyrosine kinases: principles and functions in glio-ma invasion. - 9. tgf beta signaling and its role in glioma pathogenesis. - 10. stat signaling in glioma cells. - 11. cannabinoid signaling in glioma cells.

Fields of interestsBiomedicine general; Cancer Research; Neuros-ciences

Target groupsResearch


Available

2012. XII, 237 p. 37 illus., 25 in color. (Advances in Experimental Medicine and Biology, Volume 986) Hardcover7 $189.00ISBN 978-94-007-4718-0

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S. S. Batsanov, Russian Academy of Sciences, Chernogolovka, Russia; A. S. Batsanov, Durham University, UK

Introduction to Structural ChemistryA concise description of models and quantitative parameters in structural chemistry and their inter-relations, with 280 tables and >3000 references giving the most up-to-date experimental data on energy characteristics of atoms, molecules and crystals (ionisation potentials, electron affinities, bond energies, heats of phase transitions, band and lattice energies), optical properties (refractive index, polarisability), spectroscopic characteris-tics and geometrical parameters (bond distances and angles, coordination numbers) of substances in gaseous, liquid and solid states, in glasses and melts, for various thermodynamic conditions. Systems of metallic, covalent, ionic and van der Waals radii, effective atomic charges and other empirical and semi-empirical models are critically revised. Special attention is given to new and gro-wing areas: structural studies of solids under high pressures and van der Waals molecules in gases.

Features 7 Ample tables for practical work - not just for illustration 7 All numbers revised and corrected on most recent data 7 Covers fast-growing areas: high pressure, nano-matter

Contents 1. Atom. - 2. Chemical bond. - 3. “Small” molecu-le. - 4. Intermolecular forces. - 5. Crystal structure – idealised. - 6. Crystal structure – real. - 7. Amor-phous state. - 8. Between molecule and solid. - 9. Phase transitions. - 10. Extreme conditions. - 11. Structure and optical properties.

Fields of interestsBiomedicine general; Physical Chemistry; Crystal-lography



Available

2012. X, 440 p. 73 illus. Hardcover7 approx. $209.00ISBN 978-94-007-4770-8

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www.springer.com/978-1-62703-019-9



News 6/2012 Biomedicine

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J. V. Burnier, M. N. Burnier, McGill University Health Centre, Montreal, QC, Canada (Eds)

Experimental and Clinical MetastasisA Comprehensive Review

Features 7 Discusses basic and clinical aspects as well as translational aspects of metastatic research 7 In-cludes the latest developments in the field 7 Pro-vides a clear and extensive review of experimental implications of metastatic disease

Contents Introduction.- Interactions of Normal Tissues and Systems with Metastatic Cells: Impact on Location, Survival and Growth.- Introduction to Metastasis Suppressor Genes.- Metastasis suppres-sor genes.- Metastatic Dormancy & Metastatic Suppressor Genes.- Clinical Implications.- Growth Factor Systems and Cell Cycle Regulation.- An-giogenesis.- Inflammatory mediators in Tumori-genesis and Metastasis.- Role of stroma in disease progression.- Local spread.- Lymphatic – GI tract and Breast Cancer.- Hematogenous – Uveal Melanoma.- Other methods.- Haematogenous Models of Metastases.- Spontaneous, Induced, and Transgenic Models of Metastasis.- Orthotopic and Ectopic Models of Metastasis.- Animal Model Imaging Techniques.- Diagnosis of Metasta-sis.- Cancer Staging.- Diagnostic Immunohis-tochemistry in Tumor metastasis.- Genomics and Proteomics.- The role of chemotherapy for metastatic disease.- Integrating chemotherapy to surgery: Novel approaches in regionally aggressive cancer metastasis.- Palliative radiation therapy.- Role of Surgery in the Diagnosis and Management of Metastatic Cancer.- Prerequisite genetic traits for metastasis.- Metastasis Initiation.- Index.

Fields of interestsCancer Research; Pharmacology/Toxicology



Due September 2012

2012. X, 370 p. 61 illus., 47 in color. Hardcover7 approx. $209.00ISBN 978-1-4614-3684-3

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S. Choi, Ajou University, Suwon, Korea (Ed)

Encyclopedia of Signaling MoleculesContents 5-Hydrocytryptamine receptor 3a.- 5-Hydroxy-tryptamine receptor 2B.- 5-Hydroxytryptamine receptor 2C.- A-Raf.- ABCA.- Ack1.- ADAP.- Adap1.- Adenylyl cyclase.- Adenylyl cyclase type 9.- Adhesion-GPCRs.- ADP-ribosylation factor domain protein 1.- Ags (Activators of G-protein signaling).- Aif.- AKAP.- Androgen receptor.- Angiotensin II receptor 2.- Ant.- AP-3.- AP-4.- Apo2L (TRAIL).- Arap3.- Arf-like protein 8b.- Arfgap1.- Arfrp1.- ATF3.- Aurora kinase.- Bcl2 family.- Beta-Catenin.- Bradykinin receptor.- Btg/Tob.- c-Myb.- Cadherin.- Calcium channel, voltage-dependent.- Calpain.- Carma1.- Casein kinase II.- Caspase.- Cbln1.- CCL3 [chemokine (C-C motif) ligand 3].- CCL4 [chemokine (C-C motif) ligand 4]. [...]

Fields of interestsGene Function; Molecular Medicine; Cytokines and Growth Factors



Due January 2013

Print

2013. Approx. 1520 p. 300 illus., 100 in color. (In 2 volumes, not available separately) 7 approx. $1100.00ISBN 978-1-4419-0460-7

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2013. 7 approx. $1100.00ISBN 978-1-4419-0461-4

9<HTMEPB=jaegbe> Print + eReference

2013. Approx. 1520 p. 300 illus., 100 in color. (In 2 volumes, not available separately)7 approx. $1350.00ISBN 978-1-4419-0462-1

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Current Topics in Microbiology and ImmunologyR. W. Compans, M. D. Cooper, H. Koprowski, F. Melchers, Series editors: M. B. Oldstone, P. K. Vogt, T. Honjo, Y. Gleba, B. Malissen, K. Aktories

Volume 359

B. Lee, David Geffen School of Medicine, Los Angeles, CA, USA; P. A. Rota, Centers for Disease Control, Atlanta, GA, USA (Eds)

HenipavirusEcology, Molecular Virology, and Pathogenesis

Hendra virus (HeV) and Nipah virus (NiV) emerged in the 1990s in Australia and Malaysia, respectively, as zoonotic agents that caused fatal outbreaks of respiratory and/or encephalitic illness among horses (HeV), pigs (NiV) and humans who came in contact with the infected animals. The natural reservoir for henipavirus appears to be bat species found in South-east Asia and Australia, and direct bat-to-human and human-to-human transmissions is likely responsible for annual NiV outbreaks in Bangladesh since 2000. Annual spillover events of HeV have occurred in Australia since 2006 with fatal consequences for horses and humans. HeV and NiV cause zoonotic disea-ses that have resulted in major socio-economic disruptions during outbreaks and spillover events. In the last decade, much progress has been made in understanding the ecology, virology and disease pathogenesis of henipaviruses.

Fields of interestsVirology; Vaccine; Fish & Wildlife Biology & Management



Available

2012. X, 220 p. 26 illus., 19 in color. Hardcover7 approx. $189.00ISBN 978-3-642-29818-9

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D. J. Dupré, Dalhousie University, Halifax, NS, Canada; T. E. Hébert, McGill University, Montreal, QC, Canada; R. Jockers, Institut Cochin, Paris, France (Eds)

GPCR Signalling Complexes – Synthesis, Assembly, Trafficking and SpecificityFeatures 7 This is the first book addressing specifically the assembly of G protein coupled receptors signaling complexes 7 Several colors images 7 Compi-lations of manuscripts made from experts in the field

Contents 1. ER-bound steps in the biosynthesis of G protein-coupled receptors. - 2. Role of chaperones in G protein coupled receptor signalling complex assembly. - 3. GPCR oligomerization: contribution to receptor biogenesis. - 4. The functional size of GPCRs- monomers, dimers or tetramers?. - 5. Re-gulation of post-Golgi traffic of G protein-coupled receptors. - 6. Regulated GPCR trafficking to the plasma membrane: general issues and the CCR5 chemokine receptor example. - 7. Regulatory Pro-cesses Governing the Cell Surface Expression of LH and FSH Receptors. - 8. Chaperone-mediated assembly of G protein complexes. - 9. Synthesis and assembly of G protein bg dimers: comparison of in vitro and in vivo studies. - 10. Preferential assembly of G-abg complexes directed by the g subunits. - 11. G Protein Trafficking. - 12. Diffe-rential assembly of GPCR signaling complexes determines signaling specificity. - 13. GPCR and voltage-gated calcium channels (VGCC) signaling complexes. - 14. Pharmacological chaperones correct misfolded GPCRs and rescue function: trafficking as a therapeutic target.

