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a brand
I o n t o p h o r e s i s 2012
© 2
011
DJO
- 0
0-09
75-E
N -
Rev
B
ASIA-PACIFIC:DJO Asia-Pacific LimitedUnit 1905, 19/F, Tower IIGrand Central Plaza138 Shatin Rural Committee RoadShatinHONG KONGTel: +852 3105 2237Fax: +852 3105 1444Email: [email protected]
EUROPE, MIDDLE EAST & AFRICA DJO BeneluxWelvaartstraat 82200 HerentalsBELGIUMTel: +32 (0) 14248350Fax: +32 (0) 14248358Email: [email protected]
LATIN AMERICA:DJO Global, Inc1430 Decision StreetVistaCA 92081-8553U.S.A.Tel: 1 800 336 6569Fax: 1 800 936 6569Email: [email protected]
AUSTRALIA:DJO AustraliaPO Box 2057NormanhurstNSW 2076AUSTRALIATel: +1300 66 77 30Fax: +1300 66 77 40Email: [email protected]
BENELUX:DJO BeneluxWelvaartstraat 82200 HerentalsBELGIUMTel Belgium: 0800 18 246Tel Netherlands: 0800 0229442Tel Luxemburg: 8002 27 42Email: [email protected]
DENMARK, FINLAND,NORWAY & SWEDEN:DJO Nordic ABMurmansgatan 12621225 MalmöSWEDENTel Sweden: 040 39 40 00Tel Norway: 8006 1052Tel Finland: 0800 114 582Tel Denmark: +46 40 39 40 00Email: [email protected]
FRANCE:DJO France S.A.S.Centre Européen de Fret64990 MouguerreFRANCETel: +33 (0)5 59 52 86 90Fax: +33 (0)5 59 52 86 91Email: [email protected]
GERMANY:ORMED-DJO Germany GmbHMerzhauser Str. 112D-79100 FreiburgGERMANYTel: +49 761 4566 251Fax: +49 761 4566 55251Email: [email protected]
ITALY:DJO Italia SrlVia Leonardo Da Vinci 97Trezzano Sul Naviglio20090 MilanoITALYTel: +39 02 484 63386Fax: +39 02 484 09217Email: [email protected]
SWITZERLAND:Compex Médical SACh. du DéventZI Larges Pièces A1024EcublensSWITZERLANDTel: +41 (0) 21 695 2360Fax: +41 (0) 21 695 2361Email: [email protected]
UK & IRELAND:DJO UK Ltd1a Guildford Business ParkGuildfordSurreyGU2 8XGENGLANDTel: +44 (0)1483 459 659Fax: +44 (0)1483 459 470Email: [email protected]
UNITED STATES:DJO Global, Inc1430 Decision StreetVistaCA 92081-8553U.S.A.Tel: 1 800 336 6569Fax: 1 800 936 6569
CANADA:DJO Canada6485 Kennedy RoadMississaugaOntarioL5T 2W4CANADATel: +1 1866 866 5031Fax: +1 1866 866 5032Email: [email protected]
DJO GLOBAL:
DJO GLOBAL, EXPORT CENTERS:
SPAIN:DJO IbéricaCarretera de Cornellá 144, 1º 4ªEsplugues de Llobregat08950 BarcelonaSPAINTel: +34 943 638 167Fax: +34 943 638 174Email: [email protected]
a brand
I o n t o p h o r e s i s 2012
© 2
011
DJO
- 0
0-09
75-E
N -
Rev
B
ASIA-PACIFIC:DJO Asia-Pacific LimitedUnit 1905, 19/F, Tower IIGrand Central Plaza138 Shatin Rural Committee RoadShatinHONG KONGTel: +852 3105 2237Fax: +852 3105 1444Email: [email protected]
EUROPE, MIDDLE EAST & AFRICA DJO BeneluxWelvaartstraat 82200 HerentalsBELGIUMTel: +32 (0) 14248350Fax: +32 (0) 14248358Email: [email protected]
LATIN AMERICA:DJO Global, Inc1430 Decision StreetVistaCA 92081-8553U.S.A.Tel: 1 800 336 6569Fax: 1 800 936 6569Email: [email protected]
AUSTRALIA:DJO AustraliaPO Box 2057NormanhurstNSW 2076AUSTRALIATel: +1300 66 77 30Fax: +1300 66 77 40Email: [email protected]
BENELUX:DJO BeneluxWelvaartstraat 82200 HerentalsBELGIUMTel Belgium: 0800 18 246Tel Netherlands: 0800 0229442Tel Luxemburg: 8002 27 42Email: [email protected]
