8
EACTS Daily News  Tuesday 30 October 2012 33 Thoracic: Focus Sesion 14:15–15:45 Room 133/134 Cardiac: Abstract 14:15–15:45 Room 114 Cardiac: Focus Session 16:15–17:45 Room 120/121 Wolfgang Harringer Klinikum  Braunschweig, Braunschweig, Germany A lthough Trendelenburg first described surgical embolec- tomy for acute pulmonary embolism back in 1908 the procedure has only found its break through over the last decades. This be- comes most obvious in the fact that guidelines only recommend pulmonary embolectomy in case of serious hemo- dynamic instability and high risk, failure or contraindication to lysis. The low acceptance of the Trendelen- burg procedure is mainly attributed to the very high mortality that initially even reached 100%. As lysis for acute coro- nary syndroms has lost its merits over the last decade through the improvement of catheter techniques that introduced the possibility of a more goal directed treatment of culprit lesions the evolu- tion of surgical know how could like- wise change our treatment perspectives for acute pulmonary embolism. Hence giving a greater role for surgery in he- modynamically stable patients with right ventricular dysfunction in whom lysis re- mains the golden standard. This view seems justified by the radical drop of mortality in association with sur- gical treatment, mortality rates as low as 6.4% being described nowadays. Crucial for achieving such excellent results are a fast and accurate diagnosis in addition to a rapid decision making for which an interdisciplinary team approach between cardiologists and surgeons appears man- datory. Extracorporeal membrane oxy- genators could play an important role in this setup offering an excellent bridging technique between stabilization (oxygen- ation and relief of right ventricular dys- function) and definite surgical treatment. Progresses made in this field have made these devices readily available, easy to apply and reduced the associated mor- bidity to acceptable levels. Miniaturiza- tion and biocompatible coating have re- sulted in a reduction of foreign surface contact, bleeding complications and in- flammatory response. Minimized per- fusion circuits which have followed a similar philosophy may also contribute to the success of surgery especially con- sidering a reduction of inflammatory re- sponse that may play an underestimated role in the pathogenesis that follows pul- monary embolism. In conclusion a rapid diagnosis and interdisciplinary decision making for best treatment strategy will prompt a more aggressive surgical treatment even in he- modynamically stable patients with right ventricular dysfunction. The lack of scien- tific evidence in terms of prospective ran- domized trials remains the main obstacle for a more liberal choice for surgery. This barrier will only be overcome through a heart team approach. Jonida Bejko, Tomaso Bottio, Vincenzo Tarzia, Marco De Franceschi, Roberto Bianco, Michele Gallo, Massimo Castoro, Gino Gerosa Institute of Cardiovascular Surgery.  Padova, Italy S ternal wound insta- bility (SWI) and/or in- fection are still active and life-threatening complications in cardiac sur- gery. The pathogenesis is not yet clearly defined, and many authors identified several fac- tors, patient or surgeon re- lated, as potential causes. The Flexigrip (Praesidia, Bo- logna – Italy) is a sternal closure system, composed of thermo- reactive alloy of Nichel and Ti- tanium with a memory effect, which acts as a brace holding together the sternal osteotomy. We sought to assess the ef- ficiency of two different sternal closure techniques in preventing sternal wound instability in high risk patients. Between January-09 and Feb- ruary-12, 2,068 consecutive car- diac-patients have been prospec- tively collected in our database. Based on the observation that in the vast majority of cases of sternal wound infections some degree of sternal instabil- ity is always present, we com- pared the results observed in two population of matched pa- tients in whom two different sternal wiring techniques were adopted, using the same triple- layer suture for fascia, subcuta- neous tissue and skin. The 561 patients in whom the thermoreactive-Nitilium- clips (Flexigrip) have been used (Group A), were matched 1:1 with 561 patients who received a standard parasternal wiring technique (Group B) on 10 avail- able risk factors known to affect sternal wound healing (age, age > 75-year, gender, diabetes-mel- litus, cardiac-procedure, obes- ity, re-intervention, cross-clamp, and total operative times). The study was completed with a cost analysis. The two groups were well matched, although different for bilateral internal thoracic har- vesting, chronic obstructive pul- monary disease, renal insuffi- ciency, and congestive heart failure which were significantly more frequent in Group A. At 30-days of follow-up, the as- sociation wound-complication and sternal instability was sig- nificantly less frequent in Group A versus Group B (0.2% ver- sus 1.6%) (p=0.04). Overall in- cidence of sternal wound com- plication was lower in Group A (2% versus 3.5%) (p=0.28). In presence of wound infec- tion, a sternal wound instabil- ity was never observed in Group A (p=0.06). Overall costs were 8,701,854 and 9,243,702 in Group A and B, respectively, thus Flexigrip closure technique offered a 541,848 cost saving. Flexigrip used in high risk pa- tients showed a lower incidence of sternal wound instability with no need of sternal re-wiring in any case, even in presence of wound infection. Flexigrip proved to be also cost-effective. Bernard Prendergast John Radcliffe  Hospital, Oxford, UK I nfective endocarditis is an elusive and dangerous condition which challenges all those involved in its management. Cardiologists and cardiac surgeons, who encounter pa- tients with severe complications of the disease destined for complex cardiac surgery or post mortem, fear its con- sequences and have maintained the dogma of prevention by means of anti- biotic prophylaxis prior to invasive pro- cedures. The evidence to support this stance is limited and revised European and US guidelines in recent years have resulted in a major shift of emphasis in this contentious area. Moreover, guid- ance from the UK National Institute for Health and Clinical Excellence (NICE) published in 2008 abolished this prac- tice completely with no adverse con- sequences to date. Is it now time for further evaluation and a definitive ran- domised controlled trial? Changing epidemiology and evi- dence to date The clinical profile of IE is changing with increasing frequency of Staphylo- coccus aureus and falling incidence of IE secondary to oral streptococci. IE of- ten arises in patients without previously documented cardiac disease when