DocuSign Envelope IO: 1 C648099-7DB6-44BF-B095-22B642387CF7

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lnternational Foundation for Research in Paraplegia Fondation int ernationale pour la recherche en paraplegie lnternationale Stiftung fíir forschung in Paraplegie

IRP Geneve Rue Fran~o1s-Perreard 14 CH-1225 Chéne-Bourg T + 41 22 349 03 03 info@irp.ch

IRP Zíirich Neugasse 10 CH-8005 Zunch T + 41 43 268 00 90 research@irp.ch

www.irp.ch IRP Research G1rant Contract

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lmportant: al/ reports and relevant correspondence referring to th present contract

need to be addressed to the /RP Zurich office at Seestrasse 19, 8 02 Zurich,

Switzerland.

Contract Number:

Contract Dates:

Duration of Contract:

Project Title:

Amount:

Awarded by:

P 172

01 October 2021- 28th Februa 2022

5 months

Reconstruction of the SC sens ry pathway

CHF 70,383.30 transferred

IRP - lnternational Foundation f r Research in

Paraplegia

7.1 Principal lnvestigator (PI):

Banque P1ctet & C1e SA- CCP 12-109-4 - Comple 566191 001 IBAI~ (H..18 0875 5056 6191 0010 O

DocuSign Envelope ID: 1C648099-7DB6-44BF-B095-22B642387CF7

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IRP Research ~rant Contract

7.2 Name of Host lnstitution: Institute óf Experimental Medi ine CAS (IEM)

7.3 Chief Financial Officer:

7.4 Payment to:

Vídeňská 1083

Prague 4

Czech Republic

Komerč~í banka, a.s.

Na Přikopě 33

Prague 1

Czech ~epublic

7.5 Name of Original Host lnstitution: Brain Repair Centre, Cam

8. Research Project

A summary of the research project and tuli dJtails of the work pian nd schedule are

provided in the Research Grant Application of October 2016, entitl d:

Reconstruction of the SC sensory pathway.

9. Availability of facilities

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The Principal lnvestigator (PI) or Host lnstitution shall furnish the n cessary personnel,

supplies, equipment, premises and other facilities required to cond ct the research I

proposed in the Research Proposal.

1 O. Responsibility

The research performed under this contract will be under the direc on of the PI

The PI takes responsibility for fulfilling the project pian according t the outlines in the

Research Proposal. He/she undertakes to inform IRP promptly if f r any reason he/she is

unable to fulfil the project pian or if major modifications of the prop sed research pian

seem necessary.

IRP - lnternational Foundation for Research in Paraplegia. Seestrasse 19, C -8002 Zurich Tel. 004143268 00 90, Fax 0041 3 268 09 80 E-Mail: research@rp.ch

DocuSign Envelope IO: 1 C648099-7OB6-44BF-B095-22B642387CF7

I['~ ~ C\ !Jt IRP Research Grant Contract

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11. Grant Allocation

a. The project budget is composed of the follO\~ing items

ltems Original budget I in total

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IEM budget

Brain Repair Centre,

Cambridge/ UK spent

(unused funds in UK+ 3rd payment)

• Personnel • Equipment • Consumables

• Animals and animal care • Travel • Other

110267

19733 I

20000 li

65,272.38 44,994.62

4,208.S:i 15,524.13

722.7é 19,277.24

Total costs CHF 150'000 70,204.02CHF 79,795.99 CHF

The whole project budget was initially CHF 150'000 and the grant< ontract was made with Brain Repair Centre, Cambridge I UK (Original Host lnstitution) to \i hich IRP paid CHF 140' 000. The project will be transferred to the Institute pf Experimental Med i ~ine (IEM), Prague I CZ (Host lnstitution) to be finished. This contract with IEM is starting 01 01 October 2021 and includes the last payment for this project of C'7F 10'000 and the tn nsferred amount 70,383.30 as the unused funds from OriginallHost lnstitution. Financial Statement Form of Brain Repair Centre, Cambridge / UK reporting spent and unused µnds to the date of the transfer of the project contains Attachment Nb. 1 to this contract. li P declares its consent with this report (statement).

