1
Im 1 Dep Uni Introd Separa power the coi electro comme Imagin temper heating SNR S Theory Previou betwee means make r then be voxels Metho Imagin around Circuit tuned a 12cm d 1.6% C order B fibre-o were ac was 38 MRTI volume Data w 90 ° (qu with id Compl series, from th drift co 0.009 were c cycle to residua providi Mathw Result Figures quadra the SA 2. The the the locatio functio Table 1 Discus Thermo indicat measur similar Helmh SAR d peak S by the improv SAR m Ackno fibre op Refere MRM; mproving SNR partment of Medica ted Kingdom, 3 Cen duction ate labelling coil co RF amplifier to d ils can be high, the magnetic simulati ercial packages ar ng [3] (MRTI) usi rature dependence g from a pair of C AR maps. y: SAR Estimatio us studies have as en the two measure that only a small regular MRTI mea e calculated from experiencing SAR od ng was performed d a re-cycled spec ts Inc. Brooklyn, N and matched to 12 diameter, 20cm lo CuSO4 doped disti B 0 drift correction ptic thermometer cquired every 33.8 840ms. Prior to MR measurements con e acquisition, yield was acquired in fiv uadrature) and 180 dentical voxel posi ex phase images to obtain phase i he temperature cor orrection. T map 97ppm, and the tim alculated with the o obtain SAR map als between the m ing a measure of c works Inc., Natick, ts s 1 and 2 show S ature configuration AR all of the voxel e y axis is logarith ermometer probe ( n (orange), and cl ons, thin lines the 1 displays the peak ssion and Conclus ometer probe and ting that the temp rements. The fitte r spatial distributio holtz maps match w distributions betwe AR in table 1 sho IEC[2]. To conclu ve the SNR of the maps show consiste owledgements Dav ptic thermometer, ences [1] Mildner, 63 1:218–223; 20 R in small tem al Physics and Bio ntre for Neuroscie ontinuous arterial s deliver continuous erefore it is desirab ions have become re costly, and it ca ing the proton res e of the magnetisa CASL labelling co on ssumed that the on ements (2 minutes temperature rise o asurements over an the initial temper R heating and therm on a 3T Siemens ctrometer (MR500 NY, USA). Each c 23.2MHz. A whol ong cylindrical gel illed water cylindr [6]. Coils were po (ProSens with PS 84s with FOV = 21 RTI measurements nsisted of an initi ding a time-series ve separate scannin 0 ° (Maxwell). Two tions to the EPI vo were processed b increment images rrected phase of th s were calculated me series of each equation 1, where ps at 100% duty cy measured temperatu confidence. Image MA). SAR maps at the n and the left hand ls within the imagi hmic (base 10). F (blue) and in two lose to a transmitti actual data. Figure k SAR in each SAR sion d MRTI measure erature compensat d functions closely on; high local SAR well with superpo een all configurati ow good agreemen ude, presented is a initial measureme ency throughout a vid Carmichael, Je and the MRC for T., et al.; MRM; 4 010. [5] Cline, H., mperature cha Aaron Oliver-Ta oengineering, Univ nce, University of spin labelling (CA wave (CW) powe ble to obtain SAR e the prevailing m an be difficult to c sonance shift allow ation phase. Prese oils using a 3D EP nly contribution to s [5]), and if the o occurs over this sh n extended period ature change in th mal conduction, an s Tim Trio (Erlan 00, Surrey Medica channel drove an e e-body birdcage c l phantom (2% ag rical reference pha ositioned at opposi SP-62 Modules an 10 × 210mm, 2.5m s this sequence wa ial EPI volume ac of 100 phase imag ng sessions: each A o MRTI datasets w olumes was run to by dividing by th , ∆φ. A first-orde he reference phanto according to T = voxel was fit to th e c = 4200J/kg, an ycle. In addition m ure data and the m e processing was p centre of the ASL coil only, respecti ing volume with a Figure 4 is a plot o regions of interest ing coil (black). T es 3 and 4 are from R histogram. ements show goo ted B 0 correction y match the data in R close to the coils ositions of the indi ions are also seen nt, and the highest method for measu nts, from which th range of measurem eff Hand and Olive funding this resear 49 5:791–795; 200 et al.; MRM; 51 6 ange MR Ther aylor 1 , Chris Rand versity College Lon Melbourne, Melbo England ASL) [1] typically u er to the neck. Des R maps to ensure th method for produc capture the nuanc ws 3D temperatur ented is an optim PI acquisition and o the temperature c bject is at thermal hort period, and c of heating, and to he fitted data using nd fibre optic therm gen, Germany) w al Imaging System element of an ASL coil was used to tr gar, 1.6% CuSO4 , antoms were placed ite sides of the pha nd OTP-A Sensors mm slice thickness as run for 2.5 hour