Not actual patients

If you’ve been diagnosed with a chronic (long-lasting) interstitial lung disease (ILD) in which lung fibrosis continues to worsen or progress

Put OFEV to Work for You

Visit ofev.com

Learn how OFEV® (nintedanib) capsules can slow the decline in lung function.

Please see Important Safety Information throughout this brochure and accompanying Patient Information.

Please see Important Safety Information throughout this brochure and accompanying Patient Information.

2

Understanding your diseaseChronic interstitial lung disease (ILD) with worsening fibrosis is a serious, progressive disease that continues to worsen over time and can cause irreversible lung damage.

Worsening fibrosis in the lungs makes it harder for you to breathe and makes it difficult for your lungs to supply your body with the oxygen it needs. Here are some basics:

Your doctor has recommended OFEV® (nintedanib) capsules for you. OFEV can slow the rate of decline in lung function in people with chronic interstitial lung disease in which lung fibrosis continues to worsen.

Interstitial Lung Disease

› Scarring and/or inflammation that develops around the tiny air sacs in the lungs, called alveoli

› Space around the air sacs is called interstitial space and scarring occurs in that space, giving the disease its name

Lung Fibrosis (also called pulmonary fibrosis)

› Scarring of the lung tissue that can worsen and spread throughout the lungs over time

› Damages the lung structure

› As it worsens, it makes it more difficult for your lungs to work properly

What is OFEV? › OFEV is a prescription medicine used to treat people with a chronic (long lasting) interstitial lung disease in which lung fibrosis continues to worsen (progress).

› It is not known if OFEV is safe and effective in children.

Please see Important Safety Information throughout this brochure and accompanying Patient Information.

3

Understanding OFEVOFEV helps slow the decline in lung function with just 1 capsule twice daily.

OFEV is the only twice-daily prescription medication that helps slow the progression of chronic ILD with worsening fibrosis. It is known to block some of the activity that causes scarring in the lungs.

How to take OFEV

The usual dose of OFEV is one 150-mg capsule twice a day (one in the morning and one in the evening)

Take OFEV with adequate food approximately 12 hours apart and swallow it whole with liquid

If you miss a dose, skip it and take your next dose at the regular time. Do not take 2 doses at the same time

Do not chew or crush OFEV

If you take too much OFEV (more than 300 mg in one day) call your doctor or go to the nearest emergency room right away

Before you begin taking OFEV, your doctor will schedule several tests, including a liver function test and a pregnancy test, if appropriate

Important Safety InformationWhat is the most important information I should know about OFEV?OFEV can cause harm, birth defects, or death to an unborn baby. Women should not become pregnant while taking OFEV. Women who are able to become pregnant should have a pregnancy test before starting treatment and should use highly effective birth control at the start of treatment, during treatment, and for at least 3 months after your last dose. Talk with your doctor about what birth control method is right for you during this time. Birth control pills may not work as well in women having vomiting, diarrhea, or other problems reducing the drug absorption. If you have any of these problems, talk with your doctor about what highly effective birth control method is right for you. If you become pregnant or think you are pregnant while taking OFEV, tell your doctor right away.

Please see Important Safety Information throughout this brochure and accompanying Patient Information.

4

Important Safety InformationWhat should I tell my doctor before using OFEV?Before you take OFEV, tell your doctor about all of your medical conditions, including if you have:

› liver problems.

› heart problems.

› a history of blood clots.

› a bleeding problem or a family history of a bleeding problem.

› had recent surgery in your stomach (abdominal) area.

Preserve more lung function with OFEV

Results were determined by measuring the participants’ forced vital capacity (FVC) after 1 year of therapy.

FVC is the amount of air you can forcibly exhale after taking the deepest breath possible. It is used to indicate the status of your lung function and, over time, can show how much the disease is progressing.

In a 1-year medical study, participants taking OFEV® (nintedanib) capsules experienced

57% less(107 mL/yr) decline in lung function

when compared to participants not taking OFEV.

5

Important Safety InformationWhat should I tell my doctor before using OFEV? (cont’d)Tell your doctor if you:

› are pregnant or plan to become pregnant.

