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Informatics for the Neuroimaging Research Enterprise. Dan Marcus Washington University NITRC Enhancement Grantee Meeting Monday, June 30, 2008. The Central Neuroimaging Data Archive. Supporting Wash U investigators since 2003 - PowerPoint PPT Presentation
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Informatics for the Neuroimaging Research
EnterpriseDan Marcus
Washington UniversityNITRC Enhancement Grantee Meeting
Monday, June 30, 2008
The Central Neuroimaging Data Archive
• Supporting Wash U investigators since 2003• Currently holds 25000 MR, PET and CT scans
from over 5000 individual studies• ~100 active users from two dozen labs• Supports all of the Univ.’s imaging facilities
and many of its research centers.
Defining the enterprise
Lab
Stakeholders: Principal investigator, students, postdocs, research techs.
Defining the enterprise
Center
LabLab Lab
Stakeholders: Director, scanner facility, IT department, human studies
Defining the enterprise
Center
LabLab Lab
Center
LabLab Lab
Center
LabLab Lab
Multisite collaborationMultisite collaboration
Stakeholders: study PI, individual PIs, research cores, coordinating center
Defining the enterprise
• Labs: Focused on data & analysis• Centers: Focused on operations & oversight• Multisite studies: Focused on technical &
scientific coordination and logistics
Defining informatics: Data Capture
NEUROIMAGING
GENETICS
OTHER SOURCES
Integrity: Do I have the data?Quality Control: Are the data any good?
Defining informatics: Local Use
NEUROIMAGING
GENETICS
OTHER SOURCES
Application: Can I do things with the data?Automation: Am I optimizing throughput?
Defining informatics: Collaboration
NEUROIMAGING
GENETICS
OTHER SOURCES
Access: Are colleagues getting the data they need?Security: Are colleagues getting data they shouldn’t?
Defining informatics: Public access
NEUROIMAGING
GENETICS
OTHER SOURCES
Privacy: Am I respecting the rights of the study participants?Convenience: How usable are the data?
QUARANTINE LOCAL USE COLLABORATION PUBLIC ACCESSCAPTURE
NEUROIMAGING
GENETICS
OTHER SOURCES
The XNAT workflow
• Quality control• Data archiving• Data access• Security
• Visualization• Automation• Integration• Data sharing
Lessons learned: stakeholders
• Identify the stakeholders and their personalities– The Micromanager– The Empire builder– The Outsourcer– The Benefactor
• N investigators ≠N databases
Lessons learned: budgets
• Hardware costs will be over budgeted.• Personnel costs will be under budgeted.
Lessons learned: personnel
• Hire software engineers.• Good Java programmers are rare.• Good Java programmers who will work for
what you want to pay them? Forget about it.• There are no rules.• Except: your software engineering team is
your most important asset.
Lessons learned: software engineering
• Use the least possible technology.• Half the features. Twice the usability.• Compliance issues (HIPAA, IRBs, IT security)
becomes increasingly burdensome• Open source is your friend.
Lessons learned: data
• Remain agnostic to formats• Except DICOM. Drink the Kool-Aid.