the question of prophylaxis is irrelevant. Even if antibiotic prophylaxis is ap- plied appropriately, the evidence to support its efficacy is limited to case- control analyses. Even if these studies are negative, they also fail to demon- strate that antibiotic prophylaxis of IE is ineffective. They do, however, sug- gest that a huge number of prophy- laxis doses are necessary to prevent a very low number of IE cases and that the risk of developing IE after an un- protected at-risk dental procedure is extremely low. Whilst a randomised placebo controlled trial to address the benefits of antibiotic prophylaxis in preventing IE is desirable, such a study would be a massive undertaking, re- quiring large numbers of patients in each arm to provide adequate statis- tical power. The heterogeneity of the underlying cardiac conditions and in- vasive procedures would make stratifi- cation extremely difficult but a trial fo- cussing on the highest risk groups (eg. those with a prosthetic valve) could be achieved with sufficient statistical power to allow extrapolation to other lower risk cohorts. The UK is the only nation where such a trial could be eth- ically performed and preliminary plans are currently being conceived. Guidelines and philosophy The original “treat all” philoso- phy was based upon an understanda- ble fear of infective endocarditis and its complications. However, the number needed to treat for effective prevention is exceedingly high and routine antibi- otic administration is not risk free. Ana- phylaxis to  -lactam antibiotics occurs in 15-40 per 100,000 uses and there are legitimate concerns regarding commu- nity-derived antibiotic resistance. More- over, the cost-effectiveness of routine antibiotic prophylaxis is questionable. The European and US guidelines ad- vocate the “number needed to treat” or “bang for your buck” philosophy, re- stricting use of antibiotic prophylaxis to patients at the highest risk of IE under- going the highest risk procedures. An- tibiotic prophylaxis is no longer recom- mended for patients with native valve disease nor for any gastrointestinal or genitourinary procedures. Going one step further, the UK NICE guidelines espouse the “proof of princi- ple” philosophy and recommended an end to the practice of antibiotic proph- ylaxis altogether. To date, this seemingly radical recommendation has not been accompanied by the predicted surge in the incidence or mortality of infec- tive endocarditis in the UK, though con- tinued prescribing to high risk groups seems likely may be a confounding source of positive reassurance. Let’s test the hypothesis... Notwithstanding the current paucity of evidence, it is clear that the efficiency of current practice is restricted due to the exorbitant number needed to treat to prevent a single case of IE, with po- tential for overall harm. A shift of the fundamental question from “Who is at risk?” to “Who might benefit?” there- fore seems appropriate. National or in- ternational registries may provide use- ful information and previous ethical concerns obstructing the required ran- domised controlled trial have now been removed. Whether, there will be suffi- cient political imperative and enthusiasm to undertake such a major endeavour remains to be seen. Is there a role for surgery in acute pulmonary embolism? Nitinol flexigrip sternal closure system and standard sternal steel wiring: Insight from a matched comparative analysis Antibiotic prophylaxis for infective endocarditis: Time for a definitive answer? Wolfgang Harringer 09:40 How to do a mini aortic valve replacement P. Sardari Nia (Breda) 10:10 How to do a mini-maze W.-J. Van Boven (Amsterdam) 10:30 Break 11:00 How to do a thoracic endovascular aortic repair M. Czerny (Berne) 11:20 How to do an endovascular coronary artery bypass N. Bonaros, (Innsbruck) 11:40 How to do video-assisted thoracoscopic epicardial lead placement B. Van Putte (Breda) 12:00 Ends Advanced Techniques 09:00 Lateral Thinking Room 111 09:00 Why are we here today? Introduction, background and goals of this session J. Seeburger (Leipzig) 09:09 How simple ideas can influence our practice O. Alfieri (Milan) 09:18 What do patients want and need? M. Misfeld (Leipzig) 09:27 Societies (EACTS, AATS, STS, ESC...): Lobby for whom? V. Falk (Zürich) 09:36 A randomized trial in the NEJM: the holy grail of marketing? M. Mack (Dallas) 09:45 The next generation of cardiac surgeons: where to go? T. Noack (Leipzig) 09:54 Doctor and business man: conflict of interest? J. Pomar (Barcelona) 10:03 Technology transfer in cardiac medicine: money, ego, career? E. Schwammenthal (Tel Aviv) 10:12 Break 10:30 How to make the most of your ideas and your future self F. Litvack (Los Angeles) 10:39 Is cardiac medicine worth the effort? Insights from economy M. Rosenmoller, IESE Business School (Barcelona) 10:48 Will I make money investing in cardiac surgery? J Mack (Mounds View) 10:57 On the road again: why give up cardiac surgery? M. Studer (Dübendorf) 11:06 Think Tank cardiac surgery S. Haider (Erlangen) 11:15 Discussion 11:51 Closing Remarks V. Falk (Zürich) Advanced Techniques 09:00 The mitral and tricuspid valves: repair techniques Room 113 Moderator: J. R. Pepper, London; P. van de Woestijne, Rotterdam 09:00 Pathophysiology of functional mitral and tricuspid regurgitation K. M. J. Chan (London) 09:25 Assessment of functional mitral and tricuspid regurgitation L Pierard (Liege) 09:50 Natural history and medical treatment of functional mitral and tricuspid regurgitation T. McDonagh (London) 10:15 Break 10:45 Surgical treatment of functional mitral regurgitation R. Dion (Genk) 11:10 Surgical treatment of functional tricuspid regurgitation G. Dreyfus (Monte-Carlo) 11:35 Newer approaches: when do percutaneous techniques offer a solution? F. Maisano (Milan) 11:35 An alternative surgical treatment to tricuspid regurgitation J-P Couetil (Paris) 11.55 Newer approaches: when do percutaneous techniques offer a solution F. Maisano (Milan) 12:15 Conclusion This session is supported by an unrestricted educational grant from Edwards Lifesciences Advanced Techniques 09:00 New surgical treatment concepts for heart failure Rooms 131/132 Organized by the the Roland Hetzer International Cardiothoracic Vascular Surgery Society (RHICS) Moderators: F. Beyersdorf, Freiburg; R. Hetzer (Berlin) 09:00 Organ-conserving surgery F. Beyersdorf (Freiburg) 09:20 Cardiac resynchronization therapy C. Butter (Berlin) 09:40 Revascularization surgery J. Ennker (Lahr) 10:00 State of the art in heart transplantation R. Hetzer (Berlin) 10:20 Role of left ventricular assist device M. Morshuis (Bad Oeynhausen) 10:40 Role of right ventricular assist device T. Krabatsch (Berlin) Continued from page 32 Continued on page 34 Tomaso Bottio

