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Ira A. Fulton College of Engineering and Technology
Biomedical Engineering
Bill Pitt
Chemical Engineering
801-422-2589
Areas of Interest:
Polymeric biomedical materials and drug delivery, with recent
emphasis on nanoparticle delivery.
Today I am looking for collaboration with those needing
nanoparticles for drug delivery or other applications.
I have several years experience in
making nanoparticles for drug
delivery.
• Micelles
• Liposomes
• Solid degradable nanoparticles
• Gold nanorods
Micelles• Past work over 20 years
• Drug delivery micelles composed of
polymers
• Size: spherical 10 – 100 nm
• Stable for hours to days; biocompatible
• Interior sequesters hydrophobic drugs
• Delivered chemotherapeutics to tumors in
rats
Uptake of Stained Micelles (~10 nm)
Liposomes• Past work over 10 years
• Liposomes composed of natural and biocompatible
phosphatidylcholines and other phospholipids, plus
cholesterol
• Size: spherical 25 – 2,000 nm
• Stable for days to months; biocompatible
• Interior sequesters water-soluble drugs (hydrophilic)
• Delivered chemotherapeutics
• Can put nanodroplets and nanoparticles inside
Liposome with emulsion droplets
Solid Nanoparticles• Developed in past year
• Composed of poly(lactic-glycolic acid) (PLGA)
• Stabilized by coating of poly(vinyl alcohol)
• Size: spherical 20 – 300 nm
• ~90% yield (up from 5% yield using published methods)
• Degradation by hydrolysis in water into biocompatible lactic and glycolic acid
• Stable for hours to days in water
• Interior sequesters hydrophobic molecules and drugs
• We have encapsulated small fluorescent molecules, lipids, ceramides and short polypeptides inside
Solid Nanoparticles
Possible Applications of Nanoparticles
• Transdermal drug delivery
• Transmucosal delivery
• Oral delivery
• Blood or tissue injection
• Inhalation
• Eye drops
• Please contact me! [email protected]
Gold Nanorods• Developed 5 yrs ago following literature reports
• 9 x 40 nm rods
• Quickly heated to high temperature by NIR laser
• Used for tissue heating
• Delivery of drugs and nucleic acids by coating and
then heating by NIR laser
• Non-biodegradable (at least quickly)
• I can also make gold nanospheres and nanoshells
Gold Nanorods
TheoryandSimulationofSoft
MatterandComplexFluidsDouglas R.Tree
BYU Faculty Networking Event
Chemical Engineering
(801) 422-5162
29 August 2017image credit: http://veggieats.com
About me
PhD, Chemical Engineering.,. University of Minnesota
.,. 2009–2014
.,. Polymer Physics of Confined DNA
Postdoc, Materials Research Lab..,. UC Santa Barbara
.,. 2014–2017
.,. Dynamics of Polymer Phase Transitions
Assistant Professor, Chem. Engineering
.,. Brigham Young Univ.
.,. May 2017 – present
H
w
2
length
tim
e
Polymer
crystallization
Chromosomal
dynamics
2D soft materials
Multiphase flow
Reversible
networks
General Research Interests
.,. Functional/Bio-inspired soft materials
.,. Non-equilibrium processes/Rheology
Skills & Expertise
.,. Computation: HPC,software, molecular
modeling, PDEs
.,. Theory: statistical
mechanics (particle
& field), low Re-fluid
dynamics, polymer
physics
Microfluidics (Lab-on-a-Chip)
Gregory P. Nordin
Electrical and Computer Engineering
(801) 422-1863
Areas of Interest:
3D printed microfluidics, biological and chemical sensors, nanophotonics and integrated optics, micro- and nanofabrication, MEMS, and microfluidics
Traditional Microfluidic Device Fabrication
Layers:
– Hot-embossed or injection molded plastics
• External valves
– PDMS
• Elastomeric
• Integrated valves
Individual layers
Align&
Bond
Completed deviceLaser-drilledor punchedholes
• Stacked 2D configuration
• Few layers
Stereolithography:Digital Light Processing (DLP)
http://www.smashingrobotics.com/moonray-3d-printer/dlp-print/
http://www.soundandvision.com/content/hd2dlp-next-wave#9W2W3tZzCmCULHsc.97
Custom 3D Printer and Resin
18 mm x 20 mm Channels
41 mm Channel in 1/8 mm3
3D Printed Membrane Valve
0.4% Sudan I PEGDA resin
3D Printed Pump
3-to-2 Multiplexer
Electric Power Generation in a Carbon Constrained World
Andrew Fry
Chemical Engineering
(801) 422-6235
Areas of Interest:
Combustion, Electric Power Production, Mineral Matter Transformation, Mercury Emission
Trill
ion
Kilo
wat
t H
ou
rs
Projected Worldwide Electric Energy Production by Source
Bill
ion
Met
ric
Ton
s
Projected Worldwide Energy-related CO2 Emissions
eia – US Energy Information Administration
Motivation and Objective
My Research Objective:
Ensure the continued relevance of fossil fuels for power production, even in a carbon constrained world
“We conclude that CO2 capture and sequestration (CCS) is the critical enabling technology that would reduce CO2 emissions significantly while also allowing coal to meet the world’s pressing energy needs” Deutch and Moniz 2007
The Future of Coal (Report) - MIT
N2 CO2 H2O
SO2 NOX
Particles
Coal
Air
* Plant representation from Babcock & Wilcox – Steam, Its Generation and Use
Electric Power From Coal
www.netl.doe.gov/research/coal/carbon-storage/carbon-storage-faqs/what-is-carbon-capture-and-storage