Fields of interestsBiomedicine general; Pharmacology/Toxicology; Receptors



Available

2012. X, 240 p. 50 illus., 40 in color. (Subcellular Biochemistry, Volume 63) Hardcover7 approx. $189.00ISBN 978-94-007-4764-7

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N. Engel, Temple University, Philadelphia, PA, USA (Ed)

Genomic ImprintingMethods and Protocols

Features 7 Surveys cutting-edge technologies applied in the field 7 Features detailed and practical laboratory protocols 7 Includes expert tips on troubleshooting and avoiding pitfalls

Contents Uniparental Embryos in the Study of Genomic Imprinting.- Derivation of Induced Pluripotent Stem Cells by Retroviral Gene Transduction in Mammalian Species.- Generation of Trophoblast Stem Cells.- Immunomagnetic Purification of Murine Primordial Germ Cells.- Whole Genome Methylation Profiling by Immunoprecipitation of Methylated DNA.- Identification of Imprinted Loci by Transcriptome Sequencing.- Data Mining as a Discovery Tool for Imprinted Genes.- Engi-neering of Large Deletions and Duplications In Vivo.- Methylated DNA Immunoprecipitation (MeDIP) from Low Amounts of Cells.- Chro-matin Immunoprecipitation to Characterize the Epigenetic Profiles of Imprinted Domains.- Quan-titative Chromosome Conformation Capture.- Genome-Wide Analysis of DNA Methylation in Low Cell Numbers by Reduced Representation Bisulfite Sequencing.- Isolation of RNA and DNA from Single Preimplantation Embryos and a Small Number of Mammalian Oocytes for Imprinting Studies.- Generation of cDNA Libraries from RNP-Derived Regulatory Non-Coding RNAs.- Co-Immunoprecipitation of Long Non-Coding RNAs.- Specialized Technologies for Epigenetics in Plants.- Computational Studies of Imprinted Genes.- Insights on Imprinting from Beyond Mice and Men.- Non-Mammalian Parent-Of-Origin Effects.

Fields of interestHuman Genetics



Due August 2012

2012. X, 338 p. 40 illus., 19 in color. (Methods in Molecular Biology, Volume 925) Hardcover7 $139.00ISBN 978-1-62703-010-6

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M. A. Geyer, University of California, San Diego, CA, USA; G. Gross, Abbott GmbH & Co. KG, Ludwigshafen, Germany (Eds)

Novel Antischizophrenia Treatments

Features 7 Provide up-to-date information on approa-ches to the discovery of treatments for cognitive deficits in schizophrenia 7 Provide information on promising new targets for therapeutics in the treatment of schizophrenia 7 Describe potential use of adjunctive co-treatments for use together with traditional antipsychotics

Contents Preface.- Clinical instruments to evaluate and guide treatment in schizophrenia.- Cognitive deficits in schizophrenia- Muscarinic mechanisms in psychotic disorders.- Nicotinic mechanisms in psychotic disorders.- GABAergic circuits in schizophrenia: targets for new treatments in schizophrenia.- Inhibitors of glycine transport as potential new treatments in schizophrenia.- The role of glutamate in schizophrenia.- Metabotropic glutamate receptors as targets for new treatments in schizophrenia.- 5-HT2C agonism as a principle for new treatments in schizophrenia.- The role of dopamine D3 receptors for antipsychotic activity and cognitive functions.- Phosphodies-terase inhibitors as potential new treatments in schizophrenia.- Disease modifying approaches to schizophrenia.- A novel therapeutic strategy: medication-enhancement of cognitive therapies in schizophrenia.- Transgenic animals reflecting as-pects of schizophrenia.- Behavioral animal models of pro-cognitive treatments for schizophrenia.

Fields of interestsPharmacology/Toxicology; Pharmacy; Psycho-pharmacology



Available

2012. VII, 496 p. 20 illus., 15 in color. (Handbook of Experimental Pharmacology, Volume 213) Hardcover7 approx. $419.00ISBN 978-3-642-25757-5

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J. M. Gidday, Washington University School of Medicine, St. Louis, MO, USA; M. A. Perez-Pinzon, University of Miami, FL, USA; J. H. Zhang, Loma Linda University, Loma Linda, CA, USA (Eds)

Innate Tolerance in the CNSTranslational Neuroprotection by Pre- and Post-Conditioning

Contents Preface.- Section I. Comparative Physiology and Historical Background.- 1. Tolerance, Historical Review.- 2. Anoxia resistance in lower and higher vertebrates.- 3. Hibernation: A Natural Model of Tolerance to Cerebral Ischemia/Reperfusi-on.- 4. Preconditioning in the Heart.- Section II. Conditioning Methods.- 5. Neuroprotection and Physical Preconditioning: Exercise, Hypothermia, and Hyperthermia.- 6. A New Future in Brain Preconditioning Based on Nutraceuticals: Focus on α-Linolenic Omega-3 Fatty Acids for Stroke Protection.- 7. Medical Gases for Conditioning: Volatile Anesthetics, Hyperbaric Oxygen, and Hy-drogen Sulfide.- 8. Hypoxic Preconditioning in the CNS.- 9. Pharmacologic Preconditioning.- 10. Sur-gical Methods to Induce Brain Preconditioning.- Section III. Conditioning Models for Cerebral Ischemia.- 11. Tolerance Against Global Cerebral Ischemia: Experimental Strategies, Mechanisms, and Clinical Applications.- 12. Preconditioning and Neuroprotection in the Immature Brain.- 13. Conditioning Studies in Focal Cerebral Ischemia: Model Selection, Physiological Monitoring, and Other Methodological Issues.- 14. Preconditioning for Subarachnoid Hemorrhage.- 15. Precondi-tioning for Intracerebral Hemorrhage.- 16. The Protective Effects of Ischemic Postconditioning in Experimental Stroke.- Section IV. Mechanisms of Preconditioning.- 17. Synaptic Signaling in Ische-mic Tolerance.- 18.- The Genomics of Precondi-tioning and Ischemic Tolerance. [...]

Fields of interestsNeurosciences; Neurology; Neurobiology

Target groupsGraduate


Due September 2012

2012. VII, 658 p. 60 illus., 41 in color. (Springer Series in Translational Stroke Research) Hardcover7 $239.00ISBN 978-1-4419-9694-7

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P. Gresele, University of Perugia, Italy; G. Born, University of London, UK; C. Patrono, Università Cattolica del Sacro Cuore, Rome, Italy; C. P. Page, King‘s College London, UK (Eds)

Antiplatelet AgentsAntiplatelet therapy is the cornerstone of treat-ment of ischemic cardiovascular disease and over the last few years spectacular advancements in this field have been recorded. This is the first comprehensive handbook entirely dedicated to all the aspects of antiplatelet therapy. The book is divided into three main sections, pathophysio-logy, pharmacology and therapy, for a total of 23 chapters. A large group of leading experts from different European countries and from the USA, both from academia and industry, have contribut-ed to the book. Besides a detailed overview on the pharmacology and clinical applications of all the currently used or of the novel antiplatelet agents, innovative approaches (e.g. intracellular signalling as an antiplatelet target, small RNAs as platelet therapeutics, etc.) or unconventional aspects (e.g. pharmacologic modulation of the inflammatory action of platelets are also treated. The book is ori-ented to both basic investigators and to clinicians involved with research on platelet inhibition or with the clinical use of antiplatelet therapies.

Features 7 Written by leading experts in the field 7 With numerous illustrations 7 Gives an overview on the current state of the art

Contents Foreword.- Preface.- Part 1. Pathophysiology.- Part 2. Pharmacology.- Part 3. Therapy.