Is there a role for surgery in acute pulmonary embolism?

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EACTS Daily News  Tuesday 30 October 2012  33

Thoracic: Focus Sesion 14:15–15:45  Room 133/134

Cardiac: Abstract 14:15–15:45  Room 114

Cardiac: Focus Session 16:15–17:45  Room 120/121

Wolfgang Harringer  Klinikum 

Braunschweig, Braunschweig, Germany

AlthoughTrendelenburgfirstdescribedsurgicalembolec-tomyforacutepulmonaryembolismbackin1908the

procedurehasonlyfounditsbreakthroughoverthelastdecades.Thisbe-comesmostobviousinthefactthatguidelinesonlyrecommendpulmonaryembolectomyincaseofserioushemo-dynamicinstabilityandhighrisk,failureorcontraindicationtolysis.

ThelowacceptanceoftheTrendelen-burgprocedureismainlyattributedtotheveryhighmortalitythatinitiallyevenreached100%.Aslysisforacutecoro-narysyndromshaslostitsmeritsoverthelastdecadethroughtheimprovementofcathetertechniquesthatintroducedthepossibilityofamoregoaldirected

treatmentofculpritlesionstheevolu-tionofsurgicalknowhowcouldlike-wisechangeourtreatmentperspectivesforacutepulmonaryembolism.Hencegivingagreaterroleforsurgeryinhe-modynamicallystablepatientswithrightventriculardysfunctioninwhomlysisre-mainsthegoldenstandard.

Thisviewseemsjustifiedbytheradicaldropofmortalityinassociationwithsur-gicaltreatment,mortalityratesaslowas6.4%beingdescribednowadays.Crucialforachievingsuchexcellentresultsareafastandaccuratediagnosisinadditiontoarapiddecisionmakingforwhichaninterdisciplinaryteamapproachbetweencardiologistsandsurgeonsappearsman-datory.Extracorporealmembraneoxy-genatorscouldplayanimportantroleinthissetupofferinganexcellentbridgingtechniquebetweenstabilization(oxygen-ationandreliefofrightventriculardys-

function)anddefinitesurgicaltreatment.Progressesmadeinthisfieldhavemadethesedevicesreadilyavailable,easytoapplyandreducedtheassociatedmor-biditytoacceptablelevels.Miniaturiza-tionandbiocompatiblecoatinghavere-sultedinareductionofforeignsurfacecontact,bleedingcomplicationsandin-flammatoryresponse.Minimizedper-fusioncircuitswhichhavefollowedasimilarphilosophymayalsocontributetothesuccessofsurgeryespeciallycon-sideringareductionofinflammatoryre-sponsethatmayplayanunderestimatedroleinthepathogenesisthatfollowspul-monaryembolism.

Inconclusionarapiddiagnosisandinterdisciplinarydecisionmakingforbesttreatmentstrategywillpromptamoreaggressivesurgicaltreatmenteveninhe-modynamicallystablepatientswithrightventriculardysfunction.Thelackofscien-

tificevidenceintermsofprospectiveran-domizedtrialsremainsthemainobstacleforamoreliberalchoiceforsurgery.Thisbarrierwillonlybeovercomethroughaheartteamapproach.

Jonida Bejko, Tomaso Bottio,

Vincenzo Tarzia, Marco De

Franceschi, Roberto Bianco,

Michele Gallo, Massimo

Castoro, Gino Gerosa 

Institute of Cardiovascular Surgery. 

Padova, Italy

Sternalwoundinsta-bility(SWI)and/orin-fectionarestillactiveandlife-threatening

complicationsincardiacsur-gery.Thepathogenesisisnotyetclearlydefined,andmanyauthorsidentifiedseveralfac-tors,patientorsurgeonre-lated,aspotentialcauses.

TheFlexigrip(Praesidia,Bo-logna–Italy)isasternalclosuresystem,composedofthermo-reactivealloyofNichelandTi-taniumwithamemoryeffect,whichactsasabraceholdingtogetherthesternalosteotomy.

Wesoughttoassesstheef-ficiencyoftwodifferentsternalclosuretechniquesinpreventing

sternalwoundinstabilityinhighriskpatients.

BetweenJanuary-09andFeb-ruary-12,2,068consecutivecar-diac-patientshavebeenprospec-tivelycollectedinourdatabase.

Basedontheobservationthatinthevastmajorityofcasesofsternalwoundinfectionssomedegreeofsternalinstabil-ityisalwayspresent,wecom-

paredtheresultsobservedintwopopulationofmatchedpa-tientsinwhomtwodifferentsternalwiringtechniqueswereadopted,usingthesametriple-layersutureforfascia,subcuta-neoustissueandskin.

The561patientsinwhomthethermoreactive-Nitilium-clips(Flexigrip)havebeenused(GroupA),werematched1:1

with561patientswhoreceivedastandardparasternalwiringtechnique(GroupB)on10avail-ableriskfactorsknowntoaffectsternalwoundhealing(age,age>75-year,gender,diabetes-mel-litus,cardiac-procedure,obes-ity,re-intervention,cross-clamp,andtotaloperativetimes).Thestudywascompletedwithacostanalysis.

