18 yo\·lm found right qroi n mass 8/70 . lliopsy interpreted as Lympho- /I!J/ sarcoma. The t umor v:dS tn:i:t ed 1·1ith local irradi ation and gi vsn -, chemother apy . ·. . . (0 Autoosv ll<tS performed and tumor ll'.:!t astas 1 s Nere found 1 n 11 ver, l ung , spleen', bone mal'rm·t, und lymph nodes . No tumor is present in testes .

CASE A 62-70 - ----....._

DX: LYHPH NOOES, BONE NA RR0\<1 AND .. LIVER - HODGKIN'S DISEASE, LY1 1PI'.OCYTE DEPT,ETIO'N (HODGKIN ' S S:\RCO:·~". Or:' JACKZCm AKD PARKER)

Kaplan, H, S., et a l.: Trea tment of Hodgkin's disease . ~:ed . Clin . N. Amer. , 50: 1591, 1966

Keller, A, R., et al. : Correlation of histopathology Hi t h othel' prognontic in~l~a t ors in Hodgki n ' s disc~ se . Canc er, '-2: 487 , 1968 .

Glatstein, E. , et al .: The va lue of la paro~omy a nd splenec t omy in the sta­ging of Hodgkin's disease . Canc er , 24 : 709, 1969 ,

Strum, S, n., e t a'r. . : Observation of c ells 1·escmbling Sternberg-Reed cells in c·ouditions o·ther than Hodgkin !s disease . Cancer, 26: 176, 1970.

' : ~~ ~-u..tv... cd.Jl ~. ~~4~ . ... tt..ov~~ / .- - . t.·ro , r-ktt.U.o lx +-·<oH O!CA.o<o<~-tA.-o ~ ••

: ~- .... yl..f. ~-~h.. . ......... ~·..,_ L.'~ /.( Yf-'11 •·

.... ·,

4 -s <JLo..o • ... :; .

' "'fffr"'f'-M... ~ .V ~·~~-..r..JL -:~1/l'rcl\of~ '1

c.- ~ ~ ..;:. . ~-c...~ I~--~~-~~ l:~~~- Pc~Cwc-h"l <M)'•n~ J..<;c.o.., fv 4""'<4 - ~ ~ ~ ~ .. J:w.~ .. ..c,·o..... ~ _ ~ ~"f4;

.~ I~~~~ "MI~ )IS

~ : ("yfrr4.. 't_f~l...i.)

~~ .;: y-J-r

'4u. l4i.p; $p> J'-!1

(q 7. 10o7.

?o P. /O 7.

3-6.?. 4V (. 3t'},

u..<....·~ ~"" : r- N. ~ ..... .....o '4'"' (.I,) or-

'- Ul<~'j<t~US ..... ~l '4'"'-- {.f 1) "' ~ &-~·~ of d..'Afl..c.r~

.,. - W'-'- lv...... N,., ~~ .........W"'-

20 yowm. Routine chest x~ray sho\'led mediast i na l mass . At operati on l arge 10 by 10 by H) ems . ante!' i or f;tectiast·!ltal mass !,:vadi ;;g LL l obe of 1L;r.g . L

~ASE S- 69- 9769)_

DX·: MlWIASTINIJH - HALIGNAt-iT GERMINAL T!JNOR, TYPE "ENDODERMAT, sumS TUNOR" ( '"i'OI,K SAC TUHOR")

Ober ma n, H, A., et al.: Hal i.gnant gertni.na l t 1,nnors of t he medias tinum. Cancer, 17:498, 1964 .

Teiluin, G. : En do der ma 1 sinus tumors of t he ova ry ana t as t is . Cancer, 12: 1092 , 1959.

H..;ntington, R, ~1 . Jr . , e t al: Yolk sac tumors of extragonadal origin . Ca ncer, 25: 1368, 1970 .

~farin-Padilla, H.: Origin , nature and ~;ignificance of t11e "emb ~·yoids" of huma n teratomas , VirchO~VS A~·ch. Path. Ana t., 340 : 105, 1965 .

-VoeiL ~ tv ......... :z. :

t:!)n~ ·v.....,

~ H ·d• i.;­w-~.