Fields of interestsPharmacology/Toxicology; Cardiology; Internal Medicine



Available

2012. IX, 628 p. 62 illus., 47 in color. (Handbook of Experimental Pharmacology, Volume 210) Hardcover7 $419.00ISBN 978-3-642-29422-8

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G. Grimaldi, University of Palermo, Italy; M. Manto, ULB Erasme, Brusells, Belgium (Eds)

Mechanisms and Emerging Therapies in Tremor DisordersFeatures 7 Detailed description of the various forms of tremor encountered in humans 7 Covers recent advances in methodologies and techniques of assessment, and provides practical information for the daily management 7 Intended for a large audience of scientists, clinicians including neu-rologists and neurosurgeons, internists, fellows, trainees, biologists, biomedical and electrical engineers

Contents Part 1: Fundamental aspects.- Definition of tremor.- Membrane mechanisms of tremor.- Ro-dent models of tremor.- Advances in genetics of human tremor.- Musculo-skeletal models of tremor.- Part 2: The various forms of tremor in clinical practice: presentation and mechanism.- Physiological tremor.- Rest tremor.- Postural tremors.- Isometric tremor.- Essential Tremor and Other Forms of Kinetic Tremor.- Dystonic tremor.- Orthostatic tremor.- Vocal tremor.- Up-date in Familial Cortical Myoclonic tremor with Epilepsy (FCMTE) .- Post-traumatic tremor and Other Post-Traumatic Movement Disorders.- Psy-chogenic tremor.- Tremor in childhood.- Part 3: Assessment of tremor: clinical, neurophysiological and neuroimaging aspects.- Assessment of tremor: clinical and functional scales.- Instrumentation: classical and emerging techniques.- Signal proces-sing.- Diffusion imaging in tremor.- The metabolic networks in Parkinson‘s disease.- Part 4: Therapies of tremor.- Pharmacological treatments of tre-mor.- Thalamotomy.- Brain Stimulation.- Dopa-minergic Influences on Rest and Action Tremors and Emerging Therapies for Tremor.

Fields of interestsBiomedicine general; Neurology

Target groupsGraduate


Due July 2012

2012. VI, 460 p. 105 illus., 63 in color. (Contemporary Clinical Neuroscience) Hardcover7 $209.00ISBN 978-1-4614-4026-0

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G. Gross, Abbott Ludwigshafen, Germany; M. A. Geyer, University of California San Diego, La Jolla, CA, USA (Eds)

Current AntipsychoticsThis volume will try to put current therapy - achievements, shortcomings, remaining medical needs - and emerging new targets into the context of increasing knowledge regarding the genetic and neurodevelopmental contributions to the patho-physiology of schizophrenia. Some of the chapters will also deal with respective experimental and cli-nical methodology, biomarkers, and translational aspects of drug development. Non-schizophrenia indications will be covered to some extent, but not exhaustively.

Features 7 Neurobiology of current and future antipsy-chotic treatments. 7 Written by leading authori-ties in the field. 7 With numerous illustrations.

Contents Preface.- Dopaminergic dysfunction in psychotic disorders.- Role of dopamine D2 receptors for antipsychotic activity.- Dopamine receptor signa-ling pathways and antipsychotics.- Serotonergic mechanisms as targets for existing and novel antipsychotics.- Antipsychotics in the treatment of psychoses during development.- Weight gain and metabolic disturbances induced by antipsychotic treatments.- Medical needs in the treatment of psychotic disorders.- Antipsychotics in the treat-ment of bipolar disorders.- Pharmacogenomics of antipsychotics.- Drug interactions and drug monitoting of antipsychotics.- Delivery systems and dosing for antipsychotics.- Imaging as tool to investigate psychoses and antipsychotics.- Bio-markers for antipsychotic therapies.- Behavioral animal models of antipsychotic drug actions.

Fields of interestsPharmacology/Toxicology; Neurosciences; Re-ceptors



Available

2013. 500 p. 25 illus. in color. (Handbook of Experimental Pharmacology, Volume 212) Hardcover7 approx. $419.00ISBN 978-3-642-25760-5

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A. Hermann, University of Salzburg, Austria; G. F. Sitdikova, Kazan Federal University, Russia; T. M. Weiger, University of Salzburg, Austria (Eds)

Gasotransmitters - Physiology and PathophysiologySince the epochal discovery of the radical and highly toxic gas nitric oxide (NO) as a signaling molecule, two other no less toxic gases – carbon monoxide (CO) and hydrogen sulfide (H2S) – have been found to also be involved in a plethora of physiological and pathophysiological func-tions. The gases termed gasotransmitters play an increasingly important role in understanding how signalling into and between cells is modulated and fine-tuned. The advent of gasotransmitters has profoundly changed our way of thinking about biosynthesis, liberation, storage and action mechanisms in cellular signaling. In recent years an impressive amount of new data, distribut-ed throughout the existing literature, has been generated.

Features 7 Reviews the biological, pharmacological and medical functions of the signalling molecules nitric oxide, carbon monoxide, and hydrogen sul-fide 7 Written by experts 7 Richly illustrated

Contents Nitric Oxide: Biological Synthesis and Functions.- The Role of Carbon Monoxide as a Gasotransmit-ter in Cardiovascular and Metabolic Regulation.- Physiological and Pathophysiological Functions of Hydrogen Sulfide.- Methods for the Detection of Gasotransmitters.- Gasotransmitters in Regulation of Neuromuscular Transmission.- Modulated by Gasotransmitters - BK Channels.

Fields of interestsHuman Physiology; Neurosciences; Cell Physio-logy



Available

2012. VII, 214 p. 33 illus., 10 in color. Hardcover7 $189.00ISBN 978-3-642-30337-1

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H.-G. Joost, German Institute of Human Nutrition, Nuthetal, Germany; H. Al-Hasani, Heinrich Heine University Düsseldorf, Germany; A. Schürmann, German Institute of Human Nutrition, Nuthetal, Germany (Eds)

Animal Models in Diabetes ResearchContents The Non-Obese Diabetic (NOD) Mouse as a Model of Human Type 1 Diabetes.- Assessment of Diabetic Nephropathy in the Akita Mouse.- The BB Rat as a Model of Human Type 1 Diabetes.- Diabetes in Mice with Monogenic Obesity: The db/db Mouse and Its Use in the Study of Cardiac Consequences.- Pathophysiology and Genetics of Obesity and Diabetes in the New Zealand Obese Mouse: A Model of the Human Metabolic Syndrome.- The TALLYHO Mouse as a Model of Human Type 2 Diabetes.- Diet-Induced Diabetes in the Sand Rat (Psammomys obesus).- Diabetes in Zucker Diabetic Fatty Rat.- The GK Rat: A Prototype for the Study of Non-Overweight Type 2 Diabetes?.- Experimentally Induced Rodent Models of Type 2 Diabetes.- Investigation and Treatment of Type 2 Diabetes in Nonhuman Primates.- Determination of Beta-Cell Function: Insulin Secretion of Isolated Islets.- Determination of Beta-Cell Function: Ion Channel Function in Beta Cells.- Measurement of Glucose Homeostasis In Vivo: Glucose and Insulin Tolerance Tests.- Measurement of Glucose Homeostasis In Vivo: Combination of Tracers and Clamp Techniques.- Measurement of Insulin Sensitivity in Skeletal Muscle In Vitro.- Beta-Cell Autoimmunity.- Po-sitional Cloning of Diabetes Genes.- Retinal Digest Preparation: A Method to Study Diabetic Retinopathy.- Lineage Tracing of Pancreatic Stem Cells and Beta Cell Regeneration.- Genetic Linea-ge Tracing of Beta Cell Neogenesis.

Fields of interestsMolecular Medicine; Endocrinology



Due August 2012


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A. R. Karpf, University of Nebraska Medical Center, Omaha, NE, USA (Ed)

Epigenetic Alterations in OncogenesisThe purpose of this book is to provide an up to date review of the nature and consequences of epigenetic changes in cancer.

Features 7 Epigenetic gene silencing in cancer 7 Gene activation by DNA hypomethylation in oncogene-sis 7 Epigenetic cancer biomarkers 7 Epigene-tic dysregulation of miRNAs in cancer

Contents Preface.- Section I: Epigenetic Marks and Mecha-nisms.- DNA methyltransferases (DNMTs), DNA damage repair, and cancer.- DNA hypomethyla-tion and hemimethylation in cancer.- Ten Eleven Translocation (TET) Enzymes and 5-hydroxy-methylation in Mammalian Development and Cancer.- Altered histone modifications in cancer.- Nucleosome occupancy and gene regulation during tumorigenesis.- Section II: The Impact of Epigenetic Alterations on Cancer Biology.- Epige-netic regulation of miRNAs in cancer.- DNA hy-pomethylation and activation of germline-specific genes in cancer.- APC and DNA demethylation in cell fate specification and intestinal cancer.- Epige-netic changes during cell transformation.- Epige-netic reprogramming of mesenchymal stem cells.- Section III: Clinical Implications and Analysis Methods.- Environmental toxicants, epigenetics, and cancer.- Blood derived DNA methylation markers of cancer risk.- Epigenetic therapies in MDS and AML.- Epigenetic targeting therapies to overcome chemotherapy resistance.- Methods for cancer epigenome analysis.- Index

Fields of interestsCancer Research; Human Genetics; Oncology



Due August 2012

2013. XV, 439 p. 22 illus. in color. (Advances in Experimental Medicine and Biology, Volume 754) Hardcover7 approx. $189.00ISBN 978-1-4419-9966-5

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Y. Keisari, Tel Aviv University, Israel (Ed)

Tumor AblationEffects on Systemic and Local Anti-Tumor Immunity and on Other Tumor-Microenvironment Interactions

The growing knowledge on tumor-immune res-ponse interactions and on the tumor microenvi-ronment did not translate so far into better control of cancer by anti-tumor vaccination. The percenta-ge of patients who benefited from vaccination strategies is still too small to justify their general use. It is the aim of this book to present an alter-native to the conventional approach of developing injected tumor vaccines to activate anti-tumor immunity, which will fight cancer.

