INTEGRALMEDICINEPART1–REFERENCESSlideNo Reference–/pubmedno.(www.ncbi.nlm.nih.gov/pubmed/12345678)16 J.E.Castillo-Fernandezetal.,‘Epigeneticsofdiscordantmonozygotic

twins:implicationsfordisease’,GenomeMedicine(2014),vol.6(7):60.doi:10.1186/s13073-014-0060-z

18 L.M.Bekrisetal.,‘GeneticsofAlzheimerDisease’,JournalofGeriatricPsychiatryandNeurology(2010),vol.23(4),pp.213-227.doi:10.1177/0891988710383571K.Heininger,‘AunifyinghypothesisofAlzheimer’sdisease.III.Riskfactors’,HumanPsychopharmacology(2000),vol.15(1),pp.1-70.doi:10.1002/(SICI)1099-1077(200001)15:1<1::AID-HUP153>3.0.CO;2-1P.Ridgeetal.,‘Alzheimer’sdisease:Analyzingthemissingheritability’,PLoS1(2013),vol.8(11),e:79771.doi:10.1371/journal.pone.0079771

23 J.A.VinsonandP.Bose,‘Comparativebioavailabilitytohumansofascorbicacidaloneorinacitrusextract’,AmericanJournalofClinicalNutrition(1988),vol.48(3),pp.601-604.doi: 10.1093/ajcn/48.3.601J.A.VinsonandJ.Jang,‘Invitroandinvivolipoproteinantioxidanteffectofacitrusextractandascorbicacidonnormalandhypercholesterolemichumansubjects’,JournalofMedicinalFood(2001),vol.4(4),pp.187-192.doi:10.1089/10966200152744454

31 Seehttp://jamanetwork.com/journals/jama/article-abstract/260822134 PClayton,JRowbotham,JRoyalSocietyofMedicine,200836 G.Blocketal.,‘Usagepatterns,health,andnutritionalstatusoflong-

termmultipledietarysupplementusers:across-sectional’,NutritionJournal(2007),vol.6:20.doi: 10.1186/1475-2891-6-30

45 J.Baoetal.,‘Predictionofpostprandialglycemiaandinsulinemiainlean,young,healthyadults:glycemicloadcomparedwithcarbohydratecontentalone’,AmericanJournalofClinicalNutrition(2011),vol.93(5),pp.984-996.doi:10.3945/ajcn.110.005033

46 L.Q.Qinetal.,‘Milkconsumptionandcirculatinginsulin-likegrowthfactor-Ilevel:Asystematicliteraturereview’,InternationalJournalofFoodSciencesandNutrition(2009),vol.60(7),pp.330-340.Doi:10.1080/09637480903150114;B.C.Melnick,‘Milk–thepromoterofchronicWesterndiseases’,MedicalHypothesis(2009),vol.72(6),pp.631-639.doi:10.1016/j.mehy.2009.01.008

EXTRA K.Halletal,‘Energyexpenditureandbodycompositionchangesafteranisocaloricketogenicdietinoverweightandobesemen‘AmericanJournalofClincialNutrition(2016),vol.104(2),pp.324-333.Doi:10.3945/ajcn.116.133561

EXTRA Z.Abidetal.,‘Meat,dairyandcancer’,AmericanJournalofClinicalNutrition,vol.100(1),pp.386S-393S.doi:10.3945/ajcn.113.071597

EXTRA M.C.L.Phillipsetal.,‘Low-fatversusketogenicdietinParkinson’sdisease:Apilotrandomisedcontrolledtrial’,MovementDisorders(2018),vol.33(8),pp.1306-1314.doi:10.1002/mds.27390

49 H.Koponenetal.,‘Metabolicsyndromepredisposestodepressivesymptoms:apopulation-based7-yearfollow-upstudy’,JournalofClinicalPsychiatry(2008),vol.69(2),pp.178-182;

K.Yaffeetal.,‘Themetabolicsyndromeanddevelopmentofcognitiveimpairmentamongolderwomen’,ArchNeurology(2009),vol.66(3),pp.324-328.doi:10.1001/archneurol.2008.566;

E.S.Epel,‘Psychologicalandmetabolicstress:arecipeforacceleratedcellularaging?’,Hormones(2009),vol.8(1),pp.7-22;

I.KryouandC.Tsigos,‘Chronicstress,visceralobesityandgonadaldysfunction’,Hormones(2008),vol.7(4),pp.287-293;