cquisition, followe ges. To avoid the s ASL coil element were collected in e facilitate precise l he first image in t er 2D linear fit ge oms was subtracte = ∆φ/αγB 0 TE[3], w he equation 1. SA nd divided by the maps of the sum of model fit were ge performed in Matl L coil array, obtai ively. Figure 3 is a a sum of squares e of the temperature t (ROI) positioned Thicker lines repres m the quadrature c d agreement with produces accurate n both ROIs. SAR s. The quadrature, ividual coil SAR m n in the SAR hist measured SAR; 8 uring the SAR of a he SAR is calculat ments. Further wo er Josephs for usef rch. 03. [2] IEC 6601-2 6:1129–1137; 2004 rmometry to a dell 2 , Roger J Ordid ndon, London, Eng ourne, Victoria, Au d, United Kingdom utilises a close fitt spite the low total hat local SAR lim cing SAR maps. H es/imperfections o re maps to be acq mised method for a an image process change within a v l equilibrium when consequently the m o then fit the temp g equation 2. The mometer probe da whole-body scanne ms, Guildford, UK L labelling transm ransmit the imagin , 0.9% NaCl) was d equilaterally aro antom. The temper s, OpSens, Quebe s, TE=32.86ms, TR rs, establishing a d ed by 99 blocks o saturation of spins, pulsing individua each scan session. location of the tem the time enerated d for B0 with α = AR maps RF duty f squares enerated, lab (The ined from the a histogram of error less than e measured by d at the probe sent the fitted configuration. h each other, e temperature R maps show a Maxwell and maps. Similar ograms. The 8.78±0.38W/kg for a transmitter RF co ted. MRTI measur ork will be to valid ful discussions, An 2-33, Edition 3; 20 4. [6] Poorter, J.D. Right Left C Helmh Quadra Maxw Table acquire SAR M dge 3 , and David L gland, United Kin ustralia, 4 Institute m ting surface coil co power (1-2W), lo mits [2] are not exc However the softw of ‘home-built’ co quired by taking acquiring an MRT sing technique for voxel is from SAR n heating commen measurements suff perature change to e fitting function w ata from the same l er, interfaced to a K), equipped with mit array, comprisin ng RF pulses, and s positioned within ound the gel phant erature of each pha ec, Canada). 3D g R=80ms, and GRA dynamic thermal eq of transmitting at f , RF heating was a ally, and both coil After MRTI meas mperature probe. r the Helmholtz co oil, by acquiring a rements were valid date the SAR maps ntoine Lutti for pu 010. [3] Ishihara, Y , et al.; MRM; 33 Fig 3: Quadratur Fi SAR max (W/kg) Coil 5.51±0.19 Coil 7.79±0.69 holtz 8.78±0.38 ature 7.73±0.20 well 7.89±0.78 e 1: Peak SAR Maps of a pair L Thomas 4 ngdom, 2 PulseTeq P e of Neurology, Un oupled with a low ocal SAR close to ceeded. Full-wave ware is complex, oils. MR Thermal advantage of the RTI time series of r calculating high R [4, 5], valid only nces. The low pow fer from low SNR equation 1 on a v was empirically fo locations. two-channel in-h h 1W nominal RF ng of two 45mm i d a 12 channel rec n the head coil an tom. The three refe antom was logged gradient echo EPI APPA 2× accelerat quilibrium to acco full power for 30s applied at 100 kHz elements pulsing surements had bee onfiguration is wit time series of EPI dated against a fibr s against full wave ulse sequence code Y ., et al.; MRM; 34 1:74–81; 1995. re SAR Histogram ig 1: Quadrature S r of ASL Labe Products Division, iversity College L y if thermal condu wer level used in s R. To increase SNR voxel-by-voxel bas ound to closely ma house built transm F power amplifiers inner diameter cir ceive-only head co nd three 32mm dia erence phantoms w during MRTI mea volumes of resolu tion. The time to a ount for heating of s on the ASL coil z higher than the i with phase shifts en made a turbo s thin the 10W/kg l I phase images and re optic thermome e electromagnetic e, Nikolaus Weisk 4 6:814–823; 1995 ݔ ܣT fit (1/2) te c: voxel spݐ߂: time betw Fig 2: L SAR Map Fig 4: Quadratu lling Coils , Renishaw PLC, ondon, London, uction is negligible eparate coil CASL R it is proposed to sis. SAR maps can atch MRTI data in mitter system based s (ZHL-3A, Mini rcular surface coil oil for reception. A ameter, 30cm long were used for first asurements using a ution 128×128×48 acquire one volume f the gradient coils l array and an EP imaging frequency of 0 ° (Helmholtz) pin echo sequence ocal SAR limit se d fitting the data to eter, and calculated simulations. opf for lending the 5. [4] Oh, S., et al. ݔ ሺ1ሻ ሺ2ሻ െ ሺ1ሻቁ ݐ߂ሺ2emperature at 1 st /2 measuremenecific heat capacit ween measuremenLeft Coil SAR Map ure ΔT Plot e L o n n d - s A g - a 8 e . I y . , e t o d e ; nd t. y ts p 2665 Proc. Intl. Soc. Mag. Reson. Med. 20 (2012)