Features 7 Comprehensive description and compari-son of tumor ablation methods 7 Conceptual and practical aspects of cancer immunothera-py 7 Combination treatments of cancer

Contents Preface.-1 Effect of chemotherapy on the tumor microenvironment and anti-tumor immunity.-2 Hyperthermia, the tumor microenvironment and immunity.-3 Radiofrequency Ablation in Cancer Therapy: Tuning in to in situ tumor vaccines.-4 High Intensity Focused Ultrasound (HIFU) Abla-tion.-5 The interrelationship between cryoablation the immune Response and the tumor microenvi-ronment: Stimulatory and Suppressive Effects.-6 In situ tumor ablation with radiation therapy – its effect on the tumor microenvironment and anti-tumor immunity.-7 Tumor-localized insult delivered by photodynamic therapy and the breakdown of tumor immunotolerance.-8 Effect of electric based ablation treatments on the tumor microenvironment and anti-tumor immunity. Index.

Fields of interestsBiomedicine general; Cancer Research; Oncology



Available

2012. X, 150 p. 9 illus., 5 in color. (The Tumor Microenvironment, Volume 5) Hardcover7 approx. $189.00ISBN 978-94-007-4693-0

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M. Kiselevsky, Russian Academy of Medical Science (Ed)

Malignant EffusionsPleurites, Ascites, Pericardites

Malignant effusions (pleurites, ascites and peri-carditis) are some of the most frequent manifes-tations of dissemination process of malignant tumors. Accumulation of the malignant fluid in serous cavities results in impairment of respira-tory and cardiac functions, however long-term evacuation of the fluid leads to severe disorders of homeostasis that may directly cause the patient’s death. The aim of this comprehensive book is to provide detailed information of pathogenesis and management of malignant effusions. The current book focuses on three of these categories: pleuritis, acsites and pericarditis. This book, written by recognized experts in the field, provides a detailed overview of current knowledge on this subject.

Features 7 About 50 illustrations 7 Main diagnostics criteria Etiology and pathogenesis of malignant effusion 7 Intracavitary immunotherapy and hyperthermia 7 Unique clinical data Up-to-date methods of treatment

Contents Preface. List of Contributors.-1 Morphological and functional characteristics of serous cavities.-2 Pathogenesis of malignant effusions. -3 Diagnosis and treatment of malignant pleural effusion.-4 Malignant ascites: diagnosis and treatment.-5 Malignant pericardial disease.-6 Adoptive immu-notherapy of malignant effusions.-7 Hyperthermia and intracavitary chemotherapy in prevention and treatment of malignant effusions. Index.

Fields of interestsBiomedicine general; Cancer Research; Oncology



Available

2012. Approx. 150 p. 85 illus. Hardcover7 approx. $139.00ISBN 978-94-007-4782-1

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C. W. Kreipke, John D. Dingell VA Medical Center, Detroit, MI, USA; J. A. Rafols, Wayne State University, Detroit, MI, USA (Eds)

Cerebral Blood Flow, Metabolism, and Head TraumaThe Pathotrajectory of Traumatic Brain Injury

Features 7 Represents the first concise compilation of information related to blood flow and head trau-ma 7 Showcases the most timely and cutting-edge advances in understanding both basic science and medical data pertaining to TBI 7 Provides a unique translational quality by containing both mechanistic and clinical observational informa-tion

Contents Historical perspectives in understanding trau-matic brain injury and in situating disruption in CBF in the pathotrajectory of head trauma.- Si-tuating Cerebral Blood Flow in the Pathotrajec-tory of Head Trauma.- Modeling of traumatic brain injury and its implications in studying the pathology of repeated mild impacts to the head.- The presence of venous damage and microbleeds in traumatic brain injury and the potential future role of angiographic and perfusion magnetic reso-nance imaging.- Situating the Endothelin System in the pathotrajectory of TBI-induced changes in haemodynamics.- Age and Sex Differences in Cerebral Blood Flow and Autoregulation after Pediatric Traumatic Brain Injury.- New Frontiers in Clinical Trials Aimed at Improving Outcome Following Traumatic Brain Injury.

Fields of interestsNeurosciences; Human Physiology; Pathology



Due August 2012

2012. X, 190 p. 37 illus., 11 in color. Hardcover7 $189.00ISBN 978-1-4614-4147-2

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J. D. Lambris, University of Pennsylvania, Philadelphia, PA, USA (Ed)

Complement TherapeuticsContents Progress and Trends in Complement Therapeu-tics.- Inhibition of the serine proteases of the complement system.- The role of MASP-1/3 in complement activation.- Membrane-bound com-plement regulatory proteins as biomarkers and potential therapeutic targets for SLE.- DAF as a therapeutic target for steroid hormones: implica-tions for host pathogen interactions.- Targeting gC1qR domains for therapy against infection and inflammation.- The Alternative C5a Receptor Function.- The effects of selective complement- and CD14-inhibition on the E. coli-induced tissue factor mRNA up-regulation, monocyte tissue factor expression and tissue factor functional activity in human whole blood.- CR2-Mediated Targeting of Complement Inhibitors: Bench-to-Bedside Using a Novel Strategy for Site-Specific Complement Modulation.- Paroxysmal nocturnal hemoglobinuria and the complement system: recent insights and novel anti-complement strate-gies.- Defective Complement Action and Control Defines Disease Pathology for Retinal and Renal Disorders and Provides a Basis for new Therapeu-tic Approaches.- C3 Glomerulonephritis/CFHR5 Nephropathy is an endemic disease in Cyprus: Clinical and molecular findings in 21 families.- Complement-targeted therapeutics in periodonti-tis.- Complement system activation in cardiac and skeletal muscle pathology: Friend or foe?.- Innate immunity as orchestrator of bone marrow homing for hematopoietic stem/progenitor cells.- Com-plement-mediated microvascular injury leads to chronic rejection.- Targeting complement at the time of transplantation.- Evaluation of the blood compatibility of materials, cells and tissues: Basic concepts, test models and practical guidelines. [...]

Fields of interestsImmunology; Microbiology; Infectious Diseases



Due September 2012

2012. Approx. 300 p. 85 illus., 50 in color. (Advances in Experimental Medicine and Biology, Volume 734) Hardcover7 $189.00ISBN 978-1-4614-4117-5

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W. Linert, Technical University of Vienna, Austria; H. Kozlowski, Univeristy of Wroclaw, Poland (Eds)

Metal Ions in Neurological SystemsContents 1. R.R. Crichton, D.T. Dexter, R.J. Ward: Brain iron metabolism and its perturbation in neu-rological diseases.- 2. E. Milward et al.: Brain changes in iron loading disorders.- 3. I. Paris, J. Segura-Aguilar: The role of metal ions in dopa-minergic neuron degeneration in Parkinsonism and Parkinson’s disease.- 4. E. Siakkou, G.N.L. Jameson: Iron, cysteine and neurodegeneration during Parkinson’s disease.- 5. G. Crisponi et al.: Copper uptake and trafficking in the brain.- 6. Y. Nishida: Prion diseases and manganism.- 7. A. Granzotto, P. Zatta: Metal ions and beta-amyloid: conformational modifications and biological aspects.- 8. A. Granzotto et al.: Beta-amyloid toxicity increases with hydrophobicity in the presence of metal ions.- 9. Ch. Exley, E.R. House: Aluminium in the human brain.- 10. V.M. Nurchi, G. Crisponi, V. Bertolasi, G. Faa, M. Remelli: Alu-minium dependent human diseases and chelating properties of aluminium chelatots for bio-medical applications.-11. M. Suwalsky P.L. Henrnandez, C.P. Sotomayor: Aluminum increases toxic effects of amyloid beta-peptides on human erythrocyte membrane and molecular models.- 12. E. Gaggelli, G. Valensin: Oxidative stress in neurodegenerati-on: targeting mitochondria as a therapeutic aid.- 13. Y. Nishsida: The chemical process of oxidative stress by copper(II) and iron(III) ions in several neurodegenerative disorders.- 14. O.G. Tsay, K. Kim, D.G. Churchil: Metal ion role in the CNS under toxic organophosphonate exposure: Traces of understanding and various open questions.- 15. S. Casito, M. [...]