M.J.Gunteretal.,‘Insulin,Insulin-LikeGrowthFactor-I,andriskofbreastcancerinpostmenopausalwomen’,JournaloftheNationalCancerInstitute(2009),vol.101(1),pp.48-60.doi:10.1093/jnci/djn415;

J.Ahnetal.,‘Adiposity,adultweightchange,andpostmenopausalbreastcancerrisk’,ArchInternalMedicine(2007),vol.167(19),pp.2091-2102.doi:10.1001/archinte.167.19.2091

75 S.J.Kimetal.,‘Effectsofdietarypulseconsumptiononbodyweight:asystematicreviewandmeta-analysisofrandomisedcontrolledtrials’,AmericanJournalofClinicalNutrition(2016),vol.103(5),pp.1213-1223.doi:10.3945/ajcn.115.124677;D.Jenkins,‘Effectoflegumesaspartofalowglycemicindexdietonglycemiccontrolandcardiovascularriskfactorsintype2diabetesmellitus:arandomisedcontrolledtrial’,ArchInternMed(2012),vol.172(21),pp.1653-1660.doi:10.1001/2013.jamainternmed.70

78 E.M.Balketal.,‘Effectofchromiumsupplementationonglucosemetabolismandlipids:Asystematicreviewofrandomisedcontrolledtrials’,DiabetesCare(2007),vol.30(9),e103-e103.doi:10.2337/dc07-1121;S.D.Antonetal.,‘Effectsofchromiumpicolinateonfoodintakeandsatiety’,DietabetesTechnology&Therapeutics(2008),vol.10(5),pp.405-412.doi:10.1089/dia.2007.0292;K.A.Brownleyetal.,‘Chroniumsupplementationformenstrualcycle-relatedmoodsymptoms’,JournalofDietarySupplements(2013),vol.10(4),pp.345-356.doi:10.3109/19390211.2013.830678;K.A.Brownleyetal.,‘Adouble-blind,randomisedpilottrialofchromiumpicolinateforbingeeatingdisorder:resultsoftheBingeEatingandChromium(BEACh)study’,JournalofPsychosomaticResearch(2013),vol.75(1),pp.36-42.doi:10.1016/j.jpsychores.2013.03.092Seewww.patrickholford.com/advice/chromium-the-evidence

79 M.M.Guimarãesetal.,‘Effectofchromiumsupplementationontheglucosehomeostasisandanthropometryoftype2diabeticpatients:Doubleblind,randomizedclinicaltrial:Chromium,glucose

homeostasisandanthropometry’,JournalofTraceElementsinMedicineandBiology(2016),vol.36,pp.65-72.doi:10.1016/j.jtemb.2016.04.002

80 A.N.Paivaetal.,‘Beneficialeffectsoforalchromiumpicolinatesupplementationonglycemiccontrolinpatientswithtype2diabetes:Arandomizedclinicalstudy’,JournalofTraceElementsinMedicineandBiology(2015),vol.32,pp.66-72.doi:10.1016/j.jtemb.2015.05.006

81 N.Chengetal.,‘Follow-upsurveyofpeopleinChinawithtype2diabetesmellitusconsumingsupplementalchromium’,JournalofTraceElementsinExperimentalMedicine(1999),vol.12(2),pp.55-60.Doi:10.1002/(SICI)1520-670X(1999)12:2%3C55::AID-JTRA2%3E3.0.CO;2-G

82 M.Douetal.,‘Combinedchromiumandmagnesiumdecreasesinsulinresistancemoreeffectivelythaneitheralone’,AsiaPacificJournalofClinicalNutrition(2016),vol.25(4),pp.747-753.doi:10.6133/apjcn.092015.48

83 M.Thaseetal.,‘Arandomised,double-blindcomparisonofolanzapine/fluoxetinecombination,olanzapine,andfluoxetineintreatment-resistantmajordepressivedisorder’,JournalofClinicalPsychiatry(2007),vol.68(2),pp.224-236;A.Lasserreetal.,‘Depressionwithatypicalfeaturesandincreaseinobesity,bodymassindex,waistcircumferenceandfatmass:Aprospective,population-basedstudy’,JAMAPsychiatry(2014),vol.71(8),pp.880-888.doi:10.1001/jamapsychiatry.2014.411

84 J.R.Davidsonetal.,‘Effectivenessofchromiuminatypicaldepression:aplacebo-controlledtrial’,BiologicalPsychiatry(2003),vol.53(3),pp.261-264.

