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Introducing GeneSTAR® MVP™
Molecular Value Predictions for Beef Quality and
Production Traits
2
Welcome!
A new DNA era for GeneSTAR®
Review of technical background and materials Customer applications
• Customer report• Value discussion
3
What is GeneSTAR?
Pfizer Animal Genetics’ DNA-testing platform for economically important traits• Feed efficiency, marbling and tenderness
Facilitates genetic improvement in seedstock and cow-calf operations
Enables precision management in cow-calf, stocker and feedlot operations
4
Evolution of GeneSTAR
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Molecular Value Predictions (MVPs) Are:
Molecular breeding values, in units of the trait, that incorporate the sum total of marker effects, and have an associated reliability value
Based currently on a panel of 56 DNA markers that are used to predict feed efficiency, marbling, and tenderness in beef cattle
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Traits – Measures
Feed efficiency—net feed intake
Marbling—Degree of marbling
Tenderness—Warner-Bratzler shear force (WBSF) at 14 days postmortem
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MVP Advantages
Quantifies animal’s ability to perform Measured in relevant units for each
trait on a single scale Accounts for relative size of marker
effects Reliability of MVP provided Compatible with EPD Applicable for multi-trait selection
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GeneSTAR MVP Development
Intensive four-step process:
1. Marker discovery
2. Development of marker predictions – MVPs
3. Internal validation of relationship between MVPs and phenotypic performance
4. Third-party validation
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MVP Populations
In the first three steps, Pfizer Animal Genetics employed the use of:• 13 cattle populations • More than 7,000 animals representing diverse breeds and composite lines• Range of environmental and
management conditions 2,866 animals in the discovery
and prediction phase 4,455 animals in the internal
validation phase Included both Australian and
North American populations
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MVP Populations
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MVPs – Selection Opportunity
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MVP Reliability
Standard for assessing accuracy and predictive power of the MVP for a trait
Based on correlation (R) between the MVP and the animal’s genetic breeding value if all information were known
Expressed as a percentage of the maximum accuracy attainable
Indicates how much information may be added in the future as greater numbers of markers are added to the panels used to calculate the MVP
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MVPs – Selection Opportunity
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MVPs – Third-party Validation
Designed to confirm the statistical significance of relationships between MVPs and performance
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MVPs – External Validation
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Meta-Analysis
Combined statistical results into outcome groups by geographic location and cattle subpopulations
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Validation Conclusions
Validation for tenderness across all populations and markets
Validation of feed efficiency in U.S. and Australia in Bos Taurus• Feed efficiency for Bos Indicus in Australia
Significant association in NBCEC validations with % IMF estimated by ultrasound scanning 60 days prior to harvest• Significant association documented in U.S. Bos Indicus
with % Choice
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MVPs – Reporting Format
MVP expressed on a +/- scale from 0, where 0 = average of all animals in our research database
Reliability based on individual genotype and marker effects
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MVPs – Reporting Format
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MVPs – Reporting Format
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MVPs – Selection Example
Potential Sires• Sire A:
FE = -0.73 lbs Marb = 0.4
• Sire B: FE = +0.60 lbs Marb = 0.3
• Sire C: FE = -0.20 lbs Marb = -0.4
The genetic merit of sires for average daily gain was assumed equivalent
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Decision Tree: DNA Test or Don’t DNA Test!
$69,595
$68,977
$64,344
$66,962
$69,595
MVP Selection Example – Test or Not?
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Best decision is to test with MVPs:
Difference = $2,633
MVPs enable superior decisions in choosing sires based on feed intake, marbling potential and tenderness
Best economic decision avoids uncertainty and chooses Sire A instead of making an uninformed decision
MVP Selection Example – Test or Not?
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Stars to MVPs
11 individual markers 56-marker panel
Number of STARS Trait units for greater selection opportunity
Number of favorable alleles Collective effects of markers contribute to trait prediction
Equal effects of each marker Accounts for varying individual marker effects
No calculated reliability % reliability described: 26 – 49%
Good selection tool A new era in genetic improvement
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Bottom Line
Valuable Selection
Tool
More markers, more reliability.
More Powerful Tool!
Next Step – Mating Schemes
Planned mating tool in development
Predicts genetic outcomes based on MVP
analysis of potential sire matings Interactive tool available
late 2009
Quantitative Genetics“New” Reduced Animal ModelQuantitative Genetics“New” Reduced Animal Model
Unknowngenes
Phenotypicdata
“Breeding Value” for unknown and known polygenes
EPDs including DNA marker information
DNA Marker infoGenetic effects
Feed Efficiency EPD -1.9 .45 acc.
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Literature
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New Web Site
Resource center for
genomic technology Interactive sales map Webinars and
presentations Public results
section (coming soon!)
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New Location
Lab operations and customer service team now located in Kalamazoo, Michigan
Based within Pfizer Animal Health Research and Development headquarters
New contact information:
333 Portage Road
Kalamazoo, MI 49007-4931
877-BEEF DNA
Customer Service: 269-833-4629
Fax: 269-833-4711
www.pfizeranimalgenetics.com
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Conclusions
The time is now to enter the new era in precision management with DNA-marker technology.
Pfizer Animal Genetics portfolio of testing includes:• GeneSTAR MVPs• SireTRACE®
• SureTRAK®
• GeneSTAR Elite Tender®
• Arthrogryposis Multiplex testing
Contact your Pfizer Animal Genetics representative, call 1-877-BEEF DNA or go to www.pfizeranimalgenetics.com to order your
test kit today.