Fields of interestsNeurochemistry; Neurosciences; Organometallic Chemistry



Available

2013. 400 p. 30 illus. in color. Hardcover7 approx. $209.00ISBN 978-3-7091-1000-3

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19

A. Ma‘ayan, B. MacArthur, Mount Sinai School of Medicine, New York, NY, USA (Eds)

New Frontiers of Network Analysis in Systems BiologyThe rapidly developing field of systems biology is influencing many aspects of biological research and is expected to transform biomedicine.

Features 7 Provides in depth knowledge in an area of research that is difficult to master because it is new and emerging, as well as very multidisciplina-ry 7 Covers topics not yet available in other text books 7 Discusses concepts and ideas in a novel point of view about emerging design patterns observed in empirical complex systems including biological regulatory molecular networks

Contents Preface.- 1. Gene expression profiling of single cells, Fumio Arai et al.- 2. Cell Fate Regulatory Networks, Sonya J. Ridden and Ben D. MacAr-thur.- 3. Noise in Regulatory Networks, Srinandan Dasmahapatra.- 4. Generalised Modelling in Systems Biology, Thilo Gross.- 5. Relative quanti-fication mass spectrometry using iTRAQ isobaric tags, Richard D. Unwin et al.- 6. Deciphering Pro-tein Complexes and Protein Interaction Networks for Stem Cell Pluripotency, Jianlong Wang.- 7. Omics era in stem cell research: data integration of multi-regulatory layers, Ana Sevilla et al.- 8. High Throughput Affinity Purification and Mass Spectrometry to Determine Protein Complex Interactions, Anna Malovannaya et al.- 9. Network Pharmacology to Aid the Drug Discovery Process, Ruth Dannenfelser et al.- 10. What can networks do for you?, Bernhard M. Schuldt et al.- Index.

Fields of interestsBiomedicine general; Cell Biology; Systems Biology



Available

2012. IV, 156 p. 24 illus., 4 in color. Hardcover7 $189.00ISBN 978-94-007-4329-8

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J.-R. Martin, CNRS UPR-3294, Gif-sur-Yvette, France (Ed)

Genetically Encoded Functional IndicatorsFeatures 7 Presents a comprehensive overview of the bio-physical and biochemical properties of the titular probes 7 Features easy and accessible descrip-tions of the main imaging tools and methods now available 7 Includes detailed protocols based on the most cutting-edge biological advances

Contents In Vivo Functional Brain Imaging Using a Gene-tically Encoded Ca2+-Sensitive Bioluminescence Reporter, GFP-Aequorin.- Ca2+ Imaging in Brain Slices Using Bioluminescent Reporters.- Calci-um Imaging of Neural Activity in the Olfactory System of Drosophila.- Functional Imaging of Antennal Lobe Neurons in Drosophila with Synapto-pHluorin.- Performing Electrophysiology and Two-Photon Calcium Imaging in the Adult Drosophila Central Brain During Walking Behavi-or.- In Vivo Optical Recording of Brain Interneu-ron Activities from a Drosophila Male on a Tread-mill.- Two-Photon Imaging of Population Activity with Genetically Encoded Calcium Indicators in Living Flies.- Engineering and Application of Ge-netically Encoded Calcium Indicators.- Imaging cAMP Dynamics in the Drosophila Brain with the Genetically Encoded Sensor Epac1-Camps.

Fields of interestsNeurosciences; Human Genetics; Neurology



Due August 2012

2012. X, 154 p. 35 illus., 18 in color. (Neuromethods, Volume 72) Hardcover7 approx. $119.00ISBN 978-1-62703-013-7

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J. A. Prahlow, South Bend Medical Foundation, IN, USA; R. W. Byard, University of Adelaide, SA, Australia

Atlas of Forensic PathologyFor Police, Forensic Scientists, Attorneys, and Death Investigators

Contents Introduction to Pathology.- Introduction to Forensic Sciences.- Introduction to Forensic Pathology.- Death Investigation.- Death Certifica-tion.- Overview of Anatomy and Physiology.- The Forensic Examination and Autopsy.- Postmortem Changes and Time of Death. Identification of Human Remains.- Natural Deaths.- Drug-Related and Toxin-Related Deaths.- Blunt Force Injury Deaths.- Gunshot Wound Deaths.- Sharp Force Injury Deaths.- Asphyxial Deaths.- Drowning Deaths.- Electrical Deaths.- Temperature-Related Deaths.- Burns- and Fire-Related Deaths.- Deaths in Infancy and Childhood.- Miscellaneous Topics.

Fields of interestsForensic Science; Forensic Medicine; Pathology



Available

Print

2012. XII, 906 p. 1500 illus. in color. 7 $679.00ISBN 978-1-61779-057-7

9<HTMGMH=hjafhh> eReference

2012. 7 $679.00ISBN 978-1-61779-058-4

9<HTMGMH=hjafie> Print + eReference

2012. XII, 906 p. 1500 illus. in color. 7 $849.00ISBN 978-1-61779-059-1

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20

J. Reineke, Wayne State University, Detroit, MI, USA (Ed)

NanotoxicityMethods and Protocols

Contents Historical Overview of Nanotechnology and Nanotoxicology.- Characterization of Nanoma-terials for Toxicological Studies.- Methods for Understanding the Interaction Between Nanopar-ticles and Cells.- Single-Cell Gel Electrophoresis (COMET) Assay in Nano-Genotoxicology.- Sing-le-Cell Nanotoxicity Assays of Superparamagnetic Iron Oxide Nanoparticles (SPIONs).- Western Blot Analysis.- Application of Reverse Transcrip-tion-PCR and Real-Time PCR in Nanotoxicity Research.- Deriving TC50 Values of Nanoparticles from Electrochemical Monitoring of Lactate De-hydrogenase (LDH) Activity Indirectly.- Enzyme-Linked Immunosorbant Assay of IL-8 Production in Response to Silver Nanoparticles.- Metabolo-mics Techniques in Nanotoxicology Studies.- Na-noparticle Uptake Measured by Flow Cytometry.- Determining Biological Activity of Nanoparticles as Measured by Flow Cytometry.- Whole Cell Impedance Biosensoring Devices.- Free Energy Calculation of Permeant-Membrane Interactions Using Molecular Dynamics Simulations.- Scree-ning of Fullerene Toxicity by Haemolysis Assay.- Assessment of In Vitro Skin Irritation Potential of Nanoparticles: RHE Model.- In Vivo Methods of Nanotoxicology.- The Luminescent Bacteria Test to Determine the Acute Toxicity of Nanoparticle Suspensions.- The Primacy of Physicochemical Characterization of Nanomaterials for Reliable To-xicity Assessment: A Review of the Zebrafish Na-notoxicology Model.- Application of Embryonic and Adult Zebrafish for Nanotoxicity Assessment.- Applications of Subsurface Microscopy.- Applica-tion of ICP-MS for the Study of Disposition and Toxicity of Metal-Based Nanomaterials. [...]

Fields of interestPharmacology/Toxicology



Due August 2012


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B. Reisfeld, A. N. Mayeno, Colorado State University, Fort Collins, CO, USA (Eds)

Computational ToxicologyVolume I

Rapid advances in computer science, biology, chemistry, and other disciplines are enabling powerful new computational tools and models for toxicology and pharmacology.

Features 7 Includes cutting-edge methods and proto-cols 7 Provides step-by-step detail essential for reproducible results 7 Contains key notes and implementation advice from the experts

Contents What is Computational Toxicology?.- Computati-onal Toxicology – Application in Environmental Chemicals.- Role of Computational Methods in Pharmaceutical Sciences.- Best Practices in Mathematical Modeling.- Tools and Techniques.- Prediction of Physicochemical Properties.- Infor-ming Mechanistic Toxicology with Computational Molecular Models.- Chemical Structure Represen-tations and Applications in Computational Toxi-city.- Accessing and Using Chemical Property Da-tabases.- Accessing, Using and Creating Chemical Property Databases for Computational Toxicology Modeling.- Molecular Dynamics.- Introduction to Pharmacokinetics in Clinical Toxicology.-Mo-deling of Absorption.- Prediction of Pharmacoki-netic Parameters.- Ligand – And Structure-Based Pregnane X Receptor Models.- Non-Compart-mental Analysis.- Compartmental Modeling in the Analysis of Biological Systems.- Physicologically Based Pharmacokinetic/Toxicokinetic Modeling.- Interspecies Extrapolation.- Population Effects and Variability.- Mechanism-Based Pharmacodynamic Modeling.