N2
H2O
CO2
Carbon Capture and Storage
Engineering Building Annex (Artist Rendering)
Engineering Building Annex (Model)
Engine Test Bays(Dynamometer)
Multi-Fuel Reactor(Existing)
Molten Salt Nuclear ReactorInvited Proposal Submitted
Pressurized Oxy-Coal ReactorNew US DOE Grant
Burner-Fuel Reactor(Existing)
Conditions: Measurements:
Pressurized Oxy-coal Combustor
• 100 kW Firing Rate• > 4000 °F Gas Temperatures• ~ 300 psi Reactor Pressure
• Radiative Heat Transfer• Total• Spectral
• Total Wall Heat Flux• Material Temperatures• Fuel Burnout Behavior• Emission Characterization (SO3)
Provide fundamental data and modeling tools necessary for scale-up engineering design of the next-generation zero-emission utility boiler
Strengthening BYU's Chances for DOE Nuclear Energy Funding
Troy Munro
Mechanical Engineering [email protected]
(801) 422-6541
Areas of Interest:
Heat Transfer, Thermal Behavior of Materials, Fluorescence, Thermometry, Biophotonics, Thermal Transport, Nuclear Energy, Thermophysical Properties
BYU’s Nuclear Group
Examples:• Biological effects of radiation• Human errors in decision making
Example of how this works
• Molten Salt Reactor• How salts corrode
• Material Science
Grain boundary transport
• Electrochemistry
• Nuclear isotope tracking• Chemical separations
• Forensics/security
• High temperature properties• New instrumentation
• Transport modelling
Recent DOE Nuclear Energy Call
trtr
37
Biomedical and Biochemical Engineering
• Randy S. Lewis
• Chemical Engineering
• (801) 422-7863
Areas of Interest:
Biofuel cells, syngas fermentation, nitric oxide, humanitarian engineering
38
Biofuel Cells
• Kinetic analysis• Kinetic modeling
39
Syngas Fermentation
Biomass BioreactorGasifier
Grow, harvest and
transport
biomass
Convert biomass
to producer gas
(H2, CO2, CO)
Ferment producer gas
to biofuels (and other
useful products)
40
Nitric Oxide
Red Cell
Platelet
Platelet
Platelet
Red Cell
SH
ALB NO
ALB NO
CYSNO
CYS
ALB NO
~ 7 mM ALBNO in blood plasma
ALB
CYS
SH
NO
Blood Flow
Polymer
• Kinetic analysis and modeling• Transport analysis and modeling
41
Global Projects Course offered since 2007
Wide variety of projects
water purification
tea packaging
water heating
pumps
biodiesel
+ others
Humanitarian Engineering
Peru
Tonga
Ghana
Scientific Python (Modeling, Data Analytics, Optimization)
John Hedengren
Chemical Engineering [email protected]
(801) 422-7341
Areas of Interest:
Scientific Python (Modeling, Data Analytics, Optimization)
Scientific Computing Resources
• Python, MATLAB, Julia
• Dynamics and Process Control
• Optimization
apm.byu.edu
Additive Manufacturing
Jason Weaver
Manufacturing Engineering Technology
(801) 422-1778
Areas of Interest:
• Additive manufacturing (3D printing) in plastics, metals, ceramics, composites, and biomaterials
• Desktop fabrication
• Open source hardware
Additive Mfg Processes Lab
• Current Projects
• Measuring dimensional accuracy of metal AM processes
• Measuring mechanical properties of various materials and processes
• Faculty advisor for Venture Factory and Student Innovator of the Year contest
Additive Mfg Processes Lab
• Future Projects
• Refining a system for combining 3D printing of plastics and metals with CNC machining in a single set up
Additive Mfg Processes Lab
• Future Projects
• Coordinating the incorporation of 3D printers and prototyping tools in the new engineering building
Additive Mfg Processes Lab
• Possible Collaboration
• Prosthetics• Medical devices &
pharmaceuticals• Implants & orthotics• Synthetic organs• Robotics• Paleontology• Fine arts• Education• Operations
management
• Food science• Multimaterial
engineering• Working with
disabilities• Developing nations• Entrepreneurship &
innovation• Internet of things• Composite materials• Electronics
Tissue Engineering
Alonzo D. Cook, PhD
Chemical Engineering Dept.
(801) 422-1611
Areas of Interest:Biomedical Engineering; Cardiovascular repair; Stem Cells;Neuroscience; Vision; Renal Function; Orthopedics
Monolayer of Beating Cardiomyocytes
50
Tissue Thickness: 200 µm (cryostat)
Creation of beating heart tissuesCombining IPS cells with cECM slice
51
Biomechanical Stimulation Machine
Improving the alignment and maturation of cardiomyocytes on the cECM
Arduino controlled
Linear motion
Autoclavable
52
FRESH Gelatin Matrix, 4.0% Sodium Alginate Bioink – Single Bifurcation
FRESH Gelatin Matrix - Melt
Cataracts
• Approximately 33% of all visual impairments• By 80 years of age more than half of all
Americans either have a cataract or have had cataract surgery
• Caused by accumulation and deformation of proteins in the nucleus and cortex
Lin, H., Ouyang, H., Zhu, J., Huang, S., Liu, Z., Chen, S., & ... Liu, Y. (2016).Lens regeneration using endogenous stem cells with gain of visual function.
Lens Capsule Imitation
• Using the scale model of eye (depicted) a model was made that imitated the shape of the lens capsule
• Flow of nutrients and medium was required to feed the cells as they proliferate and generate the lens
Apparatus
Apparatus
