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W.B. SAUNDERS COMPANY A Harcourt Health Sciences Company The Curtis Center Independence Square West Philadelphia, Pennsylvania 19106 http: // www.wbsaunders.com THE PEDIATRIC CLINICS OF NORTH AMERICA Volume 47, Number 5 Editor: Carin Davis Production Editor: Heather L. Long0 Copyright 0 2000 by W.B. Saunders Company. All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information retrieval system, without written permission from the publisher. The appearance of the code at the top of the first page of an article in this periodical indicates the consent of the W.B. Saunders Company that copies of the article may be made for personal or internal use, or for the personal or internal use of specific clients, for those registered with the Copyright Clearance Center, Inc. (222 Rosewood Drive, Danvers, MA 01923: (978) 750-8400; www.copyright.com). This consent is given on the condition that the copier pay the stated per-copy fee f i r that article through the Copyright Clearance Center, Inc. for copying beyond that permitted by Sections 107 or 108 of the US Copyright Law. This consent does not extend to other kinds of copying, such as copying for general distribution, for advertising or promotional purposes, for creating new collective works, or for resale. Absence of the code indicates that the material may not be processed through the Copyright Clearance Center, Inc. The ideas and opinions expressed in The Pediatric Clinics of North America do not necessarily reflect those of the Publisher. The Publisher does not assume any responsibility for any injury and/or damage to persons or property arising out of or related to any use of the material contained in this periodical. The reader is advised to check the appropriate medical literature and the product information currently provided by the manufacturer of each drug to be administered to verify the dosage, the method and duration of administra- tion, or contraindications. It is the responsibility of the treating physician or other health care professional, relying on independent experience and knowledge of the patient, to determine drug dosages and the best treatment for the patient. Mention of any product in this issue should not be construed as endorsement by the contributors, editors, or the Publisher of the product or manufacturers' claims. The Pediatric Clinics of North America (ISSN 0031-3955) is published bi-monthly by W.B. Saunders Company, Corporate and Editorial Offices: The Curtis Center, Independence Square West, Philadelphia, PA 19106-3399. Accounting and Circulation Offices: 6277 Sea Harbor Drive, Orlando, FL 328874300. Periodicals postage paid at Orlando, FL 32862, and additional mailing offices. Subscription price per year is $107.00 (US individuals), $160.00 (US institutions),$159.00 (foreign individuals), $196.00 (foreign institutions),$141.00 (Cana- dian individuals), and $196.00 (Canadian institutions). To receive student/resident rate, orders must be accompanied by name of affiliated institution, date of term, and the signaturr of program/residency coordinator on institution letterhead. Orders will be billed at indi- vidual rate until proof of status is received. Foreign air speed delivery is included in all Cfinics subscription prices. All prices are subject to change without notice. POSTMASTER Send address changes to W.B. Saunders Company, Periodicals Fulfillment, Orlando, FL 328874300. Customer Service 1-800454-2452 (US). From outside the US, call 1-407-39.5400. The Pediatric Clinics of North America is also published in Spanish by McGraw-Hill Inter- americana Editores S.A., Mexico City, Mexico; in Portuguese by Reichmann and Affonso Editores, Rua Comandante Coelho 1085, CEP 21250, Rio de Janeiro, Brazil; and in Greek by Althayia SA, Athens, Greece. The Pediatric Clinics of North America is covered in Index Medicus, Excerpta Medica, Current Contents, Current ContentslClinical Medicine, Science Citation Index, ASCA, ISIIBIOMED, and BIOSIS. Printed in the United States of America. October 2000 ISSN 0031-3955

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Page 1: Information for Readers

W.B. SAUNDERS COMPANY A Harcourt Health Sciences Company

The Curtis Center Independence Square West Philadelphia, Pennsylvania 19106 http: // www.wbsaunders.com

THE PEDIATRIC CLINICS OF NORTH AMERICA Volume 47, Number 5

Editor: Carin Davis Production Editor: Heather L. Long0

Copyright 0 2000 by W.B. Saunders Company. All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information retrieval system, without written permission from the publisher.

The appearance of the code at the top of the first page of an article in this periodical indicates the consent of the W.B. Saunders Company that copies of the article may be made for personal or internal use, or for the personal or internal use of specific clients, for those registered with the Copyright Clearance Center, Inc. (222 Rosewood Drive, Danvers, MA 01923: (978) 750-8400; www.copyright.com). This consent is given on the condition that the copier pay the stated per-copy fee f i r that article through the Copyright Clearance Center, Inc. for copying beyond that permitted by Sections 107 or 108 of the US Copyright Law. This consent does not extend to other kinds of copying, such as copying for general distribution, for advertising or promotional purposes, for creating new collective works, or for resale. Absence of the code indicates that the material may not be processed through the Copyright Clearance Center, Inc.

The ideas and opinions expressed in The Pediatric Clinics of North America do not necessarily reflect those of the Publisher. The Publisher does not assume any responsibility for any injury and/or damage to persons or property arising out of or related to any use of the material contained in this periodical. The reader is advised to check the appropriate medical literature and the product information currently provided by the manufacturer of each drug to be administered to verify the dosage, the method and duration of administra- tion, or contraindications. It is the responsibility of the treating physician or other health care professional, relying on independent experience and knowledge of the patient, to determine drug dosages and the best treatment for the patient. Mention of any product in this issue should not be construed as endorsement by the contributors, editors, or the Publisher of the product or manufacturers' claims.

The Pediatric Clinics of North America (ISSN 0031-3955) is published bi-monthly by W.B. Saunders Company, Corporate and Editorial Offices: The Curtis Center, Independence Square West, Philadelphia, PA 19106-3399. Accounting and Circulation Offices: 6277 Sea Harbor Drive, Orlando, FL 328874300. Periodicals postage paid at Orlando, FL 32862, and additional mailing offices. Subscription price per year is $107.00 (US individuals), $160.00 (US institutions), $159.00 (foreign individuals), $196.00 (foreign institutions), $141.00 (Cana- dian individuals), and $196.00 (Canadian institutions). To receive student /resident rate, orders must be accompanied by name of affiliated institution, date of term, and the signaturr of program/residency coordinator on institution letterhead. Orders will be billed at indi- vidual rate until proof of status is received. Foreign air speed delivery is included in all Cfinics subscription prices. All prices are subject to change without notice. POSTMASTER Send address changes to W.B. Saunders Company, Periodicals Fulfillment, Orlando, FL 328874300. Customer Service 1-800454-2452 (US). From outside the US, call 1-407-39.5400.

The Pediatric Clinics of North America is also published in Spanish by McGraw-Hill Inter- americana Editores S.A., Mexico City, Mexico; in Portuguese by Reichmann and Affonso Editores, Rua Comandante Coelho 1085, CEP 21250, Rio de Janeiro, Brazil; and in Greek by Althayia SA, Athens, Greece.

The Pediatric Clinics of North America is covered in Index Medicus, Excerpta Medica, Current Contents, Current ContentslClinical Medicine, Science Citation Index, ASCA, ISIIBIOMED, and BIOSIS.

Printed in the United States of America.

October 2000 ISSN 0031-3955