Fields of interestsPharmacology/Toxicology; Computer Appl. in Life Sciences



Due August 2012

2012. XIV, 704 p. 156 illus., 74 in color. (Methods in Molecular Biology, Volume 929) Hardcover7 $159.00ISBN 978-1-62703-049-6

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B. Reisfeld, A. N. Mayeno, Colorado State University, Fort Collins, CO, USA (Eds)

Computational ToxicologyVolume II

Features 7 Includes cutting-edge methods and proto-cols 7 Provides step-by-step detail essential for reproducible results 7 Contains key notes and implementation advice from the experts

Contents Methods for Building QSARs.- Accessing and Using Chemical Databases.- From QSAR to QSIIR: Searching for Enhanced Computational Toxicology Models.- Mutagenicity, Carcinogeni-city and Other Endpoints.- Classification Models for Safe Drug Molecules.- QSAR and Metabolic Assessment Tools in the Assessment of Genotoxi-city.- Gene Expression Networks.- Construction of Cell Type-Specific Logic Models of Signaling Networks Using CellNetOptimizer.- Regulatory Networks.- Computational Reconstruction of Metabolic Networks from KEGG.- Biomarkers.- Biomarkers: Environmental Public Health Indi-cators.- Modeling for Regulatory Purposes (Risk and Safety Assessment).- Developmental Toxicity Prediction.- Predictive Computational Toxicology to Support Drug Safety Assessment.- Developing a Practical Toxicogenomics Data Analysis System Utilizing Open-Source Software.- Systems Toxico-logy from Genes to Organs.- Agent Based Models of Cellular Systems.- Linear Algebra.- Ordinary Differential Equations.- On the Development and Validation of QSAR Models.- Principal Compo-nents Analysis.- Partial Least Square Methods: Partial Least Squares Correlation and Partial Least Square Regression.- Maximum Likelihood.- Baye-sian Inference.

Fields of interestsPharmacology/Toxicology; Computer Appl. in Life Sciences



Due August 2012

2012. XX, 925 p. 148 illus., 62 in color. (Methods in Molecular Biology, Volume 930) Hardcover7 $159.00ISBN 978-1-62703-058-8

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21

J. Scott, Zürcher Hochschule der Künste, Switzerland; E. Stoeckli, University of Zurich, Switzerland (Eds)

NeuromediaArt and Neuroscience Research

Neuromedia is an innovative examination of shared territories in neurobiological anatomy, physiology and media art.

Features 7 For a public who want to understand the actualities of scientific research and reflect on the importance of this research in the public realm 7 Deeper scientific supplement to the exhibition "Neuromedia" which will be held at the Kulturama in Zurich in August 2012 7 Seg-mented narratives and discoveries from seminal neuroscience research

Contents -Foreword: Scott, Stoekli. -Introduction: Science Communication in the Museum (Prof. Dr. Claudia Ruetsche). - Chapter 2: Your vertebrate visual system: function and behaviour, Prof. Dr. Stephan Neuhauss, Dr. Oliver Biehlmaier: The Electric Retina, 2010 an artistic interpretation of visual system research, Prof. Dr. Jill Scott. -Chapter 3: The formation of neural circuits: functional units in the nervous system, Prof. Dr. Esther Stoekli: Somabook 2010-11 An artistic interpretation of neural tube development, Prof. Dr. Jill Scott. -Chapter 4: Building from the bottom up to understand Sensory Networks: A conversation between Rolf Preiffer and Jill Scott, Prof. Dr. Rolf Pfeiffer: E-skin 2001-2006 somatic perception and visual impairment, Prof. Dr. Jill Scott. -Chapter 5: Understanding Skin in the public realm: Prof. Dr. Reinhard Dummer, Mitch Levesque: Dermaland 2009 Drawing analogies between our skin and the skin of the Earth, Prof. Dr. Jill Scott.

Fields of interestsNeurosciences; Arts; Science Education

Target groupsPopular/general


Available

2012. XII, 160 p. 57 illus., 52 in color. Hardcover7 approx. $109.00ISBN 978-3-642-30321-0

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N. W. Seidler, Kansas City University of Medicine and Biosciences, MO, USA

GAPDH: Biological Properties and DiversityThe book represents a comprehensive review and synthesis of the biomedical literature that spans over a half-century on a single protein called glyceraldehyde 3-phosphate dehydrogenase (or, GAPDH). Due to the protein’s involvement in a vast array of cellular activities, GAPDH is of inte-rest to the cell biologist, immunologist, virologist, biochemist etc. The protein has a significant role in fertility, cancer and neurodegeneration, sug-gesting that this book can be a vital resource for drug development. GAPDH function may provide insight into anesthesia. Furthermore, GAPDH is highly conserved meaning that the protein found in microorganisms, such as pathogens, remained relatively unchanged in evolution.

Features 7 Provides a resource of ideas and references for biomedical researchers that are preparing grant applications 7 Contains a comprehensive syn-thesis of GAPDH information from widely-diver-gent fields 7 Provides a thorough introduction for scientists developing antibiotics, anti-cancer agents, and anti-apoptotic agents

Contents 1. Basic Biology of GAPDH. - 2. GAPDH and Intermediary Metabolism. - 3. Compartmentation of GAPDH. - 4. Functional Diversity. - 5. GAPDH, as a Virulence Factor. - 6. Target for Diverse Chemical Modifications. - 7. Dynamic Oligomeric Properties. - 8. Multiple Binding Partners. - 9. GAPDH in Anesthesia.

Fields of interestsBiomedicine general; Biochemistry, general; Che-mistry/Food Science, general



Available

2012. VI, 295 p. 96 illus., 7 in color. (Advances in Experimental Medicine and Biology, Volume 985) Hardcover7 $209.00ISBN 978-94-007-4715-9

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A. Szallasi, Monmouth Medical Center, Long Branch, NJ, USA; T. Bíró, University of Debrecen, Hungary (Eds)

TRP Channels in Drug DiscoveryVolume I

Contents Introduction to TRPs: A Quest for Novel Drug Targets.- TRP-Mediated Cytoskeletal Reorganiza-tion: Implications for Disease and Drug Deve-lopment.- TRPA1 in Drug Discovery.- Canonical Transient Receptor Potential Channel (TRPC) Expression, Regulation, and Function in Vascular and Airway Diseases.- TRPM2 Function and Po-tential as a Drug Target.- The Ca2+-Activated Mo-novalent Cation Selective Channels TRPM4 and TRPM5.- The Emerging Role of TRPM7 in the Regulation of Magnesium Homeostasis.- TRPM8 Channels as Potential Therapeutic Targets for Pain, Analgesia, and Thermoregulation.- TRPML Channels in Function, Disease, and Prospective Therapies.- The TRPP Signalling Module: TRPP2/Polycystin 1 and TRPP2/PKD1L1.- TRPV1 as a Polymodal Sensor: Potential to Discover TRPV1 Antagonists Selective for Specific Activating Mo-dalities.- Nociceptive and Non-Nociceptive Roles of TRPV3 and Its “Druggability”.- TRPV4 and Drug Discovery.- TRP Expression and Function in the Lung Airways.- Hypoxia-Dependent TRP Channel Function in Pulmonary Arterial Smooth Muscle Cells.- Endotoxin-Induced Airway Inflam-mation and Asthma Models.- Enhanced Cough, Animal Models.- Capsaicin Inhalation Test in Man.- TRP Channels in the Genitourinary (GU) Tract.- Animal Models of Cystitis.- Overactive Bladder Models.

Fields of interestsPharmacology/Toxicology; Proteomics



Due August 2012

2013. XXI, 700 p. 39 illus., 13 in color. (Methods in Pharmacology and Toxicology) Hardcover7 approx. $139.00ISBN 978-1-62703-076-2

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22

W. Tang, X. Tu, University of Rochester Medical Center, Rochester, NY, USA (Eds)

Modern Clinical Trial AnalysisThis volume covers classic as well as cutting-edge topics on the analysis of clinical trial data in bio-medical and psychosocial research and discusses each topic in an expository and user-friendly fa-shion. The intent of the book is to provide an over-view of the primary statistical and data analytic issues associated with each of the selected topics, followed by a discussion of approaches for tackling such issues and available software packages for carrying out analyses.

