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Clinical Decision Support Track Kick-Off: Improving Outcomes with Clinical Decision Support Session S03 AMIA Spring Congress 22 May 2007

Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

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Page 1: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

Clinical Decision Support Track Kick-Off:Improving Outcomes with Clinical Decision

Support

Session S03

AMIA Spring Congress

22 May 2007

Page 2: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

Track Co-Chairs

Robert A. Jenders, MD, MS, FACP, FACMIAssociate Professor, Department of Medicine, Cedars-Sinai Medical Center

and the University of California, Los AngelesCo-Chair HL7 Clinical Decision Support Technical Committee

Dean F. Sittig, PhD, FACMIDirector of Applied Research in Medical Informatics, Northwest Permanente; Adjunct Associate Professor of Medical Informatics and Clinical Epidemiology, Oregon Health and Science University

Page 3: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

CDS Track:Voting with Your Feet

Track Name TotalClinical Decision Support 92Nursing Informatics 36Personal Health Records 35Public Health Informatics 54Translational Research Informatics 37

Page 4: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

CDS Definition“Providing clinicians or patients with clinical knowledge and patient-related information, intelligently filtered or presented at appropriate times, to enhance patient care.”

NOT just physicians…

NOT just rules and alerts…

(NOT just computer-based…)

Page 5: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

CDS Track: Learning Objectives

• To learn a framework for developing, deploying and assessing clinical decision support.

• To acquire techniques for implementing specific clinical decision support interventions.

• To appreciate how clinical decision support may be deployed to enhance patient safety and disease management.

• To review and gain an understanding of key lessons learned by clinical decision support implementers.

Page 6: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

Types of CDS Goals

• Best clinical practices- quality measures, dz mgt, accreditation, EBM

• Patient/medication safety- Avoid sentinel events, litigation/malpractice

• Patient empowerment- satisfaction (MD/patient), retention, quality

• Financial well-being- P4P, cost-effective care, adverse events

Deliver the right information to the right personin the right format at the right point in workflowthrough the right channel

Page 7: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

CDS Track Presentations

• 4 panels (18 speakers)

• 8 individual presenters

• 16 posters (2 sessions)

Page 8: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

Panel S03: CDS in ContextRobert A. Jenders, MD, MS, FACP, FACMI

Dean F. Sittig, PhD, FACMI

Bimal R. Desai, MDDivision of General PediatricsCenter for Biomedical InformaticsThe Children’s Hospital of Philadelphia

Bill Galanter, MD, PhDMedical Director of Clinical Information SystemsDepartment of MedicineUniversity of Illinois at Chicago

Mark Graber, MDChief, Medical Service, Northport, NY VAMCSUNY Stony Brook School of Medicine

Page 9: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

How can we improve care process/outcomes with CDS?

I. Identify goals/people

II. Surveyinfo systems

III. Select interventions

IV. Specify and build

V. Test and launch

VI. Evaluate and enhance

Page 10: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

Step 1: CDS Stakeholders, Goals

• Who needs to be involved?

• What goals will the CDS program address?

• How will CDS activities be governed/managed?

• How can the CDS program be cost-justified?

Page 11: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

Stakeholders

CDS is a team sport!

• Positions: CMO, CMIO, CQO• Committees: quality, safety, P&T• Admin: hospital/office staff• Clinicians: Nurses, pharmacists, MDs• Patients!• Others…

Page 12: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

Determining CDS Goals

• External drivers• P4P• Reporting, accreditation

• Internal drivers• Process/outcome data• Committees (quality, safety, P&T, UR) • Departments• Clinicians/patients/community

Page 13: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

Step 2: Catalogue Available Information Systems

• Key Steps• Prepare an inventory of available information

systems• Document:

• CDS capabilities: 6 types.• Coding systems and vocabularies

• Tip: CPOE and EHR systems are key but not the only game in town

Page 14: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

Systems to Consider:Data & Knowledge

• Departmental data management• Lab, radiology and pharmacy systems

• Clinical Records• EHR, OR systems, medication administration

• Ordering• CPOE and e-prescribing.

