Infinito, a novel high performance fungicide with an ICM … · · 2008-05-02Bayer CropScience China ... Antracol 70WP Melody Duo 66.8WP Scala 400SC ... r i n p r o te i n s m e

Presentation • May 2, 2008 • Slide 1

Guo JQ (PhD), BCS China Development

Infinito, a novel high performance fungicide with an ICM profile to control late blight in tomatoes and potatoes.

JingJing QuanQuan GUO (PhD)GUO (PhD)Bayer CropScience China

The Third International Late Blight ConferenceBeijing, China 3-6 April, 2008

Presentation • May 2, 2008 • Slide 2Guo JQ (PhD), BCS China Development

Development Launch Declining End Growing Maturity

Kalaili 840SL

Infinito 687.5SC

Sportak 450 EW / Sporgon 50WP

2 molecules

Previcur N 722AS Rovral 500SC

Antracol 70WP

Melody Duo 66.8WP

Scala 400SC

Horizon430SC / Raxil 60FS

Bayleton 25WP

Hinonsan 400ECBaytan 25DS

BCS Fungicides introduced into China

2005 2000 1995 1990 1985 1980


BCS Fungicide Product Portfolios in ChinaProducts Oomycete

diseasesLeaf

sportsBotrytis

grey moldPowdery mildew

Antrac-nose

Wheat rusts

Rice blast

Crop smuts

Infinito 687.5SC ++++

+++++++++++

++++++++

+++

Kalaili 840SL +++Previcur 722AS +++Melody Duo 66.8WP +++ +++Antracol 70WP +++ +++ ++ ++Horizon 430SC ++++ ++++ ++++ +++ ++++Rovral 500SC ++++ ++++ +++ ++Scala 400SC +++ ++++ ++Sportak 450EW ++ +++ ++ +++Sporgon 50WP ++ +++ ++ +++Bayleton 25WP ++++ ++++ ++ ++Raxil 60FS +++ ++++ ++++ ++++Hinonsan 400EC ++++

++++: Excellent; +++: Good; ++: Acceptable; +: not good. PHT


Fluopicolide is a new molecule in the Chemical class of Acylpicolides with a specific mode of action & high bio-activity which differs to the available Oomycete fungicides .


Highly effective oomycetes fungicide for use in potatoes, grapes and vegetables

Novel mode of action - no cross resistance (spectrin delocalization)

Fast acting and long-lasting activity

Consistently high level of disease control

Favorable profile for the food chain

The new standard foroomycetes control

Fluopicolide – Novel Highly Effective Oomycetes Control

N

ClCF3

NH

O

Cl

Cl


Infinito - A modern tool for IPM / ICMLow acute toxicity (oral, dermal, inhalation)Not carcinogenic /mutagenic No developmental or reproductive toxicity

Non-toxic to birds, bees, silkworm & non-target organismsNot toxic to aquatic organisms practicallyNo residues in potatoes

Acute oral >2500

Acute dermal

Inhalation

Eye sensitivitySkin sensitivity

>3195

Non

>4000

Non


Biochemical Mode of Action

Cytoskeleton

Membrane

Spectrin proteins linkingmembrane to cytoskeleton

delocalisation

A unique mode of action which is notobserved with other Oomycete fungicides

treateduntreated

zoospores

mycelium

10 ppm

3 ppm

Redistribution of spectrin-like proteins(immuno-localized with fluorescence microscopy)

Effect on spectrin-like proteins


In the lifecycle of P. infestans

Biological mode of action

Indirect germination - Zoospore release

Direct germination of sporangia

Cyst germination

Sporangia germination Germ tube penetration

PenetrationZoospore mobility

Protective efficacyProtective efficacy

Germination Germ tube elongation

Anti-sporulation

SporulationMycelium growth into

plant tissues

Curative efficacyCurative efficacy

Penetration-Colonization(Formation of haustoria )

““Eradicative" efficacyEradicative" efficacy

Sporulation(conidiophores & conidia)


Biological Spectrum

Brassicas Peronospora parasitica

Cucurbits Pseudoperonospora cubensis

Lettuce Bremia lactucae

Onions Peronospora destructor

Peppers Phytophthora capsici

Potato Phytophthora infestans

Roses Peronospora sparsa

Tobacco Peronospora tabacina

Tomato Phytophthora infestans

Vines Plasmopara viticola Late blight Downy mildew Damping-off


A: control represents zoospores treated with solvent (1% DMSO);

B: zoospores treated with fluopicolide at 3ppm, 10 minutes post treatment.