Features 7 Discusses cutting-edge topics 7 Provi-des analysis of data from dynamic treatment regimen study design, cost-effectiveness analysis, analysis of genomic data, and causal inference to 7 Addresses confounding issues such as con-current medication use and mechanism of action using marginal structural and structural equation models.

Contents Preface.- Survival Analysis.- Longitudinal Data Analysis.- Assessment of Diagnostic Tests and Instruments.- Analysis of Sequential Clinical Trials.- Dynamic Treatment Regimes.- Statistical Issues with Trial Data and Economic Modeling for Cost-effectiveness Evaluation.- Active-controlled Clinical Trials.- Thorough QT/QTc Clinical Trials .- Causal Inference in Cancer Clinical Trials.- In-dex.

Fields of interestsCancer Research; Oncology; Bioinformatics



Due September 2012

2012. V, 162 p. 15 illus., 1 in color. (Applied Bioinformatics and Biostatistics in Cancer Research) Hardcover7 $189.00ISBN 978-1-4614-4321-6

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B. H. Weber, University of Regensburg, Germany; T. LANGMANN, University Hospital of Cologne, Germany (Eds)

Retinal DegenerationMethods and Protocols

Contents Identification and Analysis of Inherited Reti-nal Disease Genes.-Mouse Models for Studies of Retinal Degeneration and Diseases.-Retinal Fundus Imaging in Mouse Models of Retinal Diseases.-Functional Phenotyping of Mouse Models with ERG.-Phenotyping of Mouse Models with OCT.-Light Damage as a Model of Retinal Degeneration.-N-Methyl-D-Aspartate (NMDA)-mediated Excitotoxic Damage – A Mouse Model of Acute Retinal Ganglion Cell Damage.-Generation of Transgenic X. laevis Models of Retinal Degeneration.-Analysis of Photoreceptor Degeneration in the Zebrafish Danio rerio.-Analysis of Optokinetic Response in Zebrafish by Computer Based Eye Tracking.-Analysis of the Drosophila Compound Eye with Light and Electron Microscopy.-Cell Specific Markers for the Identification of Retinal Cells by Immunofluo-rescence Microscopy.-A Method of Horizontally-Sliced Preparation of the Retina.-Detection of DNA Fragmentation in Retinal Apoptosis by TUNEL.-High-throughput RNA in situ Hybridi-zation in Mouse Retina.- Assessment of Mito-chondrial Damage in Retinal Cells and Tissues using Quantitative Polymerase Chain Reaction for Mitochondrial DNA Damage and Extracel-lular Flux Assay for Mitochondrial Respiration Activity.-Analysis of Photoreceptor Rod Outer Segment Phagocytosis by RPE Cells in situ.-Ca2+ Microfluorimetry in Retinal Müller Glial Cells.-Functional Analysis of Retinal Microglia and their Effects on Progenitors.-Analysis of Photoreceptor Outer Segment Phagocytosis by RPE Cells in Culture. [...]

Fields of interestsMolecular Medicine; Ophthalmology



Due September 2012

2012. 335 p. 98 illus., 7 in color. (Methods in Molecular Biology, Volume 935) Hardcover7 $139.00ISBN 978-1-62703-079-3

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C. Wittmann, TU Braunschweig, Germany; S. Y. Lee, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea (Eds)

Systems Metabolic EngineeringContents Preface, Christoph Wittmann, Sang Yup Lee.- 1. Genome-scale network modeling, Sang Yup Lee et al.- 2. Kinetic modeling of metabolic networks, Daniel C. Zielinski and Bernhard O. Palsson.- 3. Design of superior cell factories based on systems wide omics analysis, Hiroshi Shimizu et al.- 4. Technologies for bio-systems engineering, Sven Panke et al.- 5. Systems metabolic engineering of Escherichia coli for chemicals, materials, biofuels, and pharmaceuticals, Sang Yup Lee et al.- 6. Systems metabolic engineering of Coryne-bacterium glutamicum for biobased production of chemicals, materials and fuels, Judith Becker, Stefanie Kind, Christoph Wittmann.- 7. Towards a synthetic biology of the stress-response and the tolerance phenotype: systems understanding and engineering of the Clostridium acetobutylicum stress-response and tolerance to toxic metabolites, Eleftherios T. Papoutsakis, Keith V. Alsaker.- 8. Model-based design of superior cell factory: an illustrative example of Penicillium chrysogenum, I. Emrah Nikerel.- 9. Bridging Omics Techno-logies with Synthetic Biology in Yeast Industrial Biotechnology, António Roldão, Il-Kwon Kim, Jens Nielsen.- 10. Design of superior cell factories for a sustainable biorefinery by synthetic bioengi-neering, Tomohisa Hasunuma, Fumio Matsuda, Akihiko Kondo.- 11. Systems-level analysis of cancer metabolism, Paulo A. Gameiro, Christian M. Metallo, Gregory Stephanopoulos.- Index.

Fields of interestsGene Expression; Systems Biology; Biotechnology



Available


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23

L.-J. C. Wong, Ph.D., Baylor College of Medicine, Houston, TX, USA (Ed)

Mitochondrial Disorders Caused by Nuclear GenesContents Part 1: Overview.- The Clinical Spectrum of Nuclear DNA-Related Mitochondrial Disorders.- Biochemical and Molecular Methods for the Study of Mitochondrial Disorders.- Part 2: Genes Involved in Mitochondrial DNA Biogenesis and Maintenance of Mitochondrial DNA Integrity.- Mitochondrial Disorders Associated with the Mitochondrial DNA Polymerase g: A Focus on Intersubunit Interactions.- Alpers-Huttenlocher Syndrome, Polymerase Gamma 1, and Mitochon-drial Disease.- Deoxyguanosine Kinase.- MPV17-Associated Hepatocerebral Mitochondrial DNA Depletion Syndrome.- Mitochondrial DNA Multiple Deletion Syndromes, Autosomal Domi-nant and Recessive (POLG, POLG2, TWINKLE and ANT1).- Defects in Mitochondrial Dynamics and Mitochondrial DNA Instability.- Depletion of mtDNA with MMA: SUCLA2 and SUCLG1.- RRM2B-Related Mitochondrial Disease.- Part 3: Complex Subunits and Assembly Genes.- Com-plex Subunits and Assembly Genes: Complex I.- Mitochondrial Respiratory Chain Complex II.- Mitochondrial Complex III Deficiency of Nu-clear Origin: Molecular Basis, Pathophysiological Mechanisms and Mouse Models.- Mitochondrial Cytochrome c Oxidase Assembly in Health and Human Diseases.- Part 4: Mitochondrial Protein Translation Related Diseases.- Mitochondrial Aminoacyl-tRNA Synthetases.- Mitochondrial Protein Translation Related Disease: Mitochond-rial Ribosomal Proteins and Translation Factors.- Disorders of Mitochondrial RNA Modification.- Part 5: Others.- Pyruvate Dehydrogenase Complex Deficiencies. [...]

Fields of interestsHuman Genetics; Molecular Medicine; Biomedi-cine general



Due September 2012

2012. VII, 483 p. 31 illus., 18 in color. Hardcover7 approx. $209.00ISBN 978-1-4614-3721-5

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L. Wu, The Ohio State University, Columbus, OH, USA; O. Schwartz, Institut Pasteur, Pairs, France (Eds)

HIV Interactions with Dendritic CellsInfection and Immunity

Given rapid research progress and advance of the techniques in studying HIV interactions with host cells and factors, there is a critical need for a book on HIV interactions with DCs. The proposed book will aim for a broad readership to facilitate HIV/AIDS research and provide a practical tool for HIV researchers to continuously address novel questions.

Features 7 Systematically addresses HIV interactions with dendritic cells with emphasis on HIV infection and immunity 7 Features state-of-the-art research on HIV interactions with dendritic cells using virological and immunological approa-ches 7 Provides future directions for the specific research topic in each chapter

Contents Preface.- Immunobiology of dendritic cells and the influence of HIV infection.- Antiviral immune responses by human Langerhans cells and dendritic cells in HIV-1 infection.- Plasma-cytoid dendritic cells in HIV infection.- Cellular and viral mechanisms of HIV transmission by dendritic cells.- Role of glycosphingolipid in dendritic cell-mediated HIV-1 trans-infection.- Simian immunodeficiency virus interactions with macaque dendritic cells.- Interactions between HIV-1 and innate immunity in dendritic cells.- HIV impairment of immune responses in dend-ritic cells.- HIV-derived vectors for gene therapy targeting dendritic cells.- Targeting dendritic cells for improved HIV-1 vaccines.- Index.