85 Seewww.patrickholford.com/advice/cinnamon-may-help-weight-loss90 I.Onakpoyaetal.,‘Theuseofgarciniaextract(hydroxycitricacid)asa

weightlosssupplements:Asystematicreviewandmeta-analysisofrandomisedclinicaltrials’,JournalofObesity(2011):509038.doi:10.1155/2011/509038

91 C.Cangianoetal.,‘Eatingbehaviourandadherencetodietaryprescriptionsinobeseadultssubjectstreatedwith5-hydroxytryptophan’,AmericanJournalofClinicalNutrition(1992),vol.56(5),pp.863-867.doi:10.1093/ajcn/56.5.863;C.Cangianoetal.,‘Effectsoforal5-hydroxytryptophanonenergyintakeandmacronutrientselectioninnon-insulindependentdiabeticpatients’,InternationalJournalofObesityandRelatedMetabolicDisorders(1998),vol.22(7),pp.648-654.

95 L.L.Moiseyetal.,‘Caffeinatedcoffeeconsumptionimpairsbloodglucosehomeostasisinresponsetohighandlowglycemicmealsinhealthymen’,AmericanJournalofClinicalNutrition(2008),87(5),pp.1254-1261.,2008;87:1254–61.doi:10.1093/ajcn/87.5.1254

100 V.Kaciniketal.,‘EffectofPGX,anovelfunctionalfibresupplement,onsubjectiveratingsofappetiteinoverweightandobesewomen

consuminga3-daystructured,low-caloriediet’,Nutrition&Diabetes(2011),vol.1:e22.doi:10.1038/nutd.2011.18

101 G.Katzetal,JournaloftheAmericanCollegeofNutrition,2016[PatrickIcannotfindthisone]

102 See https://www.drugs.com/npp/glucomannan.html 103 H.V.T.Hoetal.,‘Asystematicreviewandmeta-analysisof

randomizedcontrolledtrialsoftheeffectofkonjacglucomannan,aviscoussolublefiber,onLDLcholesterolandthenewlipidtargetsnon-HDLcholesterolandapolipoproteinB’,AmericanJournalofClinicalNutrition(2017),vol.105(5),pp.1239-1247.doi:10.3945/ajcn.116.142158

108 K.Hanhinevahetal.,‘Impactofdietarypolyphenolsoncarbohydratemetabolism’,InternationalJournalofMolecularSciences(2010),vol.11(4),pp.1365-1402.doi:10.3390/ijms11041365

109 M.C.Klempeletal.,‘Intermittentfastingcombinedwithcalorierestrictioniseffectiveforweightlossandcardio-protectioninobesewomen’,NutritionJournal(2012),vol.11:98.doi:10.1186/1475-2891-11-98

M.N.Harvieetal.,‘Theeffectsofintermittentorcontinuousenergyrestrictiononweightlossandmetabolicdiseaseriskmarkers:arandomisedtrialinyoungoverweightwomen’,InternationalJournalofObesity(2011),vol.35(5),pp.714-727.doi:10.1038%2Fijo.2010.171

M.C.Klempeletal.,‘Intermittentfastingcombinedwithcalorierestrictioniseffectiveforweightlossandcardio-protectioninobesewomen’,NutritionJournal(2012),vol.11:98.doi:10.1186/1475-2891-11-98

S.EshghiniaandF.Mohammadzadeh,‘Theeffectsofmodifiedalternate-dayfastingdietonweightlossandCADriskfactorsinoverweightandobesewomen’,JournalofDiabetes&MetabolicDisorders(2013),vol:12:4.doi:10.1186/2251-6581-12-4

S.Bhutanietal.,‘Alternatedayfastingandenduranceexercisecombinetoreducebodyweightandfavorablyalterplasmalipidsinobesehumans’,Obesity(2013),vol.21(7),pp.1370-1379.doi:10.1002/oby.20353

114 A.H.Hardingetal.,‘PlasmavitaminClevel,fruitandvegetableconsumption,andtheriskofnew-onsettype2diabetesmellitus:theEuropeanprospectiveinvestigationofcancer-Norfolkprospectivestudy’,ArchivesofInternalMedicine(2008),vol.168(14),pp.1493-1499.doi:10.1001/archinte.168.14.1493;M.Afkhami-ArdekaniandA.Shojaoddiny-Ardekani,‘EffectofvitaminConbloodglucose,serumlipids&seruminsulinintype2diabetespatients’,IndianJournalofMedicalResearch(2007),vol.126(5),pp.471-474;M.Elluluetal.,‘EffectofvitaminConinflammationandmetabolicmarkersinhypertensiveand/ordiabeticobeseadults:arandomized

controlledtrial’,DrugDesign,DevelopmentandTherapy(2015),vol.9,pp.3405-3412.doi:10.2147/DDDT.S83144;J.S.Vinson,etal.,‘Invitroandinvivoreductionoferythrocytesorbitolbyascorbicacid’,Diabetes(1989),vol.38(8),pp.1036-1041.