Effect of Fluopicolide on P. infestans Zoospores


0

20

40

60

80

100

UTC Infinito 1,2L Infinito 1,4L Infinito 1,6L Acrobat M 2Kg Epok 0,4L

Assessment of the lesion size : 8 days after treatment (treatment done 20 h after inoculation)Severity %

Lab Test : Curative Activity of Infinito 687.5SC

N

F3C Cl

NH

O

Cl

Cl

Propamocarb-HCL

+Fluopicolide


Lab Test: New Growth Protection

3.3

18.3

27.5

36.3

0

43.8

05

101520253035404550

Untreated Infinito 1,2

Acrobat 2,0

Ranman 0,2

Shirlan 0,4

Pulsan 2,5

+(+) ? ? ? ++

(oxadixyl+cymoxanil+mz)

Lab trial in France / 2002; 2 sprays at 24h and 72 h after inoculation respectively.

% Infected

leafarea of new shoots6 DAT

N

F3C Cl

NH

O

Cl

Cl

Propamocarb-HCL

+Fluopicolide


Positioning against Potato Late Blight

GerminationEmergence Leaf & stem dvpt

Stemelongation

Rowclosure

Beginning of flowering

Flowering Tuberdvpt

Senescence

• 2-3 sprays at rate of 1.2-1.6L/ha

• Started from the flowering period

• At the interval of 7-10days


67.8

9.35.8

19.6

11.4 13.3

0

20

40

60

80

Untreated Infinito 1,2 Infinito 1,6 Acrobat 2,0 Ranman 0,2 Shirlan 0,4

RAUDPC

Leaf Blight Performance in Europe

(Efficacy on leaves in 29 trials in 2002-2004)

29 efficacy trials

+++ ++++ ++(+) +++ +++

N

F3C Cl

NH

O

Cl

Cl

Propamocarb-HCL

+Fluopicolide


Field performance against late blight in Europe

Cymoxanil / mancozeb - fluazinamUTC Infinito


Late Blight Fungicide Rating at EuroBlight Workshop (Bologna, Italy) 2007

ProductLeaf

blight

New growing

pointStem blight

Tuber blight Protectant Curative

Anti-sporulant

Rainfast-ness Mobility in the plant

Provisional / New productpropamocarb +++ ++ ++ +++ +++ ++ ++(+) ++(+) Translaminar + systemicbenthiavalicarb-isopropyl + mancozeb +++ ? +(+) L +(+) +++ +(+) + ++(+) Translaminar + contactCurzate ++(+) ? +(+) 0 ++ ++ + ++ Translaminar + contactAcrobat ++(+) ? +(+) ++ ++(+) + ++ ++(+) Translaminar + contactRanman +++ ? + +++ +++ 0 0 +++ Contact Frowncide +++ ? + ++(+) +++ 0 0 ++(+) Contact

Late blight fungicide ratings Bologna 2007Effectiveness Action mode

Infinito 687.5SC (fluopicolide + propamocarb) received the best rating among the late blight fungicides


InfinitoInfinito against Cucumber downy mildew(CDM)against Cucumber downy mildew(CDM)

http://www.ces.ncsu.edu/depts/pp/cucurbit/disease/graphics/CuDMa1.JPG


Average Efficacy of Infinito against CDM of 4 trials in ChinaAverage Efficacy of Average Efficacy of InfinitoInfinito against against CDMCDM ofof 44 trials in Chinatrials in China

20

40

60

80

7DA2ndA-2004 7DA3rdA-2004

Infinito 50ml/mu(516gai/ha) Infinito 60ml/mu(619gai/ha)Infinito 75ml/mu(773gai/ha) Previcur N 80ml/mu(866gai/ha)Previcur N 100ml/mu(1083gai/ha) Cymoxanil 150g/mu(1620gai/ha)Dimethomorph 30g/mu(225gai/ha)

Conclusion: Infinito has consistently shown the best efficacy against CDM at rates of 516-773gai/ha under heavy disease infection.Infinito has shown the better curative activity than Previcur, Cymoxanil & Dimethomorph at the recommending doses.