• Content• Reference for clinicians

• Administrative.• Charge capture, scheduling and registration

Page 15: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

Intervention Types

• Documentation forms and templates• Relevant Data Presentation• Order Creation Facilitators• Time-based Checks and Pathway support• Reference Information and Guidance• Reactive Alerts and Reminders

Page 16: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

CPOE and Decision Support

• Types of CDS common in CPOE:• Order creation facilitators• Relevant data display• Pathway support• Context sensitive reference information• Reactive alerts

• CPOE with CDS may result in as much as 55%-86% drop in medication errors.

• Bates et al. 1998-1999

Page 17: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

Step #3:Selecting CDS Interventions

Identifyobjective

Identifyobjective

class

Map OC tooptimal

interventionsand workflow

steps

Factor in ITcapabilities and

localcharacteristics

Reviewdifficulty,

adoptabilityand impact

level

Page 18: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

Objective Classes

• Prevent Errors- Errors of Omission- Errors of Commission

• Optimize Decision Making• Choice of Individual Tests and Therapies- Simple Care Guidelines Compliance• Appropriate Acute Workup• Chronic Condition Management• Compliance with Multi-Step Protocols

Page 19: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

Objective Classes

• Improve Care Processes- Improve Documentation- Improve patient education- Improve Communication

Page 20: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

Workflow Opportunities

Page 21: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

Ease / Acceptability / Impact

• An intervention that is not received is not an intervention!• Ease of use + acceptability are key

• Special considerations• Changing codes• Unavailable data• Development costs

Page 22: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

Moving right along…

[email protected]

http://jenders.bol.ucla.edu

Page 23: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

Step #4: Specifying DetailsStep #4: Specifying Detailsand Building Interventionsand Building Interventions

Dean F. Sittig, PhDDirector of Applied Research in Medical

Informatics, Northwest Permanente

Adjunct Associate Professor of Medical Informatics and Clinical Epidemiology, Oregon

Health and Science University

Page 24: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

Intervention ParametersIntervention Parameters

• When/How is intervention triggered• Criteria for intervention delivery• Source of data to satisfy intervention logic• Content of intervention• Method of intervention• Recipient of intervention• Method for feedback from recipients

Page 25: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

Optimize Intervention Optimize Intervention EffectivenessEffectiveness

• Provide clear, practical recommendations• Link recommendation to action opportunities• Prepare organization for result of successful

interventions• Special attention to interventions sent to

patients (language, education level)

Page 26: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

Optimize InterventionOptimize InterventionSafetySafety

• Consider potential adverse consequences

• Develop a fail-safe plan if system (CDSS, underlying CIS) fails

• Minimize intervention overload

Page 27: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

Management ConsiderationsManagement Considerations

• Establish clear accountability for results• Team with clinical, administrative, financial and

informatics expertise

• Pay close attention to (re-engineering) workflow

• Engage detractors

Page 28: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

Step #5: Putting Interventions Step #5: Putting Interventions into Actioninto Action

Key Tasks

• Test content, mechanics and logistics• Develop a rollout plan, including training,

feedback and monitoring• Gather and address feedback before, during

and after rollout

Page 29: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

TestingTesting

• Incorporate typical use cases into testing scenarios

• Unit testing: Check intervention components with appropriate data

• Integration testing: Bring together all the components

• User acceptance testing• Pilot launch• Full-live evaluation

Page 30: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

Aspects of CommunicationAspects of Communication

• Apprise users of what’s happening• Listen to feedback• Use champions/super users• Use multiple methods (formal & informal):

• Staff meetings• Notices: Email, brochures, posters

Page 31: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

Aspects of RolloutAspects of Rollout

• Wait for stable underlying CIS• Carefully analyze speed, scope and order of

rollout of interventions• Complex interventions may require phasing• Potentially disruptive interventions may require

limited live testing• Consider pilot locations

• Representative? Size? Availability of support staff?

• Start with greatest returns posing least disruption

Page 32: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

Step # 6: Monitoring Results and Step # 6: Monitoring Results and Refining the ProgramRefining the Program

• Evaluate intervention effectiveness using both quantitative and qualitative approaches.

