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In This Issue• $1,000 Winner
• Conference Lineup
• FSCV Software Update
• Grant Information
• Recent Publications
• Sleep Scoring Tools
• Surgery Tip
• X-Y Tracking Updates
Surgery TipTo help maintain a sterile f ield during
stereotaxic surgery , use Tegaderm™to cov er the stereotaxic mov ement
knobs. Tegaderm™ sheets can be
added during the sterile f ield setup,
and the slightly adhesiv e pieces can
be readily applied by the surgeon
using sterile glov es. This will extend
the sterile f ield to allow f or easy
manipulation of the stereotaxic arms
during implantation without the need to
re-glov e.
Technical QuestionWhat is the recommended method
for scoring data using Sirenia®
Sleep Pro?
Sirenia® Sleep Pro of f ers two
automated tools f or scoring sleep
data: threshold scoring and cluster
scoring. Both methods rely on power
spectral analy sis. Threshold scoring
allows users to set parameters or “rule
sets” to def ine power boundaries in
one or more channels. This method is
usef ul f or v isualizing changes in the
spectral bands ov er time and can be
used to rapidly score state changes
ov er long time periods. Cluster
scoring is used to manipulate the data
into a v ariety of conf igurations,
allowing the user to construct direct
comparisons between spectral bands
(e.g., EMG power and Delta/Theta
ratio). This prov ides indiv idualized
v iews of the data that can be
segregated and scored based on user-
Since our last newsletter, there has been a
lot of new activity at Pinnacle. First, we
received several new grants from the
National Institutes of Health (NIH) and the
Defense Advanced Research Projects
Agency (DARPA) to both develop new
enzymes and work on a turn-key
optogenetics system. We have made
significant updates to our Sirenia® and
FSCV software and have many new features planned for 2014. In addition, we are
branching out from the neuroscience arena by building on our biosensor expertise
with a continuous glucose monitoring system for preclinical research.
I would also like to thank everyone who visited us at Neuroscience 2013 in San
Diego. It was great to see everyone there, and we enjoyed getting time to talk to you
both on the show floor and over beer and appetizers at the mixer. For those of you
who didn’t hear, we had an unexpected visitor to our booth. This kestrel decided that
our toy mice looked a little too “inviting” moving in our sleep deprivation display and
tried to have one for lunch.
Please keep in touch.
All the best,
Donna A. Johnson, President and CEO
Important Software Updates
Sirenia® 1.5.0
def ined boundaries, prov iding a “f ine-
tuning” of the scoring parameters f or
each indiv idual animal. While both
threshold scoring and cluster scoring
can be used independently , combining
the two methods results in a powerf ul
approach to rapidly and indiv idually
tailor scoring parameters and can
increase scoring accuracy ov er one
technique used alone.
More on Sleep Pro
Call for PostersMany Pinnacle customers regularly
present their scientif ic work at
conf erences and meetings throughout
the y ear. We would lov e to share
y our research with other users of
Pinnacle products and sy stems.
Please help us continue to adv ance
neurophy siological studies by allowing
us to host y our prev iously presented
posters on our website. We will
increase the v isibility and impact of
y our research by sharing it with a
global community .
Please email us if y ou are willing to
share y our research.
CommentsHav e a technical question that needs
answering? Suggestions f or f uture
issues? Let us know what y ou want to
see in our newsletter by emailing us
We'd love to hear from you!
Information2014 Catalog
Product Brochures
Join us on LinkedIn
Request a Manual
Forward this Email
The latest release of Sirenia® (Version 1.5.0) integrates Pinnacle's X-Y Tracking
software across all Sirenia® platforms, which allows the software to be used in
conjunction with our acquisition, sleep, and seizure modules. Sirenia® X-Y Tracking
tracks locomotor behavior in real time or in previously recorded video data. The
software is compatible with tethered and wireless animals. Click here to learn more
about this innovative tracking software.