Thetwogroupswerewellmatched,althoughdifferentforbilateralinternalthoracichar-vesting,chronicobstructivepul-monarydisease,renalinsuffi-ciency,andcongestiveheartfailurewhichweresignificantlymorefrequentinGroupA.At30-daysoffollow-up,theas-sociationwound-complicationandsternalinstabilitywassig-nificantlylessfrequentinGroupAversusGroupB(0.2%ver-sus1.6%)(p=0.04).Overallin-cidenceofsternalwoundcom-plicationwaslowerinGroupA(2%versus3.5%)(p=0.28).Inpresenceofwoundinfec-tion,asternalwoundinstabil-itywasneverobservedinGroupA(p=0.06).Overallcostswere€8,701,854and€9,243,702inGroupAandB,respectively,thusFlexigripclosuretechniqueoffereda€541,848costsaving.

Flexigripusedinhighriskpa-tientsshowedalowerincidenceofsternalwoundinstabilitywithnoneedofsternalre-wiringinanycase,eveninpresenceofwoundinfection.Flexigripprovedtobealsocost-effective.

Bernard Prendergast  John Radcliffe 

Hospital, Oxford, UK

Infectiveendocarditisisanelusiveanddangerousconditionwhichchallengesallthoseinvolvedinitsmanagement.Cardiologistsand

cardiacsurgeons,whoencounterpa-tientswithseverecomplicationsofthediseasedestinedforcomplexcardiacsurgeryorpostmortem,fearitscon-sequencesandhavemaintainedthedogmaofpreventionbymeansofanti-bioticprophylaxispriortoinvasivepro-cedures.TheevidencetosupportthisstanceislimitedandrevisedEuropeanandUSguidelinesinrecentyearshaveresultedinamajorshiftofemphasisinthiscontentiousarea.Moreover,guid-ancefromtheUKNationalInstituteforHealthandClinicalExcellence(NICE)publishedin2008abolishedthisprac-ticecompletelywithnoadversecon-sequencestodate.Isitnowtimeforfurtherevaluationandadefinitiveran-domisedcontrolledtrial?Changing epidemiology and evi-dence to date

TheclinicalprofileofIEischangingwithincreasingfrequencyofStaphylo-

coccusaureusandfallingincidenceofIEsecondarytooralstreptococci.IEof-tenarisesinpatientswithoutpreviouslydocumentedcardiacdiseasewhenthequestionofprophylaxisisirrelevant.

Evenifantibioticprophylaxisisap-pliedappropriately,theevidencetosupportitsefficacyislimitedtocase-controlanalyses.Evenifthesestudiesarenegative,theyalsofailtodemon-stratethatantibioticprophylaxisofIEisineffective.Theydo,however,sug-gestthatahugenumberofprophy-laxisdosesarenecessarytopreventaverylownumberofIEcasesandthattheriskofdevelopingIEafteranun-protectedat-riskdentalprocedureisextremelylow.WhilstarandomisedplacebocontrolledtrialtoaddressthebenefitsofantibioticprophylaxisinpreventingIEisdesirable,suchastudywouldbeamassiveundertaking,re-quiringlargenumbersofpatientsineacharmtoprovideadequatestatis-ticalpower.Theheterogeneityoftheunderlyingcardiacconditionsandin-vasiveprocedureswouldmakestratifi-cationextremelydifficultbutatrialfo-cussingonthehighestriskgroups(eg.thosewithaprostheticvalve)could

beachievedwithsufficientstatisticalpowertoallowextrapolationtootherlowerriskcohorts.TheUKistheonlynationwheresuchatrialcouldbeeth-icallyperformedandpreliminaryplansarecurrentlybeingconceived.Guidelines and philosophy

Theoriginal“treatall”philoso-phywasbaseduponanunderstanda-blefearofinfectiveendocarditisanditscomplications.However,thenumberneededtotreatforeffectivepreventionisexceedinglyhighandroutineantibi-oticadministrationisnotriskfree.Ana-phylaxisto -lactamantibioticsoccursin15-40per100,000usesandtherearelegitimateconcernsregardingcommu-nity-derivedantibioticresistance.More-over,thecost-effectivenessofroutineantibioticprophylaxisisquestionable.

TheEuropeanandUSguidelinesad-vocatethe“numberneededtotreat”or“bangforyourbuck”philosophy,re-strictinguseofantibioticprophylaxistopatientsatthehighestriskofIEunder-goingthehighestriskprocedures.An-tibioticprophylaxisisnolongerrecom-mendedforpatientswithnativevalvediseasenorforanygastrointestinalorgenitourinaryprocedures.

Goingonestepfurther,theUKNICEguidelinesespousethe“proofofprinci-ple”philosophyandrecommendedanendtothepracticeofantibioticproph-ylaxisaltogether.Todate,thisseeminglyradicalrecommendationhasnotbeenaccompaniedbythepredictedsurgeintheincidenceormortalityofinfec-tiveendocarditisintheUK,thoughcon-tinuedprescribingtohighriskgroupsseemslikelymaybeaconfoundingsourceofpositivereassurance.Let’s test the hypothesis...

Notwithstandingthecurrentpaucityofevidence,itisclearthattheefficiencyofcurrentpracticeisrestrictedduetotheexorbitantnumberneededtotreattopreventasinglecaseofIE,withpo-tentialforoverallharm.Ashiftofthefundamentalquestionfrom“Whoisatrisk?”to“Whomightbenefit?”there-foreseemsappropriate.Nationalorin-ternationalregistriesmayprovideuse-fulinformationandpreviousethicalconcernsobstructingtherequiredran-domisedcontrolledtrialhavenowbeenremoved.Whether,therewillbesuffi-cientpoliticalimperativeandenthusiasmtoundertakesuchamajorendeavourremainstobeseen.

Is there a role for surgery in acute pulmonary embolism?

Nitinol flexigrip sternal closure system and standard sternal steel wiring: Insight from a matched comparative analysis

Antibiotic prophylaxis for infective endocarditis: Time for a definitive answer?