~""~f

~ .,F '1Yh

j rr~~ ~·tr 4..2-- •

~ c .e...p.l-l.. 'ik<#.u.~ ~~~-L.~ <..M ... ~,J,.,.,.;.., ~ ~II« - .'i:>vw...t lo-.~~)

(t~') )

o~tv-?: ~ ~ 4-U._ q c , Q.p

~ ~ 1':<( "dla. o- .Po

~ ~~ · ~<Q,hliu<A..J

I

7-1132 55 yol'nn ' 'lith bar k pain x 1 yr.: He showed 3 subcutaneous l esio:'ls in r ight mandibul a , right ili ac crest and right axil"la .

CASE S-67-1132

OX: SOFT TI.SSUE - GRANULAR CELL TUHORS, THREE

' Thoren, L.: On the naullre and pathogenesis of t he s o-ca Ued Abril<osoff tumour . Ac~a Soc . ~led . Upps. , 55 : 125 , 1950 .

. Strong , E . H. , et .:~1 : Gr:~nul:lr cell myoblas t oma . cancer, ZS: 415, 1970 .

Garancis, J . C. , et al : Granular cell myoblastoma . cancer, 25 : 542 , 1970.

,.. L.

/

50 yO'.·r.n presen'.:~ ~·it!l a t h i r!•er>erl r l e :.tr~ 1 .,_ \"~Y i ln1!!JC i n thP Rl l • Surgi ca 1 procedure was performed.

CASE S-70- 2542

DX : LUNG & PLEUR'\ • FioRO~NTI:lOH.<\ ( INFL.A.MNA10RY PSWDOTUHOR, SCLEROSING HEMAN(HO~lA)

Liebo,. , A. A. , e t al : Scleros ing hemt~ ngiomo ( histiocy toma , :<o nthollla ) of t he l ung , Ca ncer, 9 : 53, 1956 .

Ti tus , J. L. , et n l: Xantho..-.atou s and inflamma t or y pseudotumors of the l ung . Ca ncer, 15 : 522, 1962 .

~lentworth , P . , et al : Xantholl'.a tous pseudotumo1· of l ung . A case r eport wi th electron mi c r oscopic and l.ip i d studies . Ca ncer , 22 : 345 , 1968 .

Fos ter , E. A,, et al. : l,ocalized mesothcliomn s of the pl eura . Amct . J , Clio . Pa th . , 34 : 349, 1960 .

-535 64 yo;'lln shcrc~e-Ja rectal m<>ss wh·ich increased ir. si ze in the 1ast yr- . {\surgical in t.e t~venl.i on \'.'a ~ per1Ur 1i~2U 'oi.H~ arht.) , t;.. \..~ lii:i ) Oil.! si g:-;ro i~ col on ;·tere removed . Start·ing at the anus , and extending up into the r-ectum is a 7. 5 ems. mass ~1ith an ulcet·ated surface. Section XIV and XV is colon , XVI- anal areas . XVII-rectal mucosa.

CASE S-535-69

DX: SKIN, AN liS - ANGIOS..>\RCOHA

Stout, A. P .: Uotr,angiocndothelioma : a tumor of blood vessels fca turing vaacular endothelial cells. Ann. Surg . , 118: 44.S, 1.943 .

Girard, C., ct a l: ·cutaneous an15:tosa rcoma . C<lccer, 26 : 868 , 1.970 .

9-333 76 yom \',•ith a fi rm 1.;f t ~ i,;r~ g .,at.!.') .,. ~!c::c: kn~.:>~ a •1d • .. rL ~ loss \·Je te · i iHpressi ve . Surgical speci nwr~s came from 1ef-t 1ung and pleur a which 1·/ei' e inf i1hated by t he t umor as v1e 11 as the thoraci c vta 11 . · I Biopsy I I: Pleu;-a, Biopsy I V: f·1al'gitis of t t.mlOi' i n l ung, Biopsy V: Marginsk:J pf tumor in l ung .

CASE S-69-333

OX: LUNG - ~\RCINOSARCO~~ --Ber gmann, H,', et al: Carcinos a rcoma o£ the lung . Ca ncer , 4: 919, 1951.