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b. Modification in fund allocation: Funds over/ CHF 10'000.- may or ly be transferred from

one category of the budget to another on prior written approval rom IRP.

c. Brain Repair Centre, Cambridge is obliged to transfer directly to IEM, Prague remaining

(unused) funds before 01 October 2021. llhe total amount of thE funds to be transferred

is ............ 70,383.30 ... ....... CHF. IRP declares its consent wit ~ this direct transfer.

d. Remaining Funds at the end of the duration of the contract: An)' unused funds will revert

to IRP.

lf a new project to the same researcher is jgranted, the remainin g funds of the former

project will be settled with the granted amount of the new one.

12. Disbursement of funds

IRP - lntemational Foundation for Researc~ in Paraplegia. Seestrasse 19. C H-8002 Zurich Tel. 004143268 00 90, Fax 0041/13268 09 80 E-Mail: research~ irp.ch

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&& A IRP Research Grant Contract Page4 I R p

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Amount Da e of payment 1st payment CHF 70'000 Pa id Sept 2017* 2nd payment CHF 70'000 Pé id Sept 2019* 3rd payment CHF 10'000 r arch 2022**

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*: The 1st and 2nd payment of CHF 70'000 were already paid to t rie Brain Repair

Centre, Cambridge I UK .

**· . Prov1ded that IRP w1II have rece1ved a fmal report and a fmam::1al report at the end

of the contractual period.

13. Reports

a. Progress, financial, equipment and personnel reports are prereq isites to continued

funding or submission of an application for extension or renewal. They must be submitted

yearly, not later than four weeks after each1 completed contract y ar. lf the PI doesn ' t

submit the final and financial report within four weeks after the c ntract period , IRP has the

right to waive the last payment. Payment cpntinuation for long-t rm projects will depend on

the receipt of the required reports. Financial, equipment and per onal reports must be

signed by the PI and by the Chief Financiall Officer of the host in titution .

Progress report: lt describes the outcom1 of the proposed exp riments and summarizes

all the results that were obtained. Differences from the proposal in respect to time I

schedule or experimental scheme should be mentioned and ac ounted for.

Financial report:lt has to be submitted on the form provided by IRP (Attachment).

Equipment report: lt consists of a detaile6 inventory of all equi ment purchased with

funds from IRP. I Personnel report: Ali collaborators hired for the research proje t and/or paid out of IRP

funds shall be listed with their percentage lot time spent on the roject.

b. Additional reports of research results and information about the team of involved personnel

suitable for publication in IRP' s newsletters, annual reports an promotional literature may

be requested from the PI du ring or within six months of the ter ination of this contract.

Upon request by IRP the PI shall, within a reasonabte time and at no additional cost or I

expense, provide such reports or information including figures nd photographs to IRP.

c. Pdf-documents of all papers, including on/line publication result ng from joint IRP and OPO­

Stiftung funded research should be e-mailed to IRP in a timely ashion subsequent to

publication.

IRP - lntematíonal Foundation for Research in Paraplegia, Seestrasse 19, H-8002 ZOrich Tel. 0041 43268 00 90, Fax 0041/43 268 09 80 E-Mail: research irp.ch

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IRP Research Grant Contract Page 5

d. The PI agrees to arrange at the request of l~P for a visit to the re earch site by the IRP

research coordinator or any other representative of IRP for the pu pase of inspecting the

work and for persona! discussion of progres~.