• Plan on iteratively refining interventions to improve their use and benefits.

• Develop a systematic approach to managing organizational knowledge assets.

Page 33: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

Evaluation PhilosophyEvaluation Philosophy

• Availability – CDS must be available to clinicians.

• Use – Clinicians must use the system.

• Benefits – Only after these are assured, can you begin looking for improvements.

Page 34: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

Evaluate Availability…

• Did alerts fire?• Were order templates available in the

system?• Was the web site functioning?• Were reports printed?

• Did clinicians get the reports?

Page 35: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

Evaluate Use of the CDSEvaluate Use of the CDS• Assess intervention use and usability.

• Direct observations of users• Subjective user feedback• Input from clinical champions• Objective measurements of intervention usage.

• How often is each intervention used (reference material accessed, specific order sets and templates completed?

• How often are alerts presented? Heeded? Overridden?

• What do users perceive as the intervention’s effects on workflow?

Page 36: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

Evaluate benefits of CDSEvaluate benefits of CDS

• Let’s see how our other panelists do this…

Page 37: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

Maintain Knowledge Maintain Knowledge AssetsAssets• Re-evaluate intervention logic to ensure clinical knowledge

is accurate and up to date, • Changes to elements require revalidating to ensure that system

continues to behave as expected.

• Assign responsibility for the different content areas to respected individuals with domain expertise

• Assign an “expiration date” to all CDS interventions. • Vocabularies and coding schemes evolve

• Ensure that changes don’t have any adverse effects on the behavior of CDS interventions.

Page 38: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

Thank You!Thank You!

[email protected]

Page 39: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

Design of the CPOEUser Interface to Reduce

Medication Errors

Bimal R. Desai, MDDivision of General Pediatrics

Center for Biomedical InformaticsThe Children’s Hospital of Philadelphia

May 22, 2007

Page 40: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

CPOE circa 2004Terminal-based app: Technicon Data Systems

Local install was named “CHIPPER”

In use at CHOP since the 1980’s

Plans for CHIPPER retirement in October 2004

Transition to Eclipsys Sunrise Clinical Manager

Opportunity to revisit medication errors, build new safeguards

Page 41: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

CHIPPER to SCMHow does an organization prepare for this change?How can we derive the most value from the change?

Reduce errors?Make patient care safer?Make CPOE use easier, more efficient?

One solution: turn to other industries for guidanceFailure Mode & Effects AnalysisDevised by the US Military in 1949Used in aerospace, automotive industryLater adopted for healthcare use

Page 42: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

FMEA PrinciplesStep 1: Create detailed flow diagram of a processStep 2: For each step, describe what happens if process failsStep 3: Rate each failure on a standardized scale x 3

Severity of harm if failure occurs (S)1=none; 5=fatal

Likelihood of occurrence (O)1=rare; 5=common

Inability of existing controls to detect failure (D)1=easily detectable; 5=failure would not be evident

Step 4: Calculate Risk Priority Number (RPN = S x O x D )

Example: A fatal, but rare and detectable error = 5 x 1 x 1

Page 43: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

High-Risk Meds

Opiates / Sedativesmorphine, fentanyl, hydromorphone, codeinemidazolam, lorazepam, chloral hydrate

Electrolytesmagnesium sulfatecalcium gluconateIsotonic NaCl, 3% NaClKCl, K Phosphate, Bicarbonate

InsulinContinuous med infusions

Paralytic agentsvecuronium, pancuronium, cisatracurium

DigoxinAnticoagulants

enoxaparin, warfarin, heparinVarious antibiotics

vancomycingentamicinamoxicillin

Total Parenteral Nutrition*

Page 44: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

FMEA Analysis: Acetaminophen

AnalysisHigh RPN (very commonly ordered, errors were common)Most potential errors were interval relatedChanges frequently in newborn periodPotential for hepatotoxicity

CPOE Recommendations1. Combine various dosage forms into one order set2. Use order set layout to guide therapeutic choices3. Stratify dosing by age group to fix errors of interval4. Precalculate default doses by indication

Page 45: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens
Page 46: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens
Page 47: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens
Page 48: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

Did it work?