Wolfgang Harringer

09:40 Howtodoaminiaorticvalvereplacement  P. Sardari Nia (Breda)

10:10 Howtodoamini-maze  W.-J. Van Boven (Amsterdam)

10:30 Break11:00 Howtodoathoracicendovascularaorticrepair

  M. Czerny (Berne)

11:20 Howtodoanendovascularcoronaryarterybypass  N. Bonaros, (Innsbruck)

11:40 Howtodovideo-assistedthoracoscopicepicardialleadplacement  B. Van Putte (Breda)

12:00 Ends

Advanced Techniques

09:00 Lateral Thinking

Room 111

09:00 Whyareweheretoday?Introduction,backgroundandgoalsofthissession  J. Seeburger (Leipzig)

09:09 Howsimpleideascaninfluenceourpractice  O. Alfieri (Milan)

09:18 Whatdopatientswantandneed?  M. Misfeld (Leipzig)

09:27 Societies(EACTS,AATS,STS,ESC...):Lobbyforwhom?  V. Falk (Zürich)

09:36 ArandomizedtrialintheNEJM:theholygrailofmarketing?  M. Mack (Dallas)

09:45 Thenextgenerationofcardiacsurgeons:wheretogo?  T. Noack (Leipzig)

09:54 Doctorandbusinessman:conflictofinterest?  J. Pomar (Barcelona)

10:03 Technologytransferincardiacmedicine:money,ego,career?  E. Schwammenthal (Tel Aviv)

10:12 Break10:30 Howtomakethemostofyourideasandyour

futureself  F. Litvack (Los Angeles)

10:39 Iscardiacmedicineworththeeffort?Insightsfromeconomy  M. Rosenmoller, IESE Business School (Barcelona)

10:48 WillImakemoneyinvestingincardiacsurgery?  J Mack (Mounds View)

10:57 Ontheroadagain:whygiveupcardiacsurgery?  M. Studer (Dübendorf)

11:06 ThinkTankcardiacsurgery  S. Haider (Erlangen)

11:15 Discussion11:51 ClosingRemarks  V. Falk (Zürich)

Advanced Techniques

09:00 The mitral and tricuspid valves: repair techniques

Room 113

Moderator: J. R. Pepper, London; P. van de Woestijne, Rotterdam

09:00 Pathophysiologyoffunctionalmitralandtricuspidregurgitation  K. M. J. Chan (London)

09:25 Assessmentoffunctionalmitralandtricuspidregurgitation  L Pierard (Liege)

09:50 Naturalhistoryandmedicaltreatmentoffunctionalmitralandtricuspidregurgitation  T. McDonagh (London)

10:15 Break10:45 Surgicaltreatmentoffunctionalmitral

regurgitation  R. Dion (Genk)

11:10 Surgicaltreatmentoffunctionaltricuspidregurgitation  G. Dreyfus (Monte-Carlo)

11:35 Newerapproaches:whendopercutaneoustechniquesofferasolution?  F. Maisano (Milan)

11:35 Analternativesurgicaltreatmenttotricuspidregurgitation  J-P Couetil (Paris)

11.55 Newerapproaches:whendopercutaneoustechniquesofferasolution  F. Maisano (Milan)

12:15 Conclusion

This session is supported by an unrestricted educational grant from Edwards Lifesciences

Advanced Techniques

09:00 New surgical treatment concepts for heart failure

Rooms 131/132

Organized by the the Roland Hetzer International Cardiothoracic Vascular Surgery Society (RHICS)

Moderators: F. Beyersdorf, Freiburg; R. Hetzer (Berlin)

09:00 Organ-conservingsurgery  F. Beyersdorf (Freiburg)

09:20 Cardiacresynchronizationtherapy C. Butter (Berlin)

09:40 Revascularizationsurgery  J. Ennker (Lahr)

10:00 Stateoftheartinhearttransplantation  R. Hetzer (Berlin)

10:20 Roleofleftventricularassistdevice  M. Morshuis (Bad Oeynhausen)

10:40 Roleofrightventricularassistdevice  T. Krabatsch (Berlin)

Continued from page 32

Continued on page 34

Tomaso Bottio

34  Tuesday 30 October 2012  EACTS Daily News

11:00 Roleofbiventricularassistdevice  E. Potapov (Berlin)

11:20 Totalartificialheart  M. Loebe (Houston)

11:40 Paediatricventricularassistdevice  V. Alexi-Meskishvili (Berlin)

12:00 End-stagecongenitalheartdisease  E. M. Delmo Walter (Berlin)

12:20 Regenerativemedicine  C. Stamm (Berlin)

12:40 Paneldiscussion  R. Hetzer (Berlin), F. Beyersdorf (Freiburg),    G. Schuler (Leipzig), F. Musumeci (Rome),    C. Mestres (Barcelona), H. Schafers (Homburg/Saar)

Advanced Techniques

08:30 Controversies and catastrophies in adult cardiac surgery

Room 115

Organiser: M. Shrestha, Hannover

Moderators: R. Haaverstad, Bergen; G. Rajbhandary, Nepal; A. Martens, Hannover

08:30 Introduction  M. Shrestha (Hannover)

08:40 Completioncoronaryangiogramaftercoronaryarterybypassgrafting:isitnecessary?  J. Bauersachs (Hannover)

08:50 Presentationofsingle-centredata  F. Fleissner (Hannover)

09:00 Tissue-engineeredvalves:allsmokewithoutfire?  G. Gerosa (Padua)

Viewfromindustry  J. McKenna, (United Kingdom)

09:20 Aorticvalveendocarditis:whentooperate?  C. Mestres (Barcelona)

09:40 Aorticvalvereplacementinhigh-riskpatients:classicalaorticvalvereplacementthroughmini-thoracotomyissuperiortotranscatheteraorticvalveimplantation  M. Glauber (Massa)

10:00 ClosureofcircumflexarteryduringMICmitralvalveoperation:isthedangerreal?  V. Falk, Zürich

10:20 Coffee10:40 Redomitralvalvereplacementforreiterative

desinsertion:whattodo  T. Folliguet (Nancy)