Im proving SNR in small temperature change MR Thermometry to acquire SAR … · 2012-05-07 · SAR d peak S by the improv SAR m Ackno fibre op Refere MRM; proving SNR artment of Medica

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Page 1: Im proving SNR in small temperature change MR Thermometry to acquire SAR … · 2012-05-07 · SAR d peak S by the improv SAR m Ackno fibre op Refere MRM; proving SNR artment of Medica

Im1DepUni

IntrodSeparapower the coielectrocommeImagintemperheatingSNR STheoryPrevioubetweemeans make rthen bevoxels MethoImaginaroundCircuittuned a12cm d1.6% Corder Bfibre-owere acwas 38MRTI volumeData w90° (quwith idComplseries, from thdrift co−0.009were ccycle toresiduaprovidiMathwResultFiguresquadrathe SA2. Thethe thelocatiofunctioTable 1DiscusThermoindicatmeasursimilarHelmhSAR dpeak Sby the improvSAR mAcknofibre opRefereMRM;

mproving SNR

partment of Medicated Kingdom, 3Cen

duction ate labelling coil co

RF amplifier to dils can be high, themagnetic simulatiercial packages arng [3] (MRTI) usirature dependenceg from a pair of CAR maps. y: SAR Estimatious studies have asen the two measurethat only a small

regular MRTI meae calculated from experiencing SAR

od ng was performed d a re-cycled spects Inc. Brooklyn, Nand matched to 12diameter, 20cm loCuSO4 doped distiB0 drift correction ptic thermometer cquired every 33.8

840ms. Prior to MRmeasurements con

e acquisition, yieldwas acquired in fivuadrature) and 180dentical voxel posiex phase images to obtain phase i

he temperature cororrection. ∆T map97ppm, and the timalculated with theo obtain SAR mapals between the ming a measure of c

works Inc., Natick, ts s 1 and 2 show S

ature configurationAR all of the voxele y axis is logarithermometer probe (n (orange), and cl

ons, thin lines the 1 displays the peakssion and Conclusometer probe andting that the temprements. The fitter spatial distributioholtz maps match wdistributions betweAR in table 1 shoIEC[2]. To conclu

ve the SNR of the maps show consisteowledgements Davptic thermometer,

ences [1] Mildner, 63 1:218–223; 20

R in small tem

al Physics and Biontre for Neuroscie

ontinuous arterial sdeliver continuous erefore it is desirabions have becomere costly, and it caing the proton rese of the magnetisaCASL labelling co

on ssumed that the onements (2 minutestemperature rise o

asurements over anthe initial temper

R heating and therm

on a 3T Siemensctrometer (MR500NY, USA). Each c23.2MHz. A wholong cylindrical gelilled water cylindr[6]. Coils were po(ProSens with PS