Stackhous e, E. M. ,. et al: Prima r y mi x ed ma l i gna nc i es of lung : ca·rc i nosarcoma and blastoma . J , Thor. Ca r cliova sc Surg ., 57 : 385, 1969 .

Ratzer, E , R., e t al: Pleural meso theliomas . Ame~ . J . Roen t genol., 99: 863, 1967 .

·70- 33~0 68 ya11m who , l'lhile hammering noted pain in the ri ght ~rm and ~hen . . deve l oped a r ap i dly sv1elli ng (fc· .. 1 days) mass i n the nght ant1cub nal fossa . At surgery the a:·ea gross ly l ooked li ke a hemat a11a .

CASE S-70-3340 ----DX: SOFT TISSUE - MALIGNANT l'IBROUS XI\NTBONA (l'rBROXANTHOSARCO~lA)

Q.'Brien, J . E., e t al: Haligoant fibrous xan t homas . Cancer, 17: 1445 , 1964.

Kempson, R, L. , et al : Atypical fibroxan thoiMs of the skin . Cancer, 17 : 1463 , 1,964 .

Kempson , R, L. , et al : Fibr oxa n thosarcomas of soEt tissue . Cancer (in press)

En zinger , F. H. , et a 1: Liposar coma . A stu,ly of 103 cases . Vircho_.s Arch . Path , Anat . , 335 : 367, 1962 .

-(

·&9- 6652 ·69-5401

2:l yo·,rf vlith 'l re cur rent abdominal pain and ascites for 4 yrs . 111 she has a surgical intervention ~II ell il biuf.~Y di~g~oserJ ;,s"acutc oer·i­tonitis ~lith mesotheli al pro1iferation" . She had tvro other intervent'ions at Du~c. ->The first one has the biopsy fJ 569- 6,!01; mated a 1 submitt ed vtas : "peritoneal lin~ng of don:c of bladder a11d ovary . One month l a,ter , the ovaries , tubes, and. uterus vrere removed (S- 59-6£52)

CASE S-69-6401 & S-69-6652

OX: PERITONT~lll'! - HALIGNAN'.r }!ESOTilELIOloiA, EPITHELIAL TYPE, DIFFUSE

Wl.nsl.ow, D. J., et at.: }t•Ugnant Jleritoneal mesothel1'o1• ·"· " " 13·.

127. 1960 . ·~- voncer '

·-70- 1203 46 yom ~lith a stomach ulcel'ation fo r 10 yrs . Partial gastrecto:cy was perfor;ned.

CASI! S- 70-1803 a DX: S!ONACR - SUPERFlCL.I\L REP"nc u~ I Ul ffit I

Efi~UA<... IWRElZPIA~A Ahlb IJI1MPt\Oib "WIP\i:RP!:A'i>LA­Bragg, D. G., ct al : Roentgenologic and p~thologic aspects of super­fic i al spreading carcinomo of the stomach . Amer. J, Roentgenol., 101 : 4 37, 1_967 .

Ha son , H . K: : Surface carciooma of the stomach. Gut, 6 : 185 , 1965 .

Perez , C. A., ct al. : Benign lymphoid hyperplasia of the stomach and duodenum. P.adiol. , 87 : 505, 1966.

70-!IBS

CASE S-70-91:!8

DX : HEDIAS1.'IW~·l,'I'H'iHUS- THYJ.:Ol·:A (;dth m:;astt'nia grav i s) ---........._

/0

Lattes , R.: '111yr .. oma and other tumors of the thymus . Cancer , 15 : 1224, 1962.

Hil!tins, J , ll, H. 1 e t a 1. : Cctses of thyl)loma at t he l·1•ssachusctts General Hospita l. J. Thor . Cardiova sc . Surg . , 52 : 32 2, 1966 .

Fechner, R. E.: Recurrence of noninvas ive thymomas . C~ncer, 23: Il>23, 1.969 .

