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SEMINARIO SOBRE INVESTIGACION TRANSLACIONALINFORME DE
LECTURA
INFORME DE LECTURA No. 1 TEMTICA: Translational Medicine: A
two-way road
INFORME REALIZADO POR: Marlon Daniel Cajas ChicaizaREFERENCIA
BIBLIOGRFICA:Marincola, F. (2003. Translational Medicine: A two-way
road.!"tenido de #o$rnal o%Translational Medicine:
htt&:''www.translational-edicine.co'content'&d%')*+-+/-)-).&d%
IDEA PRINCIPAL:
The heart o% translational research resides in hase 1 trials
where noel treatents aretested %or %easi"ility and toicity in
&re&aration %or a hase 11 trial in which
thera&e$tice%%ectieness is tested. 1n the wa4e o% a
&otential 5"rea4thro$6h5 in the la", the hase 1trial o%%ers
6reat te&tation to test what co$ld "e a &ioneerin6
thera&e$tic e%%ect andlearn %ro the noel conce&ts deried
%ro clinical e&erience that co$ld "e sharedwith those "ench
scientists who ori6inally conceied the treatent. 7$t,
since,$n%ort$nately, inial clinical "ene%it is $s$ally seen in the
contet o% e&loratoryst$dies, enth$sias %ades and a hase 11
st$dy does not aterialize8 attention t$rns tonew thera&e$tic
odalities "ro$6ht to the clinical shore %ro a new 7ench to
7edside
wae. (Marincola, 2003.
IDEAS SECUNDARIAS COMENTARIO IDEA SECUNDARIA1ndeed, the
scientist atte&tin6 to dissectscienti%ically h$an diseases as
theyeole has to con%ront $ni9$e challen6esrelated with the 6enetic
&olyor&his o%o$r s&ecies, the etree and
eolin6hetero6eneity o% soe diseases (s$ch ascancer or iral disease
and o%ten eternalconstraints &osed "y ethical and
&ractical
considerations. Th$s, soe &re%er to &re-%a"ricate anial
odels rese"lin6h$an diseases to ena"le theatheatical &rediction
o% a 6ientreatent o$tcoe "y si&li%yin6 its
"iolo6y thro$6h standardization o% the6enetic a4e$& o%
anials and diseases.(Marincola, 2003.
os 6randes o"st;c$los 9$e tienen loscientine"ar6o la
co&lejidad del ser h$anoes in%inita y lo es ;s la
co&lejidad de
las en%eredades h$anas ca$sadas &oralteraciones 6en?ticas o
ir$s 9$e $tan a$n rito acelerado con la %inalidad deso"reiir en $n
a"iente hostil, todo estec@$lo de s$cesos y circ$nstanciasres$ltan
adersas &ara lle6ar a $nae%icacia %arac?$tica y &ara ejorar
lacalidad de ida de los &acientes.
!%ten scientists that desi6ned new
&otential thera&ies "ased on %$ndaentalscienti%ic
"rea4thro$6hs are not inclinedto learn why thin6s did not wor4 as
well
M$chas reistas cient
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in h$ans as they did in the &re-clinicalsettin6s "eca$se
there is no roo in
&resti6e jo$rnals %or ne6atie res$lts.1ndeed, the scienti%ic
co$nity is not6enerally interested in ne6atie res$lts. 1naddition,
di%%ic$lty in &$"lishin6 res$ltsderied %ro &hase 1 st$dies
isco&o$nded "y the %act that o%ten dataare o% co&roised
9$ality and not o% the
&ristine 9$ality achiea"le in the &re-clinical settin6.
(Marincola, 2003.
reco&ilar todos los %racasos, la raz=n de"eser 9$e no
res$ltan %acti"les &ara laor6anizaci=n a car6o de &$"licar
estosin%ores. >in e"ar6o, ser