Efficacy(%)


Dimethomorph 50%WPCymoxanil 72%WP

Field Performance in Guangdong 2004

Inifinito 687.5 SC Water


InfinitoInfinito against Tomato Late Blightagainst Tomato Late Blight (TLB)(TLB)

http://www.apsnet.org/education/LessonsPlantPath/Lateblit/text/LATEB_08.HTM

http://www.apsnet.org/education/LessonsPlantPath/Lateblit/text/LATEB_10.HTM


20

40

60

80

7DA2ndA-2004 7DA3rdA-2004

Infinito 50ml/mu(516gai/ha) Infinito 60ml/mu(619gai/ha)Infinito 75ml/mu(773gai/ha) Previcur N 80ml/mu(866gai/ha)Previcur N 100ml/mu(1083gai/ha) Cymoxanil 150g/mu(1620gai/ha)Dimethomorph 30g/mu(225gai/ha)

Average Efficacy of Infinito against TLB of 4 trial in ChinaAverage Efficacy of Average Efficacy of InfinitoInfinito against against TLBTLB of of 4 4 trial in Chinatrial in China

Conclusion: Infinito has consistently shown the best efficacy against tlb at rates of 60-75ml/mu under heavy disease infection.Infinito has shown the better curative activity than Previcur,Cymoxanil & Dimethomorph at the recommending doses.

Efficacy(%)


UTC Infinito

Cymoxanil

Dimethomorph

Field Performance in Shandong 2005


Efficacy %

Infinito positioned as a curative Oomycide against tomato late blight & cucumber downy mildew in China

Infinito positioned as a curative Oomycide against tomato late blight & cucumber downy mildew in China

0

10

20

30

40

50

60

70

80

90

100

0

10

20

30

40

50

60

70

80

90

100

untreated

Infinito 619gai/ha(60ml/mu)

Infinito 773gai/ha(75ml/mu)

Cymoxanil 1648gai/ha(156g/mu)

Dimethomorph 225gai/ha(30g/mu)

50 DAP40 DAP30 DAP20 DAP 80 DAP70 DAP60 DAP10 DAPPlantingappl.:

Untreated % infection


InfinitoInfinito against against Potato Potato Late BlightLate Blight ((PPLB)LB)


20

40

60

80

100Efficacy(%)

619gai/ha

1575+619 gai/ha

ml,g/mu

2 Infinito 1 Antracol 2 Antracol 3 Metalaxyl+MZ+2 Infinito +1 Infinito

Results on tuber blight (14 days after storage) in Sichuan 2006

Diseased tubers in Untreated:15.44%

INFINITO on Potato Late Blight protection

773gai/ha 1575+773

gai/ha

1575+619 gai/ha

1575+773 gai/ha 1044gai/ha


田间表现

Infinito Local Standard

Infinito Field Performance in Sichuan 2006


20

40

60

80

100

Efficacy(%)

1044gai/haml,g / mu

2 Infinito 1 Antracol 2 Antracol 3 Metalaxyl+MZ+2 Infinito +1 Infinito

DATE 5.29 6.5 6.13 6.20Severity (UTC) 0

Metalaxyl+MZ

0.23 11.2 62.4

Infinito

Antracol+Infinito

Results on leaf blight in Yunan 2007

INFINITO – Potato Late Blight protection

619gai/ha

1575+619 gai/ha

773gai/ha 1575+773

gai/ha

1575+619 gai/ha

1575+773 gai/ha


Metalaxyl-MZ

Infinito1.125L/ha

Untreated

田间表现Infinito Field Performance in Yunan 2007


Antracol followed by Infinito UTC

Field Performance in Yunnan 2007


South-west:: 1-3 seasons (mixed cropping)Sichuan, Yunana, Guizhou, TibetLate blight;

Geographic Distribution of Potato Culture & Key DiseasesNorth region: Single season

Heilongjiang: late blight;Inner Mogolio: late blight( dominant ) + early blightGansu: early blight ( dominant ) + late blight

Central region: 2 seasonsShandong, Henan & AnhuiLate blight ( dominant )+ early blight

South: winter CroppingGuangdong, Guangxi, HainanLate blight;


Use Patterns of INFINITO On Potato in ChinaStraight spray

Package spray

Tank-mixture spray

1 2 3

INFINITO (2-3 foliar sprays)

1 2 3

ANTRACOL + INFINITO

1 12 3 2 3

late blight

late blight

ANTRACOL followed by INFINITO

Early blight + late blight

Emergence Active growth Stable canopy Bulking


Successful Launch of Infinito 687.5SC in China 2006

1. Registered in China 2005, as the first registration worldwide;

2. Launched on cucumber and tomato against downy mildew & late blight in 2006-2007;

3. To be launched on potato, watermelon, chili and crucifer vegetables in 2009.

687.5 g/L SC

Presentation • May 2, 2008 • Slide 33

Guo JQ (PhD), BCS China Development

Thank You for Your Attention !

Documents

Infinito, a novel high performance fungicide with an ICM … · · 2008-05-02Bayer CropScience China ... Antracol 70WP Melody Duo 66.8WP Scala 400SC ... r i n p r o te i n s m e