Go l dstein , G., e t al. : The 'human thymus. l?arren U. Green , St . Louis , 1969 .

i10-8981

_C. .. SJL s_-70-898 t

!>X : LUNG - F!Bl\OXAN'rHOMA (Itl~'LAHt·lA 'IOnY PSEUllOTUHOR, SCL!':ROSING HENANGIOMA ) .. References same a s for Case S-70-3340

The patient has a mitral stenosi s c cal'C!iac f ail ure . 2 yrs. ago a cerv i cal bi opsy was diagnosed as intraepithelial carcinoma . In the middle of a recent ~lorK:UP a coin type lesion 11as found in the r i ght lung (inter l obar fiss ure . )

~ ('\

I J

"5u1U,~ gNIIto t.C6 y ~· ( 1-.J'/lr((_

~ u. '>O!iOcx.. of ~CA.LJ£. , ~. o~ ~~t..0~Y k/OV. 2.0 , f<{. 'l 0

CASE ,6 , ~2 79 (:., l)O-,[J-3- l !-J oT 1r\SOJI:¥e'ts)

OX: LYHPH NODES, BONE HARROH AND LIVER - HODGIUN' S DlSE:AS!l, LYMPHOCYTE DEPLETION (HODGKL"'' S SARCO:-'.A OF JACKSON Al<~D PARKER)

Kaplan, Ji , S. , et al.: Treatmen t of Hodgkin's di sease . Hed . Clin. N. Amer . , 50 : 1591, 1966

· Kelle>: , A. R., et al. : Con:elBtion of his topathol ogy 11ith other prognostic . in1i~~tors i n Hodgkin's disease. Cancer, 22 : 487 , 1968 .

Glal:stein , E., et al.: l'he va lue of laparotomy and splenectomy in t he sta ­ging of Hodgkin ' s disease . C.........u.,

Str um, s. Jl. , et al.: Obs erva tion of cells r ea embl i ng Sternberg-Reed cells .in conditions other than Hodgkin ~ s di se.1se. Cancer, 26 : 176, 1970 .

~ CASE S-69-9769)

OX: HED lASTINUH - HAT.IGNANT GEIU-ll:NAL TUHOl~, TYPE · "ENllO!JERl,1AL SXNUS 1'UMOR" ("YOLK SAC TUNOR")

Obe r man, II. A., et al.: ·~w l ignant germina l t umors of the med i astinulll. Canc er , 17:498, 1964 .

Tei1um, G, : Enclodcrmal s i nus tumors of the ova ry and testis . Cancer, 12 : 1092, 1959 .

Hunt ington , R,. H. J r ., e t a l: Yolk sse tumors of cxtragcnacla J. origin. Cn nce1:, 25 : 1368, 1970 .

~IDr :I. Jl·Padilla, N,: Origi11 , natu1·e a nd s :tgnificllnce of thE! "elt.bryol.ds " of hullt9 n tera toma s . Vi rc hotJs Arch . Pa th. Ana t • , 340 : 1C'5, 1 9',5 .

0 CASE S-67-1132

DX: SOFT TISSUJ> - GP-ANUU1R CELL 'rUMORS, THREE

' Thoren, 1 . : On tl>e mJM!re end patr.ogenesis oi ~he so-catll.'d Abrikoso£f tumour. Acta Soc . }fE!d. llpps., 55 :125,1950 .

Strong, E. W., et a1 : Granula r cell myoblas::oms. Canc"r , 25 : 415, 1970 .

Ga ranc is , J. C. , e t al : Granular cell tlyoblastoma . C:lncer, 25 : 542 , 1970 .

CASE S- 70-2542

DX: LUNG & PLEURA - FIBROXANTHONA (INFL/INMATORY PSEUD0Tl1t10R, SCUROS ING IIDIIINGIOo!A)

Liebo_. , A. A., e t al: Scl eros i ng hemangioma (hl s tiocyto:na, xanthoma ) of the l ung . Ca ncer, 9: 53, 1956 .

Ti.tus, J. L,, e t a 1: Xanthoma rous and inf.la!llll!oc1 to ry pseudo tumors of tho lung . Cancer , 15: 522 , 1962 .

l~ent,4orth , P., e t al : Xonthom,1tous pseudotumor of lung . A case report with e lectron mic roscopic end lipid studi es . Qlncer , 22 : 345 , 1968 .

