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Institute of Organic ChemistryNational Academy of Sciences of Ukraine

Innovative Opportunitiesand Prospects

Murmanska str., 5, 02660, Кyiv-94 www.ioch.kiev.ua

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The Institute’s Employees

Total # 243

Scientific 120

Dr. of Sci 22

PhD 73

PhD student 16

New young employees 17

Students in training 50

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The Institute’s Scientific Department

1. Organophosphorus Compounds2. Heteroatom Chemistry3. Colour and Structure of Organic Compounds4. Mechanisms of Organic Reactions5. Chemistry of Phosphoranes6. Chemistry of Bio-active Compounds7. Physico-chemical Investigations8. Chemistry of Organo-fluorine Compounds9. Chemistry of Organo-sulfur Compounds10. Bio-medical Investigations

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The Institute’s Basic Research

•fine organic synthesis•organoelement chemistry (P, S, Si)•heterocyclic chemistry•fluoroorganic chemistry•polymethyne dyes, colour theory•mechanisms of organic reactions•chemistry of biologically active compounds •supramolecular chemistry•calixarene chemistry

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Patent activity in 2013

submitted 12

granted 16

maintained 57

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Fluorination reagents and processes  

OHO

HO

F

HO OMe

O

HO

F

HO OMe

F

F

R

Alk2NSF3

OCOOMe

F

H HS

CHF2

H

RN

OCO2CH2Ph

H HS

H

FH2C

O

OO

CO2H

H

Fluoromethylpenicillins

Fluorosteroids 8-Fluorocarbapenems

Fluoroproctaglandins

Fluoroalkylated Sugars

R

OHHO

OF

COOH

N

H

O

H

COOH

S R

FH

N

N

N

N

O

NH2

OH OH

H2NSO2O

F

N

NH

O

O

H3C

O

HOHO

HO

F

Fluoronucleosids, Fluoronucleotids

DAST

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DEVELOPMENT OF THE ACID SENSING ION CHANNELS ANTAGONISTS WITH NEUROPROTECTIVE ANTIISCHEMIC PROPERTIES

Ukraine patent № 66987; Fiziol. Zh. 2011, 57, 6, 31

KMS-005IC50 = 27 nM

Known blocker AmilorideIC50 = 4000 nM

X-ray Structure of Acid Sensing Ion Channel 1a

IN COOPERATION WITH BOGOMOLETZ INSTITUTE OF PHYSIOLOGY NAS OF UKRAINE

N

N

Cl

O O

NH

NH2

N

NNH

O

NH2

NH

NH2NH2

Cl

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New nano-sized catalytic compositions for selective chlorination of alkylaromatic compounds

Innovative Aspect and AdvantagesNew catalytic compositions based on thiocrown-ethers and Lewis catalysts (SbCl5, SbCl3, FeCl3) provide better yields of para-chlorotoluene in comparison with the known industrial Lewis Acid catalytic compositions

Structure of the nano-catalyst SbCl5 – benzodithio-18-crown-6 – Cl2

Products of toluene chlorination with usage of the nano-catalyst

Patent of Ukraine № И201104813

Me Me

Cl

Me

Cl

+

62 % 38 %

nano-catalyst

Cl2

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(a). Oscillogram of trains which arise on a background of spikes of free generation.(b). The ultrashort pulse of the passively mode-locked laser on Yb-Er glass (λ = 1540 nm) with saturable absorber based on dye 4919u.

4919u

BF4Ph

S

Ph

Ph

S

Ph

Ph

Solvatochromism and passive mode locking of erbium laser

MeCN

o-C6H4Cl2

10Dependency of photoconductivity JPH on electric field strength E in Al/PEPK + 0.5 mass % dye / SnO2 sample (thickness = 1.2 μm, I = 8 W•m–2)

N

MeMe

MeNH

NH

O

O

O

PEPK(polyepoxypropylcarbazole)

N

CH2

On

(D A) + h (D+ A )*

Dye excitation

(D+ A )* + PEPK (D A) • • • • PEPK+•

Electron transfer (formation of electron-hole pair)

(D A) • • • • PEPK+• (D A) • + PEPK+•

Dissociation of electron-hole pair in external electric field

Detection of internal microcrack in a railroad rail. The hologram was recorded usinb the polymer film doped with merocyanine D–A

Photothermoplastic holographic composite

Merocyanine (D–A)

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O O O O

R RR R

R R R R

CАТIONS АNIONS МОLECULES

CALIXARENE RECEPTORS

Calixarenes selectively recognize, bind and separate similar in properties species

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Institute of Organic Chemistry NAS Ukraine

Calixarene R&DResearchDesign of selective (chiral) receptors of cations, anions, molecules

and bio-molecules

Development

Radionuclide Extractants

Chemosensors

Drug Design

J. Am. Chem. Soc. 2007. 129. 1123-1131.J. Org. Chem. 2007. 72. 3223-3231.Pure Appl. Chem. 2008. 80. 1449-1458J. Phys. Chem. C. 2009. 113. 1137-1142Curr. Med. Chem. 2009. 16. 1630-1655 Bioorg. Med. Chem. Lett. 2010, 20, 483–487J.of Catalysis. 2011. 284. 42-49FEBS Journal. 2011. 278. 1244-1251

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Actinides extraction

Distribution D between nitrobenzotrifluoride and HNO3 (0.3M)

0

2

4

6

8

10

12

14D

Am(III) Cm(III) Pu(IV) Np(V)

O OO O

P

P P

P

O O Pr

PrPr

PrO O

Pr

Pr

Pr

Pr

0.01 M

Smirnov I. V., Karavan M. D., Efremova T. I., Babain V. A., Miroshnichenko S. I., Cherenok S. A., Kalchenko V. I.Radiochemistry. 2007. 49. 423-431

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Calixarene Micellar Complex

O OO O

P

P P

P

O O Pr

PrPr

PrO O

Pr

Pr

Pr

Pr

Alk Alk Alk Alk

Hydrophilic Rim

Hydrophobic Rim

Amphiphilic Calixarenes

radionuclide

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Micelle-mediated purification of radioactive water

radioactive water

micellarcomplexes

purified water

Ultrafiltration,or cloud pointextraction

Patent of Ukraine. 28405. 2007Russian patent. 2343161. 2007

O OO O

P

P P

P

O O Pr

PrPr

PrO O

Pr

Pr

Pr

Pr

radioactivewater

16Rodik R., Rozhenko A., Boyko V., Pirozhenko V., Danylyuk O., Suwinska K., Lipkowski J., Kalchenko V. Tetrahedron. 2007. 63. 11451-11457.

Calixarene bis-Quinazolinone - Methanol Complex

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Calixarene phosphonous acidsas receptors for biomolecules

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Наукові та виробничі зв'язки з підприємствами України

ЗАТ "Фармак", Київ Виробництво препарату Мебіфон - засобу для лікування раку моло-чної залози

ЗАТ НВЦ "Борщагівський хімфармзавод", Київ

Організація випуску препаратів Боризол для лікування хвороби Паркінсона. Флокалін - для лікування серцево – судинних захворювань

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Діяльність Дослідного виробництва

№з/п

Продукція

2012 2013 2014

Випуск (кг) Випуск (кг)

1 Декаметоксин 99 37

2 Таурін 300 500

3 Етоній медицинський - -

4 Етоній ветеринарний - -

5 Вазин 1800 1000

6 Карбацид 114 - -

7 Термостабілізатори ПВХ СКСК-20, 22, 28

4998 -

8 Комплексні добрива 12000 -

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ДЯКУЮ ЗА УВАГУ !