Download Sirenia® 1.5.0
Try Sirenia® X-Y Tracking for FREE
Fast Scan Cyclic Voltammetry
We received valuable feedback from our fast scan cyclic voltammetry (FSCV)
customers and used that feedback to make important changes to the system's PAL-
8500 software. The biggest enhancement, available now in Version 1.2.5 of the
software, is import and export functionality with third-party packages, such as HDCV
Analysis. In addition, the update incorporates annotation jumping and session
saving, which allows users to navigate fi les and retrieve data with ease. Click here to
learn more about our FSCV systems.
Download PAL-8500 (V 1.2.5)
Recent GrantsOver the years, Pinnacle has been actively involved in the Small Business Innovation
Research (SBIR) and Small Technology Transfer Research (STTR) programs,
primarily through the National Institutes of Health (NIH) and Department of Defense
(DoD). We are grateful for the support. Our participation in these programs has led to
the development of a wide range of innovative products that are now available for
your research. In addition to developing new tools, we have had the pleasure of
forging collaborative relationships with leading academic researchers. The projects
that we are working on now will result in new tools that will be available in the near
future. Our current projects include the following:
A nicotine biosensor for addiction studies
NIH/NIDA 2R44 DA033701-02A1
Collaboration: University of Kansas
A turn-key optogenetics and electrophysiology measurement system
NIH/NIA 1R43AG046030-01A1
Applications and methods for continuous monitoring of physiological chemistry
DARPA W31P4Q-14-C-0015
Collaboration: University of Kansas
$1,000 WinnerKaren Boschen of the University of Delaware was the winner of $1,000 in Pinnacle
products for our drawing at Neuroscience 2013.
ConferencesWe’re looking forward to another year full of exciting conferences and events,
including the following. Visit our website for a complete schedule.
APSS SLEEP MEETING 2014
May 31-June 4 in Minneapolis, MN
ADA 74TH SCIENTIFIC SESSIONS
June 13-17 in San Francisco, CA
FENS FORUM OF NEUROSCIENCE
July 5-9 in Milan, Italy
NEUROSCIENCE 2014
November 15-19 in Washington, DC
AES ANNUAL MEETING 2014
December 5-9 in Seattle, WA
Employee Spotlight
Dave Johnson
Dave Johnson, Chief Technology Officer, oversees all engineering and software
development at Pinnacle. Dave and Donna Johnson (CEO) are the brother-sister team
who co-own Pinnacle. Since 1996, Dave has worked with the engineering team to
develop numerous projects into commercial products. Despite being an integral part
of Pinnacle, Dave modestly claims that he works in the background and is occasionally
allowed to regale fellow employees, customers, and passersby with decades-old golf
stories. “I’ve got the game figured out,” he says. “You stop playing and just tell
everyone how good you used to be.”
Before Pinnacle, Dave received an MS and PhD in Electrical Engineering. These
degrees were earned at North Carolina State University and Arizona State University,
which causes Dave to continually lose the office March Madness bracket pool (“Go
Wolfpack!”). His college research centered on semiconductor physics, specifically Gallium Arsenide, “the semiconductor
of the future,” he jokes. Since then he has assisted development projects in both academic and industrial settings,
including as a tenured professor at Kettering University and as senior process engineer for Microchip Technology.
These days, Dave enjoys spending time with his wife, Maureen, and their two children. “The kids are wonderful!” he
says. “We are always juggling school, sports, and other activities. Sometimes Maureen and I find ourselves
communicating by cell phone, but I wouldn’t change a thing.”
Recent PublicationsFor a complete list of publications by Pinnacle customers, visit our website at
http://www.pinnaclet.com/publications.html.
Seizure Publications
Briggs, S.W., Mowrey, W., Hall, C.B., & Galanopoulou, A.S. (2014). CPP-115, a vigabatrin analogue, decreases spasms
in the multiple-hit rat model of infantile spasms. Epilepsia, 55(1), 94-102. doi:10.1111/epi.12424
Howard, M.A., Rubenstein, J.L.R., & Baraban, S.C. (2013). Bidirectional homeostatic plasticity induced by interneuron
cell death and transplantation in vivo. Proceedings of the National Academy of Sciences of the United States of
America. Advance online publication. doi:10.1073/pnas.1307784111
Mistry, A.M., Thompson, C.H., Miller, A.R., Vanoye, C.G., George, A.L., & Kearney, J.A. (2014). Strain- and age-
dependent hippocampal neuron sodium currents correlate with epilepsy severity in Dravet syndrome mice.
