Interaksi Obat Diluar Tubuh Manusia

8/20/2019 Interaksi Obat Diluar Tubuh Manusia

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ATIKA JAYA RANI (13330716)

INTERAKSI OBATDILUAR TUBUH

MANUSIA


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Defenisi•

Inte!"si #$!t !%!&!' eisti! %i*!n! !"si s+!t+ #$!t%i +$!' !t!+ %ien,!+'i #&e' #$!t &!in -!n, %i $ei"!n$es!*!!n. Inte!"si #$!t te/!%i /i"! s+!t+ #$!t*en,+$!' efe" #$!t &!inn-!. Ke/! #$!t -!n, %i+$!'%!!t *en/!%i &e$i' !t!+ "+!n, A"tif

• !%! inte!"si #$!t *e&i$!t"!n %+! /enis #$!t -!it+O$!t esiit!n -!"ni #$!t -!n, *e*en,!+'i !t!+

*en,+$!' !"si efe" #$!t &!in

O$!t O$/e" *e+!"!n #$!t -!n, '!si& !t!+ efe"n-!

%ien,!+'i !t!+ %i+$!' #&e' #$!t &!in


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4/12

1. Me"!nis*e te/!%in-! inte!"si2#$!t

• Inte!"si f!*!seti"

• Inte!"si f!*!"#"ineti"

• Inte!"si f!*!"#%in!*i"

5. S!s!!n inte!"si

• Inte!"si O$!t2#$!t

• Inte!"si O$!t M!"!n!n

• Inte!"si O$!t en-!"it• Inte!"si O$!t H!si& L!$


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TUBUH

•Inte!"si -!n, te/!%i %i&+! t+$+'( se$e&+* #$!t %i $ei"!n) !nt!! #$!t-!n, ti%!" $is! %i !*+ %ise$+t

in"#*!ti$e& !t!+ int!"si f!*!setis.•insi inte!"si #$!t %i&+! t+$+'*!n+si! !%!&!' inte!"si &!n,s+n,

se!! 8si" %!n !t!+ "i*i!i4 -!n,*+n,"in te&i'!t se$!,!i e*$ent+"!nen%!!n4 e+$!'!n !n!4 %&&4 !t!+*+n,"in /+,! ti%!" te&i'!t %!i '!si&

inte!"si -!n, te/!%i.


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Mekanisme Kerja Interaksi Obat

Inte!"si -!n, te/!%i "!en! !%!n-! e+$!'!n !t!+ e!"si "i*i! %!n

8si"! !nt!! 5 #$!t !t!+ &e$i' -!n, %!!t %i"en!&9%i&i'!t -!n, $e&!n,s+n,%i&+! t+$+' %!n *en,!"i$!t"!n !"ti:it!s f!*!"#,i" #$!t tese$+t'i&!n,9$e+$!'.

M!!* *!!* in"#*!ti$i&it!s

1. In"#*!ti$i&it!s te!e+ti"

In"#*!ti$i&it!s ,#n,!n ini *e*+n-!i !ti $!'! $i&! #$!t -!n, s!t+%i!*+9 %i"#*$in!si"!n %en,!n #$!t -!n, &!in !"!n *en,!&!*ie+$!'!n2e+$!'!n se%e*i"i!n +! 'in,,! sif!t "e/!n-! %!&!* t+$+'(in :i:#) $e&!in!n %!i!%! -!n, %i'!!"!n.

5. In"#*!ti$i&it!s 8si"!

Y!n, %i*!"s+%"!n %isini !%!&!' e+$!'!n2e+$!'!n -!n, ti%!"

%iin,in"!n -!n, ti*$+& !%! !"t+ #$!t %i!*+ s!t+ s!*! &!in t!n!te/!%i e+$!'!n2e+$!'!n "i*i!.

3. In"#*!ti$i&it!s "i*i!

Y!it+ e+$!'!n2e+$!'!n -!n, te/!%i !%! !"t+ en!*+!n #$!t-!n, %ise$!$"!n #&e' $e&!n,s+n,n-! e"si "i*i!9inte!"si


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CONTOH INTERAKSI OBAT DI LUAR TUBUH

No. Obat

Prei!itant"A#

Obat

Objet "B#

Mekanisme kerja E$ek So%&si

'. enii&in L!+t!n RL

(Rin,e

L!"t!t)

Te$ent+"n-!

sen-!! "#*&e"s

%!n en%!!n

enii&&in ti%!"

!"tif (en%!!n)

obat ti(ak

(iam!&r

bersamaan). K!$enisi&in ;ent!*isin

*en,'!*$!t "e/!

,ent!*isin

;ent!*isin

ti%!" !"tif4

"!$enisi&in+s!"

Ti(ak

(iam!&r

searabersamaan

*. Rif!*isin Is#ni!=i%

(INH)

Di,e+s

$es!*!!n4

*en++n"!n

!"ti8t!s INH "!en!

sif!t if!*isin

-!n, 'i,#s"#is.

INH *en,!&!*i

en++n!n

!"ti8t!s

Pemberian

obatn+a

(i!isa,-

ti(ak

(ier&s

bersama.

0. Am$oterisin Lar&tan

aram

1sio%ois2

%ar&tan

Riner

Membent&k

sen+a3a

kom!%eks

se,ina terja(i

!roses!enen(a!an

Am$oterisin

akan

menen(a!