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IRP - lntemational Foundafion for Research in Paraplegia, Seestrasse 19, H-8002 ZOrich Tel. 004143268 00 90, Fax 0041 43 268 09 80 E-Mail: research irp.ch

DocuSign Envelope ID: 1 C648099-7DB6-44BF-8095-228642387CF7

&&1~ IRP Research Grant Contract Page6 I R P

14. Publishing and exploitation of rese~rch results a. Any substantial data and results originating from this research pr ject shall be

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communicated to the scientific community by publications in appr priate journals or books

orby presentations at scientific conferences. Support by IRP sho Id be acknowledged in

all publications.

b. Any patents or other intellectual property rights taken aut by the I as a direct result of the

project shall belong solely to the PI. ln this bonnection, Brain Re air Centre, Cambridge I

UK as Original Host lnstitution declares thaf it shall have no clai s for any patents or other

intellectual property from this research project. Host lnstitution a d PI undertakes to enter

into negotiation about possible licence regJrding the use of the r sults of the project by

Host lnstitution for justified purposes (f.e. presentation of the res lts), taking into

consideration the role of the Host lnstitutiom and fair conditions o such licence. I

c. IRP shall have the right, without payment or further permission , o reprint project-related

informational material in IRP annual reporti; , newsletters or pro otional literature.

15. Termination and Extension of contract

Both , IRP and Host lnstitution shall have the 1~ight to terminate the

time by written, substantiated notice to the other party, or may req

event, any expenditures regarding equipment incurred in good fait

into shall be settled by IRP. Neither party to ťhe contract shall mak

I 16. Supplementary agreements I

esearch project at any

est its termination. ln this

and obligations entered

any further claims.

a. Research on human beings: For research1 involving human bei gs, the PI undertakes to

obtain written consent in advance from the individuals involved, as well as the approval of

the appropriate review board or authority.1

b. Animal research: ln the case of animal tests, the Principal lnve tigator shall ensure that all

of the legal and official guidelines applicable at the experiment I location are strictly

observed. Any special conditions imposed by IRP shall be obs rved as well.

I c. No liability on the part of IRP for errors/omissions of the projec team:

IRP is in no way liable for any damage to1 persons or property t at may occur in

conjunction with the performance of the project as a result of e rors or omissions of the

project team.

IRP - lnternational Foundation for ReseaJ h in Paraplegia, Seestrasse 19, H-8002 z orich Tel. 0041 43268 00 90, Fax 004) 43 268 09 80 E-Mail: research irp.ch

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IRP Research GJrant Contract Page 7

d. No liability on the part of IRP to the contract linstitution: IRP is not iable in any fashion for

any damage that may result to persons or PfOperty at the said ins itution.

e. Project cost sharing by several entities: lf th~ research project de•$cribed in the proposal is

being jointly funded by other entities, list below the expenses not covered by IRP, giving

the names of the ether funding sources. I

Sources

IRP - lnternational Foundation for Research in Paraplegia, Seestrasse 19, ~H-8002 Ziirich Tel. 0041 43 268 00 90, Fax 0041

1

43 268 09 80 E-Mail: research@irp.ch

Amounts

OocuSign Envelope IO: 1C648099-7O86-44BF-8095-228642387CF7

IRP Research Grant Contract

17. Place of jurisdiction

The place of jurisdiction is Geneva. The contract shall be subject o Swiss law

regardless of the research site(s).

The following parties consent to the terms of this contract:

On behalf of the contracting Host lnstitution (IEM CAS):

Name ln capltals r lgnat",e

On behalf of the contracting Original Host lnstitution (Brain

Cambridge I UK):

epair Centre,

Page 8

date

24 september 2021

Name in capitals date

Principal lnvestigator (Prof. Dr. James F'awcett):

28 september 2021

Name in capitals

!RP - lnternational Foundation for Research in Paraplegia, Seestrasse 19, C -8002 Zurich Tel. 004143268 00 90, Fax 004143268 09 80 E-Mail: research@i • .ch

date

OocuSign Envelope IO: 1C648099-7086-44BF-B095-228642387CF7

,. 1: ~ <3.C'\ IA

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IRP Research Grant Contract

IRP - lnternational Foundation for Research

in Paraplegia

Rue Frarn;:ois-Perréard 14

CH-1225 Chěne-Bourg

Page 9

Attachment No. 1: Financial Statement For (Brain Repair Cent e , Cambridge / U K)

IRP - lnternational Foundation for Researc in Paraplegia, Seestrasse 19, H-8002 Zurich Tel. 004143268 00 90, Fax 004143268 09 80 E-Mail: research irp.ch