EXTRA A.Vogiatzoglouetal.,‘VitaminB12statusandrateofbrainvolumelossincommunity-dwellingelderly’,Neurology(2008),vol.71(11),pp.826-832.doi:10.1212/01.wnl.0000325581.26991.f2

EXTRA R.H.Whiteetal.,‘Incidenceofvenousthromboembolismintheyearbeforediagnosisofcancerin568,693adults’,JAMAInternalMedicine(2005),vol.165(15),pp.1782-1787.doi:10.1001/archinte.165.15.1782

EXTRA E.J.Lairdetal.,‘VoluntaryfortificationisineffectivetomaintainthevitaminB12andfolatestatusofolderIrishadults:evidencefromtheIrishLongitudinalStudyonAgeing(TILDA)’,BritishJournalofNutrition(2018),vol.120(1),pp.111-120.doi:10.1017/S0007114518001356

115 J.Maetal.,‘Associationsofserumanddietarymagnesiumwithcardiovasculardisease,hypertention,diabetes,insulin,andcarotidarterialwallthickness:theARICstudy.AtherosclerosisRiskinCommunitiesstudy’,JournalofClinicalEpidemiology(1995),vol.48(7),pp.927-940;B.N.Hopping,etal.,‘Dietaryfibre,magnesiumandglycemicloadalterriskoftype-2diabetesinamulti-ethniccohortinHawaii’,JournalofClinicalEpidemiology(1995),vol.140(1),pp.68-74.doi:10.3945/jn.109.112441F.Guerrero-Romeroetal.,‘Oralmagnesiumsupplementationimprovesglycaemicstatusinsubjectswithprediabetesandhypomagnesaemia:Adouble-blindplacebo-controlledrandomizedtrial’,Diabetes&Metabolism(2015),vol.41(3),pp.202-207.doi:10.1016/j.diabet.2015.03.010DiabetesCare,2003[Patrick,can’tfindthisone]

124 G.Grossoetal.,‘Roleofomega-3fattyacidsinthetreatmentofdepressivedisorders:Acomprehensivemeta-analysisofrandomizedclinicaltrials’,PLoSOne(2014),vol.9(5):e96905.doi:10.1371/journal.pone.0096905

125 R.GoldbergandJ.Katz,‘Ameta-analysisofanalgesiceffectsofomega-3polyunsaturatedfattyacidsupplementationforinflammatoryjointpain’,Pain(2007),vol.129(1-2),pp.210-223.

126 Seehttps://www.vitamindwiki.com/Proof+that+Vitamin+D+Works127 H.A.Bischoff-Ferrari,‘Optimalserum25-hydroxyvitaminDlevelsfor

multiplehealthoutcomes’,AdvancesinExperimentalMedicineandBiology(2014),vol.810,pp.500-525;P.J.Pludowskietal.,‘VitaminDsupplementationguidelines’,JournalofSteroidBiochemistry&MolecularBiology(2018),vol.175,pp.125-135.doi:10.1016/j.jsbmb.2017.01.021

