International perspectives on human gene editing: South Africa

KEYMANTHRI MOODLEYD I R E C T O R & P R O F E S S O RC E N T R E F O R M E D I C A L E T H I C S & L AWD E PA R T M E N T O F M E D I C I N EFA C U LT Y O F H E A LT H S C I E N C E SS T E L L E N B O S C H U N I V E R S I T YS O U T H A F R I C A

South Africa

Population +/- 52 million

GDP $350 billion

(US) 19.3%------9.1% on health-----1.3% (Pakistan)

Clinical trials +/- 2500

GINI COEFFICIENT0.77

HIV Burden of Disease

6.8 million HIV positive

340 000 new infections

200 000 deaths

42% on ARVs

Justice & Equity

Research & Capacity Development

Cost of treatmentAccess to gene editing?

Public Engagement

Vulnerable populations

Science translation

Informed Consent

Academy of Science of South Africa

National Health ActNational Health Research Ethics Council