Data demonstrating reduction of myocardial infarct size in most

characterized small animal preclinical model

nor-NOHA

- selective arginase inhibitor, affects nitric oxide pathway

- rats administered vehicle or nor-NOHA at 15 minutes prior to

induction of myocardial ischemia

0

5

10

15

20

25

30

35

40

45

Effect of nor-NOHA on MyocardialIschemia / Reperfusion Injury in the Rat

Ischemic Zone / Area at Risk (%)

Vehicle (n=7)

nor-NOHA 100mg/kg (n=6)