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Introduction to Bioengineering BIOE/ENGR.80 Stanford University Spring 2020 Class Slides Day 16 11 May 2020 These slides are made freely available to the fullest extent possible. Any copyrighted images used herein are used in good faith subject to the fair use exception for education. Please contact [email protected] directly re: any copyright concerns.

Introduction to Bioengineering Stanford University Spring 2020 … · Week 6 look ahead Diffusion of molecules (space, time, abundances) Programming patterns in autonomous systems

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Page 1: Introduction to Bioengineering Stanford University Spring 2020 … · Week 6 look ahead Diffusion of molecules (space, time, abundances) Programming patterns in autonomous systems

Introduction to BioengineeringBIOE/ENGR.80Stanford University

Spring 2020 Class Slides

Day 1611 May 2020

These slides are made freely available to the fullest extent possible. Any copyrighted images used herein are used in good faith subject to the fair use exception for education. Please contact [email protected] directly re: any copyright concerns.

Page 2: Introduction to Bioengineering Stanford University Spring 2020 … · Week 6 look ahead Diffusion of molecules (space, time, abundances) Programming patterns in autonomous systems

Week 5 reprise

DNA sequencing (reading)

DNA synthesis (writing)

Team rules & priority-setting tools

CONCEPTSKILL

Surfing exponentials

Interconvertibility of matter and information

- Sequencing-by-synthesis; pore-based

- Phosphoramidite chemistry for low-error rates

- Quantitative change poses, “when’s the right time?”

- DNA R/W together enabling networked bio/technology

- Impact versus effort; get projects on leading-edge curve

Page 3: Introduction to Bioengineering Stanford University Spring 2020 … · Week 6 look ahead Diffusion of molecules (space, time, abundances) Programming patterns in autonomous systems

Week 6 look ahead

Diffusion of molecules (space, time, abundances)

Programming patterns in autonomous systems

[Team Project] - Brainstorms (three themes)- Team Rules

CONCEPTSKILL

Programming patterns in living systems

Page 4: Introduction to Bioengineering Stanford University Spring 2020 … · Week 6 look ahead Diffusion of molecules (space, time, abundances) Programming patterns in autonomous systems

https://en.wikipedia.org/wiki/Brownian_motionhttp://sciweb.nybg.org/science2/pdfs/dws/Brownian.pdf

Page 5: Introduction to Bioengineering Stanford University Spring 2020 … · Week 6 look ahead Diffusion of molecules (space, time, abundances) Programming patterns in autonomous systems

https://www.jstor.org/stable/j.ctv7r40w6

To go twice as far takes four times as long.

1D2D3D

A particle that is twice as big, R, goes ~0.7 as far.

Page 6: Introduction to Bioengineering Stanford University Spring 2020 … · Week 6 look ahead Diffusion of molecules (space, time, abundances) Programming patterns in autonomous systems

Diffusing particles spread out over time…

https://www.jstor.org/stable/j.ctv7r40w6

http://rpdata.caltech.edu/courses/aph162/2006/Protocols/diffusion.pdf

Page 7: Introduction to Bioengineering Stanford University Spring 2020 … · Week 6 look ahead Diffusion of molecules (space, time, abundances) Programming patterns in autonomous systems

http://biodynamics.ucsd.edu/

What can we infer about the diffusion of biomolecules in this system?

Page 8: Introduction to Bioengineering Stanford University Spring 2020 … · Week 6 look ahead Diffusion of molecules (space, time, abundances) Programming patterns in autonomous systems

https://www.ncbi.nlm.nih.gov/pubmed/22178928

What can we infer about the diffusion of biomolecules in this system?

Page 9: Introduction to Bioengineering Stanford University Spring 2020 … · Week 6 look ahead Diffusion of molecules (space, time, abundances) Programming patterns in autonomous systems

https://www.ncbi.nlm.nih.gov/pubmed/22178928

What can we infer about the diffusion of biomolecules in this system?

Page 10: Introduction to Bioengineering Stanford University Spring 2020 … · Week 6 look ahead Diffusion of molecules (space, time, abundances) Programming patterns in autonomous systems

http://biodynamics.ucsd.edu/

What can we infer about the diffusion of biomolecules in this system?

Page 11: Introduction to Bioengineering Stanford University Spring 2020 … · Week 6 look ahead Diffusion of molecules (space, time, abundances) Programming patterns in autonomous systems

http://biodynamics.ucsd.edu/

What can we infer about the diffusion of biomolecules in this system?

Page 12: Introduction to Bioengineering Stanford University Spring 2020 … · Week 6 look ahead Diffusion of molecules (space, time, abundances) Programming patterns in autonomous systems
Page 13: Introduction to Bioengineering Stanford University Spring 2020 … · Week 6 look ahead Diffusion of molecules (space, time, abundances) Programming patterns in autonomous systems
Page 14: Introduction to Bioengineering Stanford University Spring 2020 … · Week 6 look ahead Diffusion of molecules (space, time, abundances) Programming patterns in autonomous systems

Text

Text

http://www.rowland.harvard.edu/labs/bacteria/movies/ecoli.php

Page 15: Introduction to Bioengineering Stanford University Spring 2020 … · Week 6 look ahead Diffusion of molecules (space, time, abundances) Programming patterns in autonomous systems

http://www.rowland.harvard.edu/labs/bacteria/movies/ecoli.php