134 G.K.Pyapalietal.,‘Prenataldietarycholinesupplementationdecreasesthethresholdforinductionoflong-termpotentiationin

youngadultrats’,JournalofNeurophysiology(2008),vol.79(4),pp.1790-1796.doi:10.1152/jn.1998.79.4.1790;W.H.MeckandC.L.Williams,‘Perinatalcholinesupplementationincreasesthethresholdforchunkinginspatialmemory’,NeuroReport(1997),vol.8(14),pp.3053-3059;S.H.Zeisel,‘Choline:neededfornormaldevelopmentofmemory’,JournalofAmericanCollegeofNutrition(2000),vol.19(5),pp.528S-531S;M.C.HungSetal.,‘LearningbehaviourandcerebralproteinkinaseC,antioxidantstatus,lipidcompositioninsenescence-acceleratedmouse:influenceofphosphatidylcholine-vitaminB12diet’,BritishJournalofofNutrition(2001),vol.86(2),pp.163-171.doi:10.1079/BJN2001391;N.Jacobetal.,‘Cysteineisacardiovascularriskfactorinhyperlipidemicpatients’,Atherosclerosis(1999),vol.146(1),pp.53-59;S.L.Laddetal.,‘Effectofphosphatidylcholineonexplicitmemory’,ClinicalNeuropharmacology(1993),vol.16(6),pp.540-549;F.Amentaetal.,‘Thecholinergicapproachforthetreatmentofvasculardementia:evidencefrompre-clinicalandclinicalstudies’,ClinicalandExperimentalHypertension(2002),vol.24(7-8),pp.697-713;R.J.Wurtman,‘Nutrientsthatmodifybrainfunction’,ScientificAmerican(1982),vol.264(4),pp.50-59.doi:10.1038/scientificamerican0482-50P.Kidd,‘Phsphatidylcholine:Asuperiorprotectantagainstliverdamage’,AlternativeMedicineReview(1996),vol.1(4),pp.258-274.

145 P.Sandersonetal.,‘Folatebioavailability:UKFoodStandardsAgencyworkshopreport’,BritishJournalofNutrition(2003),vol.90(2),pp.473-479.doi:10.1079/BJN2003889

146 A.Vogiatzoglouetal.,‘VitaminB12statusandrateofbrainvolumelossincommunity-dwellingelderly’,Neurology(2008),col.71(11),pp.826-832.doi:10.1212/01.wnl.0000325581.26991.f2;EuseenSJetal‘OralCyanocobalaminSupplementationinOlderPeopleWithVitaminB12Deficiency’ArchInternMed.2005;165:1167-1172

147 Vinson,RoyalSocietyofChemistry,1989147 B.J.Vennetal.,‘Comparisonoftheeffectoflow-dose

supplementationwithL-5-methyletetrahydrofolateorfolicacidonplasmahomocysteine:arandomisedplacebo-controlledstudy’,AmericanJournalofClinicalNutrition(2003),vol.77(3),pp.658-662.doi:10.1093/ajcn/77.3.658D.Smithetal.,‘Folicacidimpairstheuptakeof5-methyltetrahydrofolateinhumanumbilicalvascularendothelialcells’,JournalofCardiovascularPharmacology(2017),vol.70(4),pp.271–275.doi:10.1097/FJC.0000000000000514

150 SchaeferEetal,ArchNeurol.2006;

JernerénFetal.‘Brainatrophyincognitivelyimpairedelderly:theimportanceoflong-chainω-3fattyacidsandBvitaminstatusinarandomizedcontrolledtrial’.AmJClinNutr.2015Jul;102(1):215-21159 H.C.Kuiperetal,‘VitaminCsupplementationlowersurinarylevelsof4-hydroperoxy-2-nonenalmetabolitesinhumans’,FreeRadicalBiologyandMedicine(2011),vol.50(7),pp.848-853.doi:10.1016/j.freeradbiomed.2011.01.004;ReillyMetal,‘Modulationofoxidantstressinvivoinchroniccigarettesmokers’,Circulation(1996),vol.94(1),pp.19-25;A.Mastaloudisetal,‘Antioxidantsupplementationpreventsexercise-inducedlipidperoxidation,butnoinflammation,inultramarathonrunners’,FreeRadicalBiologyMedicine(2004),vol.36(10),pp.1329-41.doi:10.1016/j.freeradbiomed.2004.02.069;G.Levineetal,‘Ascorbicacidreversesendothelialvasomotordysfunctionincoronaryarterydisease’,Circulation(1996),vol.93(6),pp.1107-1113;N.Gockeetal,‘Long-termascorbicacidadministrationreversesendothelialvasometerdysfunctioninpatientswithcoronaryarterydisease’,Circulation(1999),vol.99(25),pp.3234-3240;S.J.Duffyetal,‘Treatmentofhypertensionwithascorbicacid’,Lancet(1999),vol.354(9195),pp.2048-2049.;S.Juraschek,‘EffectsofvitaminCsupplementationonbloodpressure:ameta-analysisofrandomisedcontrolledtrials’,AmericanJournalofClinicalNutrition(2012),vol.95(5),pp.1079-1788.doi:10.3945/ajcn.111.027995;S.K.OsganianSKetal.,‘VitaminCandriskofcoronarydiseaseinwomen’,JournalofAmericanCollegeofCardiology(2003),vol.42(2),pp.246-252;K.T.KhawKTetal.,‘RelationbetweenplasmaascorbicacidandmortalityinmenandwomeninEPIC-Norfolkprospectivestudy:aprospectivepopulationstudy.EuropeanProspectiveInvestigationintoCancerandNutrition’,Lancet(2001),vol.357(9257),pp.657-663.;P.K.Myintetal.,‘PlasmavitaminCconcentrationspredictriskofincidentstrokeover10yin20,649participantsoftheEuropeanProspectiveInvestigationintoCancerNorfolkprospectivepopulationstudy’,AmericanJournalofClinicalNutrition(2008),vol.87(1),pp.64-69.