Page 49: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

FMEA Project EvaluationHypothesis

Does FMEA-directed design of a CPOE user interface reduce prescribing errors?

DesignTwo-group non-equivalent quasi-experimental study

2/04 3/04 4/04 2/05 3/05 4/05

FMEA O O O X O O ONon-FMEA O O O O O O

Page 50: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

Project EvaluationCompared monthly error rates for 3 month period on CHIPPER and 3 month period on SCM

Chose time points to mitigate “training effect” and seasonality of hospital census

“Pre” observation in Feb, March, April 2004Transition took place October 2004“Post” observation in Feb, March, April 2005

Page 51: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

Project EvaluationChose three representative FMEA meds

Gentamicin - IV anti-infectiveMidazolam - IV or oral sedativeAcetaminophen - oral or rectal analgesic

Chose three representative non-FMEA meds with high error rates

Oxacillin - IV anti-infectiveHeparin - anticoagulantDigoxin - cardiac glycoside with narrow therapeutic margin

Page 52: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

Project EvaluationCompared rates of intercepted prescribing errorsData obtained from pharmacy-reported QI dataDetails the medication, intercepted-error, and actionNormalized rates per 1000 inpatient episodesCategorized errors by type:

Drug-Allergy / Drug-Drug InteractionDuplicate orderTherapeutic monitoring decisionWrong routeWrong intervalWrong dose

Page 53: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

Inpatients per MonthMonth Inpatient EpisodesFeb 2004 1747March 2004 1866April 2004 16232004 Total: 5236Feb 2005 1636March 2005 1824April 2005 16172005 Total: 5077

Page 54: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

Errors per 1000 Patients

Medication Feb-Apr 2004

Feb-Apr 2005 IRR* 95% CI

Gentamicin 0.24

0.39

0.44

0.69

0.54

0.55

Acetaminophen

0.14-0.38

0.27-0.55

0.26-0.72

0.32-1.42

0.24-1.17

Midazolam

Oxacillin

Heparin

Digoxin 0.19-1.50

p

19.1 4.5 <0.001

22.3 8.7 <0.001

10.7 4.7 <0.001

4.0 2.7 0.28

4.0 2.2 0.10

2.5 1.4 0.21

*Incidence rate ratio

Page 55: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

Gentamicin Errors

0.0

2.0

4.0

6.0

8.0

10.0

12.0

14.0

16.0

18.0

20.0

Feb 04 Mar 04 Apr 04 Feb 05 Mar 05 Apr 05

Month

Err

os

pe

r 1

00

0 I

np

t. V

isit

s

Allergy/InteractionDuplicateTherapeuticRouteIntervalDose

* * *

p < 0.001

Page 56: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

Acetaminophen Errors

0.0

5.0

10.0

15.0

20.0

25.0

Feb 04 Mar 04 Apr 04 Feb 05 Mar 05 Apr 05

Month

Allergy/Interaction

Duplicate

Therapeutic

Route

Interval

Dose

* * *

p < 0.001

Page 57: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

Midazolam Errors

0.0

1.0

2.0

3.0

4.0

5.0

6.0

Feb 04 Mar 04 Apr 04 Feb 05 Mar 05 Apr 05

Month

Allergy/Interaction

Duplicate

Therapeutic

Route

Interval

Dose

* * *

p < 0.001

Page 58: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

Oxacillin Errors

0.0

0.5

1.0

1.5

2.0

2.5

3.0

3.5

4.0

Feb 04 Mar 04 Apr 04 Feb 05 Mar 05 Apr 05

Month

Allergy/Interaction

Duplicate

Therapeutic

Route

Interval

Dose

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Heparin Errors

0.0

0.2

0.4

0.6

0.8

1.0

1.2

1.4

1.6

1.8

2.0

Feb 04 Mar 04 Apr 04 Feb 05 Mar 05 Apr 05

Month

Allergy/Interaction

Duplicate

Therapeutic

Route

Interval

Dose

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Digoxin Errors

0.0

0.5

1.0

1.5

2.0

2.5

Feb 04 Mar 04 Apr 04 Feb 05 Mar 05 Apr 05

Month

Allergy/Interaction

Duplicate

Therapeutic

Route

Interval

Dose

Page 61: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

ResultsFMEA meds

significant reduction in incidence of prescribing errorsNon-FMEA meds

no significant reduction in errors

Simply upgrading CPOE systems doesn’t reduce errorsRational design of user interface can be used for targetedreduction of prescribing errors