DENMARK, FINLAND,NORWAY & SWEDEN:DJO Nordic ABMurmansgatan 12621225 MalmöSWEDENTel Sweden: 040 39 40 00Tel Norway: 8006 1052Tel Finland: 0800 114 582Tel Denmark: +46 40 39 40 00Email: [email protected]
FRANCE:DJO France S.A.S.Centre Européen de Fret64990 MouguerreFRANCETel: +33 (0)5 59 52 86 90Fax: +33 (0)5 59 52 86 91Email: [email protected]
GERMANY:ORMED-DJO Germany GmbHMerzhauser Str. 112D-79100 FreiburgGERMANYTel: +49 761 4566 251Fax: +49 761 4566 55251Email: [email protected]
ITALY:DJO Italia SrlVia Leonardo Da Vinci 97Trezzano Sul Naviglio20090 MilanoITALYTel: +39 02 484 63386Fax: +39 02 484 09217Email: [email protected]
SWITZERLAND:Compex Médical SACh. du DéventZI Larges Pièces A1024EcublensSWITZERLANDTel: +41 (0) 21 695 2360Fax: +41 (0) 21 695 2361Email: [email protected]
UK & IRELAND:DJO UK Ltd1a Guildford Business ParkGuildfordSurreyGU2 8XGENGLANDTel: +44 (0)1483 459 659Fax: +44 (0)1483 459 470Email: [email protected]
UNITED STATES:DJO Global, Inc1430 Decision StreetVistaCA 92081-8553U.S.A.Tel: 1 800 336 6569Fax: 1 800 936 6569
CANADA:DJO Canada6485 Kennedy RoadMississaugaOntarioL5T 2W4CANADATel: +1 1866 866 5031Fax: +1 1866 866 5032Email: [email protected]
DJO GLOBAL:
DJO GLOBAL, EXPORT CENTERS:
SPAIN:DJO IbéricaCarretera de Cornellá 144, 1º 4ªEsplugues de Llobregat08950 BarcelonaSPAINTel: +34 943 638 167Fax: +34 943 638 174Email: [email protected]
1 Iontophoresis
introduction
iontophoresis
Iontophoresis is an active transdermal drug delivery system that delivers drug ions through the skin
using a low level electric current.
Direct Current is used to move a drug or therapeutically active ion through the skin. When direct
current (DC) is applied to an ionized drug solution, the ions that have the same charge as the current
are repelled by the current and are delivered through the skin. The aim is to drive active ions locally
rather than having to inject them or have them taken systemically.
Chattanooga is the world’s largest manufacturer of rehabilitation equipment for treating musculoskeletal, neurological and soft tissue disorders. For over
six decades, Chattanooga has set a benchmark for leadership, reliability and excellence. Our products contribute to better treatment outcomes in hospitals,
clinics and home settings worldwide. We lead the physiotherapy industry by example and, through continuous innovation, provide real world solutions for
clinicians and their patients.
As the world’s leading brand in rehabilitation, Chattanooga is sold in over 80 countries worldwide. Chattanooga is directly represented in our key markets but
also has long lasting relationships with dedicated distributors in the USA, Canada, Latin America, EMEA and Asia Pacific. Our Chattanooga distributors and
customers are supported for order placement, training, product delivery and after sales service by a dedicated team of highly skilled DJO employees based all
over the world.
Chattanooga is a brand of DJO Global Inc. DJO Global provides solutions for musculoskeletal health, vascular health and pain management. Our products help
prevent injuries or rehabilitate after surgery, injury or from degenerative disease, enabling patients to regain or maintain their natural motion.