Neurobiology of Disease, 65, 1-11. doi:10.1016/j.nbd.2014.01.006
O’Toole, K.K., Hooper, A., Wakefield, S., & Maguire, J. (2014). Seizure-induced disinhibition of the HPA axis increases
seizure susceptibil ity. Epilepsy Research, 108(1), 29-43. doi:10.1016/j.eplepsyres.2013.10.013
Simeone, K.A., Matthews, S.A., Samson, K.K., & Simeone, T.A. (2014). Targeting deficiencies in mitochondrial
respiratory complex I and functional uncoupling exerts anti-seizure effects in a genetic model of temporal lobe epilepsy
and in a model of acute temporal lobe seizures. Experimental Neurology, 251, 84-90.
doi:10.1016/j.expneurol.2013.11.005
Sleep Publications
Cho, S., Yoon, M., Pae, A.N., Jin, Y., Cho, N., Takata, Y., Urade, Y., Kim, S., Kim, J., Yang, H., Kim, J., Kim, J., Han,
J., Shimizu, M., & Huang, Z. (2014). Marine polyphenol phlorotannins promote non-rapid eye movement sleep in mice
via the benzodiazepine site of the GABAA receptor. Psychopharmacology. Advance online publication.
doi:10.1007/s00213-014-3445-1
Ito, H., Yanase, M., Yamashita, A., Kitabatake, C., Hamada, A., Suhara, Y., Narita, M., Ikegami, D., Sakai, H.,
Yamazaki, M., & Narita, M. (2013). Analysis of sleep disorders under pain using an optogenetic tool: Possible
involvement of the activation of dorsal raphe nucleus-serotonergic neurons. Molecular Brain, 6(59). doi:10.1186/1756-
6606-6-59
Odo, M., Koh, K., Takada, T., Yamashita, A., Narita, M., Kuzumaki, N., Ikegami, D., Sakai, H., Iseki, M., Inada, E., &
Narita, M. (2014). Changes in circadian rhythm for mRNA expression of melatonin 1A and 1B receptors in the
hypothalamus under a neuropathic pain-like state. Synapse, 68(4), 153-158. doi:10.1002/syn.21728
Pittman-Polletta, B., Hsieh, W, Kaur, S., Lo, M., & Hu, K. (2014). Detecting phase-amplitude coupling with high
frequency resolution using adaptive decompositions. Journal of Neuroscience Methods, 226, 15-32.
doi:10.1016/j.jneumeth.2014.01.006
Price, M.P., Gong, H., Parsons, M.G., Kundert, J.R., Reznikov, L.R., Bernardinell i, L., Chaloner, K., Buchanan, G.F.,
Wemmie, J.A., Richerson, G.B., Cassell, M.D., & Welsh, M.J. (2014). Localization and behaviors in null mice suggest
that ASIC1 and ASIC2 modulate responses to aversive stimuli. Genes, Brain, and Behavior, 13(2), 179-194.
doi:10.1111/gbb.12108
Yamashita, A., Hamada, A., Suhara, Y., Kawabe, R., Yanase, M., Kuzumaki, N., Narita, M., Matsui, R., Okana, H., &
Narita, M. (2014). Astrocytic activation in the anterior cingulate cortex is critical for sleep disorder under neuropathic
pain. Synapse. Advance online publication. doi:10.1002/syn.21733
Other Publications
Van Gompel, J.J., Bower, M.R., Worrell, G.A., Stead, M., Chang, S., Goerss, S.J., Kim, I., Bennet, K.E., Meyer, F.B.,
Marsh, W.R., Blaha, C.D., & Lee, K.H. (2014). Increased cortical extracellular adenosine correlates with seizure
termination. Epilepsia, 55(2), 233-244. doi:10.1111/epi.12511
Have you recently published an article that isn't l isted? Email us, and we'll include your article in our next newsletter.
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