Page 62: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

Limitations & Next StepsQuasi-experimental design

Focused on meds with high rates of prescribing errors

Only looked at 6 medications – really need all FMEA meds

Only looked at 6 months – really need a run chart, time series

Couldn’t look at total orders in time-period

Based on total charges, prescribing rate of heparin was lower and digoxin was higher in post-intervention period

Looking at all FMEA meds vs. all non-FMEA meds will minimize this variability

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AcknowledgementsCBMI

Pete WhiteBob Grundmeier

IRBBarbara LoDico

OHSU - MBIBill HershDean SittigPaul Gorman

CHOP - CDSRick WomerTara TrimarchiWinson Soo-HooDeb JoersGordon ZeisCDS Members

CHOP - PGRGSamir Shah

Page 64: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

CDS implementation to improve VTE prophylaxis at an academic

medical center

AMIA Spring Congress 2007CDS Panel S03

Bill Galanter MD/PhDMedical Director, Clinical Information Systems

Department of MedicineUniversity of Illinois at Chicago

Page 65: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

-450 Bed tertiary teaching hospital-400,000 outpatient visits

-Near paperless inpatient & outpatient-Large residencies

CPOE with TDS 1982 1999CPOE with Cerner Millennium® >1999

Page 66: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

Implemented CDS at UICMC

CalculationsAnion Gap

Creatinine ClearanceMDRD eGFR

Non-HDL CholesterolAdjusted Dilantin

Mean Blood Pressure

AdministrativeAdmit Order

Unsigned orders at dischargeLipid Screening Mammography

DiabeticInfluenza

VTE Risk AssessmentVTE Treatment Prompts

Quality of Care

Communication Admission notificationDischarge notification

New pathology notificationRenal Insufficiency

Medication relatedRadio contrast Renal Renal/Metformin

Enoxaparin HeparinDrug Renal Function

Drug Liver DiseaseDigoxinIV==>PO

Renal Function Nephrotoxic DrugHyperkalemia Medication

Heparin DosingPromethazine in Infants

NPO-InsulinDrug Pregnancy

MRI-PatchSaquinavir-Ritonavir-Rifampin

VTE Prophylaxis ChecksDrug Tube Feeds

Erythropoetin HCTMedication Indication Documentation

Documentation Airborne Isolation

Fall AlertsDischarge Planning

Social WorkSmoking Cessation Referral

Polypharmacy referralDiagnosis Documentation

Page 67: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

Proportion of patients with renal dysfunctionreceiving Metformin when order started by clinician

4-months pre-alert vs. 4-months post-alert

Alerts for Contraindication

0

20

40

60

80

100%

ALL

Post-Alert* (n=61)

*P=<0.001

SEVERECrClest<30

Post-Alert

MODERATECrClest 30-50

Post-Alert

MILDCrClest50-60

Post-Alert

Pre-Alert (n=63)

Galanter et al. J Am Med Inform Assoc. 2005 May-Jun;12(3):269-74

Provider

Real-TimeAlert

EMR

Page 68: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

Alerts for Contrast Studies in patients with Renal Insufficiency

Orders for IV contrast in patients with CrCL < 50 ml/min.

6/day

4/day

POST-ALERT

Provider

Real-TimeAlert

EMR

Page 69: Improving Outcomes with Clinical Decision Support Decision Su… · FMEA Principles zStep 1: Create detailed flow diagram of a process zStep 2: For each step, describe what happens

Lab results

EMR

Provider

Compliance with alert recommendationsLow [Mg++] when on Digoxin

Prop

ortio

n of

pat

ient

s

0

20%

40%

60%

80%

100%

0 1 12 24

Pre-Alert

Alert

Asynchronous Alerts

Post-Alert

Hours

Galanter et al. J Am Med Inform Assoc. 2004 Jul-Aug;11(4):270-7.