11:00 AorticvalveinacuteaorticdissectiontypeA:torepairorreplace?  C. Hagl (Munich)

11:20 Closingremarks  M. Shrestha (Hannover

Advanced Techniques

09:00 Part I: Aortic valve repair for the non-expert: a stepwise approach

Rooms 133/134

Moderators: D. Pagano, Birmingham;  R. Sádaba, Pamplona

Howtostartanaorticvalverepairprogramme  J. Vojacek (Hradec Kralove)

Howtoselectagoodcandidate V. Delgado (Leiden)

Howtorepairatricuspidaorticvalve  E. Lansac (Paris)

Howtorepairabicuspidaorticvalve  G Mecozzi, (Enschede)

Wetlab Training Session

10:45 Part II: Wetlab: Valve-sparing aortic root replacement

Rooms 120/121

Organiser: D. Pagano (Birmingham)

Lead Convenors: M. Lewis, Brighton;  E. Lansac, Paris; M. Redmond, Dublin

Learning objectives:

At the end of this wetlab, the candidate will be able to:

ndescribe the methods used to perform valve sparing root replacement

nexplain the reasons that one technique might be used in place of another

nperform the techniques in a wetlab environment

Welcome  M. Lewis

Re-implantationtechniques  M. Redmond (Dublin)

Re-modellingtechniquesincludingtheLansacRing  E. Lansac (Paris)

Wetlab session

Summary,feedbackandclose  E. Lansac, M. Lewis

Limited to 40 participants

Attendees at the wet lab should attend Part I: Aortic valve repair for the non-expert, a stepwise approach

Wetlab Training Session

09:00 Strategies to deal with mitral repair using Gore-tex chords

Rooms 122/123

Organiser: D. Pagano (Birmingham)

Lead Convenors: M. Lewis (Brighton)

Faculty: P. Perier (Bad Neustadt/Saale),  W. C. Hargrove III, Philadelphia, S. Livesey (Southampton), M. Lewis, (Brighton)

Continued from page 33

Continued on page 35

Complete EACTS Membership Applications for 2012Wearepleasedtoconfirmthatwehavereceived347completeEACTSmembershipapplicationsfor2012.TheseapplicationshavebeenformallyacceptedbytheGeneralAssemblyonMonday,29October.

Fromnowon,wearehappytoreceivenewEACTSMembershipApplicationsfortheyear2013.Please,spreadthewordamongstyourcolleagues.EACTSMembershipprovidesaccesstoanetworkofknowledgeandtheopportunitytodevelopyourownexper-tiseandsharethiswithfellowprofessionals.

http://www.eacts.org/content/membership-application

EACTS Daily News  Tuesday 30 October 2012  35

Learning objectives:

At the end of this wetlab, the candidate will be able to:

nDescribe the methods used to repair the mitral valve using Gore-tex neochords and a mitral ring

nExplain the reasons why one technique might be used in place of another

nPerform the techniques in a wetlab environment

Programme (90 minutes per iteration)

Welcome:  M. Lewis

Anatomyofthemitralvalve(Lecture,10minutes)  W. C. Hargrove III

Repairtechniques(Lecture,10minutes)  P. Perier, W. C. Hargrove III

Wetlab session (70 minutes)

Summary,feedbackandclose  M. Lewis

Limited to 40 participants

10:30 Sessionends

Congenital Heart Disease

Advanced Techniques in Cardiothoracic and Vascular Surgery Wetlab Training Session

09:00 Operative techniques – aortic valve repair and the MAZE procedure

Rooms 129/130

Co-ordinator: W. Brawn, London

Faculty: C. Brizard, Melbourne; V. Hraska, Sankt Augustin; S. Tsao, Chicago

Learning objectives:

nTo understand the aortic valve repair procedures and the maze procedure pertaining to congenital heart malformations

Programme:

nDifferent techniques for aortic valve repair V. Hraska, Sankt Augustin; C. Brizard, Melbourne

nMaze procedure: B Brawn (Birmingham) S. Tsao (Chicago); A. Coane (AtriCure)

Target Audience:

nSurgeons performing congenital heart surgery in patients from infancy through to adulthood

Limited to 40 participants

Advanced Techniques

09:00 Part I: Aortic valve repair for the non-expert: a stepwise approach

Rooms 118/119

08:30 InterestingcasesandsmallseriesonorphanaorticdiseasesandpathologicalmechanismsModerators: M. Czerny, Berne; A. Moritz, Frankfurt

08:30 AtouristicdangerintheAlps:acutetypeAaorticdissectioninalpineskiers  N. Fischler, J. Holfeld,   W. Schobersberger, A. Strasak, M. Grimm (Austria)Discussant: R. Haaverstad (Bergen)

08:45 UsefulnessofcoiltreatmentfortypeIendoleakinthoracicendovascularaorticrepairusingafenestratedstentgraft  K. Hanzawa, T. Okamoto,   O. Namura, M. Tsuchida, Y. Yokoi (Japan)Discussant: B. Zipfel (Berlin)

09:00 Arterialuzoriaasariskfactorforspinalcordischaemia  L. Bockeria, V. Arakelyan,   N. Gidaspov (Russian Federation)Discussant: D. Kotelis (Heidelberg)

09:15 Endovascularstentgraftrepairoftheascendingaorta:assessmentofaspecificnovelstentgraftdesigninphantom,cadaverandclinicalapplication  M. Funovics, M. Popovic,   G. Erman, J. Lammer (Austria)Discussant: C. Antona (Milan)

09:30 AcuteretrogradetypeAaorticdissectionaftercompletedebranchingofthesupra-aorticbranchesandstentgraftingofthetransverseaorticarch  M. Luehr, C. Etz, L. Lehmkuhl,   F. Mohr, M. Borger (Germany)Discussant: L. Di Marco (Bologna)

09:45 Break

10:00 Clinical tips and tricks in vascular access for open and endovascular therapy

