.Chemical tags ……help detect separate bases in individual DNA strands, as demonstrated by S. Howorkaand N. Mitchell in the Communication on page 5565 ff. In the sensing strategy, a singleDNA strand is threaded through a “nanotunnel”. Owing to their larger diameter,individual bases with attached chemical tags are slowed at the narrow constriction. Thepattern of modified and unmodified bases gives rise to a characteristic current signal forthe DNA. The picture was prepared by Hugh Martin.

Inside Cover

Nick Mitchell and Stefan Howorka*

Chemical tags help detect separate bases in individual DNA strands, as demonstratedby S. Howorka and N. Mitchell in the Communication on page 5565 ff. In the sensingstrategy, a single DNA strand is threaded through a “nanotunnel”. Owing to theirlarger diameter, individual bases with attached chemical tags are slowed at the narrowconstriction. The pattern of modified and unmodified bases gives rise to acharacteristic current signal for the DNA. The picture was prepared by Hugh Martin.