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VTE prophylaxis at UIH

Stakeholders:-Risk Management, VTE prophylaxis committee

Objectives:-Increase risk assessments, increase use of prophylaxis& prevent events

Challenges:-Making an accepted mandatory intervention.

Interventions:-Real time alerts-Risk assessment forms-Order sets with pushed results-Active surveillance with reminders.

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VTE risk assessment Alerts

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VTE risk assessment

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VTE risk assessment

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Order sets for VTE

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Pushed labs for VTE orders

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Nightly active surveillance

MedOrders

datarisk form

CDSEngine

Physicianteam

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What Happened

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0%

30%

50%

70%

90%

2 4 6 8 10 >10

Hours after Admission

Perc

ent o

f adm

issi

ons

VTE risk assessmentAssessment completion vs. Time

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VTE prophylaxis CDS at UIHResults of a 5-month trial on prophylaxis rates

Historical Control Trial

Number of patients 5,505 4,598

Average age 46.4 +/-18.3 years 47.1+/-18.5 years NS

% Female 64.9% 64.8% NS

Type of prophylaxis

Enoxaparin 2.94% 2.65% NS

Fondaparinux 0.16% 0.20% NS

Heparin sub-cutaneous 24.7% 33.7% P<0.001

Warfarin for total knee or hip arthroplasty

0.25% 0.24% NS

Total pharmacologic 27.6% 36.5% P<0.001

Mechanical 30.0% 29.8% NS

Any form of prophylaxis 43.1% 50.6% P<0.001

RESULTS

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Results of a 1 year trial on clinical outcomes

0.0%

100.0%

Prophylaxis

Pre

Post

+32% p<0.01

VTE Events

Pre

Post

-18% p<0.25

Bleeding

PrePost

+9% p<0.17

VTE prophylaxis CDS at UIH

NNT: 1 additional patient on Sub-Q Heparin for every 11 adult admissions

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Acknowledgements

IS: Lisa Canonge, Marla Lax, Amy Looi, Audrius Polikaitis, Jennifer Welch,

Pharmacy: Carson Bording, Rob Didomenico, Kelly Kopek, Jamie Paek, Mat Thambi

Medical Staff: Dan Hier, Mark Kushner, Holly Rosencranz, David Sarne, David Williams

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• Official deployment in 1982– Lab, pharmacy, scheduling

• Imaging - 1992• Order Entry / Results Reporting 1994• GUI 1998• BCMA 2000

History of the EHR in VHA

CPRS - Computerized Patient Record System

Mark Graber, MD

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CPRS Usage

• 1.1B orders, 1M/day• 200M Images, 350k/day• 500M Notes & Documents, 500k/day• 500M Meds admin via BCMA, 500k/day• 1M lab results /day• 200M Outpatient Rx’s dispensed/year

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Integrated Packages – Clinical

• CPRS - Order Entry / Results Reporting• Pharmacy, Laboratory, Radiology /

Imaging• Surgery, Medicine, Procedures• Nursing, Social Work, • Nutrition & Food Service• Audiology and Speech Pathology• Billing, , Scheduling, Registries

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Decision Support in CPRS

• Alerts (Order checking, allergies, meds)• Reminders• Smart orders• Dialogue notes with embedded links• Online access to books, journals, e-tools

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Using “Reminders”

• VHA has set national goals for providing preventive health services

• These goals are communicated to the field, CDS provided in the form of “Reminders”

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DECISION SUPPORT

How do you get people to

use it ??

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Give them the Beef ! Give them the Beef !