Moderators: E. Weigang, Mainz;  M. Grabenwöger, Vienna

10:00 Apicalaccess  E. Weigang (Mainz)

10:15 Ascendingaorticaccess  J. Bavaria (Philadelphia)

10:30 Carotidaccess  P. Urbanski (Bad Neustadt)

10:45 Subclavianaccess  M. Grabenwöger (Vienna)

11:00 Infrarenalaccess  M. Grimm (Innsbruck)

11:15 Retroperitonealaccess  M. Czerny (Berne)

11:30 Femoralaccess  T. Friess (Mainz)

11:45 Percutaneousaccessusingclosuredevices  M. Funovics (Vienna)

12:00 Sessionends

Continued from page 34

36  Tuesday 30 October 2012  EACTS Daily News

Floor plan

27 A&EMedicalCorporation

39 AATS

115 AbbottVascularInternationalBVBA

17 Andocor

28–29AsanusMedizintechnikGmbH

45 AtriCureInc

114 BBraunSurgicalS.A.

13–14BaxterHealthcareSA

82 BerlinHeartGmbH

16 BioCerEntwicklungs-GmbH

12 BiometMicrofixation

92–93BioVentrixInc

129 BoltonMedical

80 BracePlus/SlimstonesBV

70 CardiaInnovationAB

125 CardiaMedBV

10 CardioMedicalGmbH

53 CareFusion

90 CASMED

4–8 CircuLiteGmbH

59–61CookMedical

31 CorMatrixCardiovascularInc

122 CoroneoInc

24 CorrexInc

79 CryolifeEuropaLtd

37 CTSNET

117 Delacroix-Chevalier

98–99DendriteClinicalSystems

123 DePuySynthes

35 EACTS

104 EdwardsLifesciences

107–109 EstechInc

120 Ethicon–Johnson&Johnson

112 Euromacs

78 EurosetsSRL

118 FehlingInstrumentsGmbH&CoKG

34 GeisterMedizintechnikGmbH

119 GeneseeBioMedicalInc

69 Geomed®Medizin-TechnikGmbH&Co.KG

23 GunzeLimited

68 HamamatsuPhotonics

72 HeartandHealthFoundation

26 HeartHugger/GeneralCardiacTechnology

32 HeartWareInc

11 Integra

100–101 IntuitiveSurgicalSarl

38 ISMICS

81 JarvikHeartInc

63–64JenaValveTechnologyGmbH

121 JOTECGmbH

43–47KarlStorzGmbH&CoKG

94–95KLSMartinGroup

51 LabcorLaboratoriosLtda

66 LepuMedicalTechnology(Beijing)CoLtd

110–111 LSISolutions

102 ManiInc

86 MaquetCardiopulmonaryAG

15 MasterSurgerySystemsAS

74 MDDMedicalDeviceDevelopmentGmbH

3 MedaforInc

65 MedexResearchLtd

116 MedistimASA

40 MedosMedizintechnikAG

105 MedtronicInternationalTradingSÁRL

88–89MiCardiaCorporation

9 MicromedCVInc

67 NeoChordInc

131 NeomendInc

42 On-XLifeTechnologiesINC™

30 OxfordUniversityPress

134 PCR

124 PetersSurgical

62 PraesidiaSrl

128 QualiteamSRL

25 RedaxSRL

18 RumexInternationalCo

71 SanofiBiosurgery

33 ScanlanInternationalInc

87 SiemensAG

91 SmartcanulaLLC

85 Sorin

106 StJudeMedical

96 StarchMedicalInc

36 STS

73 SunshineHeart

41 SymetisSA

126–127 SynCardiaSystemsInc

77 TerumoEuropeCardiovascularSystems(TECVS)

103 TheSocietyforHeartValveDisease

113 ThoratecCorporation

55 TianjinPlasticsResearchInstitute

132 TransMedicsInc

19 TransonicSystemsEurope

130 ValveXchange

20–21WexlerSurgicalInc

1–2 WisepressOnlineBookshop

97 WLGore&AssociatesGmbH

42414034333231

45

23

21

19

119117

118

122120

121

125123

124

18

17

16

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14

13

12

11

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127

130

126

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39

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38

113104

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85

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87

114

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109

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107

110

6

7

8

132

134

43

47

5351

55

35

CateringCatering CateringCatering

ENTRANCEENTRANCE

Training Village

38  Tuesday 30 October 2012  EACTS Daily News

Introducing the Future of Transapical TAVI- the Medtronic Engager System*

M Yuksel  Course Director, Istanbul; 

EACTS House, Windsor, UK

ChestWallInterestGroup(CWIG)isagroupbelongingtotheEACTSThoracicDo-

main.ItwasfoundedduringTheSec-ondInternationalNussProcedureWorkshopheldinIstanbulinJune2009.

Wehavesetouttoestablishachannelofcommunicationacrossdifferentcontinentswithaviewtoallowtheexchangeofknowledgeamongthoseexperiencedpracti-tionerswhoarestudying,develop-ingandinnovatingmethodstotreatchestwalldiseases.InJune2010,wegottogetheragaininIzmir,forTheThirdInternationalWorkshopontheMinimallyInvasiveRepairofPectusDeformitiesunderthecus-todyofEACTS.TheWorkshopwasagreatsuccessandwehadthechancetodiscussthefutureprojec-tionsoftheCWIG.

OurnextimportantmeetinginthecalendarwasTheFourthInter-nationalChestWallInterestGroupWorkshoponChestWallDiseaseswhichwasheldinIstanbulonJune

22–23,2012,underthecustodyofEACTS,withtheparticipationof35invitedfacultyfromaroundtheworld.

Nowwewanttoreachabroaderspectrumofresidents,specialistsandacademicians,thusweareorganiz-ingaworkshopon“ChestWallDis-eases”inWindsor,UK,atEACTSHouse,28-30November2012.

ThemainsubjectsareCongenitalChestWallDeformities,ChestWallResectionandReconstruction,Tho-racicOutletSyndromeandSternalDehiscence.