160 MorganJMetal.AmJCardiol1998;82(12A):29U–34UCapuzziDMetal.AmJCardiol1998;82(12A):74U–81U

161 H.VersaandR.Garg,‘Effectofmagnesiumsupplementationontype2diabetesassociatedcardiovascularriskfactors:asystematicreviewandmeta-analysis’,JournalofHumanNutritionandDietetics(2017),vol.30(5),pp.621-633.doi:10.1111/jhn.12454

165 J.A.Luchsinger,etal.,Neurology,2004;A.M.Abbatecolaetal.,‘InsulinResistanceandExecutiveDysfunctioninOlderPersons’,JournalofAmericanGeriatricSociety(2004),vol.52(10),pp.1713-1718.doi:10.1111/j.1532-5415.2004.52466.x;W.L.

W.L.Xu,etal.,‘DiabetesmellitusandriskofdementiaintheKungsholemproject:a6-yearfollowupstudy’,Neurology(2004),vol.63(7),pp.1181-1186.Yaffe,K,etal.,ArchivesofNeurology,2009Kungs

166 M.MorrisArch.Neurol2003;K.Yurko-Mauro,Alz.Dem.2010:AJCN2013;Witte,Cortex,2013

184 Eswaran,S.LAmericanJournalofGastroenterology,2016187 Shu.X.etal.,ExperimentalandTherapeuticMedicine,2016:RenW,

FrontImmunol,2016188 Fasano,A..,ClinGastroenterolHepatol,2010193 SameerZ.etal.,AmericanJournalofGastroenterology2005;

100:p1550-1557194 AtkinsonW.etal.,Gut,vol53,pp.1391-1393(2004)2004196 HardmanG.andHartG.,(2007)NutritionandFoodScience37:16-23198 M.Hannon-FletcheretalAm J Clin Nutr October 2004 vol. 80 no. 4

911-918 EXTRA IgGstudies-seeslidesattheendofdocument205 GerarduzziTetal.JournalofPediatricGastroenterologyandNutrition

31(suppl)2000:S29,Abst.104209 F.Sofietal.EuropeanJournalofClinicalNutrition,2013,67;p190-195210 WhittakerHetal.,EurJNutr,2016-/26853601EXTRA M.Dinuetal.,‘AKhorasanwheat-basedreplacementdietimproves

riskprofileofpatientswithnon-alcoholicfattyliverdisease(NAFLD):Arandomisedcontrolledtrial’,JournalofAmericanCollegeofClincialNutrition(2018),vol.37(6),pp.508-514,doi:10.1080/07315724.2018.1445047

224 HallmanKetal.BreastCancer2017-28331366225 H.Sasakietal.Biol.Pharm.Bull.34(5)660-665(2011)/21532153;

alsosee/21603867227 Seehttp://www.patrickholford.com/advice//natural-pain-killers236 AssarzadeganF,IntClinPsychopharmacol.2016-271040442;ChiuH,

PainPhysician.2016-/26752497242 J.Sarris,Nutritionalmedicineasmainstreaminpsychiatry,Lancet

Psychiatry,2015EXTRA J.B.Adamsetal.,‘Comprehensivenutritionalanddietaryintervention

forautismspectrumdisorder–Arandomised,controlled12-monthtrial’,Nutritients(2018),vol.10(3):E369.doi:10.3390/nu10030369

248 D.Healeyetal,BritishMedicalJournal2005;330;396-404249 J.C.Fournier,etal.,JournaloftheAmericanMedicalAssociation,

2010;303(1):47–53251 Smith,K.A.etal(1997).Lancet,349,915-919253 TurnerEetal.,Pharmacology&Therapeutics,2005254 Seeslide129EXTRA J.Liuetal.,‘Themediatingroleofsleepinthefishconsumption–

cognitivefunctioningrelationship:acohortstudy’,ScientificReports(2017),vol.7:17961.doi:10.1038/s41598-017-17520-w