Visit www.DJOglobal.eu
Tissue Concentrations10-2
10-3
10-4
10-5
10-6
10-7
10-8
Log
Conc
entr
atio
n / G
ram
of T
issu
e
Ther
aput
ic R
ange
10-200ng
2-4mg
56µg
Oral1 Phoresor®2 Injection3
Route of Administration
References: 1. Glass, J.M., et al. 1980 Int. J dermatol 19:519-525.2. Petelenz, T.J. 1992. Controlled Release. 20:55-66.3. Dosis recomendadas
(PDR).
Active electrode
Skin surface
Epidermis
Dermis
Blood vessel
Iontophoresis Drug Delivery
TM
2www.DJOglobal.eu
indications:
iontophoresis is used to administer water-soluble ionic medications to:
• Treat Acute Tendonitis
• Treat Pain Associated with Calcific Deposits
• Provide Dermal Anesthesia
Tissue Concentrations10-2
10-3
10-4
10-5
10-6
10-7
10-8
Log
Conc
entr
atio
n / G
ram
of T
issu
e
Ther
aput
ic R
ange
10-200ng
2-4mg
56µg
Oral1 Phoresor®2 Injection3
Route of Administration
References: 1. Glass, J.M., et al. 1980 Int. J dermatol 19:519-525.2. Petelenz, T.J. 1992. Controlled Release. 20:55-66.3. Dosis recomendadas
(PDR).
Active electrode
Skin surface
Epidermis
Dermis
Blood vessel
Alternatives to iontophoresis are injections, oral medications and passive transdermal medications.Benefits of iontophoresis over the alternatives:
compared to injections:
• Virtually painless
• Non-invasive minimizing:
- Risk of infection
- Risk of tissue necrosis, tendon rupture, etc.
compared to oral medications:
• Localized drug delivery, non-systemic
• Avoid risk of systemic side effects
contraindications:
• Damaged or denuded skin
- Recent scar tissue
• Drug allergies
• Trans-cranial
• Orbital region
• Electrically sensitive support systems
- Pacemaker
considerations:
• Diabetes
• Pregnancy
• Over external metal fixation devices
• “Elderly” skin
3 Iontophoresis
orderinG inForMAtion
Part Number Description
Chattanooga Ionto
1335Chattanooga Ionto Dose Controller (Includes lead wire, batteries, case, instruction guide and warranty card)
13214Replacement Leadwire (Use Chattanooga Ionto Dose Controller)
1336 Black Snap Adapters, (Pack of 2)
5020014
Twin Lead Assembly for Phoresor II Auto Dose Controller (Use only with PM850/PM900 and Iogel, TransQ Flex, TransQ E, and Optima electrodes)
chAttAnooGA ionto™
FeAtures
The dual channel Chattanooga Ionto device delivers a constant direct current no matter the resistance level. By
varying the voltage output as resistance changes, the device consistently delivers the programmed dose.
The device’s pause feature lets you check the treatment area without restarting the session. Chattanooga Ionto
gives you the user-friendly features and reliability you expect.
• 2-channels to treat 2 sites or deliver 2 medications simultaneously
• Previous dosage can be set as default to maintain frequently used treatment parameters
• Beeping alerts if electrode fault for open current or high impedance, low battery, treatment completion or
power left on
• Automatic 30 second current ramp up and down during power on/off keeps patient comfortable
• Constant current provides precise, accurate delivery regardless of skin impedance
• Current can be set in 0.1 mA increments between 0.5 mA and 4 mA
technicAL speciFicAtions
Output Specs: ±15% unless noted
Current Range:0.5 - 4mA ±10% at 100 to 12k ohm load
Dose Range: 0 to 160mA/minute
Dose Accuracy: ±2mA minute
Ramp Up/Ramp Down: 30 seconds
Battery: 9V Alkaline
Dimensions: 2 x 6 x 9 cm (L x W x H)
Weight: 77g
Safety Tests: EN60601-1-2
4www.DJOglobal.eu
coMpAnion 80™ orderinG inForMAtion
Part Number Description
Companion 80
5000044Companion 80 Iontophoresis System = 1.1 cc fill, (6 treatment kits per box)
* In vitro test data on file at IOMED, Inc.