84s with FOV = 21RTI measurementsnsisted of an initiding a time-series ve separate scannin0° (Maxwell). Twotions to the EPI vowere processed b

increment imagesrrected phase of ths were calculated

me series of each equation 1, where

ps at 100% duty cymeasured temperatu

confidence. ImageMA).

SAR maps at the n and the left hand ls within the imagihmic (base 10). F(blue) and in two lose to a transmittiactual data. Figurek SAR in each SARsion d MRTI measureerature compensatd functions closely

on; high local SARwell with superpoeen all configuratiow good agreemenude, presented is a initial measuremeency throughout a vid Carmichael, Jeand the MRC for T., et al.; MRM; 4

010. [5] Cline, H.,

mperature chaAaron Oliver-Ta

oengineering, Univnce, University of

spin labelling (CAwave (CW) poweble to obtain SARe the prevailing man be difficult to csonance shift allowation phase. Prese

oils using a 3D EP

nly contribution tos [5]), and if the ooccurs over this shn extended period ature change in thmal conduction, an

s Tim Trio (Erlan00, Surrey Medicachannel drove an ee-body birdcage cl phantom (2% agrical reference phaositioned at opposiSP-62 Modules an10 × 210mm, 2.5ms this sequence waial EPI volume acof 100 phase imagng sessions: each Ao MRTI datasets wolumes was run to by dividing by th, ∆φ. A first-orde

he reference phantoaccording to ∆T =voxel was fit to the c = 4200J/kg, anycle. In addition mure data and the me processing was p

centre of the ASLcoil only, respectiing volume with a

Figure 4 is a plot oregions of interesting coil (black). Tes 3 and 4 are fromR histogram.

ements show gooted B0 correction y match the data in

R close to the coilsositions of the indiions are also seen

nt, and the highest method for measunts, from which thrange of measurem

eff Hand and Olivefunding this resear49 5:791–795; 200et al.; MRM; 51 6

ange MR Theraylor1, Chris Randversity College Lonf Melbourne, Melbo

England

ASL) [1] typically uer to the neck. DesR maps to ensure thmethod for produccapture the nuancws 3D temperaturented is an optimPI acquisition and

o the temperature cbject is at thermalhort period, and cof heating, and to

he fitted data usingnd fibre optic therm

gen, Germany) wal Imaging Systemelement of an ASLcoil was used to trgar, 1.6% CuSO4 ,antoms were placedite sides of the phand OTP-A Sensorsmm slice thicknessas run for 2.5 hourcquisition, followeges. To avoid the sASL coil element

were collected in efacilitate precise l

he first image in ter 2D linear fit geoms was subtracte= ∆φ/αγB0TE[3], whe equation 1. SAnd divided by the

maps of the sum ofmodel fit were geperformed in Matl

L coil array, obtaiively. Figure 3 is aa sum of squares eof the temperaturet (ROI) positioned

Thicker lines represm the quadrature c

d agreement withproduces accurate

n both ROIs. SARs. The quadrature, ividual coil SAR mn in the SAR histmeasured SAR; 8

uring the SAR of ahe SAR is calculatments. Further woer Josephs for usefrch.