258 R.Jorde,Archivesofgeneralpsychiatry,2008;Littlejohns,Neurology,2014;C.Shipowick,AppliedNursingResearch,2009;A.Lansdowne,Psychopharmacology,1998

274 JubizWetal.,JClinEndocrinolMetab.2014-/24601693275 KimHetal.NursHealthSci,2006;BryantM,BrJNutr,2005;LeeS,

AmJClinNutr,2009276 Z.MaiZetal.,‘Soyphytochemicalssynergisticallyenhancethe

preventiveeffectoftamoxifenonthegrowthofestrogen-dependenthumanbreastcarcinomainmice’,Carcinogenesis(2008),vol.28(6),pp.1217-1223.doi:10.1093/carcin/bgm004;S.Fanetal.,‘BRCA1andBRCA2asmoleculartargetsforphytochemicalsindole-3-carbinolandgenisteininbreastandprostatecancercells’,BritishJournalofCancer(2006),vol.94(3),pp.407-426.doi:10.1038/sj.bjc.6602935

277 Seewww.patrickholford.com/advice/six-essential-nutrients-women285 J.I.KimJetal.,‘Associationbetweenhomocysteineandbonemineral

densityaccordingtoageandsexinhealthyadults’,JournalofBoneMetabolism(2016),vol.23(3),pp.129-134.doi:10.11005/jbm.2016.23.3.129A.Ennerman,‘EffectofvitaminB12andfolicacidsupplementationonbonemineraldensityandquantitativeultrasoundparametersinolderpeoplewithanelevatedplasmahomocysteinelevel:B-PROOF,arandomisedcontrolledtrial’,CalcifiedTissueInternational(2015),vol.96(5),pp.401-409.doi:10.1007/s00223-015-9968-6

286 V.Taietal.,‘Calciumintakeandbonemineraldensity:systematicreviewandmeta-analysis’,BritishMedicalJournal(2015),vol.351,h4182.doi:10.1136%2Fbmj.h4183J.Wuetal.,‘Quantitativeanalysisofefficacyandassociatedfactorsofcalciumintakeonbonemineraldensityinpostmenopausalwomen’,OsteoporosisInternational(2017),vol.28(6),pp.2003-2010.doi:10.1007/s00198-017-3993-4

EXTRA A.Philipsetal.,‘Braintumours:RiseinglioblastomamultiformeincidenceinEngland1995-2015suggestsanadverseenvironmentalorlifestylefactor’,JournalofEnvironmentalandPublicHealth(2018),vol.2018:7910754.doi:10.1155/2018/7910754

M.Yangetal.,‘Mobilephoneuseandgliomarisk:Asystematicreviewandmeta-analysise’,PLoSOne(2017),vol.12(5):e0175136.doi:10.1371/journal.pone.0175136

H.Al-Serorietal.,‘MobilephonespecificelectromagneticfieldsinducetransientDNAdamageandnucleotideexcisionrepairserum-deprivedhumanglioblastomacells’,PLoSOne,vol.13(4):e0193677.doi:10.1371/journal.pone.0193677

EXTRA S.W.Mogensenetal.,‘TheintroductionofDiptheria-Tetanus-PertussisandoralPoliovaccineamongyounginfantsinanurbanAfricancommunity:Anaturalexperiment’,EBioMedicine(2017),vol.17,pp.192-198.doi:10.1016/j.ebiom.2017.01.041

294 G.I.Murrayetal.,‘Tumour-specificexpressionofcytochromeP450CYP1B1’,CancerResearch(1997),vol.57(14),pp.3026-3031.

EXTRA H.Hemilä,‘VitaminCandinfections’,Nutrients(2017),vol.9(4):339.doi:10.3390/nu9040339

298 H.Hemilä,‘VitaminCandinfections’,Nutrients(2017),vol.9(4):339.doi:10.3390/nu9040339

299 E.Cameron,L.Pauling‘Supplementalascorbateinthesupportivetreatmentofcancer:Prolongationofsurvivaltimesinterminalhumancancer’PNASOctober1,197673(10)3685-3689S.J.Padayattyetal.,‘VitaminC:intravenoususebycomplementaryandalternativemedicinepractitionersandadverseeffects’,PLoSOne(2010),vol.5(7);e11414.doi:10.1371/journal.pone.0011414G.Bonuccellietal.,‘NADHautofluorescence,anewmetabolicbiomarkerforcancerstemcells:IdentificationofvitaminCandCAPEasnaturalproductstargeting“stemness”’,Oncotarget(2017),vol.8,pp.20667-20678.doi:10.18632/oncotarget.15400