(a%am %ar&tan

aram1sio%ois2%ar&t

Am$oterisin

ti(ak

(iam!&r

bersamaan

(enanairan in$&s


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e*$!'!s!n

• enii&in *e+!"!n s!&!' s!t+ !nti$i#ti -!n, !!$i&!

%i e!"si"!n $en,!n L!+t!n RL (Rin,e L!"t!t) !"!nte$ent+" s+!t+ sen-!! "#*&e"s !nt!! enii&&in%en,!n &!+t!n in,e se'in,,! %!!t te/!%i #sesen,en%!!n. H!& ini *e*$+!t enii&&in *en/!%i ti%!"!"tif "!en! e%%!!n -!n, %i'!si&"!n. Unt+" it+

enii&&in se$!i"n-! ti%!" %i!*+ $es!*!!n %en,!n'i%#"#tis#n t!+! %!&!n '!& ini &!+t!n in,e &!"t!t.

• K!$enisi&in se$!i"n-! ti%!" %i!*+ %en,!n

;ent!*isin4 "!en! /i"! %$ei"!n $es!*! "!$enisi&in!"!n %!!t *en,'!*$!t "e/! ,ent!*isin. H!& ini*e*$+!t ;ent!*isin *en/!%i ti%!" !"tif se&!in it+"!$enisi&in !"!n +s!". O&e' "!en! it+ se$!i"n-!"e%+! #$!t tese$+t ti%!" %i!*+ se!! $es!*!!n.


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• Rif!*isin %!!t $einte!"si %en,!n Is#ni!=i%(INH) !%! #ses en!*+!n. Bi&! %i,e+s

$es!*!!n4*!"! *en++n"!n !"ti8t!s INH '!& ini%i"!en!"!n sif!t if!*isin -!n, 'i,#s"#is.Efe" -!n, %iti*$+&!"!n !%!&!' INH *en,!&!*ien++n!n !"ti8t!s. O&e' "!en! it+ e*$ei!n#$!tn-! '!+s %iis!'4 %!n ti%!" %i,e+s

$es!*! !%! s!!t e*$+!t!n

• A*f#teisin /i"! %i!*+ %en,!n L!+t!n ,!!*8si#,is9 &!+t!n Rin,e *!"! !"!n te$ent+"n-!s+!t+ sen-!! "#*&e"s !nt!! !*f#teisin%en,!n &!+t!n in,e. H!& ini %!!t*en-e$!$"!n #ses en,en%!!n. A*f#teisin!"!n *en,en%! %!&!* &!+t!n ,!!*

8si#,is9&!+t!n Rin,e. O&e' "!en! it+


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Tin%!"!n *en,'in%!i inte!"si f!*!seti"

1. J!n,!n *e*$ei"!n s+nti"!n !*+!n #$!t "e+!&i "!&!+

-!"in $et+& $!'! ti%!" !%! inte!"si !nt! *!sin,2*!sin,#$!t

5. Di!n/+"!n se%!!t *+n,"in /+,! *en,'in%!i e*$ei!n #$!t$es!*!2s!*! &e!t inf+s

3. Se&!&+ *e*e'!ti"!n et+n/+" e*$ei!n #$!t %!i

e*$+!tn-!>. Se$e&+* *e*!"!i &!+t!n +nt+" e*$ei!n inf+s4 int!:en#s!

!t!+ -!n, &!in4 %ie'!ti"!n $!'! e+$!'!n !n!4"e"e+'!n4 %!i &!+t!n

?. Si!"!n &!+t!n '!n-! "!&!+ %ie&+"!n s!/!

6. B#t#& inf+s '!+s se&!&+ %i$ei &!$e& tent!n, /enis &!+t!nn-!4#!$t2#$!t!n -!n, s+%!' %i*!s+"!n4 te*!s+" %#sis %!n!"t+n-!.

7. Ji"! '!+s *e*$ei e inf+s %+! *!!* #$!t4 $ei"!n 5 /!&+inf+s4 "e+!&i "!&!+ -!"in ti%!" !%! inte!"si.

@. Men,et!'+i sif!t *!sin,2*!sin, #$!t se'in,,! %!!t *e*i&i'#$!t -!n, ti%!" $einte!"si s!!t #ses e*$+!t!n !t!+


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"esi*+&!n•

Inte!"si #$!t !%!&!' eisti! %i*!n! !"si s+!t+ #$!t%i +$!' !t!+ %ien,!+'i #&e' #$!t &!in -!n, %i $ei"!n$es!*!!n. Inte!"si #$!t te/!%i /i"! s+!t+ #$!t*en,+$!' efe" #$!t &!inn-!. Ke/! #$!t -!n, %i+$!'%!!t *en/!%i &e$i' !t!+ "+!n, A"tif. Me"!nis*e

inte!"si #$!t %!!t *e&!&+i $e$e!! !!4 -!"niinte!"si se!! f!*!seti" (in"#*!ti$i&it!s) inte!"sise!! f!*!"#"ineti" %!n inte!"si se!!f!*!"#%in!*i".

• Inte!"si &!n,s+n, se!! 8si" %!n !t!+ "i*i!i %!!tte/!%i %i &+! t+$+' *!n+si!4 -!n, *+n,"in te&i'!tse$!,!i e*$ent+"!n en%!!n4 e+$!'!n !n!4 %&&4!t!+ *+n,"in /+,! ti%!" te&i'!t %!i '!si& inte!"si -!n,te/!%i


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Interaksi Obat Diluar Tubuh Manusia