TheLearningObjectivesare;Learningtheindications,techniquesandfollow-upofminimallyinva-siveandopensurgeryinpectusde-formities;Learningthealternativetreatments–surgicalandnonsurg-cal-forpectusdeformities;Learn-ingchestwallresectionandrecon-structiontechniquesinchestwalldiseases;Learningthesurgicaltech-niquesinthoracicoutletsyndromeandLearningthetreatmentoptions–surgicalandnonsurgical-insternaldehiscence.

TheTargetAudienceis;ThoracicSurgeryResidents,Specialistsandthe

AcademiciansworkinginthefieldofThoracicSurgery.

WeverymuchlookforwardtowelcomingyoutoWindsor.

Toregisterforthiscoursepleasevisit:www.eacts.org/academy/specialist-courses/chest-wall-diseases.aspx

Regards,Prof.MustafaYuksel,MD

Advanced Module: Heart Failure – State of the Art and Future Perspectives 12–17 November 2012 – 2 days of wetlabs

EACTSHouse,Windsor,UKCourse Directors: G Gerosa, Padua; M Mor-shuis, Bad OeynhausenThecoursewillbeorganisedin10modules:1 Epidemiology/Pathology;2 Diagnostic/Imaging;3and4

OptimalMedicalTherapy/IC;Resynchronization;5 CardiacSurgery(Indications,Techniques,

Results);6 HeartTransplant(Indications,Techniques,Re-

sults)7 VADs/TAH(Indications,Techniques,Results);8 HTx/VADsinPaediatricPopulation;9 StemCellsRegenerativeMedicine;10WetLabs/LiveinaBox/GroupProjectsCourse Objectives:Toupdateknowledgeoftheoreticalandtechnicalissuesofsurgeryforheartfailure.

Leadership and Management Development for Cardiovascular and Thoracic Surgeons20– 23 November 2012 EACTSHouse,Windsor,UKCourse Directors – J L Pomar, Barcelona

TheLeadershipandManagementDevelopment

Courseisanintensivefive-dayprogrammeintwopartswithathreedayinitialtrainingsessionfol-lowedbyafurthertwodaysoftrainingscheduledsixmonthslater.Thecoursewillutiliseamixofpreandpostprogrammeactivitiesandeachdelegatewillbetaskedwithexploringleadershipbestprac-tiseduringthebreakbetweenthetwopartsoftheprogramme.Course Objectives:Improve,enhanceandmaximiseyourleadershipat-tributes

Thoracic Surgery Part II3rd – 7th December 2012 EACTSHouse,Windsor,UKCourse Directors – P Rajesh, BirminghamnThecourseprogrammeincludes:nTrachealSurgerynTracheobronchialinjuriesnTracheal-mainbronchusobstruction;nEsophagusCancer–Staging,preoperative;nOesophagealcancer;nThoracoscopictechnique;nMesotheliomatreatments;nMetastaticdisease;nChestwallreconstruction;nCasepresentations.

Course Objectives:Togainmoreinsightandup-to-dateknowledgeondifferentaspectsofthoracicsurgeryrelatedtotracheal,pleural,mediastinalandoesophagealdis-ease.

Chest Wall Diseases 28–30 November 2012

EACTS events

PublisherDendriteClinicalSystems

Editor in ChiefPieterKappetein

Managing [email protected]

Design and [email protected]

Managing [email protected]

Head OfficeTheHubStationRoadHenley-on-Thames,RG91AY,UnitedKingdomTel+44(0)1491411288Fax+44(0)1491411399Websitewww.e-dendrite.com

Copyright2012©:DendriteClinicalSystemsandtheEuropeanAssociationforCardio-ThoracicSurgery.Allrightsreserved.Nopartofthispublicationmaybereproduced,storedinaretrievalsystem,transmittedinanyformorbyanyothermeans,electronic,mechanical,photocopying,recordingorotherwisewithoutpriorpermissioninwritingoftheeditor.

EACTSDaily News

Since our entrance into the TAVImarket,Medtronichasalwaysbeen

committed to providing multiple TAVIplatforms. Heart teams need optionstobesttreattheirpatients.Byofferingmultiple valve platforms and accessrouteoptions(transapical,transfemoral,directaortic,andsubclavian),Medtroniccan help your team achieve the bestoutcomeforeachpatient.

Fulfillingthisvision,theinterimresultsfromtheMedtronicEngagerEuropeanPivotal Trial were presented yesterdayduring the Late Breaking AbstractSession. The early clinical experienceis positive and demonstrates that theEngager System successfully puts youincontrol forprecisepositioning, tightannular sealing, and true anatomicalignment.

Precise PositioningEngager’s unique control arms

provide tactile feedback as they areplaced into the sinuses of the native

valve, securing the valve throughoutdeployment. With tactile control,deployment is simple and repeatable-during the Pivotal Trial, 100%devices were implanted in the correctanatomic position and there were noembolizations,secondvalvesimplanted,orannularruptures.

PVL MinimizedWhile the self-expanding frame

conforms to the native anatomy,Engager further seals the annulus bycapturing the native leaflets betweenthe control arms and the frame. Anindependent echo core lab found noPVLgreaterthantraceat30daysduringthePivotalTrial.

True Anatomic AlignmentTranscatheter valves must recreate

hemodynamicfunctionineverypatientregardless of aortic shape or size. TheEngagervalveisdesignedtoalignwithand conform to the native anatomy.Fixationof thenative leafletsand truecommissure-to-commissure alignmentprovide clearance for the coronaryostiawhilesupra-annularvalvepositionminimizes frame deformation at theleaflets tooptimizecoaptation innon-circularanatomy.

Please join us today for theMedtronic TAVI Symposium (Room113 12:45-14:00) to learn moreabout the futureof TAVI, including a

live-case with the Medtronic EngagerTransapical TAVI System and anintroduction to the CoreValve InVia**surgicalaccessdeliverysystem.

We look forward to sharing the future with you.

*CE submitted. **Non-CE marked