** 5000 Ohm load simulates skin resistance
FeAtures
Designed to deliver an 80 mA-minute dose over 24 hours, allowing the patient to tend to normal daily
activities while receiving treatment.
Battery-powered
• Internal 1 volt battery - no wires to connect
• Reserve battery capacity compensates for patients
with higher skin resistance
hypoallergenic Adhesive
• Adheres well, even in the shower
• Conforms well to treatment areas
• Fits comfortably beneath clothing
silver-silver chloride ph stabilizing
• Conducts more efficiently than Carbon
• Stabilizes pH without using chemical buffers
reF 5000044 - companion 80
reFerences
1. Banta CA. A prospective, nonrandomized study of iontophoresis, wrist splinting, and anti-inflammatory medication in the treatment of early-mild carpal tunnel syndrome. J Occup Med 36: 166-168, 1994.2. Bertolucci LE. Introduction of anti-inflammatory drugs by iontophoresis: Double blind placebo controlled study. J Orphop Sports Phys Ther 4: 103-108, 1982.3. Glass JM, et al. The quality and distribution of radiolabeled dexamethasone delivered to tissue by iontophoresis. Int J Dermatol 19: 519-525, 1980.4. Gudeman SD, et al. Treatment of plantar fasciitis by iontophoresis of 0.4% dexamethasone: A randomized, double-blind placebo-controlled study. Am J Sports Med 25: 312-316, 1997.5. Nirschl, RP, et al. Iontophoretic administration of dexamethasone sodium phosphate for acute epicondylitis: A randomized, double-blind, placebo controlled study. Am J Sports Med 31: 189-195, 2003.6. Pellecchia, GL, et al. Treatment of infrapatellar tendonitis: A combination of modalities and transverse friction massage versus iontophoresis. J Sports Rehabil 3: 135-145, 1994.7. Petelenz TJ, et al. Ionotophoresis of dexamethasone: Laboratory studies. J Controlled Release 20: 55-66, 1992.
These products are protected by one or more of the following U.S. Patents: 4,744,787; 4,752,285; 5,135,477; 5,374,241; 5,415,628; 5,558,632; 5,846,217; 6,731,977. Other Patents Pending.
5 Iontophoresis
trAnsQ®
optiMA™
orderinG inForMAtion
Part Number Description
TransQ
5000008TransQ E, Medium (Disposable electrodes, 2.5 cc - 3.0 cc fill, 12 kits* per box)
5000009TransQ E, Small (Disposable electrodes, 1.5 cc - 2.0 cc fill, 12 kits* per box)
5000033TransQ Flex (Disposable electrodes, 2.5 cc fill, 12 kits* per box)
* Kits above include one each: drug delivery electrode, disposable dispersive pad, and alcohol wipe
FeAtures
silver-silver chloride ph stabilizing electrodes
IOMED’s proprietary Silver-Silver Chloride conductive element prevents water hydrolysis, thereby eliminating
the need to add a chemical buffer and minimizing skin irritation.
Designed in a variety of Shapes for Treating many different areas of the body.
transQ e
• Rectangular and circular shapes for various
treatment sites
• Adhesive Foam
• Stretches and adheres well under stress
transQ Flex
• Clover Shape
• Surrounds highly contoured treatment area
• Perfect for fingers, hands, feet and ankles
• Superior Adhesion
• Adds more surface area to increase adhesion when
under stress
• Patented Hydrogel
- Provides uniform current distribution
- Consistent drug delivery
reF 5000009 - transQe small reF 5000008 - transQe Medium reF 5000033 - transQ Flex
orderinG inForMAtion
Part Number Description
Optima
5000050Optima, Small (Disposable electrodes, 1.5 cc fill, 12 kits* per box)
5000051Optima, Medium (Disposable electrodes, 2.0 cc fill, 12 kits* per box)
5000052Optima, Large (Disposable electrodes, 3.0 cc fill, 12 kits* per box)
* Kits above include one each: drug delivery electrode, disposable dispersive pad, and alcohol wipe
FeAtures
ph Buffered iontophoresis electrodes
Adjusts the pH to the ideal target of 4.5 to optimize transport when using a carbon conductive element and
maintains that ideal pH for better drug delivery.