300 Q.Chenetal.,‘Pharmacologicdosesofascorbateactasaprooxidantanddecreasegrowthofaggressivetumourxenograftsinmice’,ProceedingsoftheNationalAcademyofSciences(2008),vol.105(32),pp.11105-11109.doi:10.1073/pnas.0804226105

302 HHemila,‘Zinclozengesandthecommoncold:ameta-analysiscomparingzincacetateandzincgluconate’,andtheroleofzincdosageJRSMOpen2017May2;8(5):2054270417694291.doi:10.1177/2054270417694291

303 Z.Zakay-Ronesetal.,‘Inhibitionofseveralstrainsofinfluenzavirusinvitroandreductionofsymptomsbyanelderberryextract(SambucusnigraL.)duringanoutbreakofinfluenzaBPanama’,JournalofAlternativeandComplementaryMedicine(1995),vol.1(4).doi:10.1089/acm.1995.1.361;Z.Zakay-Ronesetal.,‘RandomziedstudyoftheefficacyandsafetyoforalelderberryextractinthetreatmentofinfluenzaAandBvirusinfections’,JournalofInternationalMedicalResearch(2004),vol.32(2),pp.132-140.doi:10.1177%2F147323000403200205

305 R.Jariwallaetal.,‘SuppressionofinfluenzaAvirusnuclearantigenproductionandneuraminidaseactivitybyanutrientmixturecontainingascorbicacid,greenteaextractandaminoacids’,BioFactors(2007),31(1),pp1-15.doi:10.1002/biof.5520310101;M.Roomietal.,‘InhibitionofcellularinvasiveparametersininfluenzaAvirus-infectedMDCKandverocellsbyanutrientmixture’,BioFactors(2008),vol.33(1),pp.61-75.doi:10.1002/biof.5520330106

313 K.P.Koetal.,‘DietaryintakeandbreastcanceramongcarriersandnoncarriersofBRCAmutationsintheKoreanHereditaryBreastCancerStudy’,AmericanJournalofClinicalNutrition(2013),vol.98(6),pp.1493-1501.doi:10.3945/ajcn.112.057760

315 T.ChristoffersonTrippingoverthetruth:Thereturnofthemetabolictheoryofcancerilluminatesanewandhopefulpathtocure.‘TrippingOvertheTruth.CreateSpaceIndependentPublishingPlatform(2014).

317 M.J.Gunteretal.,‘Insulin,insulin-likegrowthfactor-I,andriskofbreastcancerinpostmenopausalwomen’,JournaloftheNationalCancerinstitute(2009),vol.101(1),pp.48-60.doi:10.1093/jnci/djn415J.Ahnetal.,‘Adiposity,adultweightchange,andpostmenopausalbreastcancerrisk’,ArchivesofInternalMedicine(2007),vol.167(19),pp.2091-2102.doi:10.1001/archinte.167.19.2091

318 A.Tavanietal.,‘ConsumptionofsweetfoodsandbreastcancerriskinItaly’,AnnalsofOnology(2006),vol.17(2),pp.341-345.doi:10.1093/annonc/mdj051

320 Y.Onoderaetal.,‘IncreasedsugaruptakepromotesoncogenesisviaEPAC/RAP1andO-GlcNAcpathways’,JournalofClinicalInvestigation(2014),vol.124(1),pp.367-384.doi:10.1172/JCI63146

323 R.dePinho,‘Theageofcancer’,Nature(2000),vol.408(6809),pp.248-254.doi:10.1038/35041694

329 D.Ganmaaetal.,‘Incidenceandmortalityoftesticularandprostaticcancersinrelationtoworlddietarypractices’,InternationalJournalofCancer(2002),vol.98(2),pp.262-267.doi:10.1002/ijc.10185

331 Seehttps://www.patrickholford.com/advice/the-milk-cancer-link334 Seestudiesathttps://www.rgcc-group.com/?page=news-rgcc-pub;

formoreinfoemailInfo@rgcc-europe-nw.com

IgGstudies