BIG DATA IN HEALTHCARE

JUHO PAASOVP of Engineering

BC PLATFORMS FROM DATA TO DISCOVERIES

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● Finnish-Swiss bioinformatics software company established in 1997.

○ Spin-off from a unique genome project with MIT based on unique population cohort in Finland.

● Pioneers in data management and analysis software for genetic research.

○ Solutions used in 20 countries at over 70 institutions.

○ Presence in Europe, Americas, Oceania and Asia.

● Focusing on three life science market segments:

○ Pharmaceutical and Biotech industry

○ Healthcare and Biobanks

○ Academia

● All have similar challenges in managing and analyzing growing, complex data in a systematic and secure manner.

BC Platforms

GENOMICS IN HEALTHCARE

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In media

https://www.hs.fi/kotimaa/art-2000005495317.html https://www.insurancejournal.com/news/national/2018/04/09/485681.htmhttps://www.hs.fi/tiede/art-2000005629221.html https://www.hs.fi/politiikka/art-2000005636644.html

A revolution in healthcare is happening now

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Genome data production

● Not expensive anymore○ 30 € - main risk factors

(genotyping).○ 1500 € - all known and

unknown factors (whole genome sequencing).

● Will become a common practice in healthcare○ Produced for each citizen.

● Enabling○ Better preventive care.○ More accurate diagnosis.○ Personalised healthcare.

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Moving beyond the one-size-fits-all approach to treatment

Genomic prediction of coronary heart disease Eur Heart J. I 2016;37(43):3267-3278. I doi:10.1093/eurheartj/ehw450

Genomic Risk Scoring

● Improves Coronary Heart Disease (sepelvaltimotauti) risk prediction.

● Encodes different trajectories of lifetime risk not captured by traditional clinical risk scores

Knowing your genetic risk factors

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CASE EXAMPLE BIG DATA IN HEALTHCARE

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University of Colorado ● Leading translational biomedical research

organization. ● Building a next-generation service platform with

○ 5M patients with clinical data.○ 500k with whole genome data.

● Data used in○ Healthcare○ Academic research○ Pharma collaboration

● Expect to have breakthrough innovations as well as everyday benefits in their clinical workflows.

Customer case in Healthcare & Biobank

“BC Platforms has delivered a high performing platform so that we can make a difference in next generation precision medicine research and clinical workflows .”— Dr. Kathleen Barnes, Director of Unit

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HEALTHCARE USE GENOMIC RESEARCH

Population scale

genotyping (500k)

Storage: 3 PB Calculation cluster:750 CPU cores

Genomedata

Pedigrees Public annotation databases

DataLake(COMPASS)

ElectronicHealth

Records

PHARMA INDUSTRYCOLLABORATION

5M clinical data

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Customer case in Healthcare & Biobank

GLOBAL ECOSYSTEM OF HEALTH DATA

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● We are building a global network of health data for○ Academic use○ Drug development○ AI model training

● Target is to have 5M patients with clinical and genome data by 2020.○ We have 70 customers in 20 countries collecting clinical and

genomic data.

● We are looking for partners to add value on this unique database.

Ecosystem of health data

THANK YOU

Juho Paasolinkedin.com/in/juhopaaso

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