The carrot: Performance bonus;

The stick: Constant humiliation & threats

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Cancer MeasureScreening for Colorectal Cancer – 52-80yrs

79 82 81 797482

0

20

40

60

80

100

VISN JJP NJ HV NY NRP

Perc

ent

Target 75% VHA 77%

n=1109 n=128 n=321n=335 n=160 n=165

Measure 8c – Perf. Period 10/06 – 8/07

Floor = 67 %

EX =78%

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Quality MeasuresCLINICAL PERFORMANCE INDICATOR VA FY 05

HEDIS (2) Commercial 2004

HEDIS (2) Medicare 2004

HEDIS (2) Medicaid 2004

Breast cancer screening 86% 73% 74% 54%

Cervical cancer screening 92% 81% Not Reported 65%

Colorectal cancer screening 76% 49% 53% Not Reported

LDL Cholesterol < 100 after AMI, PTCA, CABGNot Reported

(3) 51% 54% 29%

LDL Cholesterol < 130 after AMI, PTCA, CABGNot Reported

(3) 68% 70% 41%

Beta blocker on discharge after AMI 98% 96% 94% 85%

Diabetes: HgbA1c done past year 96% 87% 89% 76%

Diabetes: Poor control HbA1c > 9.0% (lower is better) 17% 31% 23% 49%

Diabetes: Cholesterol (LDL-C) Screening 95% 91% 94% 80%

Diabetes: Cholesterol (LDL-C) controlled (<100) 60% 40% 48% 31%

Diabetes: Cholesterol (LDL-C) controlled (<130) 82% 65% 71% 51%

Diabetes: Eye Exam 79% 51% 67% 45%

Diabetes: Renal Exam 66% 52% 59% 47%

Hypertension: BP <= 140/90 most recent visit 77% 67% 65% 61%

Follow-up after Hospitalization for Mental Illness (30 days) 70%(4) 76% 61% 55%

Immunizations: influenza, (note patients age groups) (6) (7)

75% (65 and older or

high risk)39%

(50-64) 75%

(65 and older)68%

(65 and older)

Immunizations: pneumococcal, (note patients age groups) (6)

89% (all ages at risk) Not Reported Not Reported

65% (65 and older)

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73 74 69 6866

86

0

20

40

60

80

100

VISN JJP NJ HV NY NRP

Perc

ent

Target 68% VHA 68%

n=360 n=35 n=58n=172 n=35 n=60

EX =71%

Measure 9c1 – Perf. Period 10/06 -8/07

Cardiovascular Measure- ISHD, % Prior AMI andLDLC<100 on Most Recent Test and Had a Full Lipid Profile in

the Past 2 Years

Floor = 54 %

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Quality MeasuresCLINICAL PERFORMANCE INDICATOR VA FY 05

HEDIS (2) Commercial 2004

HEDIS (2) Medicare 2004

HEDIS (2) Medicaid 2004

Breast cancer screening 86% 73% 74% 54%

Cervical cancer screening 92% 81% Not Reported 65%

Colorectal cancer screening 76% 49% 53% Not Reported

LDL Cholesterol < 100 after AMI, PTCA, CABGNot Reported

(3) 51% 54% 29%

LDL Cholesterol < 130 after AMI, PTCA, CABGNot Reported

(3) 68% 70% 41%

Beta blocker on discharge after AMI 98% 96% 94% 85%

Diabetes: HgbA1c done past year 96% 87% 89% 76%

Diabetes: Poor control HbA1c > 9.0% (lower is better) 17% 31% 23% 49%

Diabetes: Cholesterol (LDL-C) Screening 95% 91% 94% 80%

Diabetes: Cholesterol (LDL-C) controlled (<100) 60% 40% 48% 31%

Diabetes: Cholesterol (LDL-C) controlled (<130) 82% 65% 71% 51%

Diabetes: Eye Exam 79% 51% 67% 45%

Diabetes: Renal Exam 66% 52% 59% 47%

Hypertension: BP <= 140/90 most recent visit 77% 67% 65% 61%

Follow-up after Hospitalization for Mental Illness (30 days) 70%(4) 76% 61% 55%

Immunizations: influenza, (note patients age groups) (6) (7)

75% (65 and older or

high risk)39%

(50-64) 75%

(65 and older)68%

(65 and older)

Immunizations: pneumococcal, (note patients age groups) (6)

89% (all ages at risk) Not Reported Not Reported

65% (65 and older)

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Keys to Success

• Clear goals• LEADERSHIP

• Effective communication • Appropriate incentives

• Constant feedback – hopefully POSITIVE