Fields of interestsVirology; Immunology; Medical Microbiology



Due September 2012

2012. X, 300 p. 29 illus., 20 in color. (Topics in HIV and AIDS Research, 1) Hardcover7 approx. $189.00ISBN 978-1-4614-4432-9

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Q. Yan, PharmTao, Santa Clara, CA, USA (Ed)

PsychoneuroimmunologyMethods and Protocols

Contents The Role of Psychoneuroimmunology in Persona-lized and Systems Medicine.-Psychoneuroimmu-nology – The Experiential Dimension.-Psycho-social Job Stress and Immunity –– A Systematic Review.-Immune Cells Listen To What Stress is Saying: Neuroendocrine Receptors Orchestra-te Immune Function.-Physical Activity, Stress Reduction and Mood: Insight into Immunological Mechanisms.-Translational Implications of In-flammatory Biomarkers and Cytokine Networks in Psychoneuroimmunology.-Cytokines as Potential Biomarkers for Parkinson’s Disease: A Multiplex Approach.-Exploring the Diagnostic Potential of Immune Biomarker Co-expression in Gulf War Illness.-Neuroimmune Mechanisms of Depres-sion in Heart Failure.-A Reinterpretation of the Pathogenesis and Cure of Cancer According to the Psychoneuroimmunological Discoveries.-Aging Microglia: Relevance to Cognition and Neural Plasticity.-Autism Spectrum Disorders: From Immunity to Behavior.-Mouse Testing Methods in Psychoneuroimmunology: An Overview of How to Measure Sickness, Depressive/anxietal, Cognitive and Physical Activity Behaviors.-The MRL Model: an Invaluable Tool in Studies of Autoimmunity – Brain Interactions.-Interleukin-2 and the brain: Dissecting central versus periphe-ral contributions using unique mouse models.-Psychoneuroimmunology and Natural Killer Cells: The Chromium Release Whole Body Assay.-The Application of PET Imaging in Psychoneuroim-munology Research.-The Vaccination Model in Psychoneuroimmunology Research: A Review.-Using Vaccinations to Assess in vivo Immune Function in Psychoneuroimmunology. [...]

Fields of interestsImmunology; Laboratory Medicine



Due August 2012

2012. XII, 474 p. 27 illus., 11 in color. (Methods in Molecular Biology, Volume 934) Hardcover7 $139.00ISBN 978-1-62703-070-0

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24

S.-Y. Ying, University of Southern California, Los Angeles, CA, USA (Ed)

MicroRNA ProtocolsContents The MicroRNA.- Analysis of MicroRNA Length Variety Generated by Recombinant Human Dicer.- A User-Friendly Computational Workflow for the Analysis of miRNA Deep Sequencing Data.- The RNA Gene Information: Retroelement-MicroRNA Entangling as the RNA Quantum Code.- Setting Up an Intronic miRNA Database.- Identify Intro-nic MicroRNA with Bioinformatics.- Experimen-tal miRNA Target Validation.- Enrichment Ana-lysis of miRNA Targets.- MicroRNA Expression Profiling During Neural Differentiation of Mouse Embryonic Carcinoma P19 Cells.- Evaluating the MicroRNA Targeting Sites by Luciferase Reporter Gene Assay.- Expression Pattern Analysis of Mi-croRNAs in Caenorhabditis elegans.- Use of Viral Systems to Study miRNA-Mediated Regulation of Gene Expression in Human Cells.- Cloning, Expression, and Functional Analysis of Genomic miRNA Using Retroviral System in Cancer Cells.- Preparing Synaptoneurosomes from Adult Mouse Forebrain.- Isolation of Total RNA and Detection Procedures for miRNA Present in Bovine Cultu-red Adipocytes and Adipose Tissues.- miRNA and shRNA Expression Vectors Based on mRNA and miRNA Processing.- Gene Silencing In Vitro and In Vivo Using Intronic MicroRNAs.- Vector-Free Methods for Manipulating miRNA Activity In Vi-tro and In Vivo.- MicroRNA Expression Profiling of Human Induced Pluripotent and Embryonic Stem Cells.- MicroRNA Expression During Neu-ronal Differentiation of Human Teratocarcinoma NTera2D1 and Mouse Embryonic Carcinoma P19 Cells.- Isolation and Identification of Gene-Speci-fic MicroRNAs.- Transgene-Like Animal Models Using Intronic MicroRNAs. [...]

Fields of interestsHuman Genetics; Gene Expression



Due August 2012

2nd ed. 2013. XXIII, 600 p. 61 illus., 33 in color. (Methods in Molecular Biology, Volume 936) Hardcover7 approx. $139.00ISBN 978-1-62703-082-3

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H.-G. Zhang, University of Louisville, KY, USA (Ed)

Emerging Concepts of Tumor Exosome–Mediated Cell-Cell CommunicationIn multicellular organisms, communication bet-ween cells involves secretion of proteins that bind to receptors on neighboring cells. While this has been well documented, another mode of intercel-lular communication has recently become the sub-ject of increasing interest: the release of exosomes. In cancer, tumor exosomes are involved in various aspects of pathogenesis, including proliferation, immunosuppression, and metastasis.

Features 7 Explores recent findings on vesicle-based information transfer by exosomes 7 Provides an overview of exosomes biology and func-tion 7 Discusses the role of exosomal tetraspa-nins in tumor progression

Contents Preface.- The Cell Biology of Exosomes : Historical and Perspectives.- The role of exosomal shuttle RNA (esRNA) in cell-to-cell.- Exosomal lipids in cell-cell communication.- The Functional Importance Of Tetraspanins In Exosomes.- The effects of exosomes and related vesicles on cancer development, progression, and dissemination.- Circulating Cell-derived Vesicles Mediate Tumor Progression.- Immune modulation of T cells and natural killer cells by tumor-derived exosomes.- The Role Of Tumor Exosomes In Tumorigenici-ty.- Microenvironmental regulation of metastasis by exosomes.- Microvesicles and their Emerging Role in Cellular Therapies for Organ and Tissue Regeneration.- Index

Fields of interestsCancer Research; Cell Biology; Posttranslational Modification



Due August 2012


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Y. Zheng, Cincinnati Children‘s Hospital Research Foundation, OH, USA (Ed)

Rational Drug DesignContents On Setting up and Assessing Docking simulations for Virtual Screening.-Virtual Ligand Screening Combined with NMR to Identify Dvl PDZ Do-main Inhibitors Targeting the Wnt Signaling.-Rati-onal Design of Rho GTPase Targeting Inhibitors.-Rational Design of Peptide Ligands Against a Glycolipid by NMR Studies.-A Combinatorial Strategy for the Acquisition of Potent and Specific Protein Tyrosine Phosphatase Inhibitors.-Identi-fication of Allosteric Inhibitors of p21-Activated Kinase.-Using a Modified Yeast Two-hybrid System to Screen for Chemical GEF Inhibitors.-Random Mutagenesis of Peptide Aptamers As An Optimization Strategy for Inhibitor Screening.-A Screening Strategy for Trapping the Inactive Con-former of a Dimeric Enzyme with a Small Mole-cule Inhibitor.-Use of a Fluorescent ATP Analog to Probe the Allosteric Conformational Change in the Active Site of the Protein Kinase PDK1.-Affinity Purification of Protein Kinases that Adopt a Specific Inactive Conformation.-Determination of the Kinetics and Thermodynamics of Ligand Binding to a Specific Inactive Conformation in Protein Kinases.-Purification and Specific Assays for Measuring APE-1 Endonuclease Activity.-An in vitro Screening to Identify Drug Resistant Mutations for Target-directed Chemotherapeutic Agents.-Utilizing AntagomiR (anti-sense mi-croRNA) to Knock Down microRNA in Murine Bone Marrow Cells.-Synthesis, Conjugation, and Labeling of Multifunctional pRNA Nanoparticles for Specific Delivery of siRNA, Drugs and Other Therapeutics to Target Cells.-Mouse Models for Tumor Metastasis.Rational Design of Peptide Ligands Against a Glycolipid by NMR Studies. [...]

Fields of interestsPharmacology/Toxicology; Medicinal Chemistry



Due September 2012

2012. 205 p. 59 illus., 7 in color. (Methods in Molecular Biology, Volume 928) Hardcover7 $119.00ISBN 978-1-62703-007-6

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