Interactive Preclinical Analytics via GPU Cloud Platform€¦ · On-Demand HPC Cloud True HPC in the cloud on a pay-as-you-go basis, rate varies by commitment (hourly, monthly, annual)

Copyright © 2011 Penguin Computing, Inc. All rights reserved

Interactive Preclinical Analytics

via GPU Cloud Platform


Penguin POD – Innovative HPC as a Service platform

> Strong Life Sciences business

> Proven models for delivery of SaaS on parallel platforms

Numira – Groundbreaking imaging technologies

> Medical imaging as a biomarker: rich analytics

> Cloud-based delivery of data, analytics, and collaboration

Results for Numira customers

> Globally available advanced pre-clinical imaging services

> Faster, more detailed and expressive imaging capabilities

> Ease of utilization, collaboration and communication tools

Numira and Penguin Partnership

2


Scyld

ClusterWare™

Scyld TaskMaster™

Enterprise Linux

Compilers & Tools

Penguin provides Linux HPC Solutions

Professional

Services and

Engineering

Cluster

Management

Software

Linux Systems

Storage

Workstations Servers

HPC Clusters

HPC as a Service -

Penguin on

Demand

Optimized for Linux Ease of Management Elastic Computing Linux and Cluster Expertise

Intel® & AMD®

Rackmount

Servers

Storage

Networking

Infrastructure

GPGPUs

Professional

Workstations

Factory Integration

Onsite Installation

Training

Product Support

Software Support

Customized Service

Engagements

On-demand

environment

HPC ‘optimized’

Tiered ‘Pay-as-

you-go’ pricing

Premium set-up

and support

services

3


On-demand HPC system

> Compute, storage, low latency fabrics, GPU, non-virtualized

Robust software infrastructure

> Full automation

> User and administration space controls

> Secure and seamless job migration

> Extensible framework

> Complete billing infrastructure

Services

> Custom product design

> Site and workflow integration

> Managed services

> Application support

HPC support expertise

> Skilled HPC administrators

> Leverage 13 yrs serving HPC market

POD Platform

Internet (150Mb, burstable to 1Gb)

4


Base GPU server configuration

> 8 core, 2.6GHz Nehalem servers

> 24 GB RAM (DDR3-1333)

Dual C2075 NVIDIA Tesla GPUs

> Number of processor cores: 448

> Processor core clock: 1.15 GHz

> PCI Express Gen2 ×16 system interface

> Memory clock: 1.50 GHz

> Memory Interface: 384-bit 6GB

24 pieces 64M × 32 GDDR5 136-pin BGA, SDRAM

Full GPU management integrated into POD stack

$2.25 per server hour (volume discounts available)

Typical applications:

> NVIDIA RealityServer

> Reverse Time Migration

> MatLab

> NAMD

> custom applications

POD GPU Offering

5


Increasing customer needs for on-demand resource

> Hybrid, Overflow, Workload-specific

Growth for HPC in non-expert user base

Increased demand for research collaboration platforms

Strong cluster software platform

Low cost of goods as HPC systems manufacturer

Clear vision of product requirements for market

Broad customer base across Enterprise, Fed, EDU

Strong HPC expertise

POD Genesis

6


On-Demand HPC Cloud True HPC in the cloud on a pay-as-you-go

basis, rate varies by commitment (hourly,

monthly, annual)

Hybrid Cloud (burst-out) Penguin clusters with workflow migration to

POD, or included POD usage ( tools and

services provided as PS)

Private HPC Cloud OEM or Penguin partnership to provide a

dedicated cloud to a target group of

customers

Scyld Cloud Management System

(coming late 2012)

Software system to operate and manage a

highly secure HPC cloud system

Post-Purchase Collocation Collocation services at our Salt Lake City

Data Center

Turnkey Remote Managed Services Same remote system management

services that we use for POD, provided to

our customers!

Penguin HPC Cloud Services

7


User Portal

Direct login:

ssh

scp

rsync

Login/register

View/download billing and usage

Portal access to Login VMs

Save/manage custom Login VMs

Create/manage groups

Request cluster configurations

Launch and manage jobs

Monitor cluster usage

Monitor job progress

POD Automation Portal System 2 – releases Q2, 2012

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Virtual Login Node

Compute Node

Compute Node

Compute Node

Compute Node

Compute Node

/home

/store/[username]

VLAN

User Facing Application

Application User

POD Portal User

Head Node

iSCSI Targets

9

Numira focuses on pre-clinical drug development & the

pain points that prevent rapid, confident decisions

Numira

Testing methods that are 20 – 30 years old

The immense amount of data being generated

Pain

Points

10

Virtual HistologyTM Leader in high-resolution, 3D quantitative imaging

Birth Defects Atherosclerosis Brain / Vasculature

Arthritis Lung / Oncology Renal

Heart Defects

Ophthalmology

11

Pain Point: Current Manual Methods Example: Osteoarthritis

2,000 digital, 3D slices of whole joint

Reproducible, quantitative results

oLinear

oVolume

oThickness

oRoughness

oChanges to bone

Significant cost reduction

o Fewer animals

o 5 – 6 weeks to finish

Non-Destructive

Interactive datasets

Numira’s Solution: Virtual HistologyTM

Methods are 20 – 30 years old

Time consuming & inaccurate

Razor blades & microscope slides

Disease is routinely missed

Requires many animals

Subjective results

16 - 20 weeks

Destructive

Problem:

Microscope slide

with a vertical slice

of a rat knee joint.

12

Manage immense amount of data

1,500+ Pharma and Biotech companies

6,000+ drugs under development

Multiple imaging studies per drug

Dozens to hundreds of images per study

File sizes 1GB - 20GB per image

Access to Numira’s analytical tools

Fill the communication void

Rapid scale-up with multiple channel partners

Microsoft partnership in place

Others in process

AltaPortalTM

Cloud / SaaS solution for a large, unmet need

“It’s easier to repeat a study than find and mine data from a previous study.”

- Senior researcher at a Top 5 pharma

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Clients (HTML5)

Servers (Private or Hosted)

Encrypted

Data Storage Study Data

Imaging Data

Meta-Data

Analytics Statistical

Visual

Communication Annotation

Collaboration

Notification

Filter &

Search

Integration Other Study Data

Third party Apps

Other Databases

Galleries &

eNotebooks

Whiteboards &

Chats

Dashboards &

Tracking

Third party

Applications (via API)

Smart Phone / Tablet

(custom interface)

Standard Web

Browser

Authenticated & Secure

Network Communication

Technolo

gie

s

Serv

ices

AltaPortalTM

18

Multiple Cloud Integration

20

Documents

Interactive Preclinical Analytics via GPU Cloud Platform€¦ · On-Demand HPC Cloud True HPC in the cloud on a pay-as-you-go basis, rate varies by commitment (hourly, monthly, annual)