ph defining Agent
• Adjusts pH to ideal target to optimize transport
when using a carbon conductive element
ph Buffering Agent
• Maintains ideal pH
Viscosity enhancing element
• Creates uniform current distribution for greater
patient comfort
• Conforms to a wide variety of treatment sites
• Stretches and adheres well when under stress
reF 5000050 - optima small reF 5000051 - optima Medium reF 5000052 - optima Large
6www.DJOglobal.eu
ioGeL®
elliptical shape
• Follows the line of the tendon
clear Adhesive
• Allows precise placement on target site
Gelsponge®
• Ensures complete contact between the electrode
and the skin surface with low impedance
• Provides a conductive medium similar to ultrasound gel
eZ Fill Window™
• Protects adhesive during hydration and handling
• Provides no-stick handling
reF 5000021 - iogel small reF 5000022 - iogel Medium reF 5000023 - iogel Large
orderinG inForMAtion
Part Number Description
Iogel
5000021Iogel, Small (Disposable electrodes, 1.5 cc fill, 12 kits* per box)
5000022Iogel, Medium (Disposable electrodes, 2.5 cc fill, 12 kits* per box)
5000023Iogel, Large (Disposable electrodes, 3.55 cc fill, 12 kits* per box)
* Kits above include one each: drug delivery electrode, disposable dispersive pad, and alcohol wipe
FeAtures
silver-silver chloride ph stabilizing electrodes
Iogel, a market-leading electrode with features that allow for precise placement, pH stabilization, superior
patient comfort and ease of filling.
dupeL B.L.u.e.
dupeL White
• High efficiency, bi-layer design for optimal drug delivery
• Patented ion-exchange buffering system ensures that pH shifts occurring during iontophoresis are controlled
• Four shapes/sizes for best adhesion, conformability and coverage
• Latex Free
FeAtures
ph Balancing electrode
Patented buffer adjusts medication pH to a safe level (4-8 pH) without introducing competing ions that
decrease medication delivery. This allows maximum flexibility and safety when selecting a medication.
• Capable of delivering 80 mAmin
• Cost-Effective
• Available in various sizes
• Latex Free
FeAtures
The Dupel White Electrodes are a cost effective option in iontophoretic drug delivery. Using a patented design,
the active electrode employs a unique buffering system that enhancing efficiency and comfort.
orderinG inForMAtion
Part Number Description
Dupel B.L.U.E.
199332-001Dupel B.L.U.E., Small (Disposable electrodes, 1.5 cc fill, 12 kits* per box)
199334-001Dupel B.L.U.E., Butterfly (Disposable electrodes, 2.0 cc fill, 12 kits* per box)
199335-001 Dupel B.L.U.E., Standard (Disposable electrodes, 2.5 cc fill, 12 kits* per box)
199336-001Dupel B.L.U.E., Large (Disposable electrodes, 4.0 cc fill, 12 kits* per box)
orderinG inForMAtion
Part Number Description
Dupel White
198808-001Dupel White, Small (Disposable electrodes, 2.0 cc fill, 12 kits* per box)
198572-001Dupel White, Butterfly (Disposable electrodes, 2.5 cc fill, 12 kits* per box)
198809-001 Dupel White, Standard (Disposable electrodes, 2.5 cc fill, 12 kits* per box)
198810-001Dupel White, Large (Disposable electrodes, 4.0 cc fill, 12 kits* per box)
reF 199332 - small reF 199334 - Butterfly reF 199336 - LargereF 199335 - standard
reF 198808 - small reF 198572 - Butterfly reF 198810 - LargereF 198809 - standard