03. [2] IEC 6601-26:1129–1137; 2004

rmometry to adell2, Roger J Ordidndon, London, Engourne, Victoria, Aud, United Kingdom

utilises a close fittspite the low total hat local SAR limcing SAR maps. Hes/imperfections ore maps to be acq

mised method for aan image process

change within a vl equilibrium whenconsequently the mo then fit the tempg equation 2. Themometer probe da

whole-body scannems, Guildford, UKL labelling transmransmit the imagin, 0.9% NaCl) wasd equilaterally aroantom. The tempers, OpSens, Quebes, TE=32.86ms, TRrs, establishing a ded by 99 blocks osaturation of spins,pulsing individua

each scan session. location of the temthe time enerated d for B0 with α =

AR maps RF duty

f squares enerated, lab (The

ined from the a histogram of error less than e measured by d at the probe sent the fitted configuration.

h each other, e temperature

R maps show a Maxwell and

maps. Similar ograms. The

8.78±0.38W/kg fora transmitter RF coted. MRTI measurork will be to validful discussions, An

2-33, Edition 3; 204. [6] Poorter, J.D.

Right Left C

HelmhQuadra

Maxw

Table

acquire SAR Mdge3, and David Lgland, United Kinustralia, 4Institutem

ting surface coil copower (1-2W), lo

mits [2] are not excHowever the softwof ‘home-built’ coquired by taking acquiring an MRTsing technique for

voxel is from SARn heating commenmeasurements suffperature change to e fitting function wata from the same l

er, interfaced to a K), equipped withmit array, comprisinng RF pulses, ands positioned withinound the gel phanterature of each phaec, Canada). 3D gR=80ms, and GRAdynamic thermal eqof transmitting at f, RF heating was a

ally, and both coil After MRTI meas

mperature probe.

r the Helmholtz cooil, by acquiring a rements were validdate the SAR mapsntoine Lutti for pu

010. [3] Ishihara, Y, et al.; MRM; 33

Fig 3: Quadratur

Fi

SARmax (W/kg)

Coil 5.51±0.19Coil 7.79±0.69holtz 8.78±0.38ature 7.73±0.20well 7.89±0.78

e 1: Peak SAR

Maps of a pairL Thomas4 ngdom, 2PulseTeq Pe of Neurology, Un

oupled with a low ocal SAR close to ceeded. Full-wave ware is complex, oils. MR Thermal advantage of the

RTI time series of r calculating high

R [4, 5], valid onlynces. The low powfer from low SNRequation 1 on a v

was empirically folocations.

two-channel in-hh 1W nominal RFng of two 45mm i

d a 12 channel recn the head coil antom. The three refeantom was logged gradient echo EPI APPA 2× acceleratquilibrium to accofull power for 30sapplied at 100 kHzelements pulsing

surements had bee

onfiguration is wittime series of EPI

dated against a fibrs against full waveulse sequence code

Y., et al.; MRM; 341:74–81; 1995.

re SAR Histogram

Fig 1: Quadrature S

r of ASL Labe

Products Division,iversity College L

f

y if thermal conduwer level used in sR. To increase SNRvoxel-by-voxel basound to closely ma

house built transmF power amplifiersinner diameter cir

ceive-only head cond three 32mm diaerence phantoms wduring MRTI meavolumes of resolu

tion. The time to aount for heating ofs on the ASL coilz higher than the iwith phase shifts

en made a turbo s

thin the 10W/kg lI phase images andre optic thermomee electromagnetic e, Nikolaus Weisk

4 6:814–823; 1995

Tfit(1/2) te

c: voxel spe: time betw

Fig 2: LSAR Map

Fig 4: Quadratu

lling Coils

, Renishaw PLC, ondon, London,

uction is negligibleeparate coil CASLR it is proposed tosis. SAR maps canatch MRTI data in

mitter system baseds (ZHL-3A, Minircular surface coiloil for reception. Aameter, 30cm longwere used for firstasurements using aution 128×128×48

acquire one volumef the gradient coilsl array and an EPimaging frequencyof 0° (Helmholtz)pin echo sequence

ocal SAR limit sed fitting the data toeter, and calculatedsimulations. opf for lending the

5. [4] Oh, S., et al.

12 1 2emperature at 1st/2n

measurementecific heat capacit

ween measurement

Left Coil SAR Map

ure ΔT Plot

e L o n n

d -s

A g -a 8 e . I

y. , e

t o d

e

;

nd

t.yts

p

2665Proc. Intl. Soc. Mag. Reson. Med. 20 (2012)