› are breastfeeding or plan to breastfeed. It is not known if OFEV passes into your breast milk. You should not breastfeed while taking OFEV.

› are a smoker. You should stop smoking prior to taking OFEV and avoid smoking during treatment.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements such as St. John’s wort.

In a 1-year study, lung function, measured by FVC, was compared from the end to the start of the study. Among patients not taking OFEV, 15% maintained lung function.

*Maintained lung function is no change in FVC or up to a 10% improvement in FVC.

Maintain more lung function with OFEV

30% maintained lung function* for 1 year

while 15% of participants not taking OFEV maintained their lung function.

Not actual patients

Please see Important Safety Information throughout this brochure and accompanying Patient Information.

Please see Important Safety Information throughout this brochure and accompanying Patient Information.

6

Every step of the way, OPEN DOORS® is on your sideOPEN DOORS® is a complimentary program that offers personalized, caring support for people taking OFEV® (nintedanib) capsules.

As an OPEN DOORS® member, you are never alone. You’ll have 24/7 nursing support and a personal care team you can call, or connect with, at any time

Your OPEN DOORS® care team has a deep understanding of chronic ILD with worsening fibrosis, the challenges you’re facing, and OFEV. Even more important, they know you

The Social Resource Center (part of OPEN DOORS®) is designed for you and your caregiver. It helps you identify local support groups and access social resources. You don’t have to struggle with chronic ILD with worsening fibrosis all alone

Important Safety InformationWhat are the possible side effects of OFEV?OFEV may cause serious side effects.

TELL YOUR DOCTOR RIGHT AWAY if you are experiencing any side effects, including:

› Liver problems. Unexplained symptoms may include yellowing of your skin or the white part of your eyes (jaundice), dark or brown (tea-colored) urine, pain on the upper right side of your stomach area (abdomen), bleeding or bruising more easily than normal, feeling tired, or loss of appetite. Your doctor will do blood tests to check how well your liver is working before starting and during your treatment with OFEV.

Call 1-866-OPENDOOR (1-866-673-6366) or visit ofev.com/support/open-doors

Please see Important Safety Information throughout this brochure and accompanying Patient Information.

7

Important Safety InformationWhat are the possible side effects of OFEV? (cont’d)OFEV may cause serious side effects.

TELL YOUR DOCTOR RIGHT AWAY if you are experiencing any side effects, including:

› Diarrhea, nausea, and vomiting. Your doctor may recommend that you drink fluids or take medicine to treat these side effects. Tell your doctor if you have these symptoms, if they do not go away, or get worse, and if you are taking over-the-counter laxatives, stool softeners, and other medicines or dietary supplements.

› Heart attack. Symptoms of a heart problem may include chest pain or pressure, pain in your arms, back, neck, or jaw, or shortness of breath.

› Stroke. Symptoms of a stroke may include numbness or weakness on one side of your body, trouble talking, headache, or dizziness.

› Bleeding problems. OFEV may increase your chances of having bleeding problems. Tell your doctor if you have unusual bleeding, bruising, wounds that do not heal, and/or if you are taking a blood thinner, including prescription blood thinners and over-the-counter aspirin.

› Tear in your stomach or intestinal wall (perforation). OFEV may increase your chances of having a tear in your stomach or intestinal wall. Tell your doctor if you have pain or swelling in your stomach area.

Copyright © 2020, Boehringer Ingelheim Pharmaceuticals, Inc.All rights reserved. (11/20) PC-US-117948

Partner with your healthcare team and put OFEV® (nintedanib) capsules to work for you

Take the next step with OFEV

Important Safety InformationWhat are the possible side effects of OFEV? (cont’d)OFEV may cause serious side effects.

The most common side effects of OFEV are diarrhea, nausea, stomach pain, vomiting, liver problems, decreased appetite, headache, weight loss, and high blood pressure.

These are not all the possible side effects of OFEV. For more information, ask your doctor or pharmacist. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

CL-OF-100047 10.28.2020

Not actual patients

Please see Important Safety Information throughout this brochure and accompanying Patient Information.

Help preserve more of your lung function with 1 capsule twice daily and surround yourself with support.