~·oster, i:: , A., e t al. : Local ized mesotheliomas of t he pleur a . Amer. J. Clin . Pa t h . , 34 : 34 9 , 1960 .

CASE S-535-69

OX : SKIN , Al\'US - ANGIOsARCOMA '

Stout, A . P.: Hcmangioendo the liome : a t umor of hl ood vessels f:ca turi ng vasc ul ar endothelial cells . Ann . Surg . , 118 : 445 , 1943 ,

Girard , C., et s1: Cuta neous angiosat:como . Caocer , 26 : 868, 1970 .

CASE S-69-333

OX: LUNG - CARCINOSARCO~L'>

Bergma,n , 11., el al : Corcinosarco~ of the lu!l&. Qlnccr, 4 : 919, 1951.

Sta ckhouse , E . ~1. , e t a ]: Pr:i.mnt·y mixed ma li&nbnc ies of lung : carcinoar.J:coma and blastoma . J . Thor . Cardiovasc Sur g ., 57: 385, 1969.

Rotzer, E. R. , el a 1 : Pleural m,Go tl;-llomas . At.er . J. F.o.:>entg"nol. , 99. 863 , 1967 .

CASE S- 70- 3340

DX : SOFT TISSU\1 - HALIGNAN'£ FDl ROUS XANTHOHA (F iBROXANTHOSARCOHA)

O'Brien, J. " ..... . ) et " l : !:'i l i.~~~nt fibro~s ::an!:r.o:-:.3s . Canc~r, 17 : 1445. 196!,.

Keropson, R. l.. ) et al : Atypic11l f ibrox11 :1 thom"s of t he skin . CtJnce.r , li : 1463, 1964 .

.

Kempson , R. L._. c t <tl: Fibroxanthosarcomas of soft tissue . Ctncer (in p.res s)

. ' 1 • ?~

' I

' 1

~~ S-69-6401 AND _1:,.69-665?_

DX: PERI TONl'lUH - ~1AJ.IGNANT Hl.lSOTiiELIO~L.~, EPl11ll\LIAL TYPt::, DIFFUSE. ""· AT'lPI~ ~n.<l.o~ ~Pe-ePo..A~<rt~ -

~linsloH , D. J., et al : l'.alignant perit:o114<1l mcsotheliow.as . Cancer, 13 : 127, 1960 .

CASE S-70-1803

DX: S'l\'li'1ACJ1 - SUPERFIC I AL Pl!l?'l'IC ULCTlll, l~I'rll RP.GENEHA'CXON ATYPIA OF TU E! EPITHELIUM AND LYMPHOID HYPERPLASIA

Bragg, D. G., et ~tl : Rocnt genologgc and pathologic a spt:c ts of superficial sprcoding carcinoma of t he .stomach. A mer. J. 1\oentgenol . , 101 : t,:n , 1967 .

Hason , :;!. K.: Surface carcinor•:t of the stom3ch . Gut , 6: 185, 1965 . ~ ~ ..

Perez, c. A. , et al : lle11ign lymphoid l1ypr~rplosi.n of tho stomach and duodenum. Radiol., 87: 505, 1966 .

CASE S- 70-g 13_1!_

OX : HEDIASTI:ltn! , TJmrus - THYMO~l-'. (Hith t!lyasti!nia gravis)

LaLtes , R. : Thymo1M end othor tumors of the thymll~ . ~:lnc .. r, 15 : 1224, 1%2 .

Hilkins, J . E. \•., et sl : Cssc:; of thyc'Oma at the Ha~sa.,hnsetts General Hospital . J . Tnor . C3rdiovasc . Surg. , 52 : 322 , 1966 .

l'Pchner , R. E. : Rec l•rrence of. non i nvasive t hymo11ws . C,HTCe>.·, 23 : 11,23 , 1969 .

Goldstein, C:., et :11: The h•rronthymuc. ~:ar~'!n Tf C'rc~n, St. Lt-lliS, 19b9 .

. CASE S-70-8931

References St< me as for Ca s e li-70-33!•0 .